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Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism

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journal of Molecular Cell Biology 2023年第9期15卷 53-68页

作者： Quanxin jiang Ning Wang Sĳia Lu jie Xiong Yanmei Yuan junli Liu Suzhen Chen Shanghai Diabetes Institute Department of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

Nonalcoholic steatohepatitis(NASH)is a condition that progresses from nonalcoholic fatty liver disease(NAFLD)and is characterized by hepatic fat accumulation,inflammation,and *** has the potential to develop into cirrhosis and liver cancer,and currently no effective pharmacological treatment is *** this study,we investigate the therapeutic potential of targeting ceruloplasmin(Cp),a copper-containing protein predominantly secreted by hepatocytes,for treating *** result show that hepatic Cp is remarkedly upregulated in individuals with NASH and the mouse NASH ***-specific Cp ablation effectively attenuates the onset of dietary-induced NASH by decreasing lipid accumulation,curbing inflammation,mitigating fibrosis,and ameliorating liver *** employing transcriptomics and metabolomics approaches,we have discovered that hepatic deletion of Cp brings about remarkable restoration of bile acid(BA)metabolism during *** deletion of Cp effectively remodels BA metabolism by upregulating Cyp7a1 and Cyp8b1,which subsequently leads to enhanced BA synthesis and notable alterations in BA *** conclusion,our studies elucidate the crucial involvement of Cp in NASH,highlighting its significance as a promising therapeutic target for the treatment of this disease.

关键词： ceruloplasmin nonalcoholic steatohepatitis bile acid inflammation fibrosis

Evaluation of total protein,peroxidase,and nutrients measured by pXRF for the determination of tissue rejuvenation/reinvigoration of Eucalyptus microcorys

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journal of Forestry Research 2023年第5期34卷 1563-1576页

作者： júlio Cézar Tannure Faria Caius Ribeiro-Kumara William Macedo Delarmelina Filipe Aiura Namorato Dione Richer Momolli Anderson Cleiton josé Enéas Ricardo Konzen Dulcinéia de Carvalho Gilvano Ebling Brondani Department of Forestry and Wood Sciences Federal University of Espírito SantoJerônimo MonteiroEspírito SantoBrazil Department of Forest Sciences University of HelsinkiHelsinkiFinland Federal Institute of Education Science and Technology of Espírito SantoIbatibaEspírito SantoBrazil Department of Soil Science Federal University of LavrasLavrasMinas GeraisBrazil Department of Forest Engineering Federal University of Santa MariaSanta MariaRio Grande Do SulBrazil Department of Forestry Sciences Federal University of LavrasLavrasMinas GeraisBrazil Department Interdisciplinary Federal University of Rio Grande Do SulImbéRio Grande Do SulBrazil

Ontogenetic aging of tissues and the gradual decrease of adventitious rooting are known challenges for the clonal propagation of woody species,hampering clonal forestry *** study examined possible signatures of tissue rejuvenation/reinvigoration in different propagated materials of Eucalyptus microcorys by analyzing the total protein profile,peroxidase activity,macro-and micronutrient contents,and adventitious rooting of mini *** analyses were performed on *** shoots which were successfully obtained by seminal and grafting propagation,micropropagation with epicormic shoots,and indirect *** four mature trees used in the propagation,tissues from the one with the best propagation results were investigated for signs of tissue rejuvenation and/or *** individuals from each technique were randomly selected and transferred to a semi-hydroponic"channel"*** four weeks in the seedbed,the total protein,peroxidase activity,nutrient content and rooting of the mini cuttings were ***-PAGE enabled the differentiation of leaf samples obtained by grafting from the other propagation techniques,as revealed by two distinct *** obtained by micropropagation with epicormic shoots showed the highest peroxidase activity,while those obtained by seminal propagation and from the selected mature tree showed the lowest peroxidase activity.A portable X-ray fluorescence spectroscope(pXRF)identified adequate nutrient content in most of the nutrients tested in materials obtained by seminal and grafting propagation,and by indirect *** analysis of adventitious rooting showed that the highest rooting percentage was observed in mini cuttings from seminal propagation(75%)followed by indirect organogenesis(35%).Based on principal component analysis,it was concluded that rooting of mini cuttings from both seminal propagation and indirect organogenesis was associated with phosphorous,sulphur,and potassium

