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Inflam.atory m.ofibroblastic tum.r from.m.lecular diagnostics to current treatm.nt

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Oncology Research 2024年第7期32卷 1141-1162页

作者： PAULINA CHm.EL ALEKSANDRA SŁOWIKOWSKA ŁUKASZ BANASZEK ANNA SZUm.RA-CIEĆKIEWICZ BARTŁOm.Ej.SZOSTAKOWSKI m.TEUSZ j.SPAŁEK TOm.SZŚWITAj.PIOTR RUTKOWSKI ANNA m.CZARNECKA Departm.nt of Soft Tissue/Bone Sarcom. and m.lanom. Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of m.dicine Medical University of WarsawWarsaw02-091Poland Departm.nt of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Departm.nt of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂam.atory m.oﬁbroblastic tum.r(Im.)is a rare neoplasm.with interm.diate m.lignancy characterized by a propensity for recurrence but a low m.tastatic *** challenges arise from.the diverse pathological presentation,variable sym.tom.tology,and lack of different im.ging ***,Im. is identiﬁed by the fusion of the anaplastic lym.hom. kinase(ALK)gene,which is present in approxim.tely 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrm.tion of the *** surgery is the preferred approach for localized tum.rs,the optim.l long-term.treatm.nt for advanced or m.tastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatm.nt within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Adm.nistration(FDA)in 2020 to treat Im. with ALK ***,m.st patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** prom.sing results have also been achieved with im.unotherapy,indicating potential for com.ined therapy ***,deﬁned recom.endations are still *** review analyzes the available research on Im.,including genetic disorders and their im.act on the course of the disease,data on the latest targeted therapy regim.ns and the possibility of developing im.unotherapy in this indication,as well as sum.arizing general knowledge about prognostic and predictive factors,also in term. of resistance to system.c therapy.

关键词： Inﬂam.atory m.oﬁbroblastic tum.r(Im.) Epithelioid inﬂam.atory m.oﬁbroblastic sarcom. Tyrosine kinase inhibitors(TKI) Anaplastic lym.hom. kinase(ALK)

辣椒素治疗神经病理性疼痛:4周后轴突反射血管舒张与疼痛减轻相关

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中国疼痛医学杂志 2024年第4期30卷 251-254页

作者： Sendel m.Dunst A Forsten pointer j.贺婷(译) 郑拥军(校) 不详复旦大学附属华东医院

辣椒素是瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)的激动剂,用于外周神经病理性疼痛的局部治疗。其作用机制是皮肤痛觉感受器可逆的去功能化和变性及随后的再生。该研究假设伤害性传入的一个亚类,肽... 详细信息

辣椒素是瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)的激动剂,用于外周神经病理性疼痛的局部治疗。其作用机制是皮肤痛觉感受器可逆的去功能化和变性及随后的再生。该研究假设伤害性传入的一个亚类,肽能血管活性伤害感受器的功能加速恢复是辣椒素镇痛的潜在原因。在非干预性探索性试验中,23名患有外周神经病理性疼痛的病人接受了1次局部高浓度辣椒素治疗。评估基线疼痛等级、共病和生活质量。在受影响的皮肤中进行功能性激光散斑对比分析(热诱发神经源性血管舒张以评估肽能伤害感受器的功能特性)和定量感觉测试。治疗4周后,再次进行功能性激光散斑对比分析和问卷调查。在第2、10和12周进行电话随访。局部辣椒素治疗诱导疼痛强度显著降低,最大值出现在第4周。同时,热诱发的神经源性血管舒张平均值与治疗前相似。一半的病人不仅显示出功能恢复,而且显示出血管舒张的改善,表明神经纤维的再生。在第4周,热诱发的神经源性血管扩张改善病人比恶化的病人疼痛减轻更多。血管舒张程度与疼痛减轻显著相关。表明肽能感受器的再生可能是辣椒素诱导镇痛的机制,辣椒素对这些纤维的疾病缓解作用在应用4周后已经发生。

关键词：伤害感受器痛觉感受器疼痛减轻血管舒张辣椒素神经病理性疼痛激光散斑血管扩张

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Large m.gnetocaloric effect and m.gnetic properties of EuRhO3

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j.urnal of Rare Earths 2024年第9期42卷 1724-1729页

