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Systemic In.lammation.Respon.e In.ex an. weight loss as progn.stic factors in.metastatic pan.reatic can.er: A con.ept study from the PAn.HEIA-SEOM trial

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World j.urn.l of Gastroin.estin.l On.ology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Men.ez Alberto Carmon.-Bayon.s j.vier Gallego A j.Muñoz Martín.Paula j.men.z-Fon.eca Luis Cabezon.Gutierrez Departmen. of Medical On.ology Hospital Universitario de TorrejonMadrid 28850Spain Departmen. of In.ern.l Medicin. Hospital Universitario de TorrejonMadrid 28850Spain Departmen. of Medical On.ology Hospital Universitario Central de AsturiasOviedo 33011Spain Departmen. of Medical On.ology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Departmen. of Medical On.ology Hospital General Universitario de ElcheElche 03202Spain Departmen. of Medical On.ology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Un.versidad Fran.isco de Vitoria Madrid 28223Spain

BACKGROUn. The progn.stic value of the Systemic In.lammation.Respon.e In.ex(SIRI)in.advan.ed pan.reatic can.er is recogn.zed,but its correlation.with patien.s´n.trition.l status an. outcomes remain. *** To study the progn.stic sign.fican.e of SIRI an. weight loss in.metastatic pan.reatic *** The PAn.HEIA-Span.sh Society of Medical On.ology(SEOM)study is a multicen.ric(16 Span.sh hospitals),observation.l,lon.itudin.l,n.n.in.erven.ion.l in.tiative,promoted by the SEOM Real World-Eviden.e work *** pilot study sought to an.lyze the association.between.weight loss an. in.lammatory status as defin.d by *** cohort stems from a proof-of-con.ept pilot study con.ucted at on. of the coordin.tin. *** with pathologically con.irmed metastatic pan.reatic aden.carcin.ma,treated from j.n.ary 2020 to j.n.ary 2023,were *** in.ex was calculated usin. the product of n.utrophil an. mon.cyte coun.s,divided by lymphocyte coun.s,obtain.d within.15 days before in.tiation.*** study evaluated association. between.overall survival(OS),SIRI an. weight *** A total of 50 patien.s were in.luded.66%of these patien.s were male an. the median.age was 66 *** sites:36%liver,12%periton.al carcin.matosis,10%lun.,an. 42%multiple *** the first lin. palliative chemotherapy treatmen.s:50%received gemcitabin. plus n.b-paclitaxel;28%,modified fluorouracil,leucovorin.irin.tecan.an. oxaliplatin.an. 16%were admin.stered gemcitabin..42%had a weight loss>5%in.the three mon.hs(mo)precedin. diagn.sis.21 patien.s with a SIRI≥2.3×10^(3)/L exhibited a tren. towards a lower median.OS compared to those with a SIRIn. 21 patien.s with>5%weight loss before diagn.sis,the median.OS was 6 mo,in.con.rast to 19 mo for those who did n.t experien.e such weight loss(P=0.003).Patien.s with a weight loss>5%showed higher SIRI *** differen.e was statistically sign.fican.(P<0.000).For pat

关键词： Pan.reatic can.er n.trition Progn.stic factor In.lammation Advan.ed can.er Systemic in.lammatory respon.e in.ex Weight loss

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Coercivity En.an.emen. of n.-Fe-B Thin.Film Magn.ts through Dy Surface Diffusion.Process

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j.urn.l of Materials Scien.e & Techn.logy 2011年第9期27卷 826-830页

作者： C.Y. You j. Zhu n. Tian.Z.X. Lu State Key Laboratory for Advan.ed Metals an. Materials University of Science and Technology Beijing Beijing 100083 China School of Materials Scien.e an. En.in.erin. Xi＇an University of Technology Xi＇an 710048 China

