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Hunting for a viral proxy in bioaerosols of swine buildings using molecular detection and metagenomics

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journal of environmental Sciences 2025年第2期148卷 69-78页

作者： Valérie Létourneau Marie-josée Gagné jonathan M.Vyskocil Vincent Brochu Kim Robitaille Martin Gauthier julie Brassard Caroline Duchaine Quebec Heart and Lung Institute Research Centre-UniversitéLaval 2725 Chemin Sainte-FoyQuebecG1V 4G5Canada Saint-Hyacinthe Research and Development Centre Agriculture and Agri-Food Canada3600 Casavant Boulevard WestSaint-HyacintheJ2S 8E3Canada Department of Biochemistry Microbiologyand Bio-informaticsFaculty of Science and EngineeringUniversitéLaval1045 Avenue de la MédecineQuebecG1V 0A6Canada The Swine and Poultry Infectious Diseases Research Centre Faculty of Veterinary Medicine of Universitéde Montréal3200 Rue SicotteSaint-HyacintheJ2S 2M2Canada

There are limited biosecurity measures directed at preventing airborne transmission of viruses in *** effectiveness of dust mitigation strategies such as oil sprinkling,to decrease risk of airborne virus transmission are *** and qPCR for common fecal viruses were used to hunt for a ubiquitous virus to serve as a proxy when evaluating the efficiency of mitigation strategies against airborne viral infectious *** particles were collected from swine buildings using high-volume air *** DNA and RNA were used to perform specific RT-qPCR and qPCR and analyzed by highthroughput *** astroviruses group 2 were common(from 102 to 105 genomic copies per cubic meter of air or gc/m^(3),93%positivity)while no norovirus genogroup II was recovered from air *** torque teno sus virus were detected by qPCR in low concentrations(from 101 to 102 gc/m^(3),47%positivity).Among the identified viral families by metagenomics analysis,Herelleviridae,Microviridae,Myoviridae,Podoviridae,and Siphoviridae were *** phage vB_AviM_AVP of Aerococcus was present in all air samples and a newly designed qPCR revealed between 101 and 105 gc/m^(3) among the samples taken for the present study(97%positivity)and banked samples from5-and 15-year old studies(89%positivity).According to the present study,both the porcine astrovirus group 2 and the phage vB_AviM_AVP of Aerococcus could be proxy for airborne viruses of swine buildings.

关键词： Bioaerosols Viral metagenomics Astrovirus Aerococcus phage Swine buildings

Constraints on what controls millennial-scale basin-wide denudation across mountain belts,Asia

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Science China earth Sciences 2025年第1期68卷 74-93页

作者： Ye YANG Steven A.BINNIe Sheng XU Cong-Qiang LIU Tibor j.DUNAI Institute of Surface-earth System Science School of Earth System ScienceTianjin UniversityTianjin300072China Institute of Geology and Mineralogy University of CologneCologne50674Germany

The terrestrial cosmogenic nuclide dataset consisting of 1233^(10)Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on earth-surface denudation processes.^(10)Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr^(-1)(1σ;Central Tibetan Plateau)to 9,646_(-744)^(+777)mm kyr^(-1)(1σ;Southern Tibetan Plateau),with a median of 186 mm kyr^(-1).Comparing our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that(1)topographic

关键词： ^(10)Be-derived denudation rate Climate change Tectonic uplift Topographic gradient Asian mountains

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

New discoveries of young stars revise our star formation history in the Taurus Molecular Cloud

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Science China(Physics,Mechanics & Astronomy) 2025年第04期Mechanics & Astronomy) .卷 267-268页

作者： Gregory j.Herczeg Kavli Institute for Astronomy and Astrophysics Peking University Department of Astronomy School of Physics Peking University

As one of the nearest sites of low-mass star formation, the Taurus Molecular Cloud provides us with a foundation for how low-mass stars form and evolve. The members include T Tau, the namesake for the entire T Tauri class of stars, the famous HL Tau disk, and several of the most famous protostars. The cluster is not a single site of star formation, but a complicated combination of very young protostars, older generations of stars, along with gas and dust.

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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease:lessons from animal studies

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Neural Regeneration Research 2025年第12期20卷 3461-3475页

作者： Wouter Claeys Anja Geerts Lien Van Hoecke Christophe Van Steenkiste Roosmarijn e.Vandenbroucke Department of Internal Medicine and Paediatrics Hepatology Research UnitGhent UniversityGhentBelgium Liver Research Center Ghent Ghent UniversityGhent University HospitalGhentBelgium Barriers in Inflammation VIB-UGent Center for Inflammation ResearchVIBGhentBelgium Department of Biomedical Molecular Biology Ghent UniversityGhentBelgium Department of Gastroenterology and Hepatology Ghent University HospitalGhentBelgium Department of Gastroenterology and Hepatology Antwerp UniversityAntwerpBelgium Department of Gastroenterology and Hepatology Maria Middelares HospitalGhentBelgium

