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Adaptive backstepping control and synchronization of a modified and chaotic Van der Pol-Duffing oscillator

控制理论与应用（英文版） 2011年第2期9卷 273-277页

作者： U.E.VINCENT R.K.ODUNAIKE j.a.laoye A.A.GBINDINNINUOLA Department of Physics Olabisi Onabanjo University Institute of Theoretical Physics Technical University of Clausthal Department of Physics University of Ibadan

In this paper,we propose a backstepping approach for the synchronization and control of modified Van-der Pol Duffing oscillator *** method is such that one controller function that depends essentially on available circuit parameters that is sufficient to drive the two coupled circuits to a synchronized state as well achieve the global stabilization of the system to its regular *** simulations are given to demonstrate the effectiveness of the technique.

关键词： Chaos Synchronization Back-stepping Van der Pol-Duffing oscillator

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Vibrational resonance in a multistable system with position-dependent mass

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Communications in Theoretical Physics 2023年第11期75卷 115-134页

作者： T O Roy-Layinde K A Omoteso O T Kolebaje F O Ogunmefun R A Fasasi j.a.laoye U E Vincent Department of Physics Olabisi Onabanjo UniversityAgo-IwoyeOgun StateNigeria Department of Physics Adeyemi Federal University of EducationOndoNigeria Department of Physical Sciences Redeemer’s UniversityP.M.B.230EdeNigeria Department of Physics Lancaster UniversityLancaster LA14 YBUnited Kingdom

The occurrence of vibrational resonance(VR)in a dual-frequency-driven multistable system with a spatially varying mass modelling particle with position-dependent mass(PDM)and evolving in a one-dimensional symmetric periodic potential has been investigated and reported in this *** numerically compute and analyze the response amplitude,the effects of the PDM parameters(m0,a)on the potential structure,the occurrence of VR and the bifurcation of the equilibrium *** is shown that the PDM parameters,besides controlling VR,can induce unconventional resonance patterns through the variation of the potential well *** resonant states can be influenced through the cooperation of the PDM parameters and the external forcing leading the system from multiresonance state into single and double resonance *** contributions of the fixed rest mass m0 on the VR and the PDM-induced resonance are determined by threshold conditions imposed by the magnitude of the mass nonlinear strength a.

关键词： vibrations resonance position-dependent mass multistable oscillator dualfrequency force nonlinear systems

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VitaminD3Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor-Cognitive Function in -D2R Parkinsonian Mice Model

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journal of Biomedical Science and Engineering 2015年第9期8卷 601-615页

作者： Azeez O. Ishola Babafemi j. laoye Damilola E. Oyeleke Oluwamolakun O. Bankole Mujittapha U. Sirjao Ansa E. Cobham Wasiu G. Balogun Amin Abdulbasit Ibukun D. Akinrinade Olalekan M. Ogundele Department of Anatomy College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Biological Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Biological Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Anatomy College of Medicine University of Calabar Calabar Nigeria Department of Anatomy College of Health Sciences University of Ilorin Ilorin Nigeria Department of Physiology College of Health Sciences University of Ilorin Ilorin Nigeria Instituto Gulbenkian de Ciencia Oerias Portugal Department of Anatomy Bingham University College of Medicine Karu Nigeria