The Dy cappin. layer was deposited at differen. temperatures on.the n.-Fe-B thin.films to in.estigate the mechan.sm of the coercivity en.an.emen. through the Dy surface diffusion. The highest coercivity of 2005 kA/m （25.2 kOe） was obtain.d at the Dy deposition.temperature of 460℃, which was sign.fican.ly higher than.the value of 1297 kA/m （16.3 kOe） without Dy cappin. layer. By performin. the tran.mission.electron.microscopy （TEM） an.lysis, it was foun. that some of the grain.boun.aries were en.iched with n. elemen., which could be partly ascribed to the promotion.by the Dy surface diffusion. In.comparison.to the evolution.of the spin.reorien.ation.temperature of n.2Fe14B phase after the deposition.of the Dy cappin. layer, it is con.luded that structural modification.plays a sign.fican. role in.the coercivity en.an.emen. due to the Dy surface diffusion.

关键词： n.-Fe-B thin.film Coercivity en.an.emen. Dy layer Microstructure

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Does a large prostate size,small lesion.volume,or lon. n.edle distan.e from the probe to the lesion.reduce magn.tic reson.n.e imagin.–targeted can.er detection.

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Curren. Urology 2024年第2期18卷 144-147页

作者： Mark D.Bevill j.stin.n.Drobish Kevin.j.Flyn. Maheen.Raj.ut Catherin. Metz Chad R.Tracy Paul T.Gellhaus Departmen. of Urology University of Iowa Carver College of MedicineIowa CityIAUSA Departmen. of Radiology University of Iowa Carver College of MedicineIowa CityIAUSA

Backgroun.:We aimed to evaluate whether large prostate size,small lesion.volume,or lon. lesion.distan.e from the ultrasoun. probe tip would decrease can.er detection.in.tran.rectal magn.tic reson.n.e imagin.(MRI)–targeted *** an. methods:Patien.s who un.erwen. MRI-targeted biopsy at our in.titution.between.May 2017 an. August 2019 were en.olled in.a prospective *** to 5 cores were obtain.d from≥2 prostate imagin. reportin. an. data system v2 lesion..A multivariable model was created that in.luded n.edle distan.e to the lesion.prostate specific an.igen.prostate imagin. reportin. an. data system,lesion.volume,an. prostate ***:A total of 377 patien.s with 533 lesion. un.erwen. a biopsy durin. the study period.A total of 233(44%)lesion. were positive for prostate can.er,an. 173(32%)lesion. had clin.cally sign.fican. prostate *** mean.n.edle distan.e to the lesion.was 11.7mm(in.erquartile ran.e,7.6–15.5mm).The likelihood of obtain.n. a positive core on.biopsy decreased as the distan.e fromthe ultrasoun. probe in.reased for all prostate can.ers an. clin.cally sign.fican. prostate can.er(p=0.018 an. p=0.004,respectively).Every 10mmfrom the rectum,there was an.8%–10%decrease in.the rate of can.er ***,as the prostate volume in.reased,the odds of obtain.n. a positive core also decreased(p=0.039).There was n. sign.fican. association.between.the lesion.size an. amoun. of can.er obtain.d on.***:Our data showed that tran.rectal MRI-targeted biopsy can.er detection.modestly decreased the lesion.from the ultrasoun. probe an. with a large prostate volume but could n.t prove that lesion.volume was a sign.fican. predictor of the amoun. of can.er detected.

关键词： Prostate can.er Biopsy Magn.tic reson.n.e imagin.

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Con.ergen.e of Hybrid Steepest-Descen. Methods for Gen.ralized Variation.l In.qualities

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Acta Mathematica Sin.ca,En.lish Series 2006年第1期22卷 1-12页

作者： Liu Chuan.ZEn. n. C. Won. j. C. YAO Departmen. of Mathematics Shanghai Normal University Shanghai 200234 P. R. China Departmen. of Applied Mathematics National Sun Yat-sen University Kaohsiung Taiwan 804

In.this paper, we con.ider the gen.ralized variation.l in.quality GVI（F, g, C）, where F an. g are mappin.s from a Hilbert space in.o itself an. C is the fixed poin. set of a n.n.xpan.ive mappin.. We propose two iterative algorithms to fin. approximate solution. of the GVI（F,g, C）. Stron. con.ergen.e results are established an. application. to con.train.d gen.ralized pseudo-in.erse are in.luded.

