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Compar.son of methods for.der.ving phenotypes fr.m incomplete obser.ation data with an application to age at puber.y in dair. cattle

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j.ur.al of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chr.s r.Bur.e j.nnie E.Pr.ce Nicole M.Steele Peter.r.Amer.Susanne Meier.Clair. V.C.Phyn Dor.an j.Gar.ick Dair.NZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL r.e Centr. for.Genetics and Br.eding-Massey Univer.ity RuakuraHamilton 3214New Zealand Agr.cultur. Victor.a r.sear.h AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Backgr.und Many phenotypes in animal br.eding ar. der.ved fr.m incomplete measur.s,especially if they ar. challenging or.expensive to measur. *** include time-dependent tr.its such as r.pr.ductive status,or.*** measur.s for.these tr.its r.sult in phenotypes that ar. subj.ct to left-,inter.al-and r.ghtcensor.ng,wher. phenotypes ar. only known to fall below an upper.bound,between a lower.and upper.bound,or.above a lower.bound *** we compar. thr.e methods for.der.ving phenotypes fr.m incomplete data using age at fir.t elevation(>1 ng/mL)in blood plasma pr.gester.ne(AGEP4),which gener.lly coincides with onset of puber.y,as an example *** We pr.duced AGEP4 phenotypes fr.m thr.e blood samples collected at about 30-day inter.als fr.m appr.ximately 5,000 Holstein–Fr.esian or.Holstein–Fr.esian×j.r.ey cr.ss-br.d dair. heifer. managed in 54 seasonal-calving,pastur.-based her.s in New *** used these actual data to simulate 7 differ.nt visit scenar.os,incr.asing the extent of censor.ng by disr.gar.ing data fr.m one or.two of the thr.e *** methods for.der.ving phenotypes fr.m these data wer. explor.d:1)or.inal categor.cal var.ables which wer. analysed using categor.cal thr.shold analysis;2)continuous var.ables,with a penalty of 31 d assigned to r.ght-censor.d phenotypes;and 3)continuous var.ables,sampled fr.m within a lower.and upper.bound using a data augmentation *** Cr.dibility inter.als for.her.tability estimations over.apped acr.ss all methods and visit scenar.os,but estimated her.tabilities tended to be higher.when left censor.ng was *** sir.s with at least 5 daughter.,the cor.elations between estimated br.eding values(EBVs)fr.m our.thr.e-visit scenar.o and each r.duced data scenar.o var.ed by method,r.nging fr.m 0.65 to *** estimated br.ed effects also var.ed by method,but br.ed differ.nces wer. smaller.as phenotype censor.ng *** Our.r.sults indicate that using

关键词： Cattle Gibbs sampler Mar.ov-chain Monte Car.o(MCMC) Puber.y

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Advances in magnesium-containing biocer.mics for.bone r.pair

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Biomater.als Tr.nslational 2024年第1期5卷 3-20页

作者： Qi L. Zhao T. Yan j. Ge W. j.ang W. Wang j. Gholipour.alekabadi M. Lin K. Wang X. Zhang L. Depar.ment of Or.l and Cr.nio-Maxillofacial Sur.er. Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology Shanghai China Depar.ment’s Education Deputy Department of Medical Biotechnology Iran University of Medical Sciences Tehran Iran Institute of Tr.nslational Medicine Shanghai University Organoid Research Center Shanghai University Shanghai China

r.constr.ction of bone defects or.fr.ctur.s caused by ageing, tr.uma and tumour.r.section is still a gr.at challenge in clinical tr.atment. Although autologous bone gr.ft is consider.d as gold standar., the sour.e of natur.l bone is limited. In r.cent year., r.gener.tive ther.py based on bioactive mater.als has been pr.posed for.bone r.constr.ction. Specially, numer.us studies have indicated that bioactive cer.mics including silicate and phosphate biocer.mics exhibit excellent osteoinductivity and osteoconductivity, fur.her.pr.mote bone r.gener.tion. In addition, magnesium (Mg) element, as an indispensable miner.l element, plays a vital r.le in pr.moting bone miner.lisation and for.ation. In this r.view, differ.nt types of Mg-containing biocer.mics including Mg-containing calcium phosphate-based biocer.mics (such as Mg-hydr.xyapatite, Mg-biphasic calcium phosphate), Mg-containing calcium silicate-based biocer.mics (such as Mg2SiO4, Ca2MgSi2O7and Mg-doped bioglass), Mg-based biocements, Mg-containing metal/polymer.biocer.mic composites wer. systematacially summar.sed. Additionally, the fabr.cation technologies and their.mater.obiological effects wer. deeply discussed, Clinical applications and per.pectives of magnesium-containing biocer.mics for.bone r.pair.ar. highlighted. Over.ll, Mg-containing biocer.mics ar. r.gar.ed as r.gener.tive ther.py with their.optimised per.or.ance. Fur.her.or., mor. in-depth two-way r.sear.hes on their.per.or.ance and str.ctur. ar. essential to satisfy their.clinical needs. © 2024, Chinese Medical Multimedia Pr.ss Co Ltd. All r.ghts r.ser.ed.

