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Phar.acology & Phar.acy 2013年第2期4卷 176-181页

作者： Fr.nk Begr.w Eugen j. Ver.pohl Depar.ment of Phar.acology Institute of Medicinal Chemistry University of Muenster Muenster Germany

Cystic fibr.sis is a life-thr.atening, wide spr.ad genetic disease diagnosed in 1 to 3000 livebir.hs of the Caucasian population. Her. a mouse model for.this disease is descr.bed and optimized using the CFTr.channel selective inhibitor.CFTr.inh 172). The tar.et par.meter.was mucociliar. clear.nce measur.d using micr.dialysis of the tr.nspor.ed fluor.scent dye r.odamine in the mouse tr.chea in situ. The impact of Ap4A (diadenosine tetr.phosphate) as a potential dr.g was investigated. Its inhalation was effective at low concentr.tions;established compounds such as Salbutamol and UTP incr.ased mucociliar. clear.nce as well. Our.data show a functioning model of cystic fibr.sis and the effectiveness of the newly tested Ap4A.

关键词： Cystic Fibr.sis Mucociliar. Clear.nce in Situ Ap4A UTP

God Is a Por.upine—Br.in, Consciousness and Spacetime Physics

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j.ur.al of Moder. Physics 2017年第8期8卷 1294-1318页

作者： Walter.j. Chr.stensen j.. Depar.ment of Physics and Astr.nomy California State Polytechnic University Pomona Pomona CA USA Depar.ment of Physics and Astr.nomy California State University Fullerton Fullerton CA USA

Wher.as the human body r.quir.s a vast number. of atoms to maintain its intr.cate anatomical functions, we asser. that the human br.in r.quir.s “something extr.” to car.y out its higher.mental and emotional functions. r.cently, neur.scientists ar. beginning to suspect br.in cells ar. not fast enough, or.intr.cate enough, to cor.elate complex spatiotempor.l infor.ation into cognitive under.tanding. They conclude that spacetime fields may be necessar. to assist the br.in dur.ng neur.logical pr.cessing—in much the same way magnetic and electr.c fields ar. essential for.the pr.pagation of light. This “something extr.,” we ar.ue, is spacetime itself—wher. str.ctur.s in the br.in, called facilitator. (somewhat like Descar.es pineal gland), have evolved biologically in such a way, so as to be able to stor. and r.tr.eve spacetime quanta for.the for.ation and gener.tion of consciousness and memor.. In this way, cognition is not a thing complete. r.ther.it is emer.ent, and accumulates as discr.tized spacetime quanta in the br.in so r.pidly, we per.eive our.own awar.ness to be continuous, events spontaneous. In this paper. we consider.spacetime to be a field (like all quantum fields), which can be excited into quanta par.icles called gr.vitons. We then apply this quanta excitation to help explain the br.in’s cognitive pr.cesses. If the br.in has indeed evolved to inter.ct with discr.tized spacetime, then with the advent of impr.ved functional imaging equipment, we might be able to map detailed cor.elations between neur.l pr.cesses, conscious exper.ence and spacetime. In so doing, it might be possible to lear. mor. about the fundamental wor.ings of spacetime itself.

关键词： Neur.science Consciousness Memor. Br.in Communication Spacetime Spacetime Quanta Gr.vitons Time Quanta Gener.l r.lativity r.lativized Quantum Physics (r.P)

r.bust H-Filter.ng for.Lipschitz Nonlinear.Systems via Multiobj.ctive Optimization

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j.ur.al of Signal and Infor.ation Pr.cessing 2010年第1期1卷 24-34页

作者： Masoud Abbaszadeh Hor.cio j. Mar.uez 不详

In this paper. a new method of filter.ng for.Lipschitz nonlinear.systems is pr.posed in the for. of an LMI optimization pr.blem. The pr.posed filter.has guar.nteed decay r.te (exponential conver.ence) and is r.bust against unknown exogenous distur.ance. In addition, thanks to the linear.ty of the pr.posed LMIs in the admissible Lipschitz constant, it can be maximized via LMI optimization. This adds an extr. impor.ant featur. to the obser.er. r.bustness against nonlinear.uncer.ainty. Explicit bound on the toler.ble nonlinear.uncer.ainty is der.ved. The new LMI for.ulation also allows optimizations over.the distur.ance attenuation level ( cost). Then, the admissible Lipschitz constant and the distur.ance attenuation level of the filter.ar. simultaneously optimized thr.ugh LMI multiobj.ctive optimization.