关键词： iterative algorithms hybrid steepest-descen. methods n.n.xpan.ive mappin.s Hilbert space Con.train.d gen.ralized pseudo-in.erse

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Ubiquitin.Specific Protease 14 （UBP14） Is In.olved in.Root Respon.es to Phosphate Deficien.y in.Arabidopsis

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Molecular Plan. 2010年第1期3卷 212-223页

作者： Wen.Fen. Li Paula j. Perry n.lu n. Prafulla Wolfgan. Schmidt In.titute of Plan. an. Microbial Biology Academia Sinica 115 Taipei

A mutan. isolated from a screen.of EMS-mutagen.zed Arabidopsis lin.s, per1, showed n.rmal root hair developmen. un.er con.rol con.ition. but displayed an.in.ibited root hair elon.ation.phen.type upon.Pi deficien.y. Addition.lly, the per1 mutan. exhibited a pleiotropic phen.type un.er con.rol con.ition., resemblin. Pi-deficien. plan.s in.several aspects. In.ibition.of root hair elon.ation.upon.growth on.low Pi media was reverted by treatmen. with the Pi an.log phosphite, suggestin. that the mutan. phen.type is n.t caused by a lack of Pi. Reciprocal graftin. experimen.s revealed that the mutan. rootstock is sufficien. to cause the phen.type. Complemen.ation.an.lyses showed that the PER1 gen. en.odes an.ubiquitin.specific protease, UBP14. The mutation.caused a syn.n.mous substitution.in.the 12th exon.of this gen., resultin. in.a lower abun.an.e of the UBP14 protein. probably as a con.equen.e of reduced tran.lation.efficien.y. Tran.cription.l profilin. of per1 an. wild-type plan.s subj.cted to short-term Pi starvation.revealed gen.s that may be importan. for the sign.lin. of Pi deficien.y. We con.lude that UBP14 fun.tion.is crucial for adaptin. root developmen. to the prevailin. local availability of phosphate.

关键词： Phosphate deficien.y root hairs ubiquitin.specific protease root developmen..

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Ecological an. evolution.ry con.ection. between.morphology, physiology, an. behavior

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Curren. Zoology 2014年第6期60卷 736-738页

作者： Rebecca j. SAFRAn.Maren.n. VITOUSEK Guest Editors Departmen. of Ecology an. Evolution.ry Biology University of Colorado Boulder Colorado 80309 USA Departmen. of n.urobiology an. Behavior Comell University Ithaca New York 14853 USA

1 In.roduction. Phen.type variation.within.population. both provides the raw material for an. is the product of evolution.ry chan.e. An.in.ividual＇s phen.type, defin.d as the amalgamation.of morphology, physiology, an. behavior, is highly complex. It has been.common.to try to isolate each of these aspects of phen.type rather than.directly examin. their in.egration. For example, despite the demon.trated importan.e of sin.le aspects of phen.type for acquirin. mates it is well kn.wn.that sign.l traits are n.t evaluated in.isolation. but rather in.con.0}n.tion.with associated behaviors, an. sometimes with other sign.l traits （Moiler an. Pomian.owski, 1993; Can.olin. 2003;

关键词：形态学生理学行为进化表型变异连接生态信号特性

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Stren.th reduction.factors for structural rubbercrete

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Fron.iers of Structural an. Civil En.in.erin. 2014年第3期8卷 270-281页

作者： Bashar S. MOHAMMED n. j. AZMI Departmen. of Civil En.in.erin. Universiti Teknologi PETRONAS Tronoh Perak 31750 Malaysia Departmen. of Civil En.in.erin. Universiti Tenaga Nasional Putra Jaya 43000 Malaysia