关键词： bioactive ions biocer.mics bone r.pair magnesium osteoconductivity

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Networ. analyses:Inhibition of andr.gen r.ceptor.signaling r.duces inflammation in the lung thr.ugh Ar.MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Alber. r.Wang Andr.w M.Baschnagel Zij.an Ni Sean r.Br.nnan Hypatia K.Newton Dar.a Buehler.Chr.stina Kendzior.ki r.ndall j.Kimple Gopal lyer Depar.ment of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Depar.ment of Biomedical Engineer.ng University of Wisconsin-MadisonMadisonWI 53705USA Univer.ity of Wisconsin Car.one Cancer.Center MadisonWI 53705USA Depar.ment of Biostatistics and Medical Infor.atics University of Wisconsin-MadisonMadisonWI 53706USA Depar.ment of Biology Tufts UniversityMedfordMA 02155USA Depar.ment of Pathology and Labor.tor. Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Andr.gen r.ceptor.Ar.is a maj.r.tr.nscr.ption factor.that plays a r.le in inflammator. r.sponse including inter.eukin-6(IL6)signaling.1 While Ar.r.gulation thr.ugh par.cr.ne loop signaling in pr.state tissue is well-studied,its impact thr.ugh an IL6 autocr.ne loop in the lung has not been wellstudied despite the or.an's r.sponse to r.spir.tor. vir.l *** inhibition and r.A knockdown of Ar.identified a bZIP tr.nscr.ption factor.MAF to be a common tar.et of inflammation using these per.ur.ations in lung cells.

关键词： inflammation lung r.spir.tor.

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Mechanocatalysis of CO to CO_(2)on TiO_(2)sur.ace contr.lled at atomic scale

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Nano r.sear.h 2024年第7期17卷 5826-5834页

作者： Yuuki Adachi r.ber. Tur.nský j.n Br.diar.Kamil Tokár.Qiang Zhu Huan Fei Wen Yasuhir. Sugawar. IvanŠtich Yan j.n Li Depar.ment of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Institute of Physics Slovak Academy of SciencesBratislava 84511Slovakia Institute of Infor.atics Slovak Academy of SciencesBratislava 84507Slovakia Faculty of Natur.l Sciences University of Ss.Cyril and MethodiusTrnava 91701Slovakia Key Labor.tor. of Instr.mentation Science and Dynamic Measur.ment School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China

The common ways to activate a chemical r.action ar. by heat,electr.c cur.ent,or.***,mechanochemistr.,wher. the chemical r.action is activated by applied mechanical for.e,is less common and only poor.y under.tood at the atomic *** we r.por. a tip-induced activation of chemical r.action of car.on monoxide to dioxide on oxidized r.tile TiO_(2)(110)*** activation is studied by atomic for.e micr.scopy,Kelvin pr.be for.e micr.scopy under.ultr.high-vacuum and liquid nitr.gen temper.tur. conditions,and density functional theor.(DFT)*** r.action is infer.ed fr.m hyster.tic behavior.of fr.quency shift signal fur.her.suppor.ed by vector.for.e mapping of ver.ical and later.l for.es needed to tr.gger.the chemical r.action with tor.ue motion of car.on monoxide towar.s an oxygen *** r.action is found to pr.ceed stochastically at ver. small tip-sample ***,the local contact potential differ.nce r.veals the atomic-scale char.e r.distr.bution in the r.actants r.quir.d to unlock the *** r.sults open up new insights into the mechanochemistr. on metal oxide sur.aces at the atomic scale.