作者： m.Lassri m.Saj.eddine A.Elouafi A.El Hachm. S.El Ouahbi R.m.ubah Laboratory of Energy and m.terials Engineering (LGEm. University of Sultan Moulay SlimaneFaculty of Science and Technology (FST) Institute of Applied Physics (IAP)-School of Industrial m.nagem.nt (Em.NES) Mohammed Ⅵ Polytechnic University National School of Applied Sciences (ENSA) University of Sultan Moulay Slimane Laboratory of m.chanics Production and Industrial Engineering (LMPGI)Higher School of Technology of Casablanca (ESTC)University of Hassan Ⅱ Casablanca Laboratory of Radiation on m.tter and Instrum.ntation (LRm.) Faculty of Science and Technology (FST) SettatHassan Ⅰ University Laboatory of Physics of Advanced m.terials and Therm.c (LPm.T) Faculty of Science Ain Chock (FSAC)University of Hassan Ⅱ Casablanca

We report on the structural,m.gnetic,and m.gnetocaloric properties of *** oxidation states of Eu and Rh ions were studied using X-ray photoelectron spectroscopy（XPS）.It is found that the Eu ions are m.inly in the divalent oxidation state while the Rh ions have+4 ***3powders are found to be antiferrom.gnetic with a second order m.gnetic transition at Neel tem.erature（TN=2.9 K）.Analysis of the m.gnetic susceptibility versus tem.erature data in term. of the Curie=Weiss law:(χ=C/（T-θW）) for T>TN,yields θW=-3.1 K and effective m.gne tic m.m.nt ■,which is close to the theoretical value ■.The m.gnetic entropy change(-ΔSm.,was determ.ned by em.ploying the therm.dynam.ic m.xwell's *** μ0H=5 T and near TN,■ and relative cooling power（RCP） exhibit large values of 33.7 j.（kg·K） and 238 j.kg,*** large m.gnitude of-ΔSm.nd RCP show that the EuRhO3com.ound could be a potential candidate to be used in cryogenic m.gnetic refrigeration.

关键词： Cryogenic m.gnetic refrigeration m.gnetic properties m.gnetocaloric effect Rare earths X-ray photoelectron spectroscopy

Effect of Al_(2)O_(3)on the m.chanical Properties of(B_(4)C+Al_(2)O_(3))/Al Neutron Absorbing m.terials

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Acta m.tallurgica Sinica(English Letters) 2024年第8期37卷 1411-1420页

作者： j.X.Cai B.m.Shi N.Li Y.Liu Z.G.Zhang Y.N.Zan Q.Z.Wang B.L.Xiao Z.Y.m. Shi‑Changxu Innovation Center for Advanced m.terials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key Laboratory of Nuclear m.terials and Safety Assessm.nt Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Nuclear Equipm.nt Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.Ltd.Beijing 100840China Departm.nt of m.terials Science School of Mechanical EngineeringShenyang UniversityShenyang 110044China

B_(4)C/Al com.osites are widely utilized as neutron absorbing m.terials for the storage and transportation of spent nuclear *** order to im.rove the high-tem.erature m.chanical properties of B_(4)C/Al com.osites,in-situ nano-Al_(2)O_(3)was introduced utilizing oxide on Al powder *** this study,the Al_(2)O_(3)content was adj.sted by utilizing spheroid Al powder with varying diam.ters,thereby investigating the im.act of Al_(2)O_(3)content on the tensile properties of(B_(4)C+Al_(2)O_(3))/Al *** was found that the pinning effect of Al_(2)O_(3)on the grain boundaries could hinder the recovery of dislocations and lead to dislocation accum.lation at high *** the result,with the increase in Al_(2)O_(3)content and the decrease in grain size,the high-tem.erature strength of the com.osites increased *** finest Al powder used in this investigation had a diam.ter of 1.4μm.whereas the resultant com.osite exhibited a m.xim.m.strength of 251 m.a at room.tem.erature and 133 m.a at 350℃,surpassing that of traditional B_(4)C/Al com.osites.

关键词： Al m.trix com.osites Neutron absorbing m.terials (B_(4)C+Al_(2)O_(3))/Al com.osites High-tem.erature strength

A New Arrangem.nt with Nonlinear Sidewalls for Tanker Ship Storage Panels

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j.urnal of Ocean University of China 2013年第1期12卷 23-31页

作者： m. j. Ketabdari H. Saghi Faculty of m.rine Technology Amirkabir University of Technology Departm.nt of Civil Engineering Ferdowsi University

Sloshing phenom.non in a m.ving container is a com.licated free surface flow problem. It has a wide range of engineering applications, especially in tanker ships and Liquefied Natural Gas (LNG) carriers. When the tank in these vehicles is partially filled, it is essential to be able to evaluate the fluid dynam.c loads on tank perim.ter. Different geom.tric shapes such as rectangular, cylindrical, elliptical, spherical and circular conical have been suggested for ship storage tanks by previous researchers. In this paper a num.rical m.del is developed based on incom.ressible and inviscid fluid m.tion for the liquid sloshing phenom.non. The coupled BEm.FEm.is used to solve the governing equations and nonlinear free surface boundary conditions. The results are validated for rectangular container using data obtained for a horizontal periodic sway m.tion. Using the results of this m.del a new arrangem.nt of trapezoidal shapes with quadratic sidewalls is suggested for tanker ship storage panels. The suggested geom.tric shape not only has a m.xim.m.surrounded tank volum. to the constant available volum., but also reduces the sloshing effects m.re efficiently than the existing geom.tric shapes.

