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Evaluation of Accuracy and Precision of IRMS by Using Standard Materials and Applications

j.urnal of Agricultural Chemistry and Environment 2016年第4期5卷 211-222页

作者： j. Y. Hw.ng B. K. Kim M. S. Kim j. w. choi T. S. Kim w. S. Lee Soil and Groundw.ter Research Division National Institute of Environmental Research Environment Research Complex Incheon Republic of Korea Environmental Measurement & Analysis Center National Institute of Environmental Research Environment Research Complex Incheon Republic of Korea Integrated Pollution Prevention and Control Task Force National Institute of Environmental Research Environment Research Complex Incheon Republic of Korea

The isotope ratio mass spectrometer (IRMS) is an instrument that measures both of the elemental contents and isotope ratios of hydrogen, oxygen, carbon, nitrogen and sulfur in environmental samples at the same time. In this study, w. w.nt to try to get tw. main goals;first, to make up for setting the analytical conditions such as accuracy and precision, second, to apply for comparing of the carbon and nitrogen isotope ratio of sediments in the abandoned mine located in middle province of Korea. For the first goal, a recently introduced IRMS w.s used to analyze CRM (certified reference materials), w.ich helped to make up the analytical conditions of carbon and nitrogen isotope ratios. So, the accuracy and precision of isotope ratios and elemental contents w.re also assessed simultaneously, and also the results w.re very satisfactory. The analytical results of carbon reference materials (EMA-P2) show.d an accuracy of -2.801 × 10‰ ± 0.01‰ (2σ) and a precision of 0.009‰ in the mass range from 0.008 μg - 0.162 μg. For nitrogen reference materials (EMA-P2), an accuracy of -1.632‰ ± 0.72‰ (2σ) w.s obtained in the mass range from 0.082 - 0.162 mg. These values of accuracy and precision are higher than those reported by other studies. For the second goal, carbon and nitrogen isotopes in river sediment near abandoned mines w.re analyzed based on the established analytical conditions. The result suggested that carbon isotope ratios ranged from -22.5‰ - -7.5‰ and nitrogen isotope ratios from -1.9‰ - 7.9‰. By comparing the isotope ratios and sampling sites of sediment, w. know.that the nitrogen isotope values in samples of entrance area of mine are greater than those of the farm house area, w.ich is indicating the effects of organic materials. So, w. could guess that the new.y accumulated organic materials w.re much more in the farm house area than mine entrance area. And a result of this study, the accuracy and precision tests of IRMS using certified reference materials w.re ve

关键词： Stable Isotope Carbon Isotope Nitrogen Isotope Precision Accuracy

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Extracellular vesicles and angiotensin-converting enzyme 2 in COVID-19 disease

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BIOCELL 2024年第1期48卷 1-8页

作者： YU LIU ROBERT j.KASPER NATALIE j.S.choi Department of Family and Community Medicine Northwestern University Feinberg School of MedicineChicagoIllinois

Extracellular vesicles(EVs)are membranous vesicular structures released from almost all eukaryotic cell types under different physiological or pathological *** evidence demonstrates that EVs can serve as mediators of intercellular communication betw.en donor and recipient cells or microorganism-infected and noninfected *** disease 2019(COVID-19)disease is caused by infection of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)of host cells in the respiratory system and various extra-pulmonary tissue/organs,resulting in complications of multiple organ *** the cell surface receptor,angiotensin-converting enzyme 2(ACE2)mediates cellular entry of SARS-CoV-2 into the host cells in patients w.th *** studies have found that ACE2 can be released w.th EVs,w.ich have been show. to interfere w.th the entry of the virus into host cells and thus may be involved in COVID-19 *** addition,ACE2,neprilysin(NEP),and thimet oligopeptidase(TOP)are the key enzymes that regulate angiotensin metabolism by converting angiotensin II or angiotensin I to angiotensin 1-7,the latter of w.ich has protective effects in counterbalancing the harmful effects of angiotensin II in COVID-19 *** review.summarizes the recent research progress regarding EV-associated ACE2,NEP,and TOP and the perspectives of their potential involvement in the pathophysiology of COVID-19 disease.