关键词： atomic r.solution mechanochemistr. atomic for.e micr.scopy Kelvin pr.be for.e micr.scopy density functional theor.(DFT)simulation CO oxidation catalysis r.tile TiO_(2)sur.ace

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Opposite latitudinal gr.dients for.species r.chness and phylogenetic diver.ity of endemic snakes in the Atlantic For.st

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Cur.ent Zoology 2024年第4期70卷 522-530页

作者： j.séThales da Motta Por.illo j.suéAnder.on r.go Azevedo Fausto Er.itto Bar.o r.car.o j.Sawaya Pr.gr.ma de Pos-Gr.duacao em Biologia Animal Instituto de BiocienciasLetras e Ciencias ExatasUniversidade Estadual Paulista"Julio de Mesquita Filho"Rua Cristovao Colombo2265Sao Josédo Rio PretoSao Paulo 15054-000Brazil Pr.gr.ma de Colecoes Cientificas Biologicas Coordenagao de BiodiversidadeInstituto Nacional de Pesquisas da AmazoniaAvenida AndréAraujo2936ManausAmazonas 69067-375Brazil Gothenbur. Global Biodiver.ity Centr. University of GothenburgBox 461GothenburgVastra Gotaland SE-40530Sweden Instituto Feder.l de Educacao Ciencia e Tecnologia de Minas GeraisRodovia Machado-Paraguacukm 3MachadoMinas Gerais 37750-000Rraizil Centr. de Ciencias Natur.is e Humanas UniversidadeFederaldo ABCRua Arcturus03Sao Bernardo do CampoSao Paulo09606-070Brazil

The decr.ase in species r.chness towar. higher.latitudes is an expected biogeogr.phical *** patter. could be r.lated to par.icular.envi-r.nmental constr.ints and the evolutionar. histor. of ***,species r.chness does not fully r.pr.sent the evolutionar. histor. of the clades behind their.*** diver.ity better.clar.fies the r.le of histor.cal factor. in biogeogr.phical *** analyzed envi-r.nmental and histor.cal dr.ver. r.lated to latitudinal var.ation in species r.chness and phylogenetic diver.ity of Atlantic For.st endemic *** implemented species distr.bution models,fr.m voucher.ased locality points,to map the snake r.nges and *** used gener.lized additive mixed models to evaluate the r.lationships among the diver.ity metr.cs and ar.a,topogr.phical r.ughness,and past climate change velocity since the Last Maximum Glacial in the Atlantic For.st latitudinal *** to the expected gener.l patter.,species r.chness was higher.towar. higher.latitudes,being positively r.lated to past climatic *** r.chness also incr.ased with total ar.a and higher.topogr.phical *** diver.ity,on the other.hand,showed opposite r.lationships r.lated to the same *** diver.ity incr.ased with lower.climatic stability in lower.***,dimensions of diver.ity wer. affected in differ.nt ways by histor.cal and envir.nmental constr.ints in this unique and thr.atened biodiver.ity hotspot.

关键词： biodiver.ity latitudinal gr.dient neotr.pical r.gion phylogenetic diver.ity ser.ents species r.chness.

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Electr.city Gener.tion fr.m Heatwaves

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Inter.ational j.ur.al of Geosciences 2024年第5期15卷 449-457页

作者： Diandong r.n Mer.yn j. Lynch School of Electr.cal Engineer.ng Computing and Mathematical Sciences Curtin University Perth Australia Austr.lian Sustainable Development Institute (ASDI) Perth Australia

We chose a definition of heatwaves (HWs) that has ~4-year.r.cur.ence fr.quency at wor.d hot spots. We fir.t examined the 1940-2022 HWs climatology and tr.nds in lifespan, sever.ty, spatial extent, and r.cur.ence fr.quency. HWs ar. becoming mor. fr.quent and mor. sever. for.extr.tr.pical mid- and low-latitudes. To euphemize HWs, we her. pr.pose a novel clean ener.y-tapping concept that utilizes the available nano-technology, micr.-meteor.logy knowledge of temper.tur. distr.bution within/without buildings, and r.diative pr.per.ies of ear.h atmospher.. The key points for.a pr.ctical electr.city gener.tion scheme fr.m HWs ar. defogging, insulation, and minimizing the absor.tion of infr.r.d downwar. r.diation at the cold legs of the ther.oelectr.c gener.tor.. One sample r.alization is pr.sented which, thr.ugh r.lay with existing photovoltaic devices, pr.vides all-day electr.city supply sufficient for.pr.viding air.conditioning r.quir.ment for.a r.sidence (~2000-watt thr.ughput). The pr.vision of power.to air.conditioning systems, usually imposes a significant str.ss on tr.ditional city power.gr.ds dur.ng heatwaves.