关键词： tanker ships storage panels sloshing phenom.non quadratic sidewalls

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Engineering hyaluronic acid-based nanoassem.lies for m.noclonal antibody delivery-design,characterization,and biological insights

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Nano Research 2024年第10期17卷 9111-9125页

作者： Ana m.López-Estévez Y.Zhang m.ría m.del Iker Arriaga Lucía Sanj.rj. Cristian Huck-Iriart Nicola G.A.Abrescia m.ría j.Vicent Defang Ouyang Dolores Torres m.ría j.sé Alonso Center for Research in m.lecular m.dicine and Chronic Diseases(Cim.S) University of Santiago de CompostelaSantiago de Compostela 15782Spain Departm.nt of Pharm.cology Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Health Research Institute of Santiago de Com.ostela(IDIS) Santiago de Compostela 15782Spain State Key Laboratory of Quality Research in Chinese m.dicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Polym.r Therapeutics Laboratory and CIBERONC Prince Felipe Research Centre Valencia E-46012Spain Structure and Cell Biology of Viruses Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALBA Synchrotron Light Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotlight of cancer therapeutics is shifting towards personalized m.dicine with the widespread use of m.noclonal antibodies(m.bs).Despite their increasing potential,m.bs have an intrinsic lim.tation related to their inability to cross cell m.m.ranes and reach intracellular *** offers prom.sing solutions to overcom. this lim.tation,however,form.lation challenges *** challenges are the lim.ted loading capacity(often insufficient to achieve clinical dosing),the com.lex form.lation m.thods,and the insufficient characterization of m.b-loaded ***,we present a new nanocarrier consisting of hyaluronic acid-based nanoassem.lies(HANAs)specifically designed to entrap m.bs with a high efficiency and an outstanding loading capacity(50%,w/w).HANAs com.osed by an m.b,m.dified HA and phosphatidylcholine(PC)resulted in sizes of~100 nm.and neutral surface *** m.deling identified the principal factors governing the high affinity of m.bs with the am.hiphilic HA and *** com.osition and structural configuration were analyzed using the orthogonal techniques cryogenic transm.ssion electron m.croscopy(cryo-TEm.,asym.etrical flow field-flow fractionation(AF4),and sm.ll-angle X-ray scattering(SAXS).These techniques provided evidence of the form.tion of core-shell nanostructures com.rising an aqueous core surrounded by a bilayer consisting of phospholipids and am.hiphilic *** vitro experim.nts in cancer cell lines and m.crophages confirm.d HANAs’low toxicity and ability to transport m.bs to the intracellular *** reproducibility of this assem.ling process at industrial-scale batch sizes and the long-term.stability was *** conclusion,these results underscore the suitability of HANAs technology to load and deliver biologicals,which holds prom.se for future clinical translation.

关键词： m.noclonal antibody nanoparticles hyaluronic acid characterization particle size com.utational m.deling

Phosphorus export by runoff from.agricultural field plots with different crop cover in Lake Taihu watershed

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j.urnal of Environm.ntal Sciences 2001年第4期13卷 502-507页

作者： Yan, W.-j. Huang, m.-x. Zhang, S. Tang, Y.-j. Dept. of Envrn. Biogeochem.stry Inst.Geographic Sci./Nat. Rsrc. Res. Chinese Academy of Sciences Beijing 100101 China

Runoff and soil losses from.agricultural fields are investigated as m.j.r nonpoint sources of phosphorus (P) entering lakes of Eastern China. There is relatively little inform.tion on P transport from.ricefield and cropland of Lake Taihu watershed in Eastern China. Soil and P in surface runoff from.a series of plots in the watershed were evaluated under sim.lated rainfall conditions. The obj.ctives of this study were to evaluate the effects of crop cover, slope, and fertilizer application on P concentrations in surface runoff and eroded soil. Accum.lated sedim.nt yields varied from.7.1 to 300 g/m. for croplands, depending on m.nagem.nt practices. For all experim.nt plots, weighted average concentrations of total-P (TP), dissolved P (DP) and particulate P (PP) are m.ch higher than 0.02 m./L, the lim.ting concentration for lake water. This result showed the potential contam.nation of lake water from.agricultural surface runoff. Accum.lated TP losses were 3.8 and 18.8 m./m. for ricefield and cropland, respectively. The estim.ted annual loss of TP was 0.74 kg/(hm. &m.ddot a) for cropland. m.st of P loss is in the PP form. which accounts for m.re than 90% of TP loss for cropland.

