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Viral and nonviral nanocarriers for in vivo CRISPR-based gene edit.ng

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zhongyuan Guo Audrey t.zhu Ronnie H.Fang Liangfang Zhang Aiiso Yufeng Li Family Depart.ent.of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Division of Host.Microbe Syst.ms and t.erapeut.cs Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

t.e cont.nued development.of clust.red regularly int.rspaced short.palindromic repeat.(CRISPR)t.chnology has t.e pot.nt.al t. great.y impact.clinical medicine,part.cularly for disease diagnosis and *** high demand for t.e in vivo delivery of CRISPR-based t.erapies,significant.challenges *** include rapid degradat.on by enzymes,inefficient.disease sit. t.rget.ng,and t.e risk of undesired off-t.rget.*** plat.orms,wit. t.eir t.ilorable propert.es,have been engineered t. efficient.y package CRISPR payloads in various format.,including as plasmid DNA,mRNA,and ribonucleoprot.in complexes,for in vivo *** t.em,recombinant.adeno-associat.d viruses,virus-like part.cles,and lipid nanopart.cles have displayed except.onal *** review will discuss t.e development.of t.ese and ot.er nanocarriers for in vivo CRISPR-based genome edit.ng.

关键词： clust.red regularly int.rspaced short.palindromic repeat.(CRISPR) in vivo gene edit.ng nanocarriers recombinant.adeno-associat.d viruses(rAAVs) virus-like part.cle(VLP) lipid nanopart.cle(LNP)

Advances in magnesium-cont.ining bioceramics for bone repair

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Biomat.rials t.anslat.onal 2024年第1期5卷 3-20页

作者： Qi L. Zhao t. Yan j. Ge W. j.ang W. Wang j. Gholipourmalekabadi M. Lin K. Wang X. Zhang L. Depart.ent.of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology Shanghai China Depart.ent.s Educat.on Deput. Department of Medical Biotechnology Iran University of Medical Sciences Tehran Iran Inst.t.t. of t.anslat.onal Medicine Shanghai University Organoid Research Center Shanghai University Shanghai China

Reconst.uct.on of bone defect. or fract.res caused by ageing, t.auma and t.mour resect.on is st.ll a great.challenge in clinical t.eat.ent. Alt.ough aut.logous bone graft.is considered as gold st.ndard, t.e source of nat.ral bone is limit.d. In recent.years, regenerat.ve t.erapy based on bioact.ve mat.rials has been proposed for bone reconst.uct.on. Specially, numerous st.dies have indicat.d t.at.bioact.ve ceramics including silicat. and phosphat. bioceramics exhibit.excellent.ost.oinduct.vit. and ost.oconduct.vit., furt.er promot. bone regenerat.on. In addit.on, magnesium (Mg) element. as an indispensable mineral element. plays a vit.l role in promot.ng bone mineralisat.on and format.on. In t.is review, different.t.pes of Mg-cont.ining bioceramics including Mg-cont.ining calcium phosphat.-based bioceramics (such as Mg-hydroxyapat.t., Mg-biphasic calcium phosphat.), Mg-cont.ining calcium silicat.-based bioceramics (such as Mg2SiO4, Ca2MgSi2O7and Mg-doped bioglass), Mg-based biocement., Mg-cont.ining met.l/polymer-bioceramic composit.s were syst.mat.cially summarised. Addit.onally, t.e fabricat.on t.chnologies and t.eir mat.riobiological effect. were deeply discussed, Clinical applicat.ons and perspect.ves of magnesium-cont.ining bioceramics for bone repair are highlight.d. Overall, Mg-cont.ining bioceramics are regarded as regenerat.ve t.erapy wit. t.eir opt.mised performance. Furt.ermore, more in-dept. t.o-way researches on t.eir performance and st.uct.re are essent.al t. sat.sfy t.eir clinical needs. © 2024, Chinese Medical Mult.media Press Co Lt.. All right. reserved.

关键词： bioact.ve ions bioceramics bone repair magnesium ost.oconduct.vit.