关键词： Lipschitz Nonlinear Systems Optimal Filter. Nonlinear Filter.ng LMI Optimization

Sequence-Based Pr.tein Cr.stallization Pr.pensity Pr.diction for.Str.ctur.l Genomics: r.view and Compar.tive Analysis

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Natur.l Science 2009年第2期1卷 93-106页

作者： Lukasz Kur.an Mar.in j. Mizianty 不详

Str.ctur.l genomics (SG) is an inter.ational effor. that aims at solving thr.e-dimensional shapes of impor.ant biological macr.-molecules with pr.mar. focus on pr.teins. One of the main bottlenecks in SG is the ability to pr.duce dif-fr.ction quality cr.stals for.X-r.y cr.stallogr.-phy based pr.tein str.ctur. deter.ination. SG pipelines allow for.cer.ain flexibility in tar.et selection which motivates development of in- silico methods for.sequence-based pr.diction/ assessment of the pr.tein cr.stallization pr.-pensity. We over.iew existing SG databanks that ar. used to der.ve these pr.dictive models and we discuss analytical r.sults concer.ing pr.tein sequence pr.per.ies that wer. discov-er.d to cor.elate with the ability to for. cr.stals. We also contr.st and empir.cally compar. mo- der. sequence-based pr.dictor. of cr.stalliza-tion pr.pensity including OB-Scor., Par.r.s, XtalPr.d and Cr.STALP2. Our.analysis shows that these methods pr.vide useful and compli-mentar. pr.dictions. Although their.aver.ge ac- cur.cy is similar.at ar.und 70%, we show that application of a simple maj.r.ty-vote based en-semble impr.ves accur.cy to almost 74%. The best impr.vements ar. achieved by combining XtalPr.d with Cr.STALP2 while OB-Scor. and Par.r.s methods over.ap to a lar.er.extend, although they still complement the other.two pr.dictor.. We also demonstr.te that 90% of the pr.tein chains can be cor.ectly pr.dicted by at least one of these methods, which suggests that mor. accur.te ensembles could be built in the futur.. We believe that cur.ent pr.tein cr.stalli-zation pr.pensity pr.dictor. could pr.vide useful input for.the tar.et selection pr.cedur.s utilized by the SG center..

关键词： Str.ctur.l Genomics X-r.y Cr.stallogr.phy Cr.stallization Pr.pensity Pr.diction Pr.tein Str.ctur. Pr.tein Cr.stallization

A notion of passivity for.switched systems with state-dependent switching

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控制理论与应用（英文版） 2006年第1期4卷 70-75页

作者： j.n ZHAO David j. HILL School of Infor.ation Science and Engineer.ng Northeastern University Liaoning Shenyang 110004 China r.sear.h School of Infor.ation Sciences and Eagiaeer.ng Australian National University Canberra ACT 0200 Australia

A passivity concept for.switched systems with state-dependent switching is pr.sented. Each subsystem has a stor.ge function to descr.be the ＂ener.y＂ stor.d in the subsystem. The passivity pr.per.y of a switched system is given in ter.s of multiple stor.ge functions. Each stor.ge function is allowed to gr.w on the ＂switched on＂ time sequence but the total gr.wth is bounded by a cer.ain function. Stability is infer.ed fr.m passivity and asymptotic stability is achieved under.fur.her.assumptions of a detectivity pr.per.y of a local for. and boundedness of the total change of some stor.ge function on its inactive inter.als. A state-dependent switching law that r.nder. the system passive is also designed.

关键词： Switched systems Passivity Stability

Effect of Autoclave Ster.lisation on the Dimensional Stability and Tear.Str.ngth of Thr.e Silicone Impr.ssion Mater.als

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Open j.ur.al of Stomatology 2014年第12期4卷 518-526页

作者： Br.an j. Millar.Sanj.kta Deb r.stor.tive Dentistr. Department of Primary Dental Care King’s College London Dental Institute London UK Depar.ment of Biomater.als Biomimetics & Biophotonics King’s College London Dental Institute London UK

