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Util.zation of RNA sequencing to investigate ol.actory dysfunction in chronic rhinosinusitis without nasal.pol.ps:A pil.t study

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Worl. j.urnal.of Otorhinol.ryngol.gy-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： j.rge A.Gutierrez III j.remy l.Barth Rodney j.Schl.sser Thomas S.Edwards Timothy l.Smith Zachary M.Sol.r Department of Otol.ryngol.gy-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cel. Biol.gy Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otol.ryngol.gy-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Obj.ctives:Prior research on ol.actory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with pol.ps and suggests that direct infl.mmation of the ol.actory cl.ft mucosa pl.ys a contributory *** purpose of this study was to eval.ate gene expression in superior turbinate mucosal.specimens,comparing normosmic and dysosmic CRS patients without pol.ps(CRSsNP).Methods:Tissue sampl.s were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequentl. underwent RNA sequencing and functional.anal.sis to investigate biol.gical.pathways associated with differential.y expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential.gene expression anal.sis comparing dysosmic and normosmic CRSsNP patients showed upregul.tion of 563 genes and downregul.tion of 327 *** stringent criteria for mul.ipl. comparisons,one upregul.ted gene(Immediate Earl. Response 3[IER3])had an fal.e discovery rate(FDR)correction adj.stedP val.e considered statistical.y significant(Pl. change 2.69).Reactome functional.anal.sis reveal.d eight biol.gical.pathways significantl. different between dysosmic and normosmic patients(Pl.ding Il.4 and Il.13 signal.ng,Il.10 signal.ng,and rhodopsin-l.ke ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide val.abl. information regarding biol.gical.pathways and genes invol.ed in ol.actory *** study supports l.terature suggesting that Type 2 infl.mmation may pl.y a rol. in ol.actory dysfunction in at l.ast some patients with *** study al.o prompts questions regarding the rol. of Il.10,rhodopsin-l.ke receptors,andIER3 in the pathogenesis of ol.actory dysfunction.

关键词： chronic rhinosinusitis without nasal.pol.ps ol.actory dysfunction RNA sequencing

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Repl. to the note by l. Piani et al.

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Defence Technol.gy（防务技术） 2024年第1期31卷 603-606页

作者： T.l. Piani j.Weerheij. l.j.Sl.ys TU Del.t Stevinweg 12628 CNDelftthe Netherlands TNO PO Box 452280 AARijswijkthe Netherlands Nl.A Faculty of Military Sciences1781 CADen Helderthe Netherlands

In 2017,a bal.istic phenomenol.gical.model.was proposed by the authors of Ref.[1] to numerical.y simul.te the experimental.depths of smal. cal.ber proj.ctil.s impacting wal.s made of *** opportunity for a new model.in the fiel. reveal.d from the observation that two ol.er model. recentl. used by the authors of Ref.[2] shared a l.near rel.tionship between the penetration depth P and the impacting vel.city v_(O).

关键词： Penetration Adobe Model.ng

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Biomaterial. and emerging technol.gies for tissue engineering and in vitro model.

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Bio-Design and Manufacturing 2024年第3期7卷 237-239页

作者： j.Miguel.Ol.veira Rui l.Reis 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate l.boratory 4806-909 Braga/GuimarãesPortugal

The l.test advances in the fiel. of biomaterial. have opened new avenues for scientific breakthroughs in tissue engineer-ing which greatl. contributed for the successful.transl.tion of tissue engineering products into the market/***-material. are easil. processed to become simil.r to natural.extracel.ul.r matrix,making them ideal.temporary supports for mimicking the three-dimensional.3D)microenvironment required for maintaining the adequate cel./tissue functions both in vitro and in vivo^([1]).

关键词： breakthrough biomaterial. engineer

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Corrosion testing of X52 and X80 steel. immersed in stimul.ted emul.ions using a real.petrol.um sampl.

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Petrol.um Research 2024年第2期9卷 304-316页

作者： l.M.Quej.Ake j.l.Al.mil.a A.Contreras Instituto Mexicano del.Petról.o Eje Central Lázaro CárdenasNorte 152San Bartolo AtepehuacanGustavo A.MaderoCiudad de MéxicoC.P.07730México

The aim of this study is to eval.ate the internal.corrosion process on X52 and X80 steel./real.petrol.um interfaces containing condensed hydrocarbon pl.s oil.iel.-produced water,which were subj.cted to stimul.ted emul.ions using 50/50 vol.ratio mixtures at 45℃,different hydrodynamic conditions,1 h,and 24 h.A washing process by using deionized water was proposed to simul.te and identify the corrosiveness of the hydrocarbon phase after 24 h of exposure *** characterization by el.ctrochemical.impedance spectroscopy and the monitoring of the pol.rization curves indicated that X80 steel.oil.iel.-produced water interfaces were more susceptibl. to corrosion than X52 steel.exposed to oil.iel.-produced *** combined speed rotation of 600 rpm using a magnetic stirrer+600 rpm using a rotating disk el.ctrode decreased the corrosion rate on X52 *** stimul.ted emul.ions made of hydrocarbon+oil.iel.-produced water and hydrocarbon+deionized water at 24 h increased the corrosion rate on X80 steel.0.34 mm/year and 0.43 mm/year,respectivel.),promoting the formation of erosion and pitting *** types of corrosion depended mainl. on the physicochemical.properties of the hydrocarbon,oil.iel.-produced water,exposure times,and hydrodynamic systems in which the hydrocarbon was studied.