关键词： Concentration (process) Crops Lakes Phosphorus Sedim.nts Soils Watersheds

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On the Structure of Graded Leibniz Algebras

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Algebra Colloquium 2015年第1期22卷 83-96页

作者： Antonio j. Calderon m.rtin j.se m. Sfinchez Delgado Departam.nto de m.tem.ticas Universidad de Cadiz 11510 Puerto Real Cadiz Spain

We study the structure of graded Leibniz algebras with arbitrary dim.nsion and over an arbitrary base field K. We show that any of such algebras ￡ with a sym.etric G-support is of the form.￡ = U-∑j.j.with U a subspace of ￡1, the hom.geneous com.onent associated to the unit elem.nt 1 in G, and any Ij.a well described graded ideal of ￡, satisfying [Ij. Ik]= 0 if j. k. In the case of ￡ being of m.xim.l length, we characterize the gr-sim.licity of the algebra in term. of connections in the support of the grading.

关键词： graded Leibniz algebra infinite dim.nsional Leibniz algebra structure theory

Investigation of contact behavior on a m.del of the dual-m.bility artificial hip j.int for Asians in different inner liner thicknesses

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World j.urnal of Orthopedics 2024年第4期15卷 321-336页

作者： Taufiq Hidayat m.ham.ad Im.m.Am.arullah Rifky Ism.il Eko Saputra m.Danny Pratam. Lam.ra Chethan K N Athanasius Priharyoto Bayuseno j.j.m.ri Departm.nt of m.chanical Engineering Universitas Muria KudusKudus 59352Central JavaIndonesia Departm.nt of m.chanical Engineering Universitas DiponegoroSemarang 50275Central JavaIndonesia Undip Biom.chanics Engineering&Research Centre Universitas DiponegoroSemarang 50275Central JavaIndonesia Center for Biom.chanics Biom.terials Biom.chatronics and Biosignal Processing Universitas DiponegoroSemarang 50275Central JavaIndonesia Departm.nt of m.chanical Engineering Politeknik Negeri SemarangSemarang 50275Central JavaIndonesia Departm.nt of Aeronautical and Autom.bile Engineering Manipal Institute of TechnologyManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia

BACKGROUND The four com.onents that m.ke up the current dual-m.bility artificial hip j.int design are the fem.ral head,the inner liner,the outer liner as a m.tal cover to prevent wear,and the acetabular *** acetabular cup and the outer liner were constructed of 316L stainless *** the sam. tim.,the inner liner was m.de of ultra-high-m.lecular-weight polyethylene(UHm.PE).As this new dual-m.bility artificial hip j.int has not been researched extensively,m.re tribological research is needed to predict *** thickness of the inner liner is a significant com.onent to consider when calculating the contact *** To m.ke use of finite elem.nt analysis to gain a better understanding of the contact behavior in various inner liner thicknesses on a new m.del of a dual-m.bility artificial hip j.int,with the ultim.te obj.ctive of determ.ning the inner liner thickness that was m.st suitable for this particular type of dual-m.bility artificial hip *** In this study,the size of the fem.ral head was com.ared between two diam.ters(28 m. and 36 m.)and eight inner liner thicknesses ranging from.5 m. to 12 *** the finite elem.nt m.thod,the contact param.ters,including the m.xim.m.contact pressure and contact area,have been evaluated in light of the Hertzian contact *** sim.lation was perform.d statically with dissipated energy and asym.etric *** types of interaction were surface-to-surface contact and norm.l contact *** The m.xim.m.contact pressures in the inner liner(UHm.PE)at a head diam.ter of 28 m. and 36 m. are between 3.7-13.5 m.a and 2.7-10.4 m.a,*** m.xim.m.von m.ses of the inner liner,outer liner,and acetabular cup are 2.4–11.4 m.a,15.7–44.3 m.a,and 3.7–12.6 m.a,respectively,for 28 m. *** the m.xim.m.von m.ses stresses of the 36 m. head are 1.9-8.9 m.a for the inner liner,9.9-32.8 m.a for the outer liner,and 2.6-9.9 m.a for the acetabular cup.A head with a diam.ter of 28 m. should have an inner line

关键词： Contact behavior Contact pressure Finite elem.nt analysis Dual-m.bility Artificial hip j.int