Hepatic encephalopathy,defined as neuropsychiatric dysfunction secondary to liver disease,is a frequent decompensating event in *** clinical impact is highlighted by a notable increase in patient mortality rates and a concomitant reduction in overall quality of ***,liver disease,liver function failure,portosystemic shunting,and associated multi-organ dysfunction result in the increase of disease-causing neurotoxins in the circulation,which impairs cerebral *** circulating neurotoxins are ammonia and inflammatory *** the brain,pathophysiology is less well understood,but is thought to be driven by glial cell *** are the only brain resident cells that have ammonia-metabolizing machinery and are therefore putatively most susceptible to ammonia *** on a large body of mostly in vitro evidence,ammonia-induced cellular and molecular disturbances include astrocyte swelling and oxidative ***,the brain resident macrophages,have been linked to the translation of systemic inflammation to the brain *** evidence from animal studies has provided novel insights into old and new downstream effects of astrocyte and microglial dysfunction such as toxin clearance disruption and myeloid cell attraction to the central nervous system ***,state of the art research increasingly implicates neuronal dysfunction and possibly even irreversible neuronal cell ***-type specific investigation in animal models highlights the need for critical revision of the contribution of astrocytes and microglia to well-established and novel cellular and molecular alterations in hepatic *** this review,we therefore give a current and comprehensive overview of causes,features,and consequences of astrocyte and microglial dysfunction in hepatic encephalopathy,including areas of interest for future investigation.

关键词： ammonia astrocytes cirrhosis hepatic encephalopathy microglia neuroinflammation osmotic stress oxidative stress systemic inflammation

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemical engineering(Integrated process) Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Republic of Korea Department of Chemical engineering and Materials Science Ewha Womans University52 Ewhayeodae-gilSeodaemun-guSeoul 03760Republic of Korea Department of Chemical engineering Pukyong National University45 Yongso-roNam-guBusan 48513Republic of Korea Resources engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol(1,6-HDO) with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments(LCAs).Strategy A was found to be the most favorable both economically(USRDSCHARDOLLAR3,402/ton) and environmentally(-26.9 kg CO_(2)eq.). This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 120-127页

作者： Lujun Huang Bin jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong Li Andrey e.Miroshnichenko School of Physics and electronic Sciences East China Normal UniversityShanghai 200241China Institute of Acoustics Tongji UniversityShanghai 200092China L.V.Kirensky Institute of Physics Krasnoyarsk 660036Russia Department of Mechanical engineering Rowan UniversityGlassboro 08028USA School of engineering and Technology University of New South Wales at CanberraACT 2610Australia

Bound states in the continuum(BICs)are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional toΔL^(−4),whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective non-Hermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Human activities are intensifying the spatial variation of landslides in the Yellow River Basin

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Science Bulletin 2025年第2期70卷 263-272页

作者： Naiman Tian Hengxing Lan Langping Li jianbing Peng Bojie Fu john j.Clague State Key Laboratory of Resources and environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Geological engineering and Geomatics Chang’an UniversityXi’an 710054China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of ecological Geology and Disaster Prevention Ministry of Natural ResourcesXi’an 710054China State Key Laboratory of Urban and Regional ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of earth Surface Processes and Resource ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Department of earth Sciences Simon Fraser UniversityBurnaby BCV5A 1S6Canada

Human activities are a triggering factor for landslides in the Yellow River Basin(YRB,China).However,the extent to which the spatial distribution of landslides is affected by human activities is *** constructed a human activity intensity index(HAII)based on nighttime light data and land cover *** and dominance analyses were used to compare the effects of the HAII,precipitation,distance to river,distance to fault,topographic relief and slope on the landslides spatial density(LSD).The results showed that in the YRB,the HAII,as a dominance influencing factor,had a significant positive influence on the ***,regional differences in the human disturbance of nature intensify the spatial variation of *** quantify the intensity of human disturbance to nature,a human-nature conflict index(HNCI)is constructed by quantifying the difference between the slope distributions of artificial and natural *** results show that in the middle section of the YRB,humans are developing more steep mountainous areas,leading to more dense *** study provides a reference for landslide risk management and land use planning in the YRB.

关键词： Landslide Human activities Spatial variation Human-nature conflict Yellow River Basin

Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition

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Neural Regeneration Research 2025年第11期20卷 3225-3226页

作者： Mahboubeh Ahmadi Nahid Rouhi javad Mirnajafi-Zadeh Bechara j.Saab Department of Physiology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Mobio Interactive Pte.Ltd. SingaporeRepublic of Singapore

Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain *** dopamine is primarily associated with pleasure,reward,and motivation,its effects can be quite complex;and this complexity is further compounded when examining how dopamine functions in typical versus disease-affected neural *** pa rticula r,epilepsy,characte rized by heightened brain excitability,is linked to cognitive dysfunction,and dopamine is implicated in elements of both its pathology and *** has been successful in describing the synaptic abnormalities believed to contribute to memory issues in epilepsy,aiding in the search for effective therapies for what persists as a major medical issue.

关键词： dopamine epilepsy primarily