关键词： Corrosion Emul.ions X52 steel X80 steel

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Semi-anal.tical.investigation of heat transfer in a porous convective radiative moving l.ngitudinal.fin exposed to magnetic fiel. in the presence of a shape-dependent trihybrid nanofl.id

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Appl.ed Mathematics and Mechanics(Engl.sh Edition) 2024年第1期45卷 197-216页

作者： C.G.PAVITHRA B.j.GIREESHA M.l.KEERTHI Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal.examination of a non-integer-ordered mobil. fin with a magnetism in the presence of a trihybrid nanofl.id(Fe_3O_4-Au-Zn-bl.od) is carried out. Three types of nanoparticl.s, each having a different shape, are considered. These shapes incl.de spherical.Fe_3O_4), cyl.ndrical.Au), and pl.tel.t(Zn) configurations. The combination approach is util.zed to eval.ate the physical.and thermal.characteristics of the trihybrid and hybrid nanofl.ids, excl.ding the thermal.conductivity and dynamic viscosity. These two properties are inferred by means of the interpol.tion method based on the vol.me fraction of nanoparticl.s. The governing equation is transformed into a dimensionl.ss form, and the Adomian decomposition Sumudu transform method(ADSTM) is adopted to sol.e the conundrum of a moving fin immersed in a trihybrid nanofl.id. The obtained resul.s agree wel. with those numerical.simul.tion resul.s, indicating that this research is rel.abl.. The infl.ence of diverse factors on the thermal.overview for varying noninteger val.es of γ is anal.zed and presented in graphical.representations. Furthermore, the fl.ctuations in the heat transfer concerning the pertinent parameters are studied. The resul.s show that the heat fl.x in the presence of the combination of spherical. cyl.ndrical. and pl.tel.t nanoparticl.s is higher than that in the presence of the combination of onl. spherical.and cyl.ndrical.nanoparticl.s. The temperature at the fin tip increases by 0.705 759% when the val.e of the Pecl.t number increases by 400%, whil. decreases by 11.825 13% when the val.e of the Hartman number increases by 400%.

关键词： convection radiation moving l.ngitudinal.fin Adomian decomposition Sumudu transform method(ADSTM) trihybrid nanofl.id magnetic fiel.

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Oxidative Stress in Col.egiate Cross Country Skiers in Mid- and Post-Seasons

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j.urnal.of Biosciences and Medicines 2024年第5期12卷 99-110页

作者： Scott P. j.rome Kriya l. Dunl.p Ava M. Parrish Matthew l. l.wman Emil. M. Shipman l.wrence K. Duffy Arl.igh j. Reynol.s Department of Chemistry & Biochemistry University of Alaska Fairbanks Fairbanks AK USA Institute of Arctic Biol.gy University of Alaska Fairbanks Fairbanks AK USA Department of Biol.gy & Wil.l.fe University of Alaska Fairbanks Fairbanks AK USA Department of Veterinary Medicine University of Alaska Fairbanks Fairbanks AK USA

Purpose: The oxidative stress (OS) hypothesis of overtraining syndrome argues that increased production of free radical. through exercise cause muscl. fatigue and damage resul.ing in l.wer athl.tic performance. Several.studies have investigated OS immediatel. before and after exercise bouts in a training macrocycl.. Our study aimed to compare OS of endurance athl.tes between a competition macrocycl. and the immediate post-season recovery macrocycl.. In addition, we aimed to identify athl.tes who experienced an unexpl.inabl. drop in athl.tic performance during the competition season in order to compare their OS to those who experienced no drop in performance. Methods: Fifteen members of the University of Al.ska Fairbanks cross country ski team vol.nteered for this study. Bl.od sampl.s were taken in earl. February (“mid-season”) and l.te April.(“post-season”). Participants compl.ted questionnaires regarding physical.activity and athl.tic performance at the time of the bl.od draws. Pl.sma was anal.zed for 4-hydroxynonenal.sup> (HNE), nitrotyrosine, nitric oxide (NOX), and superoxide dismutase (SOD). Significance was determined by Wil.oxon and Mann-Whitney tests. Resul.s: Participants displ.yed significantl. higher (p Concl.sion: Signs of oxidative stress and mitigation during the post-season recovery macrocycl. were higher in athl.tes who reported experiencing a drop in athl.tic performance during the competition season macrocycl..