关键词： Adventitious rooting juvenility Reinvigoration Rejuvenation Ontogenetic age

Ground motion prediction equations based on shallow crustal earthquakes in Georgia and the surrounding Caucasus

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Earthquake Science 2022年第6期35卷 497-509页

作者： jorjiashvili Nato Shengelia ia Godoladze Tea Gunia Irakli Akubardia Dimitri Institute of Earth Sciences and National Seismic Monitoring Center Ilia State UniversityTbilisi 0177Georgia

Strong ground motions caused by earthquakes with magnitudes ranging from 3.5 to 6.9 and hypocentral distances of up to 300km were recorded by local broadband stations and three-component accelerograms within Georgia’s enhanced digital seismic *** data mixing is particularly effective in areas where strong ground motion data are *** data were used to produce models based on ground-motion prediction equations(GMPEs),one benefit of which is that they take into consideration information from waveforms across a wide range of *** this study,models were developed to predict ground motions for peak ground acceleration and 5%-damped pseudo-absolute-acceleration spectra for periods between 0.01 and 10 ***-period ground motions decayed faster than long-period motions,though decay was still in the order of approximately 1/*** mechanisms and local soil conditions greatly influence *** spectral acceleration(SA)of thrust faults was higher than that for either strike-slip or normal faults but the influence of strike-slip faulting on SA was slightly greater than that for normal *** soils also caused significantly more amplification than rocky sites.

关键词： strong ground motion peak ground acceleration spectral acceleration shallow earthquake

Role of the intracellular receptor domain of gp130 (exon 17) in human inflammatory bowel disease

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World journal of Gastroenterology 2005年第8期11卷 1196-1199页

作者： Christoph j.Auernhammer Kathrin Zitzmann Fabian Schnitzler j..ia seiderer Peter Lohse George Vlotides Dieter Engelhardt Michael Sackmann Burkhard G(o|¨)ke Thomas Ochsenkühn Department of Internal Medicine Ⅱ-Grosshadern Department of Clinical Chemistry-Grosshadern

AIM: To study the role of the intracellular receptor domain of gp130 in human inflammatory bowel disease (IBD).METHODS: We amplified and sequenced the complete exon 17 of the human gp130 gene in 146 patients with IBD. According to clinical and histopathological signs,the 146 patients with IBD were classified as having Crohn's disease (n = 73) or ulcerative colitis (n = 63),or as indeterminate status (n = 10).RESULTS: No mutations in exon 17 of the gp130 gene could be detected in any of the 146 patients with IBD ***: There is no evidence that mutations in exon 17 of the gp130 gene are involved in the pathogenesis of human IBD.

关键词： Exon 17 Inflammatory bowel disease gp130 gene

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共同体的建构:雾霾传播的公共利益导向

宁夏社会科学 2018年第3期 94-99页

作者：贾广惠江苏师范大学传媒与影视学院江苏徐州221009

雾霾频发侵扰社会生活,大众传播将此设置为常规议题反映。与传统媒体不同,网友对雾霾问题致力于解构,通过各种娱乐、讽刺手段颠覆主流话语,然而理性的、积极建构公共利益的引导与行动缺乏有效凝聚。基于网友的雾霾议题消极表现进行揭示... 详细信息

雾霾频发侵扰社会生活,大众传播将此设置为常规议题反映。与传统媒体不同,网友对雾霾问题致力于解构,通过各种娱乐、讽刺手段颠覆主流话语,然而理性的、积极建构公共利益的引导与行动缺乏有效凝聚。基于网友的雾霾议题消极表现进行揭示,将雾霾议题导引至公共利益的自觉认同与维护的路径,以促进公民社会的良性成长。

关键词：共同体雾霾传播建构公共利益

体系辩证法与价值形式理论——阿瑟《新辩证法与马克思的〈资本论〉》解读

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上海交通大学学报（哲学社会科学版） 2018年第5期26卷 27-37页

作者：谢家新复旦大学哲学学院上海200433

体系辩证法和价值形式理论是近年来西方马克思主义理论研究中出现的两种新趋势。这两种新趋势可视为滥觞于20世纪末的黑格尔哲学在西方再度强势回归的理论产物。其中最具代表性的成果之一当属提倡"新辩证法"的理论旗手克里斯多夫·阿瑟... 详细信息