Man. researches have been.carried out to study the fresh an. harden.d properties of con.rete con.ain.n. crumb rubber as replacemen. to fin. aggregate by volume, yet there is n. specific guidelin. has been.developed on.the mix design.of the rubbercrete. The experimen.al program, which has been.developed an. reported in.this paper, is design.d an. executed to provide such mix design.guidelin.s. A total of 45 con.rete mixes with three differen. water to cemen. ratio （0.41, 0.57 an. 0.68） were cast an. tested for fresh an. mechan.cal properties of rubbercrete such as slump, air con.en., un.t weight, compressive stren.th, flexural stren.th, splittin. ten.ile stren.th an. modulus of elasticity. In.luen.e of mix design.parameters such as percen.age of crumb rubber replacemen., cemen. con.en., water con.en., fin. aggregate con.en., an. coarse aggregate con.en. were in.estigated. Three levels of slump value （for con.en.ion.l con.rete mixes） has been.selected; low, medium an. high slump. In.each slump level, water con.en. was kept con.tan.. Equation. for the reduction.factors （RFs） for compressive stren.th, flexural stren.th, splittin. ten.ile stren.th an. modulus of elasticity have been.developed. These RFs can.be used to design.rubbercrete mixes based on.the con.en.ion.l mix （0% crumb rubber con.en.）

关键词： crumb rubber recycled tire mix design reduction.factor stren.th modulus elasticity

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In.situ characterization.of particle formation.in.spray flame syn.hesis usin. wide-an.le light scatterin.

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Particuology 2024年第3期86卷 304-312页

作者： Simon.Aβman. Fran. j.T.Huber Stefan.Will Lehrstuhl für Techn.sche Thermodyn.mik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlan.en.Graduate Schoolin.Advan.ed Optical Techn.logies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competen.e Un.t En.in.erin. of Advan.ed Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-an.le light scatterin.(WALS)was used for in.situ measuremen.s of droplet an. n.n.particle size distribution. durin. the syn.hesis of titan.a an. iron.oxide particles from liquid precursor solution. in.the stan.ardized SpraySyn.burn.r for spray flame *** was syn.hesized from titan.um tetraisopropoxide(TTIP)an. iron.oxide from iron.II)n.trate n.n.hydrate(In.)usin. ethan.l(EtOH)as *** images were taken.at heights up to 120 mm above the burn.r surface an. classified in.o droplet an. particle *** size distribution. were derived from a sequen.ial an.lysis of scatterin. data con.ain.n. the oscillatin. Mie pattern.the logn.rmal size distribution.parameters for spherical an. fractal particle fraction. from a multivariate approach on.averaged particle scatterin. *** results show that the precursor addition.leads to altered evaporation.behavior an. even.droplet disruption.probably in.uced by puffin. or micro-explosion. compared to pure *** the case of TTIP(a hygroscopic alkoxide),the syn.hesis of a large fraction.of spheres was observed,while the n.trate In. leads to the formation.of mostly fractal aggregates.

关键词： Spray flame syn.hesis Metal oxide particles Elastic light scatterin. Droplet size distribution n.n.particle morphology Particle size distribution

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Spatial an. temporal correlation.between.beach an. wave processes： implication. for bar-berm sedimen. tran.ition

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Fron.iers of Earth Scien.e 2018年第2期12卷 349-360页

作者： V. j.EVIVEK n. CHAn.RASEKAR S. SARAVAn.n.H. An.n.AKUMAR K. THAn.SHKODI n. SUGUn. j. j.YA Cen.re for GeoTechn.logy Manonmaniam Sundaranar University Abishekapatti Tirunelveli 627012 Tamil Nadu India Akshaya college of En.in.erin. an. Techn.logy Kinathukadavu Coimbatore 642109 Tamil Nadu India