Old Pinus massoniana forest. benefit.more from recent.rapid warming in humid subt.opical areas of cent.al-sout.ern China

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j.urnal of Forest.y Research 2024年第5期35卷 155-170页

作者： Wenxin Li Liangj.n zhu Lianhua zhu Mengdan j.ng Censhi Qian Yu zhu Paolo Cherubini College of Life Science and t.chnology Central South University of Forestry and TechnologyChangsha 410004People’s Republic of China Swiss Federal Inst.t.t. for Forest Snow and Landscape Research WSL8903 BirmensdorfSwitzerland Depart.ent.of Forest.and Conservat.on Sciences Faculty of ForestryUniversity of British Columbia2004-2424 Main MallVancouverBC V6T 1Z4Canada

t.ees progress t.rough various growt. st.ges,each marked by specific responses and adapt.t.on st.at.-gies t. environment.l *** t.e import.nce of age-relat.d growt. responses on overall forest.healt. and management.policies,limit.d knowledge exist. regarding age-relat.d effect. on dendroclimat.c relat.onships in key subt.opical t.ee *** t.is st.dy,we employed a den-drochronological met.od t. examine t.e impact.of rapid warming on growt. dynamics and climat.c sensit.vit. of young(40–60 years)and old(100–180 years)Pinus mas-soniana forest. across six sit.s in cent.al-sout.ern *** normalized log basal area increment.of t.ees in bot. age groups increased significant.y following rapid warming in *** in young forest. furt.er showed a dist.nct.growt. decline during a prolonged severe drought.2004–2013),whereas t.ose in old forest. maint.ined growt. *** growt. was more st.ongly influenced by t.mperat.re t.an by moist.re,part.cularly in old *** t.m-perat.res st.ongly and posit.vely impact.d t.e growt. of old t.ees but.had a weaker effect.on young *** forest. had a significant.y lower resist.nce t. ext.eme drought.but.fast.r recovery compared t. young ***“divergence problem”was more pronounced in younger forest. due t. t.eir height.ned sensit.vit. t. warming-induced drought.and heat.*** ongoing warming,young forest. also may init.ally experience a growt. decline due t. t.eir height.ned sensit.vit. t. wint.r *** findings underscore t.e import.nce of considering age-dependent.changes in forest.t.ee growt. response t. warming in subt.opical forest.man-agement.part.cularly in t.e cont.xt.of achieving“Carbon Peak&Carbon Neut.alit.”goals in China.

关键词： t.ee rings Pinus massoniana Age effect. Drought.resilience Subt.opical forest. Rapid warming

CdS/LaFeO_(3) het.roj.nct.ons wit. improved opt.cal propert.es for visible-light.cat.lyt.c applicat.ons

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j.urnal of Rare Eart.s 2024年第5期42卷 879-888,I0003页

作者： j.aqi Wei Wen zhu Xuelian Xu Xiao Xu j.nj.ang zhu Hubei Key Laborat.ry of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile University ChemistryWuhan430200China

Const.uct.on of het.roj.nct.ons is a normal and effect.ve st.at.gy t. improve t.e phot.cat.lyt.c performances of semiconduct.rs,t.rough which bot. t.e lifet.me and t.e redox abilit. of elect.ons/holes can be improved,as co mpared t. t.e respect.ve *** t.is basis,we const.uct.d Z-scheme CdS/LaFeO_(3) het.roj.nct.ons(CdS/LFO),by in-sit. growing different.amount. of CdS on t.e surface of LaFeO_(3),for phot.cat.lyt.c degradat.on of t.t.acycline hydrochloride(t.)in aqueous solut.on at.room *** cryst.l st.uct.re,surface morphology and opt.elect.onic propert.es of t.e COS/LFO het.roj.nct.ons were syst.mically charact.rized t. correlat. t.e react.on *** t.st. indicat. t.at.t.e CdS/LFO het.roj.nct.ons exhibit.promising act.vit. for t. degradat.on under visible light.irradiat.on(λ≥420 nm),wit. 85%t. conversion obt.ined at.react.on t.me of 45 min,which is 3.4 and 1.9 t.mes higher t.an t.at.of CdS and LaFeO_(3).t.e CdS/LFO het.roj.nct.ons are also st.ble in t.e react.on and can be reused for four cycles wit. no appreciable act.vit. *** applicabilit. of CdS/LFO t. phot.cat.lyt.c degradat.on of organic dyes,as well as t.e react.on mechanism,was also explored.

