检索结果-南通市图书馆

NeCAB family of neuronal calcium-binding proteins in health and disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Species diversity in restoration plantings: Important factors for increasing the diversity of threatened tree species in the restoration of the Araucaria forest ecosystem

在线全文

学校读者我要写书评

暂无评论

Plant Diversity 2019年第2期41卷 84-93页

作者： taylor e.Shaw School of Biological Sciences University of East Anglia Norwich Research Park

The Araucaria forest ecosystem in southern Brazil is highly threatened: less than one percent of the original forest remains, and what is left is a fragmented agro-mosaic of mostly early-to-late secondary forest patches among high-yield agriculture and timber monocultures. Forest restoration initiatives in this region aim to restore degraded areas, however the limited number of species used in restoration projects represents a missed opportunity for species-rich plantings. High diversity plantings represent a larger number of functional groups and provide a targeted conservation strategy for the high number of threatened species within this ecosystem. This study interviewed nurseries(Ns) and restoration practitioners(RPs) in Parana and Santa Catarina states to identify what species are being cultivated and planted, and what factors are driving the species selection process. An average of 20 species were reportedly used in restoration plantings, most of which are common, widespread species. Baseline data confirms that Ns and RPs have disproportionately low occurrences of threatened species in their inventories and plantings, supporting findings from previous research. Questionnaire responses reveal that opportunities for seed acquisition are an extremely important factor in order for nurseries to increase their diversity of cultivated species. Results also suggest that facilitating speciesrich plantings for restoration practitioners would only be feasible if it did not increase the time required to complete planting projects, as it would minimize their ability to keep costs low. This study proposes solutions for increasing the number of species used in restoration practicedsuch as developing a comprehensive species list, fostering knowledge-sharing between actors, creating seed sharing programs, and increasing coordination of planting projects. Long-term strategies involve complimenting traditional ex situ approaches with emerging inter-situ and quasi in situ conserv

关键词： Restoration Araucaria forest Threatened species Nurseries Restoration practitioners Decision-making

In vivo mouse models to study bile acid synthesis and signaling

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2023年第5期22卷 466-473页

作者： Anisha Bhattacharya Rulaiha e taylor Grace L Guo Department of Pharmacology and Toxicology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNew JerseyUSA Rutgers Center for Lipid Research RutgersThe State University of New JerseyNew BrunswickNew JerseyUSA environmental and Occupational Health Sciences Institute RutgersThe State University of New JerseyPiscatawayNew JerseyUSA VA New jersey Health Care System Veterans Administration Medical CenterEast OrangeNew JerseyUSA

The synthesis of bile acids(BAs)is carried out by complex pathways characterized by sequential chemical reactions in the liver through various cytochromes P450(CYP)and other *** the integrity of these pathways is crucial for normal physiological function in mammals,encompassing hepatic and neurological *** on the deficiencies in BA synthesis genes offers valuable insights into the significance of BAs in modulating farnesoid X receptor(FXR)signaling and metabolic *** creating mouse knockout(KO)models,researchers can manipulate deficiencies in genes involved in BA synthesis,which can be used to study human diseases with BA *** KO mouse models allow for a more profound understanding of the functions and regulations of genes responsible for BA ***,KO mouse models shed light on the distinct characteristics of individual BA and their roles in nuclear receptor ***,alterations of BA synthesis genes in mouse models have distinct differences when compared to human diseases caused by the same BA synthesis gene *** review summarizes several mouse KO models used to study BA synthesis and related human diseases,including mice deficient in Cyp7a1,Cyp27a1,Cyp7a1/Cyp27a1,Cyp8b1,Cyp7b1,Cyp2c70,Cyp2a12,and Cyp2c70/Cyp2a12,as well as germ-free mice.

关键词： Bile acid Species difference Farnesoid X receptor Liver diseases

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Biomarkers of An Autoimmune Skin Disease——Psoriasis

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2015年第4期13卷 224-233页

作者： Shan jiang taylor e.Hinchliffe Tianfu Wu Department of Dermatology Renmin Hospital of Wuhan University Department of Biomedical engineering University of Houston

Psoriasis is one of the most prevalent autoimmune skin diseases. However, its etiology and pathogencsis are still unclear. Over the last decade, omics-based technologies have been exten- sively utilized for biomarker discovery. As a result, some promising markers for psoriasis have been identified at the genome, transcriptome, proteome, and metabolome level. These discoveries have provided new insights into the underlying molecular mechanisms and signaling pathways in psoriasis pathogenesis. More importantly, some of these markers may prove useful in the diagnosis of psoriasis and in the prediction of disease progression once they have been validated. In this review, we summarize the most recent findings in psoriasis biomarker discovery. In addition, we will discuss several emerging technologies and their potential for novel blomarker discovery and diagnostics for psoriasis.

