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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Laser additive manufacturing of biodegradable Mg-based alloys for biomedical applications: A review

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journal of Magnesium and Alloys 2022年第4期10卷 915-937页

作者： c.L.wu w.j.Xie H.c.Man Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Metallic implants are widely used in internal fixation of bone fracture in surgical *** are mainly used for providing mechanical support and stability during bone reunion,which usually takes a few months to *** implants made of stainless steels,Ti-based alloys and cocrMo alloys have been widely used for orthopedic reconstruction due to their high strength and high corrosion *** metallic implants will remain permanently inside the body after implantation,and a second surgery after bone healing is needed because the long-term presence of implant will lead to various *** implant removal surgery not only incurs expenditure,but also risk and psychological *** a consequence,studies on the development of biodegradable implants,which would degrade and disappear in vivo after bone reunion is completed,have drawn researchers’*** this connection,Mg-based alloys have shown great potentials as promising implant materials mainly due to their low density,inherent biocompatibility,biodegradability and mechanical properties close to those of ***,the high degradation rate of Mg-based implants in vivo is the biggest hurdle to *** from materials selection,a fixation implant is ideally tailor-made in size and shape for an individual case,for best surgical ***,laser additive manufacturing(LAM),with the advent of sophisticated laser systems and software,is an ideal process to solve these *** this paper,we reviewed the progress in LAM of biodegradable Mg-based alloys for biomedical *** effect of powder properties and laser processing parameter on the formability and quality was thoroughly *** microstructure,phase constituents and metallurgical defects formed in the LAMed samples were *** mechanical properties,corrosion resistance,biocompatibility and antibacterial properties of the LAMed samples were summarized and compared with samples fabricated by

关键词： Laser additive manufacturing Magnesium alloys Implant Biomedical applications Mechanical properties Biodegradability

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One-step multi-compositional oxidation of YSi alloy:Experiments and ab initio computation

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journal of Materials Science & Technology 2023年第27期158卷 253-262页

作者： w.j.wang j.c.Luo L.chen G.j.Yang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an jiaotong University Suzhou Institute Suzhou 215123China

YSi alloy is a promising candidate as oxidation resistant coatings for both the bond coat of environmental barrier coatings(EBcs)and anti-ablation coatings at a high temperature of∼1300℃.In this study,a one-step multi-compositional oxidation by rapid heating oxidation mode is proposed to reduce the oxidation rate by 3.6 times compared to conventional slow heating oxidation *** show that preferentially formed Y_(2)O_(3) oxide initiates a multi-step oxidation,produces a cracking and porous oxides,and thereby resulting in a fast oxidation with *** one-step multi-compositional oxidation with a compact and dense Y_(2)Si_(2)O_(7)scale contributes to the much better oxidation resistance for rapid heating oxidation mode of YSi *** stable formation of Y_(2)Si_(2)O_(7)scale is comprehensively understood by the energy barrier,charge density and electronic level based on density functional *** study demonstrates a promising application of YSi alloy by rapid heating oxidation mode.

关键词： YSi alloy One-step oxidation Multi-compositional scale Y_(2)Si_(2)O_(7) Energy barrier

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Numerical Simulation of Temperature Distribution and ThermalStress Field in a Turbine Blade with Multilayer-Structure TBcs by a Fluid–Solid coupling Method

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journal of Materials Science & Technology 2016年第5期32卷 452-458页

作者： w.Z.Tang L.Yang w.Zhu Y.c.Zhou j.w.Guo c.LU Key Laboratory of Key Film Materials and Application for Equipment(Hunan Province) School of Materials Science and EngineeringXiangtan UniversityXiangtan 411105China Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education School of Materials Science and EngineeringXiangtan UniversityXiangtan 411105China Hunan Provincial Key laboratory of Thin Film Materials and Devices School of Materials Science and EngineeringXiangtan UniversityXiangtan 411105China School of Mechanical Engineering Xiangtan University Xiangtan 411105China Department of Mechanical Engineering Curtin UniversityPerthWA 6845Australia

To study the temperature distribution and thermal-stress field in different service stages, a two-dimensional model of a turbine blade with thermal barrier coatings is developed, in which the conjugate heat transfer analysis and the decoupled thermal-stress calculation method are adopted. Based on the simulation results, it is found that a non-uniform distribution of temperature appears in different positions of the blade surface, which has directly impacted on stress field. The maximum temperature with a value of 1030 ℃ occurs at the leading edge. During the steady stage, the maximum stress of thermally grown oxide （TGO） appears in the middle of the suction side, reaching 3.75 GPa. At the end stage of cooling, the maximum compressive stress of TGO with a value of-3.5 GPa occurs at the leading edge. Thus, it can be predicted that during the steady stage the dangerous regions may locate at the suction side, while the leadine edge mav be more Drone to failure on cooling.