体系辩证法和价值形式理论是近年来西方马克思主义理论研究中出现的两种新趋势。这两种新趋势可视为滥觞于20世纪末的黑格尔哲学在西方再度强势回归的理论产物。其中最具代表性的成果之一当属提倡"新辩证法"的理论旗手克里斯多夫·阿瑟的《新辩证法与马克思的〈资本论〉》一书。在这本书中,阿瑟试图将体系辩证法和价值形式理论二者内在地勾连起来,从而通过一种"价值形式的辩证法"来重新审视黑格尔逻辑学与马克思《资本论》的内在关联,进而开辟出一条不同于传统马克思主义理论的新路线。

关键词：体系辩证法价值形式价值形式的辩证法《资本论》逻辑学

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几种最优投资组合在有效边界上相对位置

大连理工大学学报 2016年第4期56卷 420-426页

作者：周伊佳于波大连理工大学数学科学学院辽宁大连116024

讨论了均值-VaR、均值-AVaR、方差-均值比等风险-收益投资组合优化模型的最优解的有效性.基于Markowitz均值-方差模型和有效边界理论,证明了如果各模型的最优投资组合存在,则一定位于均值-方差有效边界上.计算了各投资组合模型最优解处... 详细信息

讨论了均值-VaR、均值-AVaR、方差-均值比等风险-收益投资组合优化模型的最优解的有效性.基于Markowitz均值-方差模型和有效边界理论,证明了如果各模型的最优投资组合存在,则一定位于均值-方差有效边界上.计算了各投资组合模型最优解处的均值和标准差,根据计算结果讨论了各模型的最优投资组合在有效边界上的位置.特别地,均值-VaR模型的最优投资组合在有效边界上的位置与置信水平有关.

关键词：投资组合优化模型最优投资组合有效边界

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天然油脂抗氧化剂及其产业化应用研究进展

中国调味品 2016年第8期41卷 155-160页

作者：刘威嘉天勤食品工业有限公司

动植物油脂是食品工业中应用极为广泛的一类调味品配料,而油脂氧化是影响食用油脂品质的重要问题之一,天然抗氧化剂对预防油脂氧化效果显著。对近年来天然油脂抗氧化剂的研究进行了总结与综述,重点阐述了天然抗氧化剂的种类、抗氧化机... 详细信息

动植物油脂是食品工业中应用极为广泛的一类调味品配料,而油脂氧化是影响食用油脂品质的重要问题之一,天然抗氧化剂对预防油脂氧化效果显著。对近年来天然油脂抗氧化剂的研究进行了总结与综述,重点阐述了天然抗氧化剂的种类、抗氧化机理及在各类油脂中的应用效果,旨在为抗氧化剂在油脂产业化中的应用提供理论指导。

关键词：油脂天然抗氧化剂研究进展

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基于附加阻尼的微网改进下垂控制方法

电力系统自动化 2015年第18期39卷 25-30页

作者：张野郭力贾宏杰智能电网教育部重点实验室天津大学天津市300072

采用传统有功频率、无功电压幅值下垂控制时,若下垂系数选取不合理,逆变器输出功率会出现持续振荡,当微网离网运行时,逆变器输出功率的振荡会导致微网系统频率出现波动,严重时会使整个系统出现功角稳定性问题。文中基于储能逆变器动态... 详细信息

采用传统有功频率、无功电压幅值下垂控制时,若下垂系数选取不合理,逆变器输出功率会出现持续振荡,当微网离网运行时,逆变器输出功率的振荡会导致微网系统频率出现波动,严重时会使整个系统出现功角稳定性问题。文中基于储能逆变器动态频率特性的概念,根据其产生正阻尼作用的相位条件和幅值条件,提出了基于附加阻尼的改进下垂控制方法。该方法可以在不影响系统稳态频率和逆变器输出功率的前提下,有效地增加系统的阻尼,从而抑制逆变器输出功率振荡,提高系统的稳定性。最后通过PSCAD仿真,验证了所提控制策略的有效性。

关键词：微网(微电网) 下垂控制动态频率特性储能逆变器附加阻尼小信号模型