关键词： Psoriasis Biomarker Genomics Proteomics Metabolomics

The association between Tai Chi exercise and safe driving performance among older adults： An observational study

在线全文

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2018年第1期7卷 83-94页

作者： Sally Miller Ruth e.taylor-Piliae School of Nursing Vanderbilt University Nashville TN 37240 USA College of Nursing The University of Arizona Tucson AZ 85721 USA

Background: Age-related cognitive and physical decline can impair safe driving performance. Tai Chi exercise benefits cognitive and physical function and may influence safe driving performance in older adults. The primary aim of this observational study was to compare cognitive processes and physical function related to safe driving performance among older adult Tai Chi practitioners to normative reference *** aims were to examine relationships between Tai Chi exercise habits, cognitive processes, and physical function related to safe driving performance and to explore potential predictors of safe driving ***: The Driving Health Inventory, the Driving Scenes Test, other driving-related cognitive and physical measures, and self-reported measures including the Mindful Attention Awareness Scale(MAAS) and the Vitality Plus Scale(VPS) were collected from current Tai Chi practitioners(n = 58; age 72.9 ± 5.9 years, mean ± SD) with median >3 years Tai Chi ***: Compared to normative reference values, participants performed better on numerous cognitive measures including the Driving Scenes Test(p e navigation(p = 0.017, d = 0.27), the Useful Field of View Test(p easures including the Rapid Walk Test(p e Right Foot Tapping Test,(p ed higher than normative reference values on MAAS and VPS(p espectively). Statistically significant correlations were found between several study measures. The digit span backward test was the strongest predictor of safe driving performance(β = 0.34,p = 0.009).Conclusion: Tai Chi exercise has the potential to impact cognitive processes and physical function related to safe driving performance. Further study using randomized controlled trials, structured Tai Chi exercise doses, and driving simulator or on-road driving performance as outcome measures

关键词： Automobile driving Driving performance exercise Older adults Physical activity Tai Chi

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Prograde and retrograde growth of monazite in migmatites:An example from the Nagercoil Block,southern India

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2015年第3期6卷 373-387页

作者： Tim e.johnson Chris Clark Richard j.M.taylor M.Santosh Alan S.Collins Department of Applied Geology The Institute for Geoscience Research(TIGeR)Curtin University School of the earth Sciences and Resources China University of Geosciences(Beijing) Tectonics Resources and Exploration(TRaX)Department of Earth SciencesUniversity of Adelaide

Data from a migmatised metapelite raft enclosed within charnockite provide quantitative constraints on the pressure-temperature-time （P-T-t） evolution of the Nagercoil Block at the southernmost tip of peninsular India. An inferred peak metamorphic assemblage of garnet, K-feldspar, sillimanite, plagioclase, magnetite, ilmenite, spinel and melt is consistent with peak metamorphic pressures of 6-8 kbar and temperatures in excess of 900 ℃. Subsequent growth of cordierite and biotite record high-temperature retrograde decompression to around 5 kbar and 800 ℃. SHRIMP U-Pb dating of magmatic zircon cores suggests that the sedimentary protoliths were in part derived from felsic igneous rocks with Palae- oproterozoic crystallisation ages. New growth of metamorphic zircon on the rims of detrital grains constrains the onset of melt crystallisation, and the minimum age of the metamorphic peak, to around 560 Ma. The data suggest two stages of monazite growth. The first generation of Ree-enriched monazite grew during partial melting along the prograde path at around 570 Ma via the incongruent breakdown of apatite. Relatively Ree-depleted rims, which have a pronounced negative europium anomaly, grew during melt crystallisation along the retrograde path at around 535 Ma. Our data show the rocks remained at suprasolidus temperatures for at least 35 million years and probably much longer, supporting a long-lived high-grade metamorphic history. The metamorphic conditions, timing and duration of the implied clockwise P-T-t path are similar to that previously established for other regions in peninsular India during the ediacaran to Cambrian assembly of that part of the Gondwanan supercontinent.

关键词： Monazire Migmatite Zircon Geochronology Phase equilibria modelling Gondwana

Inter-signal interaction and uncertain information in anuran multimodal signals

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2011年第2期57卷 153-161页

作者： Ryan C. taylor Barrett A. KLeIN Michael j. RYAN Department of Biological Sciences Salisbury University Salisbury MD 21801 USA Section of Integrative Biology University of Texas at Austin Austin TX 78712 USA Smithsonian Tropical Research Institute P.O. Box 0843-03092 Balboa Ancon Republic of Panama

Disentangling the influence of multiple signal components on receivers and elucidating general processes influencing complex signal evolution are difficult tasks. In this study we test mate preferences of female squirrel treefrogs Hyla squirella and female tungara frogs Physalaemus pustulosus for similar combinations of acoustic and visual components of their multimodal courtship signals. In a two-choice playback experiment with squirrel treefrogs, the visual stimulus of a male model significantly increased the attractivness of a relatively unattractive slow call rate. A previous study demonstrated that faster call rates are more attractive to female squirrel treefrogs, and all else being equal, models of male frogs with large body stripes are more attractive. In a similar experiment with female tungara frogs, the visual stimulus of a robotic frog failed to increase the attractiveness of a relatively unattractive call. Females also showed no preference for the distinct stripe on the robot that males commonly bear on their throat. Thus, features of conspicuous signal components such as body stripes are not universally important and signal function is likely to differ even among species with similar ecologies and communication systems. Finally, we discuss the putative information content of anuran signals and suggest that the categorization of redundant versus multiple messages may not be sufficient as a general explanation for the evolution of multimodal signaling. Instead of relying on untested assumptions concerning the information content of signals, we discuss the value of initially collecting comparative empirical data sets related to receiver responses.

关键词： Inter-signal interaction Multimodal signaling Signal detection Signal weighting Squirrel treefrog Hyla squirella Tfingara frog Physalaemus pustulosus Vocal sac