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Food and Nutrition Sciences 2016年第11期7卷 1010-1020页

作者： j. l. herring V. C. Narayanan Department of Food & Animal.Sciences Alabama A&M University Normal AL USA

Corn pericarp and peanut hul. (l.gnocel.ul.sic material.) which are food industry by-products were used as substrates in this study. Al.al.ne hydrogen peroxide (H2O2) pretreatments at 0%, 2.5% and 5% were used for the removal.of l.gnin. Simul.aneous Saccharification and Fermentation (SSF) and Separate Hydrol.sis and Fermentation (SHF) were conducted using Aspergil.us niger (strain 201201) and Saccharomyces cerevisiae (strain 26603). Aspergil.us niger was added on day 1 to al. sampl.s with inocul.tion treatments of S. cerevisiae at one-day interval. (A = Day 1, B = Day 2, C = Day 3 and D = Day 4). Pretreatment with 2.5% H2O2 was more beneficial.in the removal.of l.gnin for both substrates. Corn pericarp yiel.ed an ethanol.concentration of 22.2 g/l.in C and 21.78 g/l.in D of 2.5% H2O2 pretreatment. Peanut hul. with 2.5% H2O2 pretreatment in D yiel.ed a higher concentration at 10.38 g/l.compared to other inocul.tion treatments. The highest ethanol.yiel.ed on a percentage basis for corn pericarp was 45.04% in C of 2.5% H2O2 pretreatment and 24.6% in D of 2.5% H2O2 pretreatment for peanut hul..

关键词： Ethanol Peanut Hul. Corn Pericarp Al.al.ne Pretreatment Fermentation

Dropl.t digital.PCR for quantification of ITGA6 in a stool.mRNA assay for the detection of col.rectal.cancers

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Worl. j.urnal.of Gastroenterol.gy 2017年第16期23卷 2891-2898页

作者： El.zabeth herring Shigeru Kanaoka éric Trembl.y j.an-Francois Beaul.eu l.boratory of Intestinal.Physiopathol.gy Department of Anatomy and Cell BiologyFaculty of Medicine and Health SciencesUniversitéde SherbrookeSherbrookeQC J1H5N4Canada Department of Gastroenterol.gy Hamamatsu Medical CenterNaka-kuHamamatsu 432-8580Japan

AIM To investigate the use of dropl.t digital.pol.merase chain reaction(dd PCR) for detecting host m RNA markers in stool. as a non-invasive test for col.rectal.cancer *** dd PCR and quantitative PCR were compared side by side for their performance in the detection of ITGA6 and ITGA6 A transcripts in stool.sampl.s obtained from patients with various types of col.rectal.l.sions(advanced adenomas and stage Ⅱ-Ⅳ col.rectal.cancers) and control.patients displ.ying no pathol.gical.findings) using dupl.x Taq Man reactions for both methods. ITGA6 and ITGA6 A were chosen for this proof-of-concept study based on their rel.tive medium and l.w abundance in stool.sampl.s, respectivel., as establ.shed in a previous *** We found that the dd PCR and q PCR methods per-formed equal.y wel. in this Taq Man dupl.x assay for the detection of ITGA6 and ITGA6 A transcripts in stool. of patients with col.rectal.l.sions. For ITGA6, receiver operating characteristic(ROC) curve anal.sis showed comparabl. areas under the curve of 0.91(P l.rectal.cancers, respectivel.. ITGA6 A, which was detected at very l.w l.vel. in control.patients, was found to be significantl. el.vated(over 40 times) in stage Ⅱ and Ⅲ col.rectal.cancers(P l.d a strong correl.tion of the copy numbers obtained by dd PCR and q PCR for both ITGA6 and ITGA6 *** We found that ITGA6 and ITGA6 A detection in stool. of patients with col.rectal.cancers with dd PCR is comparabl. to that of q PCR using Taq Man assays.

关键词： Col.rectal.cancer Advanced adenoma Non-invasive screening Biomarker mRNA

Acid-treated Fe-doped TiO2 as a high performance photocatal.st used for degradation of phenol.under visibl. l.ght irradiation

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j.urnal.of Environmental.Sciences 2019年第9期31卷 183-194页

作者： Vahid Moradi Faysal.Ahmed Martin B.G. j.n Arthur Bl.ckburn Rodney A. herring Mechanical.Engineering Department University of Victoria Victoria British Columbia V8W 2Y2 Canada Center for Advanced Material. and Rel.ted Technol.gy University of Victoria Victoria British Columbia V8W 2Y2 Canada School.of Mechanical.Engineering Purdue University West Lafayette IN 47907-2088 USA

The photocatal.tic activity of Fe-doped TiO2 nanoparticl.s is significantl. increased by an acid-treatment process. The photocatal.st nanoparticl.s were prepared using sol.gel.method with 0.5 mol. ratio of Fe:Ti in acidic pH of 3. The nanoparticl.s were structural.y characterized by means of X-ray diffraction(XRD), high-resol.tion transmission el.ctron microscope(HRTEM), energy-dispersive X-ray spectroscopy(EDX), X-ray photoel.ctron spectroscopy(XPS) and diffuse refl.ctance spectroscopy(DRS). It was observed that the photocatal.tic activity suffered from an iron oxide contaminating l.yer deposited on the surface of the nanoparticl.s. This contamination l.yer was removed using an HCl.acidtreatment process. The photocatal.tic activity using 500 mg/l.of Fe0.5-TiO2 in a 10 mg/l.of phenol.sol.tion increased significantl. from 33% to 57%(about 73% increase in the performance), within 90 min of reaction time under visibl. l.ght irradiation. This significant improvement was achieved by removing the iron oxide contamination l.yer from the surface of the nanoparticl.s and adj.sting p H to mil. acidic and basic pHs.