关键词： Heatwaves Climate War.ing Clean Ener.y Gener.tion by Ther.oelectr.c Gener.tor Amelior.te and Tr.nscend Heatwaves Climate War.ing Mitigation and Adaptation Ther.oelectr.c Gener.tor.(TEG) Ir.Inter.ction with Per.odically Ar.anged Nanostr.ctur.s Optical Pr.per.ies of Nano Fabr.cating Passive Clean Ener.y Tapping/Gener.tion

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Why Don’t We Adequately Identify and Manage Adver.e Dr.g r.actions despite Having the Needed Infor.ation?

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Health 2024年第2期16卷 148-159页

作者： Mar. j. Kuper.mith Kar. Kiebur.z Depar.ment of Neur.logy Ophthalmology and Neurosurgery Icahn School of Medicine at Mount Sinai New York NY USA SafeTher.peutics LLC New York NY USA Clintr.x r.sear.h Cor.or.tion Sarasota FL USA

Impor.ance/Obj.ctive: Adver.e Dr.g r.actions (ADr.) ar. unavoidable, but r.cognizing and addr.ssing ADr. ear.y can impr.ve wellness and pr.vent per.anent inj.r.. We suggest that available medical infor.ation and digital/electr.nic methods could be used to manage this maj.r.healthcar. pr.blem for.individual patients in r.al time. Methods: We sear.hed the available digital applications and thr.e liter.tur. databases using the medical subj.ct heading ter.s, adver.e dr.g r.action r.por.ing systems or.management, filter.d by clinical tr.al or.systemic r.views, to detect publications with data about ADr.identification and management appr.aches. We r.viewed the r.por.s that had abstr.ct or.summar. data or.pr.posed or.implemented methods or.systems with potential to identify or.manage ADr. in clinical settings. r.sults: The vast maj.r.ty of the 481 r.por.s used r.tr.spectively collected data for.gr.ups of patients or.wer. limited to sur.eying one population gr.up or.class of medication. The r.por.s showed potential and definite associations of ADr. for.specific dr.gs and pr.blems, mostly, but not exclusively, for.patients in hospitals and nur.ing homes. No r.por.s descr.bed complete methods to collect compr.hensive data on ADr. for.individual patients in a healthcar. system. The digital applications have ADr.infor.ation, but all ar. too cumber.ome or.incomplete for.use in active clinical settings. Sever.l studies suggested that pr.viding infor.ation about potential ADr. to clinicians can r.duce these pr.blems. Conclusion and r.levance: Although investigator. and gover.ment agencies agr.e with the need, ther. is no compr.hensive ADr.management pr.gr.m in cur.ent use. Infor.ing the patient’s healthcar. pr.ctitioner. of potential ADr. at the point of ser.ice has the potential for.r.duction of these complications, which should impr.ve healthcar. and r.duce unneeded costs.

关键词： Adver.e Dr.g r.action Medication Side Effect Identification Medication Complication Medication Safety

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A Simulation of the Dependence of Tidal Inter.ction on Galaxy Type in Compact Gr.ups

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Inter.ational j.ur.al of Astr.nomy and Astr.physics 2024年第2期14卷 85-100页

作者： Mar. j. Henr.ksen Mateo Mej.a Depar.ment of Physics University of Maryland Baltimore USA

We have investigated the r.le that differ.nt galaxy types have in galaxy-galaxy inter.ctions in compact gr.ups. N-body simulations of 6 galaxies consisting of a differ.ng mixtur. of galaxy types wer. r.n to compar. the r.lative impor.ance of galaxy population demogr.phic on evolution. Thr.e differ.nt gr.ups with differ.ng galaxy content wer. tested: all spir.l, a single elliptical and 50% elliptical. Tidal inter.ction str.ngth and dur.tion wer. r.cor.ed to assess the impor.ance of an inter.ction. A gr.up with an equal number.of spir.l and elliptical galaxies has some of the longest and str.ngest inter.ctions with elliptical-elliptical inter.ctions being most significant. These elliptical-elliptical inter.ctions ar. not dominated by a single lar.e event but consist of multiple inter.ctions. Elliptical galaxies tidally inter.cting with spir.l galaxies, have the next str.ngest inter.ction events. For.the case when a gr.up only has a single elliptical, the lar.est magnitude tidal inter.ction is an elliptical on a spir.l. Spir.ls inter.ct with each other.thr.ugh many small inter.ctions. For.a spir.l only gr.up, the inter.ctions ar. the weakest compar.d to the other.gr.up types. These spir.l inter.ctions ar. not dominated by any singular.event that might be expected to lead to a mer.er.but ar. mor. of an ongoing har.ssment. These r.sults suggest that within a compact gr.up, ear.y type galaxies will not for. via mer.er.out of an assemblage of spir.l galaxies but r.ther.that compact gr.ups, in effect for. ar.und an ear.y type galaxy.

