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Scalable gas-phase processes to create nanostructured particles

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Particuology 2010年第6期8卷 572-577页

作者： j.ruud van ommen Caner U.Yurteri Naoko Ellis Erik M.Kelder Delft University of Technology Department of Chemical EngineeringJulianalaan 1362628 BL DelftThe Netherlands University of British Columbia Department of Chemical and Biological Engineering2360 East MallVancouverB.C.Canada V6T 1Z3

The properties of nanoparticles are often different from those of larger grains of the same solid material because of their very large specific surface area. This enables many novel applications, but properties such as agglomeration can also hinder their potential use. By creating nanostructured particles one can take optimum benefit from the desired properties while minimizing the adverse effects. We aim at developing high-precision routes for scalable production of nanostructured particles. Two gas-phase synthesis routes are explored. The first one - covering nanoparticles with a continuous layer - is carried out using atomic layer deposition in a fluidized bed. Through fluidization, the full surface area of the nanoparticles becomes available. With this process, particles can be coated with an ultra-thin film of constant and well-tunable thickness. For the second route - attaching nanoparticles to larger particles - a novel approach using electrostatic forces is demonstrated. The micron-sized particles are charged with one polarity using tribocharging. Using electrospraying, a spray of charged nanoparticles with opposite polarity is generated. Their charge prevents agglomeration, while it enhances efficient deposition at the surface of the host particle. While the proposed processes offer good potential for scale-up, further work is needed to realize large-scale processes.

关键词： Nanoparticles Nanocomposite materials Coating Films Particle coating Atomic layer deposition Core-shell particles Electrospraying Electrohydrodynamic atomization Electrostatic forces Fluidization

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间隔部心肌切除术对梗阻性肥厚型心肌病患者生存状况的远期影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 61-62页

作者： ommen S. R. Maron B. j. Olivotto I. 任付先 Mayo Clinic 200 First Street SW Rochester MN 55905 United States

OBj.CTIVES: This study sought to determine the impact of surgical myectomy on long-term survival in hypertrophic cardiomyopathy(HCM). BACKGROUND: Left ventricular(LV) outflow tract obstruction in HCM increases the likelihood of heart failure and cardiovascular death. Although surgical myectomy is the primary treatment for amelioration of outflow obstruction and advanced drug-refractory heart failure symptoms, its impact on long-term survival remains unresolved. METHODS: Total and HCM-related mortality were compared in three subgroups comprised of 1,337 consecutive HCM patients evaluated from 1983 to 2001: 1) surgical myectomy(n=289); 2) LV outflow obstruction without operation(n=228); and 3) nonobstructive(n=820). Mean follow-up duration was 6±6 years. RESULTS: Including two operative deaths(procedural mortality, 0.8%), 1-, 5-, and 10-year overall survival after myectomy was 98%, 96%, and 83%, respectively, and did not differ from that of the general U.S. population matched for age and gender(p=0.2) nor from patients with nonobstructive HCM(p=0.8). Compared to nonoperated obstructive HCM patients, myectomy patients experienced superior survival free from all-cause mortality(98%, 96%, and 83%vs. 90%, 79%, and 61%, respectively; p< 0.001), HCM-related mortality(99%, 98%, and 95%vs. 94%, 89%, and 73%, respectively; p< 0.001), and sudden cardiac death(100%, 99%, and 99%vs. 97%, 93%, and 89%, respectively; p=0.003). Multivariate analysis showed myectomy to have a strong, independent association with survival(hazard ratio 0.43; p< 0.001). CONCLUSIONS: Surgical myectomy performed to relieve outflow obstruction and severe symptoms in HCM was associated with long-term survival equivalent to that of the general population, and superior to obstructive HCM without operation. In this retrospective study, septal myectomy seems to reduce mortality risk in severely symptomatic patients with obstructive HCM.

关键词：切除术远期影响远期生存率心衰症状流出道梗阻非梗阻性药物治疗左心室肌切开术总死亡率

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脑利钠肽水平在对肥厚型心肌病患者的临床评价中的作用

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 26-页

作者： Binder j. ommen S.R. 刘少伟 Mayo Clinic College of Medicine Rochester MN United States.Dr

肥厚型心肌病(HC)常伴随心力衰竭症状和舒张功能障碍。虽然目前人们对脑利钠肽(BNP)水平在收缩功能障碍患者治疗中的影响有了新的认识,但是很少有关于BNP在HC患者治疗中的作用的资料。纳入217例HC患者,将BNP与临床变量和超声心动图变量... 详细信息

肥厚型心肌病(HC)常伴随心力衰竭症状和舒张功能障碍。虽然目前人们对脑利钠肽(BNP)水平在收缩功能障碍患者治疗中的影响有了新的认识,但是很少有关于BNP在HC患者治疗中的作用的资料。纳入217例HC患者,将BNP与临床变量和超声心动图变量(包括舒张期充盈的指标)进行比较。即使在校正了年龄、性别、肾脏功能和体型后,BNP值与纽约心脏协会心功能分级、超声心动图舒张期充盈压测值以及右室收缩期压力仍存在相关关系。

关键词：肥厚型心肌病脑利钠肽 BNP 患者

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TAVI术前应用MDCT评估主动脉根部及主动脉瓣以获得心动周期中的最佳成像时间点

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国际医学放射学杂志 2015年第5期 492-492页

作者： T.j.rencak j.Turek B.L.j.H.Kietselaer C.Mihl M.Kok V.G.V.A.van ommen 宋茜 Department of Radiology Maastricht University Medical Center

摘要目的通过综合评估主动脉根部以确定制定经导管主动脉瓣置换术治疗计划的最佳成像时间点。方法回顾连续64例行TAVI术前评估的病人资料,所有病人均已行带心电门控的多层螺旋CT(MDCT)检查。在心动周期11个不同时间点评估主动脉根部的1... 详细信息

摘要目的通过综合评估主动脉根部以确定制定经导管主动脉瓣置换术治疗计划的最佳成像时间点。方法回顾连续64例行TAVI术前评估的病人资料,所有病人均已行带心电门控的多层螺旋CT(MDCT)检查。在心动周期11个不同时间点评估主动脉根部的18个不同参数,确定最大或最小测量尺寸的时间点,然后评估与其他时间点尺寸的差异,比较基于不同测量的理论假体大小。结果在心动周期的

关键词：心动周期时间点成像时间主动脉大动脉 TAVI MDCT