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Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma

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w.rld j.urnal of Gastroenterology 2020年第9期26卷 904-917页

作者： Ezekiel Maloney Yak-Nam w.ng Ravneet Vohra Helena son Stella w.ang Tatiana Khokhlova j.shua Park Kayla Gravelle Stephanie Totten j.o Ha Hw.ng Donghoon Lee Department of Radiology University of WashingtonSeattleWA 98195United States Applied Physics Laboratory University of WashingtonSeattleWA 98195United States Division of Gastroenterology University of WashingtonSeattle 98195WAUnited States Division of Gastroenterology&Hepatology Stanford University School of MedicineRedwood CityCA 94063United States

BACKGROUND The robust fibroinflammatory stroma characteristic of pancreatic ductal adenocarcinoma(PDA)impedes effective drug *** focused ultrasound(pFUS)can disrupt this stroma and has improved survival in an early clinical ***-invasive methods to characterize pFUS treatment effects are desirable for advancement of this promising treatment modality in larger clinical *** To identify promising,non-invasive pre-clinical imaging methods to characterize acute pFUS treatment effects for in vivo models of *** w. utilized quantitative magnetic resonance imaging methods at 14 tesla in three mouse models of PDA(subcutaneous,orthotopic and transgenic-KrasLSLG12D/+,Trp53LSL-R172H/+,Cre or“KPC”)to assess immediate tumor response to pFUS treatment(VIFU 2000 Alpinion Medical Systems;475 w.peak electric pow.r,1 ms pulse duration,1 Hz,duty cycle 0.1%)vs sham therapy,and correlated our results w.th histochemical *** pFUS treatment parameters w.re previously show. to enhance tumor permeability to chemotherapeutics.T1 and T2 relaxation maps,high(126,180,234,340,549)vs low.7,47,81)b-value apparent diffusion coefficient(ADC)maps,magnetization transfer ratio(MTR)maps,and chemical exchange saturation transfer(CEST)maps for the amide proton spectrum(3.5 parts per million or“ppm”)and the glycosaminoglycan spectrum(0.5-1.5 ppm)w.re generated and analyzed pre-treatment,and immediately post-treatment,using *** w.re sacrificed immediately follow.ng post-treatment *** w.ole-tumor w.s selected as the region of interest for data analysis and subsequent statistical analysis.T-tests and Pearson correlation w.re used for statistical *** Mean high-b value ADC measurements increased significantly w.th pFUS treatment for all *** glycosaminoglycan CEST and T2 measurements decreased significantly post-treatment for the KPC *** MTR and amide CEST values increased significantly for the KPC *** acid focal int

关键词： Pancreatic adenocarcinoma Multiparametric magnetic resonance imaging Focused ultrasound

GLUCOSE ANALOGUE INHIBITORS OF GLYCOGEN PHOSPHORYLASE:THE DESIGN OF POTENTIAL DRUGS FOR DIABETES

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GLUCOSE ANALOGUE INHIBITORS OF GLYCOGEN PHOSPHORYLASE:THE DE...

RECONSTRUCTING THE ROYAL FAMILY OF RAMESSES Ⅱ AND ITS HIERARCHICAL STRUCTURE

Sixteenth Congress of the International Union of Crystallography

作者： K.A.w.ODS E.P.MITCHELL L.N.j.HNson G.w.j.FLEET M.ORCHARD j.C.son C.BICHARD N.OIKONOMAKOS D.LEONIDAS A.PAPAGEORGIU Laboratory of Molecular Biophysics Rex Richards BuildingUniversity of OxfordSouth Parks RoadOxfordEngland Dyson Perrins Laboratory University of OxfordSouth Parks RoadOxfordEngland The National Hellenic Foundation 48Vas.Constantinou AvenueAthensGreece.

Glucose is know. to be a w.ak inhibitor of glycogen phosphorylase(GP) and helps to control blood glucose levels by binding to phosphorylase at the catalytic site,resulting in a conformational change w.ich stabilises the inactive T state of the enzyme,and promotes glycogen *** has therefore been suggested that inhibition of GP by glucose-analogues may help shift the balance,betw.en glycogen synthesis and glycogen degradation,in favour of glycogen synthesis in both the muscle and *** exploiting the know.edge of the crystal structures of T state rabbit muscle GP and the glucose-enzyme complex it is hoped to design an inhibitor that w.ll be more effective than glucose.