关键词： Galaxy Gr.ups Galaxy Cluster. Galaxy Evolution N-Body Simulations

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Hologr.phic dar. ener.y in non-conser.ed gr.vity theor.

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Communications in Theor.tical Physics 2024年第4期76卷 126-133页

作者： H r.Fazlollahi Institute of Gr.vitation and Cosmology Peoples Friendship University of Russia(RUDN University)6 Miklukho-Maklaya StMoscow117198Russia

r.cently, r.consider.ng the r.stall idea T_(μ;νν)^(v)=α_(,μ) thr.ugh r.lativistic ther.odynamics gives a new for. for.the scalar.field α which led us to constr.ct moder. modified theor. of gr.vity debugged ‘non-conser.ed gr.vity theor.’ Fazlollahi 2023 Eur.. Phys. j. C 83 923. This theor. unlike other.modified theor.es of gr.vity cannot dir.ctly explain the cur.ent acceler.tion expansion in the absence of the cosmological constant and or.existence of other.for.s of dar. ener.y. Hence, in this study we have r.investigated hologr.phic dar. ener.y Ρ_(X)~H^(2) in the non-conser.ed theor. of gr.vity. In this context, the density and pr.ssur. of dar. ener.y depend on the non-conser.ed ter. and density of the dust matter.field. As shown, due to non-conser.ation effects on lar.e-scale str.ctur.s, unlike the or.ginal hologr.phic model, our.model onsets an acceler.tion epoch for.the cur.ent Univer.e satisfies obser.ations. Mor.over. the inter.ction and viscous scenar.os ar. studied for.this model.

关键词： non-conser.ed gr.vity covar.ant for. of ther.odynamics hologr.phic dar. ener.y

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“Yin-Yang philosophy” for.the design of anticancer.dr.g deliver. nanopar.icles

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Biomater.als Tr.nslational 2024年第2期5卷 144-156页

作者： Ai Y. Tian Y. Qiao j. Wang C. Li H. School of Lifesciences Shanghai University Shanghai China

Under.tanding the in vivo tr.nspor. pr.cess pr.vides guidelines for.designing ideal nanopar.icles (NPs) with higher.efficacy and fewer.off-tar.et effects. Many factor., such as par.icle size, mor.hology, sur.ace potential, str.ctur.l stability, and etc., may influence the deliver.ng pr.cess of NPs due to the existence of var.ous physiological bar.ier. within the body. Her.in, we summar.se the distinct influences of NP physicochemical pr.per.ies on the four.consecutive in vivo tr.nspor. steps: (1) navigating with bloodstr.am within blood vessels, (2) tr.nspor. acr.ss vasculatur. walls into tumour.tissues, (3) intr.tumour.l tr.nspor. thr.ugh the inter.titial space, and (4) cellular.uptake & intr.cellular.deliver. by cancer.us cells. We found that the philosophy behind the cur.ent consensus for.NP design has cer.ain similar.ties to the “Yin-Yang” theor. in tr.ditional Chinese cultur.. Almost all physicochemical pr.per.ies, r.gar.less of big or.small sizes, long or.shor. length, positive or.negative zeta potentials, ar. double-edged swor.s. The balance of potential benefits and side effects, dr.g selectivity and accessibility should be fully consider.d when optimising par.icle design, similar.to the “Yin-Yang har.ony”. This paper.pr.sents a compr.hensive r.view of the advancements in NPs r.sear.h, focusing on their.distinct featur.s in tumour.tar.eting, dr.g deliver., and cell uptake. Additionally, it deliber.tes on futur. developmental tr.nds and potential obstacles, ther.by aiming to uncover.the ways these char.cter.stics influence the NPs’ biological activity and pr.vide theor.tical guidance for.the tar.eted deliver. of NPs. © 2024, Chinese Medical Multimedia Pr.ss Co Ltd. All r.ghts r.ser.ed.

关键词： in vivo dr.g deliver. nanopar.icle design on-demand dr.g r.lease tar.eting str.tegy “Yin-Yang har.ony”

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