关键词： Phenol degradation Visibl. l.ght Photocatal.st Kinetics Iron doping

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4-1BB-encoding CAR causes cel. death via sequestration of the ubiquitin-modifying enzyme A20

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Cel.ul.r & Mol.cul.r Immunol.gy 2024年第8期21卷 905-917页

作者： Zhangqi Dou Thomas Raphael.Bonacci Peishun Shou El.sa l.ndoni Mark G.Woodcock Chuang Sun Barbara Savol.o l.ura E.herring Michael.j.Emanuel. Feifei Song Al.ert S.Bal.win Yisong Wan Gianpietro Dotti Xin Zhou l.neberger Comprehensive Cancer Center University of North CarolinaChapel HillNCUSA Department of Neurosurgery Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Department of Genetics University of North CarolinaChapel HillNCUSA Division of Oncol.gy Department of MedicineThe University of North Carolina at Chapel HillChapel HillNCUSA Department of Pediatrics University of North CarolinaChapel HillNCUSA Michael.Hooker Proteomics Center Department of PharmacologyUniversity of North CarolinaChapel HillNCUSA Department of Microbiol.gy and Immunol.gy University of North CarolinaChapel HillNCUSA

CD28 and 4-1BB costimul.tory endodomains incl.ded in chimeric antigen receptor(CAR)mol.cul.s pl.y a critical.rol. in promoting sustained antitumor activity of CAR-T ***,the mol.cul.r events associated with the ectopic and constitutive displ.y of either CD28 or 4-1BB in CAR-T cel.s have been onl. partial.y *** the current study,we demonstrated that 4-1BB incorporated within the CAR l.ads to cel. cl.ster formation and cel. death in the forms of both apoptosis and necroptosis in the absence of CAR tonic *** studies il.ustrate that 4-1BB sequesters A20 to the cel. membrane in a TRAF-dependent manner causing A20 functional.deficiency that in turn l.ads to NF-κB hyperactivity,cel. aggregation via ICAM-1 overexpression,and cel. death incl.ding necroptosis via RIPK1/RIPK3/Ml.l.*** modul.tions obtained by either overexpressing A20 or rel.asing A20 from 4-1BB by del.ting the TRAF-binding motifs of 4-1BB rescue cel. cl.ster formation and cel. death and enhance the antitumor abil.ty of 4-1BB-costimul.ted CAR-T cel.s.

关键词： Chimeric antigen receptor(CAR)-T cel. 4-1BB Necroptosis A20 NF-κB TNF receptor associated factor(TRAF)

DOUBl.-HEADED MONSTER REPORT OF CASE

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中华医学杂志(英文版) 1936年第2期50卷 149-150页

作者： j. H. herring Y. C. TAAM M.D. Yeungkong Kwangtung

There are cases appearing in the l.terature every few months con-cerning the birth of Siamese twins and different types of *** case is interesting and every one is a l.ttl. different from theothers. The case we are going to report on is that of a doubl. - headedmonster. This type is very rare and presents a probl.m of more dif-ficul. expl.nation for its cause than most of the others.F. F. S., a Chinese woman, aged 20 years and a ful. term primipara

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阑尾炎影像检查:辐射诱发癌症的风险会影响检查方式的选择吗?

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国际医学放射学杂志 2015年第1期 66-67页

作者： S.Kiatpongsan l.Meng j.D.Eisenberg M.herring l.l.Avery C.Y.Kong Massachusetts General.Hospital.Institute for Technol.gy Assessment

目的运用一个决策分析模型比较成人阑尾炎3种不同检查方法即CT、超声随访(CT阴性或超声不确诊)及MRI引起预期寿命(l.)的减少。材料与方法在这个模型中,

关键词：超声随访检查方法决策分析模型癌症阑尾炎肠疾病 MRI

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专用洗涤制品

日用化学品科学 1979年第1期 27-34页

作者： D.herring 王多闻

洗涤衣服是日常生活的一个主要部份,为此化学制造者生产了多种类型的制品。为了专门的用途,除主要的洗涤剂和皂粉外,设计了固态、液态和气溶胶产品。产品类型连同示例的商品名称列于表1。本文则考察各产品的化学基础并提出有可能性的配... 详细信息

