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P2X7 receptor signaling during adult hippocampal neurogenesis

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Neural Regeneration Research 2019年第10期14卷 1684-1694页

作者： Hannah C. Leeson Tailoi Chan-Ling Michael D. Lovelace j.remy C. Brownlie Ben j. gu Michael W. Weible II Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia Griffith Institute for Drug Discovery Griffith UniversityBrisbaneQueenslandAustralia Discipline of Anatomy and Histology School of Medical ScienceThe University of SydneySydneyNew South WalesAustralia Bosch Institute The University of SydneySydneyNew South WalesAustralia Applied Neurosciences Program Peter Duncan Neurosciences Research UnitSt. Vincent’s Centre for Applied Medical ResearchSydneyNew South WalesAustralia Faculty of Medicine St. Vincent’s Clinical SchoolUniversity of New South Wales SydneySydneyNew South WalesAustralia School of Environment and Science Griffith UniversityBrisbaneQueenslandAustralia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoriaAustralia

Neurogenesis is a persistent and essential feature of the adult mammalian *** neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new *** of hippocampal neurogenesis is complex and multifaceted,and numerous signaling pathways converge to modulate cell proliferation,apoptosis,and clearance of cellular debris,as well as synaptic integration of newborn immature *** expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored.P2X7 receptors are exceptionally versatile:in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation.P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication,and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form,which induce apoptotic cell death through cytosolic ion ***,as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis,as well as during some disease *** how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative *** review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus,and neural stem and progenitor cells.

关键词： P2X7 P2X7R adult neurogenesis neural stem cells neural progenitor cells hippocampus SGZ calcium signaling purinergic signaling

COUPLED NUMERICAL SIMULATION ON COLD ROLLER'S TEMPERATURE FIFLD-PHASE TRANSFORMATION - STRESS FIELD DURING ITS QUENCHING PSOCESS

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Acta Metallurgica Sinica(English Letters) 2000年第1期13卷 254-262页

作者： j. F. gu j. S. Pan M. j. Hu and F. F. Shen (School of Materials Science and Engineering, Shanghai j.ao Tong University, Shanghai 200030, China)

Complicated changns occur inside the steel parts during quenching process. The abruptly changed boundary conditions make the temperature field,micro - structure and stress field change dramatically in very short time, and these variables take a contact interactions in the whole process. In this paper, a three dimensional non - linear mathematical model for queeching process has been founded and the numerical simulation on temperature field,microstructre and stress field has been *** the FEM analysis, the incremental iteration method is used to deal with such complicated nonlinear as boundary nonlinear, physical property nonlinear,transformation nonlinear *** effect of stress on transformation kinetics has been considered in the calculation of microstructure. In the stress field anal- ysis,a thermo- elasto - plastic model has been founded, which considers such factors as transforma- tion strain,transformation plastic strain, themal strain and the effect of temperature and transforma- tion on mechanical propertier etc. The transient temperature field, microstructure distribution and stress field of the roller on any time can be displayed vividly,and the cooling curve and the changes of stress on any position can also be given.

关键词： quenching,phase transformation,temperature field stress field finite element method (FEM) numerical simulation

FABRICATION OF SUBMICRON GRAINED TITANIUM ALLOY BY COMPRESSIVE DEFORMATION

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Acta Metallurgica Sinica(English Letters) 2000年第2期13卷 638-644页

作者： X. j. Sun, j. L. gu, B. Z. Bai, B. Dai and N. P. Chen (Department of Materials Science and Engineering, Tsinghua University, Beij.ng 100084, China

This paper reviews various fabrication methods of ultrafine grained materials and their limitations briefly, and examines the possibility to produce ultrafine grained titanium alloy by compressive deformation preliminarily. It has been shown that submicrongrained TC11 alloy can be obtained by compressive deformation below 725°C. During microstructure refinement, dynamic recrystallization occurs only in α phases, and β phases undergo a process of precipitation and growth. Compared with the situation of static annealing, deformation can not only enhance the precipitation and growth of β phases but also change the morphology of βprecipitates.

关键词： TC11 alloy submicron grain compressive deformation superplasticity

Fault current Characterization Based on Fuzzy Algorithm for DOCR Application

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Energy and Power Engineering 2013年第4期5卷 932-936页

作者： Luly Susilo j. C. gu S. K. Huang Electrical Engineering Department National Taiwan University of Science and Technology

Penetration of distribution generation (DG) into power system might disturb the existing fault diagnosis system. The detection of fault, fault classification, and random changes of direction of fault current cannot always be monitored and determined via on-line by conventional fault diagnosis system due to DG penetration. In this paper, a fault current characterization which based on fuzzy logic algorithm (FLA) is proposed. Fault detection, fault classification, and fault current direction are extracted after processing the measurement result of three-phase line current. The ability of fault current characterization based on FLA is reflected in directional overcurrent relay (DOCR) model. The proposed DOCR model has been validated in microgrid test system simulation in Matlab environment. The simulation result showed accurate result for different fault location and type. The proposed DOCR model can operate as common protection device (PD) unit as well as unit to improve the effectiveness of existing fault diagnosis system when DG is present.