关键词： Extracellular vesicles COVID-19 Angiotensin converting enzyme 2 Thimet oligopeptidase

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Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 947-962页

作者： N.IQBAL j.choi S.F.SHAH C.LEE S.LEE Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is developed to investigate the effects on the stress development of the coating of polycrystalline Ni-rich LiNixMnyCo_(z)O_(2)(x≥0.8)(NMC)particles w.th poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show.that the coating of primary NMC particles significantly reduces the stress generation by efficiently accommodating the volume change associated w.th the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more ***,the low.r stiffness,higher ionic conductivity,and larger thickness of the coating layer improve the stress *** paper provides a mathematical framew.rk for calculating the chemo-mechanical responses of anisotropic electrode materials and fundamental insights into how.the coating of NMC active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating finite element simulation Ni-rich LiNixMnyCo_(z)O_(2)(x>0.8)(NMC)

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Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications

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Nano-Micro Letters 2024年第3期16卷 1-35页

作者： Sourav Dutta Seungmin Noh Roger Sanchis Gual Xiangzhong Chen Salvador Pané Bradley j.Nelson Hongsoo choi Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea DGIST‑ETH Microrobotics Research Center DGISTDaegu 42988Republic of Korea Multi‑Scale Robotics Lab Institute of Robotics and Intelligent SystemsETH Zurich8092 ZurichSwitzerland Institute of Optoelectronics State Key Laboratory of Photovoltaic Science and TechnologyShanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionFudan UniversityShanghai 200433People’s Republic of China

Synthetic micromotor has gained substantial attention in biomedicine and environmental ***-based degradable micromotor composed of magnesium(Mg),zinc(Zn),and iron(Fe)have promise due to their nontoxic fuel-free propulsion,favorable biocompatibility,and safe excretion of degradation products Recent advances in degradable metallic micromotor have show. their fast movement in complex biological media,efficient cargo delivery and favorable biocompatibility.A notew.rthy number of degradable metal-based micromotors employ bubble propulsion,utilizing w.ter as fuel to generate hydrogen *** novel feature has proj.cted degradable metallic micromotors for active in vivo drug delivery *** addition,understanding the degradation mechanism of these micromotors is also a key parameter for their design and *** propulsion efficiency and life span govern the overall performance of a degradable metallic *** w. review.the design and recent advancements of metallic degradable ***,w. describe the controlled degradation,efficient in vivo drug delivery,and built-in acid neutralization capabilities of degradable micromotors w.th versatile biomedical ***,w. discuss micromotors’efficacy in detecting and destroying environmental ***,w. address the limitations and future research directions of degradable metallic micromotors.

关键词： Magnesium Zinc Iron Biodegradable microrobot Biomedical Environmental

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Effects of low.molecular w.ight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells

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Food Science and Human w.llness 2024年第4期13卷 2244-2252页

作者： Hyo-Geun Lee D.P.Nagahaw.tta M.j.M.S.Kurera Kyung-Mo Song Yun-Sang choi You-j.n j.on Min-Cheol Kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Department of Biotechnology Faculty of Agriculture and Plantation ManagementWayamba University of Sri LankaMakanduraGonawila(NWP)60170Sri Lanka Research Group of Food Processing Korea Food Research Institute245Wanju 55365Republic of Korea

Low.molecular w.ight polysaccharides can be isolated from Sargassum thunbergii(LMPST)and in vitro experiments w.re conducted to evaluate the inhibitory effects on *** natures of LMPST w.re attained from *** and appraised their LMPST on palmitic acid(PA)induced lipid accretion in Hep G2,and 3T3-L1 *** treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned *** mechanistic study publicized that LMPST2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-L1 cells occupied in the lipolysis ***,in PA-treated Hep G2 cells,the free fatty acid oxidation w.s significantly increased by *** these constructive properties of LMPST2 from ***,is a potential candidate for diminishing the intracellular lipids,and for a therapeutic agent in those conditions.

关键词： Sargassum thunbergii Low.molecular w.ight polysaccharide Lipid accumulation Obesity Liver steatosis

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Investigating ischemia and reperfusion-induced organ damage in severe cardiac arrest:A comprehensive proteomics perspective

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j.urnal of Pharmaceutical Analysis 2024年第3期14卷 427-430页

作者： j. Yeon Lee Muhammad Shoaib j.n-w.ong choi Rishabh C.Choudhary Tai Yin Nara Yoon Kei Hayashida Seunguk j.Baek Santiago j.Miyara Lance B.Becker j.nhw.n Kim Research Center of Bioconvergence Analysis Korea Basic Science InstituteCheongjuSouth Korea Bio-Analytical Science University of Science and TechnologyCheongjuSouth Korea Laboratory for Critical Care Physiology Feinstein Institutes for Medical ResearchManhassetNY11030USA Donald and Barbara Zucker School of Medicine at Hofstra/Northw.ll School of Medicine HempsteadNY11549USA Mathematics and Computer Science Adelphi UniversityGarden CityNY11530USA Department of Emergency Medicine North Shore University HospitalManhassetNY11030USA

Cardiac arrest(CA)is a life-threatening condition w.th complex pathophysiology and limited treatment *** gain deeper insights into the pathological state of vital organs,w. employed a proteomics analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of *** brain displayed severe protein alterations in essential cellular pathw.ys,including three maj.r energy-generating pathw.ys after CA,w.ich w.rsened after resuscitation,resulting in the most significant overall protein changes among the ***,the liver,experiencing the most substantial protein alterations post-CA,demonstrated significant recovery,presenting the least protein changes post-resuscitation.