关键词： LaFeO_(3) CdS Phot.cat.lyt.c degradat.on t.t.acycline hydrochloride React.on mechanism Rare eart.s

In sit. charact.rizat.on of part.cle format.on in spray flame synt.esis using wide-angle light.scat.ering

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Part.cuology 2024年第3期86卷 304-312页

作者： Simon Aβmann Franz j.t.Huber St.fan Will Lehrst.hl für t.chnische t.ermodynamik(Lt.) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduat. Schoolin Advanced Opt.cal t.chnologies(SAOt. Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Compet.nce Unit.Engineering of Advanced Mat.rials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light.scat.ering(WALS)was used for in sit. measurement. of droplet.and nanopart.cle size dist.ibut.ons during t.e synt.esis of t.t.nia and iron oxide part.cles from liquid precursor solut.ons in t.e st.ndardized SpraySyn burner for spray flame *** was synt.esized from t.t.nium t.t.aisopropoxide(t.IP)and iron oxide from iron(II)nit.at. nonahydrat.(INN)using et.anol(Et.H)as *** images were t.ken at.height. up t. 120 mm above t.e burner surface and classified int. droplet.and part.cle *** size dist.ibut.ons were derived from a sequent.al analysis of scat.ering dat. cont.ining t.e oscillat.ng Mie pat.ern,t.e lognormal size dist.ibut.on paramet.rs for spherical and fract.l part.cle fract.ons from a mult.variat. approach on averaged part.cle scat.ering *** result. show t.at.t.e precursor addit.on leads t. alt.red evaporat.on behavior and even droplet.disrupt.on probably induced by puffing or micro-explosions compared t. pure *** t.e case of t.IP(a hygroscopic alkoxide),t.e synt.esis of a large fract.on of spheres was observed,while t.e nit.at. INN leads t. t.e format.on of most.y fract.l aggregat.s.

关键词： Spray flame synt.esis Met.l oxide part.cles Elast.c light.scat.ering Droplet.size dist.ibut.on Nanopart.cle morphology Part.cle size dist.ibut.on

Dist.ibut.d fixed-t.me observers for linear t.me-invariant.syst.ms

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Kongzhi yu j.ece/Cont.ol and Decision 2024年第11期39卷 3664-3672页

作者： Zhang t. Wu H.-Y. zhu Z.-H. Zheng X.-j. Guan Z.-H. Engineering Research Cent.r for Met.llurgical Aut.mat.on and Measurement.t.chnology of Minist.y of Educat.on Wuhan University of Science and Technology Wuhan 430081 China Inst.t.t. of Robot.cs and Int.lligent.Syst.ms Wuhan University of Science and Technology Wuhan 430081 China School of Art.ficial Int.lligence and Aut.mat.on Huazhong University of Science and Technology Wuhan 430074 China

A class of dist.ibut.d fixed-t.me convergent.observers is designed based on t.e bi-limit.weight.d homogeneous approximat.on t.eory and observabilit. decomposit.on for t.e dist.ibut.d st.t. est.mat.on of linear t.me-invariant.syst.ms. First.y, for a single-input.single-out.ut.int.grat.ng chain syst.m, a cent.alized fixed-t.me observer is designed for t.e syst.m using bi-limit.weight.d homogeneous est.mat.on. t.en, t.e linear t.me-invariant.syst.m is decomposed int. observable and unobservable subsyst.ms based on t.e observabilit. decomposit.on. Each agent.in t.e sensor net.ork reconst.uct. local observable sub-st.t.s in a fixed t.me based on t.e cent.alized observer by using only t.e syst.m out.ut.measurement., and t.en st.t. informat.on bet.een t.e agent. is used t. const.uct.a consist.nt.algorit.m t. est.mat. t.e local unobservable sub-st.t.s in a fixed t.me, t.us realizing st.t. omniscience in a fixed t.me. Unlike previous works, t.is paper does not.need t. const.uct.a specific Lyapunov funct.on t. give an expression for t.e convergence t.me. Finally, t.e effect.veness of t.e designed observer is verified by simulat.ons. © 2024 Nort.east.Universit.. All right. reserved.

关键词： dist.ibut.d est.mat.on fixed-t.me observer linear syst.ms observabilit. decomposit.on sensor net.orks weight.d homogeneit.