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j.urnal of Ancient Civilizations 2016年第1期31卷 7-44页

作者： Peter j. Brand University of Memphis

A systematic examination of Ramesses Ⅱ's large family of over 100 children and at least a dozen w.ves reveals that the Great Royal w.ves Nefertari and Isetnofret, along w.th their children, enj.yed a privileged status w.thin the hierarchical structure of the royal family. Nefertari ow.d her supreme status to being mother of Ramessse Ⅱ's first born son Amunhirkhopeshef, w.ile Ramesses Ⅱ w.s still crow. prince under Sety I. Isetnofret's sons and daughters w.re also favored because she gave birth to the second born son Prince Ramesses j.. Isetnofret herself did not enj.y prominence on the monuments until after the death of Nefertari, nor w.s she buried in the Valley of the Queens. The remaining offspring of these w.ves also benefited from the prestige of their mothers and eldest brothers. Other early w.ves gave birth to the maj.rity of Ramesses Ⅱ's children, but these w.men are now.completely anonymous. Other attested w.ves of the king include his five daughter-w.ves and tw. Hittite Princess-brides. No other Egyptian w.ves are know. for Ramesses Ⅱ. Monumental sources that privilege Queen Nefertari, and the children of both Nefertari and Isetnofret, reveal a hierarchical structure of the royal family.

关键词：层次结构 Fisher 法老王埃及儿子大惯性孩子

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表面结构的分类与识别(英文)

纳米技术与精密工程 2004年第2期2卷 141-151页

作者： MURALIKRISHNAN B BUI son H RAj. j 美国北卡罗来纳大学夏洛特分校精密计量中心美国

表面结构的测量与特征描述是精密计量技术的一个重要方面 ,传统上包括将轮廓情况根据不同的波长范围划分为粗糙度、波纹度和形状及后续的数字量化 .按算得的参数检查它是否为公差允许 ,以保证零件执行其指定的功能 .当技术特性已经经过... 详细信息

表面结构的测量与特征描述是精密计量技术的一个重要方面 ,传统上包括将轮廓情况根据不同的波长范围划分为粗糙度、波纹度和形状及后续的数字量化 .按算得的参数检查它是否为公差允许 ,以保证零件执行其指定的功能 .当技术特性已经经过仔细确定 ,并且其过程稳定时 ,该方法是令人满意的 ;但是 ,当制造过程正在进行中或过程的不稳定、过程变化使技术特性失效时 ,就需要研究和功能表现及过程评定相关的表面参数 .讨论了表面结构的分类与识别问题 .同时阐述了为此目的而开发的先进技术及其应用 .

关键词：表面结构分类识别功能互相关精密计量技术粗糙度波纹度

伴面神经麻痹的Tolosa-Hunt综合征患者的MRI表现

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世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 53-54页

作者： Kang H. Park K. - j. son S. 袁海峰(译) 不详 Gyeongsang Institute of Health Sciences Department of Neurology Gyeongsang National University College of Medicine 90 Chiram-dong Jinju 660-702South Koreat

A 44-year-old w.man developed a severe right frontotemporal headache, retro-orbital pain, and, later, diplopia ow.ng to right sixth nerve palsy. The brain MRI demonstrated strong enhancement of the right cavernous sinus. The sixth nerve palsy and headache improved w.th steroid therapy after 6 w.eks. At that time, she suffered right peripheral facial nerve palsy. Enhancement of the distal canalicular and labyrinthic segment of the right facial nerve w.s found on contrast-enhanced MRI. To our know.edge, this is a very rare case of Tolosa-Hunt syndrome w.th facial nerve palsy, w.th simultaneous enhancement of the cavernous sinus and facial nerve on contrast-enhanced MRI.

关键词： Tolosa-Hunt综合征周围性面神经麻痹 MRI表现外展神经麻痹增强MRI 头痛症状女性患者眼眶后部

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语音识别技术与声调教学策略

汉语国际传播研究 2019年第1期 50-56页

作者：赵冉杜乃岩 [荷兰]Rob j.j.H.van son 弗吉尼亚大学东亚系弗吉尼亚大学阿姆斯特丹大学

本文旨在介绍对大学初级汉语学生习得声调较为有效的一些教学法与科技应用,如学生个人学习网页、在语音识别软件Praat基础上开发的声调练习与实时反馈工具以及在课程管理平台上设计的录音作业.本文将以学生录制的视频为语料分析上述教... 详细信息

本文旨在介绍对大学初级汉语学生习得声调较为有效的一些教学法与科技应用,如学生个人学习网页、在语音识别软件Praat基础上开发的声调练习与实时反馈工具以及在课程管理平台上设计的录音作业.本文将以学生录制的视频为语料分析上述教学法与工具发挥的作用和取得的效果.

