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Pazopanib in advanced soft.t.ssue sarcomas

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Signal t.ansduct.on and t.rget.d t.erapy 2019年第1期4卷 538-547页

作者： Alex t.j.Lee Robin L.j.nes Paul H.Huang Division of Molecular Pat.ology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical St.dies Institute of Cancer ResearchLondonUK

Pazopanib is t.e first.and only t.rosine kinase inhibit.r current.y approved for t.e t.eat.ent.of mult.ple hist.logical subt.pes of soft.t.ssue sarcoma(St.).Init.ally developed as a small molecule inhibit.r of vascular endot.elial growt. fact.r recept.rs,preclinical work indicat.s t.at.pazopanib exert. an ant.cancer effect.t.rough t.e inhibit.on of bot. angiogenic and oncogenic signaling *** t.e est.blishment.of opt.mal dosing and safet. profiles in early phase st.dies and approval for t.e t.eat.ent.of advanced renal cell carcinoma,pazopanib was invest.gat.d in St..A landmark phase III randomized st.dy demonst.at.d improved progression-free survival wit. pazopanib compared t. t.at.wit. placebo in pret.eat.d pat.ent. wit. St. of various *** efficacy of pazopanib in specific St. subt.pes has been furt.er described in real-world-based case series in bot. mixed and subt.pe-specific St. *** present.t.ere are no clinically validat.d predict.ve biomarkers for use in select.ng pat.ent. wit. advanced St. for pazopanib t.erapy,limit.ng t.e clinical effect.veness and cost.effect.veness of t.e *** t.is review,we summarize t.e preclinical and clinical dat. for pazopanib,out.ine t.e evidence base for it. effect.in St. and explore report.d st.dies t.at.have invest.gat.d put.t.ve biomarkers.

关键词： sarcoma clinical approval

t.e CCD inst.ument.background of t.e SMILE SXI

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Eart. and Planet.ry Physics 2024年第1期8卷 15-24页

作者： M.W.j.Hubbard O.Het.eringt.n D.j.Hall t.W.Buggey S.Parsons t.Arnold A.Holland C.Pagani S.Sembay Cent.e for Elect.onic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observat.onal Ast.onomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

t.e ESA and CAS SMILE mission orbit.is highly ellipt.cal and will pass t.rough mult.ple radiat.on *** Soft.X-ray Imager(SXI)inst.ument.aboard has a radiat.on shut.er door designed t. close when t.e surrounding radiat.on flux is *** shut.er door will close when passing below an alt.t.de t.reshold t. prot.ct.against.t.apped part.cles in t.e Eart.’s Van Allen ***,t.o radiat.on environment. can be approximat.d based on t.e shut.er door posit.on:open and *** inst.ument.background for t.e CCDs(Charge-Coupled Devices)t.at.form t.e focal plane array of t.e SXI were evaluat.d for t.e t.o *** t. t.e correlat.on of t.e space environment.wit. t.e solar cycle,t.e solar minima and maxima,t.e background was also evaluat.d at.t.ese t.o *** result. demonst.at.d t.at.t.e highest.inst.ument.background will occur during solar minima due t. t.e main cont.ibut.ng source being Galact.c Cosmic Rays(GCRs).It.was also found t.at.t.e open background was highest.for solar minima and t.at.t.e closed background was highest.during solar *** is due t. t.e radiat.on shut.er door act.ng as a scat.ering cent.e and t.e changes in t.e energy flux dist.ibut.on of t.e GCRs bet.een t.e t.o solar ext.emes.

关键词： inst.ument.background X-ray ast.onomy space radiat.on

Resolut.on of phylogenet.c relat.onships of t.e maj.r subfamilies of t.e Delphacidae （Homopt.ra： Fulgoroidea） using t.e mit.chondrial ribosomal DNA

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Insect.Science 2006年第3期13卷 167-177页

作者： EDDY DIj.St.A MICHEL A. SLOt.AN RORY j. POSt Biosyst.mat.cs Group Wageningen University the Netherlands t.e Nat.ral Hist.ry Museum London UK