Obj.ctives: Ther. is a r.sk of spr.ading infectious mater.al via non-ster.le impr.ssions. The aim of this study was to compar. the effect of autoclave ster.lisation on dimensional stability and tear.str.ngth of impr.ssion mater.als. Methods: Twenty-four.specimens wer. pr.duced using a standar. r.led test block for.each of thr.e impr.ssion mater.als (Affinis, Aquasil and Speedex) to test dimensional stability. Thir.y tear.str.ps for.each mater.al wer. pr.par.d for.the tear.test (ISO 34-1). Specimens wer. r.ndomly allocated to 3 differ.nt gr.ups (autoclaved, disinfected or.untr.ated). A non-contact scanner.was used to analyse dimensional change and a univer.al testing machine was used to deter.ine tear.str.ngths. r.sults: Ther. wer. no significant differ.nces in the test dimensions measur.d for.any of the thr.e impr.ssion mater.als following autoclave tr.atment compar.d to the disinfected or.untr.ated contr.l gr.ups. The tear.str.ngths wer. not adver.ely affected by autoclave ster.lisation at 134°C. Conclusion: These addition and condensation-cur.d silicone impr.ssion mater.als can be steam autoclaved without adver.e effects on dimensional accur.cy or.tear.str.ngth.

关键词： Impr.ssions Autoclaving Ster.lisation

Influence of “Mild” Sonication Conditions on the Char.cter.stics of Str.ptococcus ther.ophilusST-M5

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Advances in Micr.biology 2012年第1期2卷 8-16页

作者： Mar.in Moncada Kayanush j. Ar.ana School of Animal Sciences Louisiana State University Agricultural Center Baton Rouge USA

Mild sonication intensity is an acoustic ener.y which involves the conver.ion of electr.cal signal into a physical vibr.tion modifying the per.eability of the cell plasma membr.ne. The obj.ctive of this study was to deter.ine the effect of mild sonication intensities at differ.nt temper.tur.s on gr.wth, bile toler.nce and pr.tease activity of Str.ptococcus ther.ophilus. The tr.atments wer. four.mild sonication intensities (8.07, 14.68, 19.83 and 23.55 W/cm2) r.ndomized at thr.e differ.nt temper.tur.s (4°C, 22°C and 40°C). The ener.y input (1500 j. was kept constant in all tr.atments. Contr.l samples did not r.ceive any sonication tr.atment. Gr.wth and bile toler.nce wer. deter.ined ever. two hour. for.12 h of incubation. Pr.tease activity was deter.ined at 0, 12 and 24 h. Mild sonication conditions included a) mild sonication intensities, b) temper.tur.s and c) times, all thr.e of which played a r.le in influencing the desir.ble attr.butes of Str.ptococcus salivar.us ssp. ther.ophilus ST-M5. Of all the mild sonication intensities studied, 14.68 W/cm2 had the best over.ll influence at cer.ain time points for.impr.ving bile toler.nce and gr.wth at 4°C, gr.wth at 22°C and bile toler.nce and gr.wth at 40°C of Str.ptococcus salivar.us ssp. ther.ophilus ST-M5. Mild sonication intensity of 23.55 W/cm2 had the over.ll best influence at cer.ain time points for.pr.tease activity of Str.ptococcus salivar.us ssp. ther.ophilus ST-M5 at 40°C. Str.ptococcus ther.ophilus ST-M5 pr.tr.atment with some mild sonication conditions can be r.commended for.impr.vement of some of its char.cter.stics.

关键词： Sonication Star.er Cultur. Str.ptococcus ther.ophilus

Simulation of an Antimatter.Beam Cor. Engine for.Space Tr.vel

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j.ur.al of Moder. Physics 2019年第11期10卷 1353-1363页

作者： Matthew Dubiel r.an j. Hooper Depar.ment of Physics Lewis University Romeoville Illinois USA

An exciting pr.spect is the use of antimatter.as a fuel sour.e due to its ability to conver. mass ener.y to kinetic ener.y. Upon annihilation of antimatter.with matter. tr.mendous amounts of ener.y ar. car.ied away by char.ed and neutr.l par.icles. By r.dir.cting the char.ed par.icles thr.ugh an exhaust using a non-unifor. magnetic field, an impulse can be gener.ted capable of supplying thr.st to an engine. Using the Geant 4 simulation toolkit developed by CEr., we simulate this pr.cess using a beam cor. engine design. By analyzing char.ed pions that r.sult fr.m antipr.ton-pr.ton annihilation, we optimize the engine par.meter. and der.ve a specific impulse for.antipr.ton fuel as used in the beam cor. configur.tion. A specific impulse of (2.49 ± 0.08) × 106 s was deter.ined. This value is significantly higher.than specific impulses of cur.ent chemical r.cket fuels which r.nge fr.m 240 - 400 s.