关键词： Thermal barrier coatings Temperature distribution Thermal-stress field conjugate heat transfer Decoupled thermal-stress calculation Fluid–solid coupling

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On the microstructural origin of premature failure of creep strength enhanced martensitic steels

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journal of Materials Science & Technology 2021年第28期87卷 269-279页

作者： j.Li c.Xu G.Zheng w.j.Dai c.c.Bu G.chen MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology Engineering Research Center of Materials Behavior and DesignMinistry of EducationNanjing University of Science and TechnologyNanjing210094China Nanjing jiuzhu New Materials Institute co. Ltd.Nanjing211151China condensed Materials Laboratory co. Ltd.Yangzhou225200China Yangzhou chengde Steel Pipe co. Ltd.Yangzhou225200China

The creep strength enhanced martensitic steels are key material for the main power generating units in ultra-supercritical *** on the evaluation of their creep rupture life show there is an overestimation of rupture life after long-term creep,which is known as premature ***,the microstructural origin of the premature failure remains *** in this study,we have carefully investigated the microstructural transformations and their influences on creep rupture behavior,showing that the evolution of martensite and M_(23)c_(6) carbides as well as Laves phase are responsible for the premature *** using multi-step TTP-LMP method,we confirmed a three-stage creep rupture behavior under different stress *** quantitative analysis showed that the coarsening of M_(23)c_(6) carbides and recovery of martensite exert equal and dominant effects on the premature failure in the medium stress region,while precipitation and coarsening of Laves phase are responsible for the premature failure in the low stress region.

关键词： creep strength enhanced martensitic steel Premature failure M_(23)c_(6)carbides Martensite recovery Laves phase

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Decision support model for effects estimation and proportionality assessment for targeting in cyber operations

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Defence Technology（防务技术） 2021年第2期17卷 352-374页

作者： c.Maathuis w.Pieters j.van den Berg Delft University of Technology Jaffalaan 52628 BXDelftNetherlands TNO Military Operations Oude Waaldorperweg 632597 AKDen HaagNetherlands Netherlands Defense Academy De la Reyweg 1204818 BBBredaNetherlands Open University of the Netherlands Valkenburgerweg 1776419 ATHeerlenNetherlands

cyber operations are relatively a new phenomenon of the last two *** that period,they have increased in number,complexity,and agility,while their design and development have been processes well kept under *** a consequence,limited data(sets)regarding these incidents are *** various academic and practitioner public communities addressed some of the key points and dilemmas that surround cyber operations(such as attack,target identification and selection,and collateral damage),still methodologies and models are needed in order to plan,execute,and assess them in a responsibly and legally compliant *** on these facts,it is the aim of this article to propose a model that i))estimates and classifies the effects of cyber operations,and ii)assesses proportionality in order to support targeting decisions in cyber *** order to do that,a multi-layered fuzzy model was designed and implemented by analysing real and virtual realistic cyber operations combined with interviews and focus groups with technical e military *** proposed model was evaluated on two cyber operations use cases in a focus group with four technical e military *** the design and the results of the evaluation are revealed in this article.

关键词： cyber operations cyber warfare cyber weapons Artificial intelligence Fuzzy logic Targeting

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Precipitation on stacking faults in Mg–9.8wt%Sn alloy

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journal of Materials Science & Technology 2020年第10期42卷 230-240页

作者： c.Q.Liu c.He H.w.chen j.F.Nie International joint Laboratory for Light Alloys(Ministry of Education) College of Materials Science and EngineeringChongqing UniversityChongqing400044China Department of Materials Science and Engineering Monash UniversityVictoria3800Australia Electron Microscopy center Chongqing UniversityChongqing400044PR China