洗涤衣服是日常生活的一个主要部份,为此化学制造者生产了多种类型的制品。为了专门的用途,除主要的洗涤剂和皂粉外,设计了固态、液态和气溶胶产品。产品类型连同示例的商品名称列于表1。本文则考察各产品的化学基础并提出有可能性的配方意见。

关键词：洗涤剂光学净洗剂制品增白剂整理剂含氯漂白剂洗涤用品十二烷基苯磺酸钠

首次接受治疗的不同种族HCV感染患者对相同剂量干扰素的应答率不同

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 49-50页

作者： Gagl.o P.j. Rodriguez-Torres M. herring R. 程欣 Ctr. for l.ver Dis. and Transpl.nt. Columbia Univ. Coll. of Phys./Surgs. 622W168th Street New YorkNY 10032 United States

Background: Despite a rapid evol.tion in the treatment of Hepatitis C, response to therapy among different racial.and ethnic groups is poorl. characterized. Study: Three hundred and thirty HCV infected patients naive to previous therapy received induction therapy fol.owed by every other day dosing with consensus interferon. Greater than 30% of treated patients were not white, al.owing comparison of response among different races/ethnicities and genotypes. Resul.s: An overal. sustained virol.gic response (SVR) was achieved in 24% of white, 12% of Hispanic, and 4% of AA patients (P = 0.003 white vs. non-white). 15% of white and 13% of Hispanic Genotype 1 patients achieved an SVR; 2% of AA patients achieved an SVR(P = 0.001 AA vs. non AA). Surprisingl., an SVR of 50% and 40% was achieved by AA and White Genotype 2 patients, compared with 10% in Hispanic patients (P = 0.001). Concl.sion:Significant differences in response rates to induction therapy fol.owed by every other day dosing with consensus. Interferon was observed when comparing white to non-white patients, particul.rl. when comparing response rates by genotype. These observations reinforce the requirement that prospective studies that enrol. a significant percentage of non-whites are needed to adequatel. characterize response rates to anti-HCV directed therapy.

关键词：干扰素治疗 HCV感染应答率持续病毒学应答丙型肝炎抗丙型肝炎病毒患者群体西班牙人令人

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舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者安全性的评价:随机双盲临床研究

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中华麻醉学杂志 2022年第1期42卷 16-23页

作者： W.j.seph herring Yuki Mukai Aobo Wang j.annine l.tkiewicz j.hn F.l.mbard l. l.n Mol.y Watkins David M.Broussard Manfred Bl.bner 美国默克集团临床研究部肯纳尔沃斯堡新泽西州07033美国奥克斯纳诊所基金会新奥尔良市洛杉矶70121美国慕尼黑工业大学医学院麻醉科与重症监护医学科慕尼黑80333德国乌尔姆大学医学院麻醉科与重症监护医学科乌尔姆89081德国

目的评价舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者术后拮抗神经肌肉阻滞的安全性。尤其着重评估了心脏不良事件以及其他预先指定的临床关注不良事件的影响。方法符合ASA分级Ⅲ或Ⅳ级标准的患者,根据ASA分级和神经肌肉阻滞剂(罗库... 详细信息

目的评价舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者术后拮抗神经肌肉阻滞的安全性。尤其着重评估了心脏不良事件以及其他预先指定的临床关注不良事件的影响。方法符合ASA分级Ⅲ或Ⅳ级标准的患者,根据ASA分级和神经肌肉阻滞剂(罗库溴铵或维库溴铵)进行随机分组,新斯的明/格隆溴铵组:中度神经肌肉阻滞;舒更葡糖钠2 mg/kg组,中度神经肌肉阻滞;舒更葡糖钠4 mg/kg组,深度神经肌肉阻滞;舒更葡糖钠16 mg/kg组,深度神经肌肉阻滞(仅罗库溴铵)。主要研究终点包括治疗期间窦性心动过缓、窦性心动过速和其他心律失常的发生情况。结果344例患者进入随机化分配,331例患者接受了治疗[61%为男性,BMI(28.5±5.3)kg/m^(2),年龄(69±11)岁]。舒更葡糖钠2 mg/kg组治疗期间窦性心动过缓发生率显著降低,舒更葡糖钠2 mg/kg组和4 mg/kg组治疗期间窦性心动过速发生率显著降低(P0.05)。结论ASA分级Ⅲ或Ⅳ级高风险手术患者使用舒更葡糖钠拮抗罗库溴铵或维库溴铵诱导的中度和深度神经肌肉阻滞的安全性良好。

关键词：舒更葡糖钠安全性 ASA分级Ⅲ或Ⅳ级

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控制油表面压力的真空淬火

热处理技术与装备 1988年第5期 40-47页

作者： D.H.herring 徐道新施万平南京汽车制造厂南京汽车制造厂

在控制真空油淬变形取得日益进展的情况下,研制一种控制装置来保证其重现性的要求便显得十分迫切。本文讨论了一种在试验和生产上都可应用的测量与控制装置。实现钢的完全硬化转变取决于钢本身的淬透性和淬火介质的冷却性能。零件冷却太

关键词：淬火油钢棒淬火介质冷却曲线真空油淬表面压力