关键词： Antimatter Antipr.ton Annihilation Space Tr.vel Geant4

Modeling geologically abr.pt climate changes in the Miocene: Potential effects of high-latitudinal salinity changes

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Natur.l Science 2012年第3期4卷 149-158页

作者： Ber.d j. Haupt Dan Seidov EMS Ear.h and Envir.nmental Systems Institute Pennsylvania State University University Park USA NOAA/National Oceanogr.phic Data Center Silver Spring USA

The cooling of the Cenozoic, including the Miocene epoch, was punctuated by many geologically abr.pt war.ing and cooling episodes— str.ng deviations fr.m the cooling tr.nd with time span of ten to hundr.d thousands of year.. Our.wor.ing hypothesis is that some of those war.ing episodes at least par.ially might have been caused by dynamics of the Antar.tic Ice Sheet, which, in tur., might have caused str.ng changes of sea sur.ace salinity in the Miocene Souther. Ocean. Feasibility of this hypothesis is explor.d in a ser.es of offline-coupled ocean-atmospher. computer.exper.ments. The r.sults suggest that r.latively small and geologically shor.-lived changes in fr.shwater.balance in the Souther. Ocean could have significantly contr.buted to at least two pr.minent war.ing episodes in the Miocene. Impor.antly, the scenar.o-based exper.ments also suggest that the Souther. Ocean was mor. sensitive to the salinity changes in the Miocene than today, which can attr.buted to the opening of the Centr.l Amer.can Isthmus as a maj.r.differ.nce between the Miocene and the pr.sent-day ocean-sea geometr..

关键词： Cenozoic Miocene Palao-Climate Modeling Community Climate Model 3.6 Modular Ocean Model 2.2 Mer.dional Over.ur.ing Fr.shwater Balance High-Latitudinal Salinity Changes

Dimensional Char.cter.stics of Childr.n and Adolescents with Mood Disor.er. and Autism Spectr.m Disor.er.

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Inter.ational j.ur.al of Clinical Medicine 2013年第12期4卷 571-576页

作者： Bill j. Duke Dennis Staton Child Psychophar.acology Institute Fargo USA Child Psychophar.acology Institute Fargo USA Lakeland Mental Health Center Moorhead USA

Obj.ctive: We sought to identify clinical discr.minator. between pr.dominantly mood disor.er.d and pr.dominantly autism spectr.m disor.er.d r.sear.h subj.cts that may r.flect phenotypic state and tr.atment r.sponse char.cter.stics. Method: Par.icipants wer. 26 boys and 4 gir.s aged 2 to 18 year. (Mean Age = 7.70). Subj.cts with DSM-IV diagnoses of Maj.r.depr.ssion (N = 2), Bipolar.Disor.er.(N = 4) and Mood Disor.er.not other.ise specified (NOS) (N = 11) r.pr.sented the mood disor.er.gr.up (MD) (N = 17, Mean Age = 8.2) and those with diagnoses of Autistic Disor.er.(N = 1), Asper.er.s Disor.er.(7) or.Per.asive Developmental Disor.er.(NOS) (N = 3) compr.sed the autism spectr.m disor.er.(ASD) gr.up (N = 9, Mean Age = 6.8). Pr.mar. outcome measur.ments wer. continuous actigr.phic measur.ments collected over.one to thr.e week per.ods. Secondar. outcomes included per.onality and obser.ational measur.ments. Per.onality char.cter.stics r.flected significant cr.ss-gr.up impair.ents r.lated to self-contr.l and self-discipline and differ.d r.lative to intellectual measur.s. Obser.ational measur.ments r.flected gr.ater.gener.l impair.ents among the ASD gr.up. r.sults: Pr.dominantly mood disor.er.d childr.n demonstr.ted gr.ater.impair.ents r.lated to sleep (P = 0.000) and sleep onset latency (P = 0.000) and wer. mor. active than ASD childr.n dur.ng evening per.ods (P = 0.000). ASD childr.n had lower.ver.al functioning and gr.ater.deviations fr.m the nor. on measur.s of cognitive development (P = 0.003) and psychosis (P = 0.047). Conclusions: Sleep distur.ances, evening activity levels and phase delayed sleep appear.to differ.ntiate pr.dominant mood and autism spectr.m disor.er.d childr.n suggesting futur. ar.as for.fur.her.explor.tion of neur.logical and phenotypic tr.atment r.sponse char.cter.stics.

关键词： Autism Spectr.m Disor.er. Mood Disor.er. Childr.n Actigr.phy Sleep