Background: fourth generation antipsychotics have been implicated in the blockade of calcium signalling through inhibition of dopamine receptive sites on dopaminergic D2 Receptor (D3R). As a result of the abnormal calcium signalling associated with D2R inhibition, changes occur in the motor and memory neural axis leading to the observed behavioural deficits after prolonged haloperidol. Thus, Vitamin D3 receptor (VD3R), a calcium controlling receptor in the striatum can be targeted to relief the neurological symptoms associated with haloperidol (-D2R) induced PD. Aim: This study sets to investigate the role of VD3R activation in vitro and in vivo after haloperidol-induced Dopaminergic (D2R) blockade. In addition, we examined the associated neural activity and behavioural changes in parkinsonian and VDRA intervention mice. Methods: Dopaminergic D2R inhibition was investigated in vitro using Melanocytes isolated from the scale of a Tilapia. In four separate set ups, the cells were cultured in calcium free Ringer’s solution as follows;300 μM haloperidol, 100 μM VD3, 100 mM calcium chloride and a combination of 300 μM haloperidol and 100 μM VD3. Subsequently, dopaminergic vesicle accumulation and calcium signalling were observed in bright field microscopy using blue and green fluorescence probes. In the second phase, PD was induced in adult BALB/c mice (-D2;n = 8) after 14 days of intraperitoneal haloperidol treatment (10 mg/Kg). A set of n = 4 mice were untreated (-D2) while the other group (n = 4) received 100 mg/Kg of VD3 for 7 days (-D2/+VDR). The control groups (n = 4 each) were treated with normal saline (NS) and VD3 (+VDR) for 14 days. At the end of the treatment phase, the animals were assessed in Rotarod, parallel bar-, cylinder-, Y-Maze-, one trial place recognition- and novel object recognition-(NOR) tests. Neural activity was measured using chronic electrode implants placed in the M1 (motor cortex), CPu (striatum), CA1 (hippocampus) and PFC (prefrontal cortex

关键词： Dopamine Calcium Signalling D2R VD3R Corticostriatal Neural System

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Vitamin D3Receptor Activation Rescued Corticostriatal Neural Activity and Improved Motor Function in –D2R Tardive Dyskinesia Mice Model

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journal of Biomedical Science and Engineering 2015年第8期8卷 520-530页

作者： Oluwamolakun O. Bankole Babafemi j. laoye Mujittapha U. Sirjao Azeez O. Ishola Damilola E. Oyeleke Wasiu G. Balogun Amin Abdulbasit Ansa E. Cobham Ibukun D. Akinrinade Olalekan M. Ogundele Department of Biological Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Anatomy College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Anatomy College of Health Sciences University of Ilorin Ilorin Nigeria Department of Physiology College of Health Sciences University of Ilorin Ilorin Nigeria Department of Anatomy College of Medicine University of Calabar Calabar Nigeria Instituto Gulbenkian de Ciencia Oerias Portugal Department of Anatomy Bingham University College of Medicine Karu Nigeria

Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of dopamine receptive sites on D2-receptor (D2R). As a result of D2R inhibition, calcium-linked neural activity is affected and seen as a decline in mo-tor-cognitive function after prolonged haloperidol use in the treatment of psychotic disorders. In this study, we have elucidated the relationship between haloperidol-induced tardive dyskinesia and the neural activity in motor cortex (M1), basal nucleus (CPu), prefrontal cortex (PFC) and hippocampus (CA1). Also, we explored the role of Vitamin D3 receptor (VD3R) activation as a therapeutic target in improving motor-cognitive functions in dyskinetic mice. Dyskinesia was induced in adult BALB/c mice after 28 days of haloperidol treatment (10 mg/Kg;intraperitoneal). We established the presence of abnormal involuntary movements (AIMs) in the haloperidol treated mice (-D2) through assessment of the threshold and amplitude of abnormal involuntary movements (AIMs) for the Limbs (Li) and Orolingual (Ol) area (Li and Ol AIMs). As a confirmatory test, the dyskinetic mice (-D2) showed high global AIMs score when compared with the VD3RA intervention group (-D2/+VDR) for Li and Ol AIMs. Furthermore, in the behavioral tests, the dyskinetic mice exhibited a decrease in latency of fall (LOF;Rotarod-P 2/+VDR), 100 mg/Kg for 7 days, CPu-CA1 burst activity was restored leading to a decrease in abnormal movement, and an increase in motor function. Ultimately, we deduced that VD3RA activation reduced the threshold of abnormal movement in haloperidol induced dyskinesia.

关键词： Haloperidol VD3R Dyskinesia D2R Neural Activity Corticostriatal

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