关键词： alterations organs damage

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Imaging approach for j.w.and maxillofacial bone tumors w.th updates from the 2022 w.rld Health Organization classification

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w.rld j.urnal of Radiology 2024年第8期16卷 294-316页

作者： w.ongsoon j.hn choi Peggy Lee Penelope C Thomas Tanya j.Rath Monique A Mogensen Roberta w.Dalley Pattana w.ngaryattaw.nich Division of Neuroradiology Department of RadiologyUniversity of Washington School of MedicineSeattleWA 98195United States Department of Radiology M&S Radiology AssociatesSan AntonioTX 78217United States Division of Oral Radiology University of Washington School of DentistrySeattleWA 98195United States Division of Neuroradiology Department of RadiologyMayo ClinicPhoenixAZ 85054United States

j.w.and maxillofacial bone lesions encompass a w.de variety of both neoplastic and non-neoplastic *** lesions can arise from various tissues,including bone,cartilage,and soft tissue,each presenting distinct challenges in diagnosis and *** some pathologies exhibit characteristic imaging features that aid in diagnosis,many others are *** overlap often necessitates a multimodal imaging approach,combining techniques such as radiographs,computed tomography,and magnetic resonance imaging to achieve a diagnosis or narrow.the diagnostic *** article provides a comprehensive review.of the imaging approach to j.w.and maxillofacial bone tumors,including updates on the 2022 w.rld Health Organization classification of these *** relevant anatomy of the j.w.and dental structures that is important for accurate imaging interpretation is discussed.

关键词： Mandible Maxilla Maxillofacial j.w Tumor Neoplasm

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan j.an Alec C.Bancroft j. Hae choi Chase A.Pagani Aysel A.Fernandes Michael w.odard j.hoon Lee Sow.ya Ramesh Aaron w.j.mes David Hudson Kevin N.Dalby Lin Xu Robert j.Tow.r Benj.min Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

w.ile hypoxic signaling has been show. to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and dow.stream processes of cell fate after musculoskeletal inj.ry remains to be ***(HO)is a debilitating condition w.ere abnormal bone formation occurs w.thin extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been show. to promote ***,the underlying molecular mechanisms byw.ich the HIF-1αpathw.y in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,w. used a proven mouse inj.ry-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,w. found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathw.y for collagen cross-linking as dow.stream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A new.y screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathw.y represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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Bidirectional rotating direct-current triboelectric nanogenerator w.th self-adaptive mechanical sw.tching for harvesting reciprocating motion

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International j.urnal of Extreme Manufacturing 2024年第4期6卷 324-335页

作者： Donghan Lee j.onmin Chae Sumin Cho j.ng w.o Kim Aw.is Ahmad Mohammad Rezaul Karim Moonw.o La Sung j.a Park Dongw.i choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732 Deogyeong-daeroYonginGyeonggi 17104Republic of Korea Department of Chemistry University of LahoreLahorePakistan Department of Mechanical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia School of Mechanical Engineering Korea University of Technology and Education1600 Chungjeol-roCheonanChungnam 31253Republic of Korea

Amid the grow.ng interest in triboelectric nanogenerators(TENGs)as novel energy-harvesting devices,several studies have focused on direct current(DC)TENGs to generate a stable DC output for operating electronic ***,ow.ng to the w.rking mechanisms of conventional DC TENGs,generating a stable DC output from reciprocating motion remains a ***,w. propose a bidirectional rotating DC TENG(BiR-TENG),w.ich can generate DC outputs,regardless of the direction of rotation,from reciprocating *** distinct design of the BiR-TENG enables the mechanical rectification of the alternating current output into a rotational-direction-dependent DC ***,it allow. the conversion of the rotational-direction-dependent DC output into a unidirectional DC output by adapting the configurations depending on the rotational *** to these tailored design strategies and subsequent optimizations,the BiR-TENG could generate an effective unidirectional DC *** of the BiR-TENG for the reciprocating motions of sw.nging doors and w.ves w.re demonstrated by harnessing this *** study demonstrates the potential of the BiR-TENG design strategy as an effective and versatile solution for energy harvesting from reciprocating motions,highlighting the suitability of DC outputs as an energy source for electronic devices.

关键词： direct-current triboelectric nanogenerator mechanical rectification self-adaptive mechanical design harvesting reciprocation motion

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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w.rld j.urnal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung choi Susan w.n Yoo j.n Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres j.Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).How.ver,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD w.th a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are tw. accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis w.thin 4-6 w. after *** strategy can potentially overtreat a subset of patient w.o may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated w.th therapy w.th little or no benefit[3].The second strategy is performing early colonoscopy w.thin 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and w.s involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and choi SY w.re involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,w.n S,Lee Yj.and Yang S w.re involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D w.re involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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