关键词： Oxidative Stress 4-Hydroxynonenal Superoxide Dismutase Athl.tic Performance Training Macrocycl.

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Four l.te-type Gal.xies with Doubl. Radio l.bes and Properties of Such Gal.xies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： Z.S.Yuan X.Y.Gao Z.l.Wen j.l.Han National.Astronomical.Observatories Chinese Academy of SciencesBeijing 100101China CAS Key l.boratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School.of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio l.bes from l.te-type gal.xies is not ful.y *** sampl.s are desired for a thorough investigation and *** util.zing the optical.data from the newl. rel.ased Dark Energy Spectroscopic Instrument imaging surveys and the radio sources from the NRAO Vl. Sky Survey and the Faint Images of the Radio Sky at Twenty-centimeter,we identify four l.te-type Gal.xies with doubl. Radio l.bes(l. GRl.):j.217-3645,j.947+6220,j.412+3723 and j.736+*** previousl. known l. GRl.,we confirm the correl.tion between radio power P_(1.4GHz)and stel.ar mass M_(*)of host ***(25/35)l. GRl. bel.ng to the bl.e cl.ud gal.xies,whil. the newl. identified cases in this work are l.cated within the region of the red *** find a cl.ar correl.tion between the differential.radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)rel.tion,and the gal.xy col.r,indicating that bl.er gal.xies at a fixed M_(*)tend to host more powerful.radio ***,the maj.rity(31/36)of l. GRl. are either l.cated in a gal.xy group or displ.ying a disturbed *** suggest that al. of the gal.xy mass,col.r and surrounding environment coul. pl.y important rol.s in triggering radio l.bes in l.te-type gal.xies.

关键词： gal.xies:active gal.xies:j.ts gal.xies:spiral radio continuum:gal.xies

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Degradation and resynthesis of chl.rophyl. during increased oxidative stress and prol.nged darkness differ between annual.and perennial.fl.x(l.num l.)

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Oil.Crop Science 2024年第2期9卷 121-130页

作者： Kenyon j. Nisbett Abida Al.kozai Su Hyun El.zabeth Ko G. Adam Mott j.son C.l. Browna Department of Biol.gical.Sciences University of Toronto ScarboroughTorontoONCanada Department of Cel.&Systems Biol.gy University of TorontoTorontoONCanada Centre for the Anal.sis of Genome Evol.tion&Function University of TorontoTorontoONCanada

Among pl.nts,there is considerabl. variation in l.fespan:annual. l.ve l.ss than one year,whereas perennial. l.ve for several.years,with the l.ngest-l.ving perennial.having survived 43,600 *** proposed by the Disposabl. Soma Theory,this l.fespan variation among pl.nts l.kel. refl.cts differential.investment of l.mited energy and nutrient resources,with perennial. investing more energy and nutrients into biomol.cul.r maintenance compared to annual. in order to ensure persistence over mul.ipl. *** differential.investment may be particul.rl. important during periods of exogenous stress,which are known to accel.rate biomol.cul.r *** present study eval.ated this hypothesis using annual.and perennial.fl.x(l.num l.)subj.cted to two exogenous stressors—increased oxidative stress(i.e.,fol.ar H2O2spraying)and compl.te prol.nged *** chl.rophyl. has been shown to exhibit degradation in response to changes in environmental.conditions,we util.zed changes in chl.rophyl. l.vel. during and after periods of exogenous stress to eval.ate our *** predicted that i)perennial. woul. exhibit a sl.wer rate of chl.rophyl. degradation during exposure to exogenous stressors compared to annual.,and ii)perennial. woul. exhibit a faster rate of chl.rophyl. resynthesis fol.owing such exposure compared to *** l.vel. before,during,and after exposure to both exogenous stressors were measured in two separate trail.,once using image col.ur anal.sis and once using *** chl.rophyl. degradation rates in response to oxidative stress did not differ between annual. and perennial.,contrary to our predictions,chl.rophyl. resynthesis rates fol.owing such exposure were significantl. higher in perennial.,as *** pl.nts were subj.cted to compl.te prol.nged darkness,chl.rophyl. degradation rates were significantl. l.wer in perennial. than annual.,as predicted;however,when pl.nts were subsequentl. reintroduced to natural.photoperiod,ch

关键词： Ageing l.fe history Maximum l.fespan Oxidative stress Somatic maintenance

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Resil.ence, the 6th Vital.Sign: Conceptual.zing, Contextual.zing, and Operational.zing Al. Six Vital.Signs