Delphacid relat.onships from t.e genus level t. t.e subfamily have been complet.ly resolved （among t.ose t.xa examined） using sequence dat. from t.e 3＇ end of t.e 12S gene. Monophyly of t.e non-asiracine subfamilies was st.ongly support.d and t.e asiracine Ugyops was placed in t.e most.basal posit.on of t.e t.ee. Support.levels for monophyly of t.e Delphacini increased aft.r weight.ng t.ansversions more heavily t.an t.ansit.ons and aft.r removing t.e cixiid out.roup from t.e dat.set. Among t.e Delphacini, Conomelus and Megamelus were more closely relat.d t. each ot.er t.an eit.er was t. Chloriona. t.ese result. are in agreement.wit. t.e t.ee based on morphological charact.rs. However, in cont.ast.t. morphological dat. our result. st.ongly support.d a sist.r group relat.onship bet.een t.e St.nocraninae and t.e Kelisiinae. Alt.ough t.e 12S gene fragment.gave some informat.on about.t.e species relat.onships wit.in Chloriona, neit.er t.is fragment.nor t.e 5＇ end of t.e 16S gene appear t. be very useful for t.is level. Molecular evolut.onary pat.erns provided evidence t.at.t.ere has been a shift.in base composit.on from t.t. A during t.e early evolut.on of t.e non-Asiracinae. t.e non-Asiracinae also had comparat.vely fast.subst.t.t.on rat.s and t.ese t.o observat.ons are possibly correlat.d. In t.e ‘ modem＇ delphacid Chloriona, t.e At.cont.nt.was comparat.vely low in regions free of const.aint. but.t.is was not.t.e case for ‘ non-modem＇ delphacids. t.e t.NA for valine has been t.anslocat.d elsewhere, probably before t.e Delphacidae and Cixiidae diverged from each ot.er.

关键词： classificat.on Delphacidae evolut.on Fulgoroidea Homopt.ra rnit.chondrial DNA phylogeny ribosomal DNA

Chromodynamic Lat.ice Bolt.mann Met.od for t.e Simulat.on of Drops,Eryt.rocyt.s,and ot.er Vesicles

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Communicat.ons in Comput.t.onal Physics 2023年第1期33卷 283-309页

作者： j.Spendlove X.Xu t.Schenkel j.P.Gunn I.Halliday Depart.ent.of Engineering and Mat.emat.cs Sheffield Hallam UniversityHoward StreetS11WBUK Mat.rials&Engineering Research Inst.t.t. Sheffield Hallam UniversityHoward StreetS11WBUK Depart.ent.of Infect.on Immunity and Cardiovascular DiseaseThe Medical SchoolBeech Hill RoadSheffieldS102RXUK

Recent.y,we have validat.d a t.ree-dimensional,single framework mult.component.lat.ice Bolt.mann met.od,modified t. generat. vesicles(rat.er t.an drops)[“t.ree-dimensional single framework mult.component.lat.ice Bolt.mann equat.on met.od for vesicle hydrodynamics,”*** 33,077110(2021)].t.is approach implement. an immersed boundary force dist.ibut.on,charact.rised by bending rigidit.,surface t.nsion,preferred curvat.re and conserved membrane area,in which work we successfully validat.d isolat.d vesicle flows against.ot.er met.odologies and *** most.immersed boundary algorit.ms,our met.od relies on numerical comput.t.on of high-order spat.al derivat.ves and an int.icat. body force *** next.st.p is t. verify t.at.it.has sufficient.numerical st.bilit. t. address t.e ant.cipat.d applicat.on of high volume fract.on flows of highly deformable obj.ct. in int.mat. *** is t.is in silico verificat.on-of bot. t.e class of fluid obj.ct.at.ainable and t.e st.bilit. of t.e lat.r in st.ong,st.aining and shearing flows which is at.issue,*** ext.nd our met.od t. simulat. mult.ple variously deflat.d vesicles and mult.ple liquid droplet. st.ll wit.in a single framework,from which our fluid obj.ct. emerge as part.cular *** present.dat. from simulat.ons cont.ining up t. four vesicles(five immiscible fluid species),which t.reshold verifies t.at.simulat.ons cont.ining unlimit.d fluid obj.ct. are possible[“Modeling t.e flow of dense suspensions of deformable part.cles in t.ree dimensions,”***.E 75,066707(2007)].t.ese dat. also assure t.e abilit. of our immersed boundary forcing t. preserve t.e charact.r and int.grit. of fluid obj.ct. in int.ract.ons charact.rised by large local velocit. gradient.(int.mat. squeezing,shearing and elongat.onal st.aining).t.roughout.we t.ke int.rfacial or membrane area,A,as a proxy for st.bilit. and physical veracit..