In this work,we have systematically investigated precipitation ofβ’-Mg3Sn phase on intrinsic stacking faults I1 and I2 in a Mg-9.8 wt%Sn alloy using aberration-corrected scanning transmission electron *** observed I1 faults are generated by the dissociation of c+a perfect dislocations and bounded by Frank partial dislocations having a Shockley *** ofβ’on I1 involves a shear of 1/3α,similar to its formation directly from theα-Mg ***β’phase often nucleates at one end of an I1 fault due to the interaction between shear strain fields ofβ’and the Shockley component of the Frank partial at that end,and subsequently grows towards the other end of the *** theβ’reaches to the other end,the Shockley partial bounding the lengthening end of theβ’reacts with the Frank partial bounding the fault,generating an a perfect dislocation that can glide away from the precipitate and the *** observed I2 faults are generated by the dissociation of a perfect dislocations and bounded by Shockley *** ofβ’on I2 does not need a shear of 1/3α,since the pre-existing I2 fault already provides an ABcA four-layer structure ofβ’.Thickening of theβ’that has already formed on the I2 involves the successive occurrence of three crystallographically equivalent shears of 1/3αon every second(0002)αplane of theα-Mg *** this thickening mechanism is similar to that of theβ’formed directly from theα-Mg matrix,an a perfect dislocation will be produced when theβ’is thickened to eight layers,and it can again glide away from the precipitate and the fault.

关键词： Heterogeneous precipitation HAADF-STEM Shockley partial dislocation Frank partial dislocation Dislocation reaction

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DEcREASING PITTING SUScEPTIBILITY OF PASSIVE FILMS ON X70 PIPELINE STEEL IN Nacl SOLUTIONS BY ILLUMINATION

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Acta Metallurgica Sinica(English Letters) 2006年第2期19卷 91-97页

作者： w.c. Zhu w.H. Leng j.Q. Zhang c.N. cao Department of chemistry Zhejiang University Hangzhou 310027 China State Key Laboratory for corrosion and Protection of Metals Institute of Metal Research The Chinese Academy of Sciences Shenyang 110016 China

The influence of UV illumination on passivity and pitting susceptibility on X70 pipoeline steel in a borate buffer （pH=8.4 ） solution containing Nacl is described. It is observed that illumination of the sample leads to a decrease in its pitting susceptibility as indicated by pitting potential and incubation time measurements in chloride containing electrolytes. This effect is strongly dependent on the applied potential during passivation. The electronic properties of the passive films on X70 steel were studied by Mott-Schottky analysis and photocurrent transient measurements. The results indicated that illumination during passivation led to modifications in the electronic properties of the passive films, mainly to a decrease of the bulk doping and an increase in the surface state density. The cause for the decrease in the pitting susceptibility is preliminary explained in terms of such modifications of the passive flm.

关键词： X70 pipeline steel pitting susceptibility illumination passivation

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Long-term administration of large doses of paracetamol impairs the reproductive competence of male rats

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Asian journal of Andrology 2000年第4期2卷 247-255页

作者： w.D.Ratnasooriya j.R.A.c.jayakody Department of Zoology University of Colombo Colombo 3 Sri Lanka.Department of Zoology University of Colombo Colombo 3 Sri Lanka.

Aim: To evaluate the antireproductive effect of paracetamol in male rats. Methods: Male rats were orally adminis-tered daily with 500 mg/kg or 1000 mg/kg of paracetamol for 30 consecutive days. Their sexual behaviour and fertilitywere evaluated using receptive females. Results: At 2 h after treratment, sexual behaviour was not inhibited but onday 30 both doses of paracetamol caused marked impairment of libido (assessed by % mounting, % intromission and% ejaculation), sexual vigour (number of mounts and intromissions and copulatory efficiency) or sexual performance(intercopulatory interval). In mating experiments, the fertility (in terms of quantal pregnancy, fertility index, implan-tation index and number of implants) was significantly reduced. All these effects were reversible. The antireproductiveeffect was not due to a general toxicity but due to an increase in pre-implantation losses resulting from oligozoospermia,impairments of normal and hyper-activated sperm motility, and reduction in the fertilizing potential of ***: Long-term use of high doses of paracetamol may be detrimental to male reproductive competence.( Asian j Andro12000 Dec; 2: 247-255 )

关键词： paracetamol fertility sexual behaviour oligozoospermia pre-implantation loss capacitation sperm motility

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