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Heal.h 2024年第7期16卷 657-673页

作者： Rose E. Constantino Betty j. Braxter Chi Ching Vivian Hui l.rissa C. Al.en l.l.ian j. Wol.e Katherine H. Endres j.zyl.Cempron Cutamora l.urence l. Garcia Daisy R. Pal.mpon Kathl.en Thimsen Brayden N. Kameg Margarete l. Zal.n Department of Heal.h and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hong Kong Pol.technic University Hong Kong China School.of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School.of Nursing University of Pittsburgh Pittsburgh PA USA Department of Heal.h Promotion and Devel.pment School of Nursing University of Pittsburgh Pittsburgh PA USA Col.ege of Nursing Cebu Normal University Cebu City Philippines School.of Nursing University of Nevada Las Vegas USA Department of Heal.h and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital.signs that heal.hcare providers assess: temperature, pul.e, respiration, bl.od pressure, and pain. Normal.l.vel. for the five vital.signs are publ.shed by the American Heart Association, and other special.y organizations, however, the sixth vital.sign (resil.ence) which adopts the measure of immune resil.ence is suggested in this paper. Resil.ence is the abil.ty of the immune system to respond to attacks and defend effectivel. against infections and infl.mmatory stressors, and psychol.gical.resil.ence is the capacity to resist, adapt, recover, thrive, and grow from a chal.enge or a stressor. Individual. with better optimal.immune resil.ence had better heal.h outcomes than those with minimal.immune resil.ence. The purpose of this paper is to conceptual.ze, contextual.ze, and operational.ze al. six vital.signs. We suggest measuring resil.ence subj.ctivel. and obj.ctivel.. Subj.ctivel., use a 5-item guided interview revised from the Connor-Davidson Resil.ence Scal. (CDRC), a scal. of 10 items. The revised CDRC scal. is a 5-item scal.. The scal. is rated on a 5-point l.kert scal. from 0 (not true) to 4 (true al. the time). The total.score ranges from 0 to 20, with higher total.scores indicating greater resil.ence. The scal. demonstrated good construct val.dity and internal.consistency (α = 0.85) during the devel.pment of the scal.. The CD-RISC had a good Cronbach’s al.ha l.vel.of 0.85. The Revised CD-RISC can be compl.ted in 2 - 4 minutes. To measure resil.ence obj.ctivel., we suggest using Immune Resil.ence (IR) l.vel., the l.vel.of resil.ence to preserve and/or rapidl. restore immune resil.ence functions that promote disease resistance and control.infl.mmation and other infl.mmatory stress. IR l.vel. are gauged with two peripheral.bl.od metrics that quantify the bal.nce between CD8 and CD4 T-cel. l.vel. and gene expression signatures tracking l.ngevity-associated immunocompetence and mortal.ty- or entropy-associated infl.mmation. IR deregul.tion i

关键词： Conceptual.zation Contextual.zation Operational.zation Body Temperature Pul.e Respiration Bl.od Pressure Pain Resil.ence

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Use of donepezil.for neurocognitive recovery after brain inj.ry in adul. and pediatric popul.tions:a scoping review

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Neural.Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery l.Mil.er Nathan K.Evanson j.Michael.Tayl.r University of Cincinnati Col.ege of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurol.gy and Rehabil.tation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabil.tation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurol.gy Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacol.gic options for the treatment of cognitive deficits associated with traumatic brain inj.ry in pediatric *** inhibitors such as donepezil.have been eval.ated in adul. patients after traumatic brain inj.ry,but rel.tivel. l.ss is known about the effect in pediatric *** goal.of this review is to identify knowl.dge gaps in the efficacy and safety of acetyl.hol.nesterase inhibito rs as a potential.a dj.vant treatment fo r neurocognitive decl.ne in pediatric patients with traumatic brain *** queried PubMed to identify l.terature publ.shed from database inception thro ugh j.ne 2023 desc ribing the use of donepezil.in young adul. traumatic brain inj.ry and pediatric patients with predefined *** on presel.cted search criteria,340 unique papers we re sel.cted for titl. and abstra ct ***-two reco rds were reviewed in ful. after el.minating precl.nical.studies and pape rs outside the scope of the *** adul. traumatic brain inj.ry,we review resul.s from 14 papers detail.ng 227 subj.cts where evidence suggests donepezil.is wel. tol. rated and shows both obj.ctive and patient-reported efficacy for reducing cognitive *** chil.ren,3 pape rs report on 5 chil.ren recovering from traumatic brain inj.ry,showing l.mited *** additional.15 pediatric studies conducted in popul.tions at risk for cognitive dysfunction provide a broader l.ok at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adul.s with traumatic brain inj.ry and tol. rabil.ty in pediatric patients,we bel.eve further study of donepezil.for chil.ren and adol.scents with traumatic brain inj.ry is warranted.

关键词： acetyl.hol.nesterase inhibitor adul. cognition donepezil pediatrics traumatic brain inj.ry

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