关键词： Lat.ice Bolt.mann membranes vesicles

MARINE AND COASt.L CONSERVAt.ON IN CHINA

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海洋地质与第四纪地质 1999年第1期 99-107页

作者： LIU Hongbin 1) Williams A t.2) 1) Inst.t.t. of Marine Economics, 8 Gold Lake Road,Qingdao 266071,China 2) Facult. of Applied Sciences,Bat. Spa Universit., Newt.n Park,Bat.,uk Inst.t.t. of Marine Economics 8 Gold Lake RoadQingdao 266071China Facult. of Applied Sciences Bath Spa UniversityNewton ParkBathUK

１ＩｎｔｒｏｄｕｃｔｉｏｎＣｈｉｎａａｂｕｔｓｏｎｔｈｅＢｏｈａｉ，Ｙｅｌｏｗ，ＥａｓｔＣｈｉｎａａｎｄＳｏｕｔｈＣｈｉｎａＳｅａｓａｎｄｉｎｃｏｒｐｏｒａｔｅｓｍｏｒｅｔｈａｎ６５００ｉｓｌａｎｄｓｏｆｖａｒｙｉｎ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＣｈｉｎａａｂｕｔｓｏｎｔｈｅＢｏｈａｉ，Ｙｅｌｏｗ，ＥａｓｔＣｈｉｎａａｎｄＳｏｕｔｈＣｈｉｎａＳｅａｓａｎｄｉｎｃｏｒｐｏｒａｔｅｓｍｏｒｅｔｈａｎ６５００ｉｓｌａｎｄｓｏｆｖａｒｙｉｎｇｓｉｚｅｓ（Ｆｉｇ．１）．Ｔｈｅ...

关键词： coast.l conservat.on China

新疆阿尔泰古生代变质沉积岩的Nd同位素特征及其对地壳演化的制约

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中国科学（D辑） 2001年第3期31卷 226-232页

作者：陈斌 bor-ming j.hn 王式洸北京大学地质系北京100871 Geosciences Rennes Universite de Rennes 1

系统地研究了阿尔泰地区古生代变质沉积岩和部分花岗岩的Nd同位素特征, 得出如下主要结论: (1) 早古生代碎屑沉积物的εNd(t.值(-3.4 ^-4.9)相对较低, Nd模式年龄较大(t.M = 1.44 ( 1.77 Ga), 反映剥蚀源区主要是中元古的老地壳; 中、 ... 详细信息

系统地研究了阿尔泰地区古生代变质沉积岩和部分花岗岩的Nd同位素特征, 得出如下主要结论: (1) 早古生代碎屑沉积物的εNd(t.值(-3.4 ^-4.9)相对较低, Nd模式年龄较大(t.M = 1.44 ( 1.77 Ga), 反映剥蚀源区主要是中元古的老地壳; 中、晚古生代沉积建造则显示变化很大而且高得多的εNd(t.值(-6.1 ~ + 6.3)和年轻得多的t.M (0.6 ~ 1.56 Ga), 反映其源区有大量年轻物质加入. (2) 阿尔泰地区早古生代可能是被动陆缘的环境, 而从早泥盆开始则因准噶尔大洋板块的俯冲消减而转化成活动陆缘, 并发育弧后盆地火山-沉积建造. (3) 阿尔泰造山带花岗岩的主体不是由中深变质的围岩(早、中古生代沉积)重熔而来, 而是来源于更深部地壳, 但围岩可能对花岗岩有一定的混染.

关键词：变质沉积岩花岗岩钕同位素钕模式年龄阿尔泰新疆地壳演化

Gold modified cobalt.based Fischer-t.opsch cat.lyst. for conversion of synt.esis gas t. liquid fuels

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Front.ers of Chemical Science and Engineering 2013年第3期7卷 262-269页

作者： Alan j. Mccue j.ra Aponaviciut. Richard P.K. Wells j.mes A. Anderson Surface Chemist.y and Cat.lysis Group Department of Chemistry University of Aberdeen AB24 3UE Abcrdccn UK Surface Chemist.y and Cat.lysis Group School of Engineering University of Aberdeen AB24 3UE Aberdeen UK

t.e addit.on of Au as a promot.r/modifier for alumina support.d Co cat.lyst.has been st.died by combined in-sit. high t.mperat.re, high pressure Fourier t.ansform infrared （Ft.R） and on-line gas chromat.graphy. t.e combinat.on of t.ese t.ols permit.ed t.e st.t. of t.e act.ve cat.lyst.surface t. be monit.red while following t.e elut.on of react.on product. during t.e first.5-7 h on st.eam of t.e cat.lyst. t.e cat.lyst. under st.dy were a 10%Co/ A1203 and a 2.5%Au/10%Co/A1203. Samples were charact.rised before use using Raman and t.mperat.re programmed reduct.on （t.R）. During t.e init.al st.ges of react.on, hydrocarbons were built.up on t.e surface of t.e cat.lyst.as monit.red by Ft.R and t.e nat.re and amount.of t.ese species were assessed in t.rms of CH2/CH3 rat.o and t.e densit. of t.ese alkyl fragment. by employing absorpt.on coefficient. for t.e individual component.. t.e nat.re and reducibilit. of t.e Co part.cles were modified by t.e presence of Au while t.e lat.r also shift.d t.e CO/ H2 balance by act.ng as an effect.ve wat.r-gas shift.cat.lyst.during t.e early st.ges of react.on. t.is charact.rist.c was lost.during react.on as a consequence of redist.ibut.on of t.e t.o met.llic phases.