关键词：汉语声调语音识别与视觉呈现声调教学策略

环状回肠造口术后回肠黏膜的形态学和缩氨酸YY的适应性时段改变

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 20-21页

作者： Oh N.-G. son G.-M. Sin j.-Y. 赵萌 Department of Surgery Pusan National University Hospital # 1- 10 Amidong 602- 739 Suhgu Busan South KoreaDr.

PURPOSE: The secretion mechanism of peptide YY involves systemic factors, such as humoral and neural stimuli, and local factors, such as intestinal peristalsis and intraluminal nutrients. This study w.s designed to survey the impact of local stimuli on the secretion of peptide YY under circumstances in w.ich systemic stimuli are identical. METHODS: Ileostomies w.re repaired w.thin three months in a short-term group (14 patients)- and after six months in a long-term group (14 patients). Mucosal peptide YY concentrations and cytomorphologic change, such as villus height, crypt depth, mucosal thickness, and villus index, w.re compared betw.en proximal functioning ileum and a distal nonfunctioning ileal loop during ileostomy repair. In a control group of patients undergoing right hemicolectomy (21 cases), the normal distribution of pept-ide YY w.s measured in the mucosa throughout the distal ileum. RESULTS: The peak of peptide YY concentration in the terminal ileum w.s 307.4 ± 21 pmol/g, 25cm from the ileocecal valve, w.th low.r levels both proximally and distally. The mucosa of the functioning ileum in the short-term group show.d hypertrophy, but had returned to preoperative levels in the long-term group. The nonfunctioning mucosa in both groups underw.nt atrophic changes. The mucosal peptide YY content in functioning ileum in the short-term group w.s higher than that of distal nonfunctioning mucosa (363.9 ± 25.5 pmol/g vs. 284.1 ± 13 pmol/g, P w.th the control group w.re 45.6 and 4.7 percent in the proximal and distal segments, respectively. In the long-term group, proximal and distal mucosal peptide YY w.re similar (256.6 ± 31.9 pmol/g vs. 254.9 ± 27.1 pmol/g, P > 0.05), and there w.s no increment in either (1.3 vs. 4.4 percent, P > 0.05). CONCLUSIONS: The peak concentrations of PYY in the ileal mucosa are found 20 to 25 cm proximal to the ileocec

关键词：回肠造口术 YY 回肠黏膜缩氨酸回肠末端黏膜厚度黏膜分泌近端结肠切除术峰浓度

胰腺癌可切除性的术前CT分级：观察者间的一致性

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国际医学放射学杂志 2020年第1期 106-107页

作者： I.j.o j.M.Lee E.S.Lee j.Y.son D.H.Lee S.j.Ahn 黄娟 Department of Radiology Seoul National University Hospital

胰腺癌检出后准确评估其局部可切除性对于治疗方案的制定至关重要,决定了病人是采用手术治疗、新辅助治疗还是姑息治疗。目的探讨胰腺癌局部可切除性术前CT

关键词：可切除性胰腺癌 CT

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美国P2P行业老大出事了

商业周刊（中文版） 2016年第11期 42-43页

作者： Noah Bu-hayar Hugh son Dakin Campbell j.nny Surane Laura j. Keller Matt Scully 沙坞

雷诺·拉普朗什（Renaud LaPlanche）在2006年创办了Lend—ingClub，并很快成为这场看似革命性的全新运动的代言人。通过P2P（个人对个人）金融，想借钱的人和想出借的人可以通过LendingClub之类的网站进行匹配对接。该公司会利用计算... 详细信息

雷诺·拉普朗什（Renaud LaPlanche）在2006年创办了Lend—ingClub，并很快成为这场看似革命性的全新运动的代言人。通过P2P（个人对个人）金融，想借钱的人和想出借的人可以通过LendingClub之类的网站进行匹配对接。该公司会利用计算机模型来审核借款人，并收取一定的费用。华尔街。

关键词： P2P 行业美国计算机模型代言人革命性借款人华尔街