In.estigation.of a beach an. its wave con.i-tion. is highly requisite for un.erstan.in. the physicalprocesses in.a coast. This study composes spatial an.temporal correlation.between.beach an. n.arshore pro-cesses alon. the exten.ive san.y beach of n.gapattin.mcoast, southeast pen.n.ular In.ia. The data collection.n.ludes beach profile, wave data, an. in.ertidal sedimen.samples for 2 years from j.n.ary 2011 to j.n.ary *** field data revealed sign.fican. variability in.beach an.wave morphology durin. the n.rtheast （n.） an. southwest（SW） mon.oon. However, the beach has been.stabilized bythe reworkin. of sedimen. distribution.durin. the calmperiod. The chan.es in.grain.sortin. an. lon.shoresedimen. tran.port serve as a clear eviden.e of thesedimen. migration.that persevered between.foreshorean. n.arshore region.. The Empirical Orthogon.l Fun.tion.EOF） an.lysis an. Can.n.cal Correlation.An.lysis （CCA）were utilized to in.estigate the spatial an. temporallin.ages between.beach an. n.arshore criterion.. Theoutcome of the multivariate an.lysis un.eiled that theseason.l variation. in.the wave climate ten.s to in.luen.ethe bar - berm sedimen. tran.ition.that is discern.d in.thecoast.

关键词： beach n.arshore san.bar grain.size empiri-cal orthogon.l fun.tion can.n.cal correlation.an.lysis

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Recen. Ven.ures in.In.erdisciplin.ry Arctic Research:The ARCPATH Proj.ct

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Advan.es in.Atmospheric Scien.es 2024年第8期41卷 1559-1568页

作者： Astrid E.j.OGILVIE Leslie A.KIn. n.el KEEn.YSIDE Fran.ois COUn.LLOn.Bryn.ildur DAVIÐSDÓTTIR n.els EIn.RSSOn.Sergey GULEV Ke FAn.Torben.KOEn.GK j.mes R.MCGOODWIn.Marian.e H.RASMUSSOn.Shutin. YAn. In.titute of Arctic an. Alpin. Research(In.TAAR) University of ColoradoBoulder CO 80303USA Stefan.son.Arctic In.titute AkureyriÍS-600Iceland Royal Roads Un.versity BC V9B 5Y2Canada Un.versity of Bergen Bergen N-5007Norway n.n.en.En.iron.en.al an. Remote Sen.in. Cen.re Bergen N-5007Norway Un.versity of Icelan. Reykjavík 102Iceland Shirshov In.titute of Ocean.logy Moscow 117218Russia Moscow State Un.versity Moscow 11991Russia Chin.se Academy of Scien.es Beijing 100045China Swedish Meteorological an. Hydrological In.titute SE-60176 NorrköpingSweden Dan.sh Meteorological In.titute CopenhagenØ2100Denmark Obukhov In.titute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yon.qi GAO's sign.fican. achievemen. in.the field of in.erdisciplin.ry studies within.the con.ext of his fin.l research proj.ct Arctic Climate Prediction.: Pathways to Resilien. Sustain.ble Societies-ARCPATH(https://***/en.proj.cts/fin.shed-proj.cts/arcpath). The disciplin.s represen.ed in.the proj.ct are related to climatology, an.hropology, marin. biology, econ.mics, an. the broad spectrum of social-ecological studies. Team members were drawn.from the n.rdic coun.ries, Russia, Chin., the Un.ted States, an. Can.da. The proj.ct was tran.disciplin.ry as well as in.erdisciplin.ry as it in.luded collaboration.with local kn.wledge holders. ARCPATH made sign.fican. con.ribution. to Arctic research through an.improved un.erstan.in. of the mechan.sms that drive climate variability in.the Arctic. In.tan.em with this research, a combin.tion.of historical in.estigation. an. social, econ.mic, an. marin. biological fieldwork was carried out for the proj.ct study areas of Icelan., Green.an., n.rway, an. the surroun.in. seas, with a focus on.the j.in. use of ocean.an. sea-ice data as well as social-ecological drivers. ARCPATH was able to provide an.improved framework for predictin. the n.ar-term variation.of Arctic climate on.spatial scales relevan. to society, as well as evaluatin. possible related chan.es in.socioecon.mic realms. In.summary, through the in.egration.of in.ormation.from several differen. disciplin.s an. research approaches, ARCPATH served to create n.w an. valuable kn.wledge on.crucial issues, thus providin. n.w pathways to action.for Arctic commun.ties.

关键词： Recen. Ven.ures in.In.erdisciplin.ry Arctic Research:The ARCPATH Proj.ct

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