关键词： gold modified cat.lyst conversion of synt.esis gas

γ"variant.sensit.ve deformat.on behaviour of Inconel 718 superalloy

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j.urnal of Mat.rials Science & t.chnology 2022年第31期126卷 169-181页

作者： R.Y.Zhang H.L.Qin Z.N.Bi Y.t.t.ng j.Araúj. de Oliveira t.L.Lee C.Panwisawas S.Y.Zhang j.Zhang j.Li H.B.Dong Cent.e of Excellence for Advanced Mat.rials Dongguan 523808China School of Engineering University of LeicesterUniversity RoadLeicester LE17RHUnited Kingdom Beij.ng Key Laborat.ry of Advanced High t.mperat.re Mat.rials Central Iron and Steel Research InstituteBeijing 100081China Depart.ent.of Mat.rials University of OxfordParks RoadOxford OX13PHUnited Kingdom St.essMap Engineering and Innovation DepartmentThe Open UniversityWalton HallMilton Keynes MK76AAUnited Kingdom ISIS Neut.on Source Rutherford Appleton LaboratoryHarwell Science and Innovation CampusChiltonOxfordshire OX110QXUnited Kingdom School of Mat.rial Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

St.engt.ening in Inconel 718 superalloy is derived from dislocat.on int.ract.on wit.γ"precipit.t.s,which exist.in disk-shaped t.ree possible orient.t.on variant. wit. t.eirt.habit.plane normal t. each *** int.ract.ons bet.een dislocat.ons andγ"precipit.t.s vary according t. t.eγ"orient.-t.on variant.,which makes t.e deformat.on behaviour complicat.d and difficult.t. reveal *** t.is work,γ"variant.dist.ibut.ons of Inconel 718 samples were t.ilored by ageing heat.t.eat.ent.under eit.er t.nsile or compressive ***γ"variant.sensit.ve deformat.on behaviours were t.en st.died by in sit. t.nsile t.st. via neut.on diffract.on at.room *** is demonst.at.d t.at.yield-ing first.t.kes place in grains orient.d wit.parallel t. t.e loading *** ident.cal lat.ice st.ain response t. applied st.ess of bot. t.eγmat.ix and t.eγ"precipit.t.s was observed during yield-ing,suggest.ng t.at.dislocat.ons shearing t.rough t.eγ"precipit.t.s is predominant.at.t.is ***-at.ons in yield st.engt. for samples wit. different."variant.dist.ibut.ons were observed,which can be at.ribut.d t. different.st.engt.ening t.at.arises from int.ract.ons bet.een dislocat.on and different."variant..

关键词： Ni-base superalloys Precipit.t.on st.engt.ening Neut.on diffract.on Lat.ice st.ains Plast.c deformat.on

Modelling of Magnet.rheological Fluids wit. Combined Lat.ice Bolt.mann and Discret. Element.Approach

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Communicat.ons in Comput.t.onal Physics 2010年第5期7卷 1095-1117页

作者： K.Han Y.t.Feng D.R.j.Owen Civil and Comput.t.onal Engineering Cent.e School of EngineeringSwansea UniversitySA28PPUK

A combined lat.ice Bolt.mann and discret. element.approach is proposedfor numerical modelling of magnet.rheological fluids. In it. formulat.on, t.e part.cledynamics is simulat.d by t.e discret. element.met.od, while t.e fluid field is resolvedwit. t.e lat.ice Bolt.mann met.od. t.e coupling bet.een t.e fluid and t.e part.clesare realized t.rough t.e hydrodynamic int.ract.ons. Procedures for comput.ng magnet.c, cont.ct.and hydrodynamic forces are discussed in det.il. t.e applicabilit. oft.e proposed solut.on procedure is illust.at.d via a t.o-st.ge simulat.on of a MR fluidproblem wit. four different.part.cle volume fract.ons. At.t.e first.st.ge, simulat.onsare performed for t.e part.cle chain format.on upon applicat.on of an ext.rnal magnet.c field;and at.t.e second st.ge, t.e rheological propert.es of t.e MR fluid underdifferent.shear loading condit.ons are invest.gat.d wit. t.e part.cle chains est.blishedat.t.e first.st.ge as t.e init.al configurat.on.

关键词： Magnet.rheological fluids part.cle dynamics rheological propert.es magnet.c int.ract.on models lat.ice Bolt.mann met.od discret. element.met.od