关键词： Fault Current Characterization Fuzzy Logic Algorithm DOCR Distributed Generation

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软包装材料设计中需要考虑的问题

中国食品工业 2011年第8期 32-33页

作者： j. Georgia gu 北京丹贝尔仪器有限公司

在软包装设计中，包装的色彩和美观造型固然重要，但我们这里更感兴趣的是如何设计和选择包装材料，使包装能达到提供维护产品质量，延长货架寿命的目的。不同商品需要不同的包装材料，所以必须透彻了解要包装的产品的性能，之后根据储... 详细信息

在软包装设计中，包装的色彩和美观造型固然重要，但我们这里更感兴趣的是如何设计和选择包装材料，使包装能达到提供维护产品质量，延长货架寿命的目的。不同商品需要不同的包装材料，所以必须透彻了解要包装的产品的性能，之后根据储藏环境条件以及货架期要求等多项综合考虑，来合理选择阻隔材料的级别、厚度、尺寸等等。当选定了材料后，还要对终极成型包装在实际应用条件下做进一步测试，以确证包装的阻隔性、物理强度在加工、运输和销售环节中未受损坏。由测试结果对包装加工过程进行调整，必要的话采用气调包装技术，从而保证产品在保质期内的安全。

关键词：材料设计软包装产品质量气调包装技术包装材料加工过程包装设计货架寿命

Taxonomic dependency and spatial heterogeneity in assembly mechanisms of bacteria across complex coastal waters

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Ecological Processes 2024年第1期13卷 80-97页

作者： Huizhen Yan Dandan Lin Gaoke gu Yuj.e Huang Xuya Hu Zhenhao Yu Dandi Hou Demin Zhang Barbara j.Campbell Kai Wang State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products School of Marine SciencesNingbo University Key Laboratory of Marine Biotechnology of Zhej.ang Province School of Marine Sciences Ningbo University Department of Biological Sciences Clemson University

Background Understanding community assembly mechanisms across taxa and space is fundamental for microbial ecology. However, the variability and determinants of assembly processes over taxa and space remain unclear. Here, we investigated taxonomic dependency and spatial heterogeneity in bacterial assembly mechanisms across coastal waters in the East China Sea using neutral and null models with customized visualization *** Overall, bacterial assembly mechanisms varied across broad taxonomic groups(phyla and proteobacterial classes) and space at the regional scale. A determinism–stochasticity balanced mechanism governed total bacterial assembly, while taxonomic dependency existed in assembly mechanisms and ecological processes. Among community ecological features, niche breadth and negative-to-positive cohesion ratio were strongly associated with the determinism-to-stochasticity ratio of bacterial groups. Bacterial assembly mechanisms commonly exhibited spatial heterogeneity, the extent and determinants of which varied across taxonomic groups. Spatial assembly of total bacteria was directly driven by many environmental factors and potential interactions between taxa, but not directly by geographic factors. Overall, the bacterial groups with higher spatial heterogeneity in assembly mechanisms were more related to environmental and/or geographic factors(except Bacteroidetes), while those with lower heterogeneity were more related to ecological *** Our results confirm the pervasiveness of taxonomic dependency and spatial heterogeneity in bacterial assembly, providing a finer understanding about regulation across complex coastal waters.

关键词： Bacterioplankton Assembly mechanism Niche breadth Null model Environmental gradient Biogeography

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阻隔性能及其对食品包装的影响

塑料制造 2009年第9期 26-29页

作者： j. Georgia gu 王丹枫美国MOCON公司北京丹贝尔仪器有限公司

阻隔性材料和渗透现代包装有如下主要功能：（1）产品的容器：有合理尺寸，形状，方便使用。

关键词：食品包装阻隔性能阻隔性材料现代包装合理尺寸

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阻隔性能及其对食品包装的影响

中国食品工业 2012年第1期 44-46页

作者： j. Georgia gu 王丹枫美国MOCON公司北京丹贝尔仪器有限公司

随着现代科学和技术的发展，包装材料发生了由传统到现代的演变。传统包装材料例子有玻璃瓶，金属罐和纸袋。现代包装材料实例有聚合物袋或瓶子和多层复合材料包装。传统的包装材料均非渗透性，如玻璃，金属；或高渗透，如纸张。对于玻... 详细信息

随着现代科学和技术的发展，包装材料发生了由传统到现代的演变。传统包装材料例子有玻璃瓶，金属罐和纸袋。现代包装材料实例有聚合物袋或瓶子和多层复合材料包装。传统的包装材料均非渗透性，如玻璃，金属；或高渗透，如纸张。对于玻璃和金属等非渗透材料，有可能泄漏路径有接缝和瓶盖界面。现代包装材料的主要是高分子复合材料，

关键词：食品包装阻隔性能高分子复合材料包装材料多层复合材料玻璃瓶金属罐现代科学

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货架期安全和包材的阻隔性研究

全球软包装工业 2011年第3期 72-73页

作者： j. Georgia gu 王丹枫美国MDCON公司北京丹贝尔仪器有限公司

一、包装材料的阻隔性和渗透消费者越来越关注食品和药品的货架期安全，而货架期安全离不开包装材料的阻隔性。影响货架期安全的四大因素有：氧气、水、光和微生物。以氧气为例，过量的氧气进入包装。会造成食品的腐败变质，而氧气进入... 详细信息

一、包装材料的阻隔性和渗透消费者越来越关注食品和药品的货架期安全，而货架期安全离不开包装材料的阻隔性。影响货架期安全的四大因素有：氧气、水、光和微生物。以氧气为例，过量的氧气进入包装。会造成食品的腐败变质，而氧气进入包装的途径，除了食品本身夹带的氧气外，

关键词：货架期阻隔性安全包装材料腐败变质氧气食品消费者