检索结果-南通市图书馆

An Application of Prony’s Sum of Exponentials Method to Pharmacokinetic Data Analysis

Communications in Computational Physics 2007年第1期2卷 87-98页

作者： j.Fuite R.E.Marsh j.a.tuszynski Department of Physics University of AlbertaEdmontonAlbertaT6G 2J1Canada.

We discuss the basic concept of compartmental modelling in pharmacokinetics and demonstrate that all the solutions admitted by multi-compartment models of classical pharmacokinetics are expressed as linear combinations of exponential functions of *** lends itself to data analysis that depends on fitting exponential functions to finite size sets.A mathematical method developed a long time ago to deal with this type of problem is called Prony’s *** discuss the usefulness of this method in pharmacokinetic modeling and apply it to a particular data set obtained for the drug *** spite of the method’s power in dealing with well-behaved data sets,we indicate the existence of severe limitations since real concentration curves coming from pharmacokinetic data are seldom purely exponential.

关键词： Data analysis pharmacokinetics modelling Prony’s method.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Model of Directed Binding to Microtubules by Kinesin and Ncd Motor Proteins

A Model of Directed Binding to Microtubules by Kinesin and N...

引用

2002年微纳米国际会议

作者： H.Bolterauer j.a.tuszynski Institute of Theoretical Physics j. Liebig Universitaet Giessen Giessen Germany Department of Physics University of Alberta Edmonton Alberta T6G 2Jl Canada

＜正＞ We propose a new the mechanism of the two-headed kinesin’s walk along a microtubule treating the heads as extended objects that are connected by an elastic neck linker region. In our simple mathematical model ATP hydrolysis provides the chemical energy and directed binding plays the key role in force generation coupled with the presence of the elastic neck linker region that stores mechanical energy. The electrostatic charge distributions known for both the kinesin motor domains and tubulin are also shown to be consistent with the physical picture presented here. Our computer simulations based on the model developed here are in good agreement with experimental observations not only for kinesin but also for its analog Ncd.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Organizing and Disorganizing Resonances of Microtubules, Stem Cells, and Proteins Calculated by a Quantum Equation of Coherence

引用

journal of Modern Physics 2022年第12期13卷 1530-1580页

作者： Hans j. H. Geesink Marcus Schmieke DSM-Research Geleen Netherlands Institute of Existential Consciousness Research (ECR) Berlin Germany Dev Sanskriti University Haridwar India

Conformational states of microtubules and proteins have typical spatial-spectral arrangements of atoms, called spatial coherence, that are characteristic for building, homeostasis, decay, and apoptosis. Microtubules show a principle of a self-organizing-synergetic structure called a Fröhlich-Bose-Einstein state. The spatial coherence of this state can be described by a toroidal quantum equation of coherence. In this space, microtubules and proteins have typical discrete frequency patterns. These frequencies comply with two proposed quantum wave equations of respective coherence (regulation) and decoherence (deregulation), that describe quantum entangled and disentangled states. The proposed equation of coherence shows the following typical scale invariant distribution of energy: En = ħωref 2q3m. The proposed model supports quantum entanglement and is in line with the earlier published models of Fröhlich, Davydov, and Chern. A meta-analysis shows a semi-harmonic scale-invariant pattern for microtubules, stem cells, proteins, and EEG- and MEG-patterns. A fit has been found for about 50 different organizing frequencies and 5 disorganizing frequencies of measured microtubule frequencies that fit with the calculated values of the proposed quantum equations, which are positioned in a nested toroidal geometry. All measured and analysed frequencies of microtubules comply with the same energy distribution found for Bose-Einstein condensates. The overall results show a presence of an informational quantum code, a direct relation with the eigenfrequencies of microtubules, stem cells, DNA, and proteins, that supplies information to realize biological order in life cells and substantiates a collective Fröhlich-Bose-Einstein type of behaviour and further support the models of tuszynski, Hameroff, Bandyopadhyay, Del Giudice and Vitiello, Katona, Pettini, and Pokorny.

关键词： Quantum Coherence Coherence and Decoherence Electromagnetic Frequencies Quantum Biology Quantum Wave Equation Fröhlich Microtubules Proteins Healthy and Unhealthy Frequency Patterns

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：