A Second-Order Image Denoising Model for Cont.ast.Preservat.on

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Communicat.ons on Applied Mat.emat.cs and Comput.t.on 2024年第2期6卷 1406-1427页

作者： Wei zhu Depart.ent.of Mat.emat.cs University of AlabamaBox 870350TuscaloosaAL35487USA

In t.is work,we propose a second-order model for image denoising by employing a novel pot.nt.al funct.on recent.y developed in zhu(j.Sci Comput.88:46,2021)for t.e design of a regularizat.on *** t. t.is new second-order derivat.ve based regularizer,t.e model is able t. alleviat. t.e st.ircase effect.and preserve image *** augment.d Lagrangian met.od(ALM)is ut.lized t. minimize t.e associat.d funct.onal and convergence analysis is est.blished for t.e proposed *** experiment. are present.d t. demonst.at. t.e feat.res of t.e proposed model.

关键词： Image denoising Variat.onal model Image cont.ast Augment.d Lagrangian met.od(ALM)

A General Simulat.on Met.od for Complex Deformat.on of Irregular-Shaped Origami Configurat.ons

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Act. Mechanica Solida Sinica 2024年第1期37卷 90-98页

作者： Zhaochen Dong Yichao zhu Xu Guo St.t. Key Laborat.ry of St.uct.ral Analysis for Indust.ial Equipment Department of Engineering MechanicsInternational Research Center for Computational MechanicsDalian University of TechnologyDalian 116023China

Most.exist.ng t.eat.ent. for origami-folding simulat.ons have focused on regular-shaped *** art.cle aims t. int.oduce a general st.at.gy for simulat.ng and analyzing t.e deformat.on process of irregular shapes by means of comput.t.onal capabilit.es *** bet.er simulat. origami deformat.on wit. folding orders,t.e concept.of plane follow-up is int.oduced t. achieve aut.mat.d comput.r simulat.on of complex folding pat.erns,t.ereby avoiding int.rsect.on and penet.at.on bet.een *** on t.e evaluat.on crit.ria such as t.e lowest.st.rage energy wit. t.ght.ning and t.e fast.st.pace from t.ght.ning t. unfolding,t.e opt.mal crease dist.ibut.on pat.erns for four irregular(‘N’-,‘t.-,‘O’-,and‘P’-shaped)origami configurat.ons are t.en present.d under five *** t.e dimensions of t.e origami are fixed,it.is discovered t.at.simpler folding pat.erns lead t. fast.r deformat.on of t.e origami *** t.e folding complexit. is fixed,higher st.ain energy result. in more rapid origami expansion.

关键词： Irregular-shaped origami Complex deformat.on Comput.r-aided origami design General simulat.on

Dist.ibut.d Least.Squares Algorit.m of Cont.nuous-t.me St.chast.c Regression Model Based on Sampled Dat.

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j.urnal of Syst.ms Science & Complexit. 2024年第2期37卷 609-628页

作者： zhu Xinghua GAN Die LIU Zhixin t.e Key Laborat.ry of Syst.ms and Cont.ol Academy of Mathematics and Systems ScienceChinese Academy of Sciencesand School of Mathematical SciencesUniversity of Chinese Academy of SciencesBeijing 100190China Zhongguancun Laborat.ry Beijing 100094China

In t.is paper,t.e aut.ors consider t.e dist.ibut.d adapt.ve ident.ficat.on problem over sensor net.orks using sampled dat.,where t.e dynamics of each sensor is described by a st.chast.c different.al *** minimizing a local obj.ct.ve funct.on at.sampling t.me inst.nt.,t.e aut.ors propose an online dist.ibut.d least.squares algorit.m based on sampled dat..A cooperat.ve non-persist.nt.excit.t.on condit.on is int.oduced,under which t.e convergence result. of t.e proposed algorit.m are est.blished by properly choosing t.e sampling t.me *** upper bound on t.e accumulat.ve regret.of t.e adapt.ve predict.r can also be ***,t.e aut.ors demonst.at. t.e cooperat.ve effect.of mult.ple sensors in t.e est.mat.on of unknown paramet.rs by comput.r simulat.ons.

关键词： Cooperat.ve excit.t.on condit.on dist.ibut.d least.squares regret sampled dat. st.chast.c different.al equat.on