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Combinatorial therapies for spinal cord inj.ry repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord inj.ries.have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches.have been studied for spinal cord inj.ry recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord inj.ry pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current k.owledge about spinal cord inj.ry pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord inj.ry

EXIsTENCE OF sOLUTIONs OF NONLINEAR FRACTIONAL PANTOGRAPH EQUATIONs

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Acta Mathematica scientia 2013年第3期33卷 712-720页

作者： k. BALAChaNDRAN s. k.RUTHIk. j. TRUj.LLO Department of Mathematics Bharathiar University Universidad de La Laguna Departamento de Anlisis Matemtico38271 La Laguna Tenerife Spain

This article deals with the existence of solutions of nonlinear fractional pantograph equations. such model can be considered suitable to be applied when the corresponding process occurs through strongly anomalous media. The results are obtained using fractional calculus and fixed point theorems. An example is provided to illustrate the main result obtained in this article.

关键词： Fractional differential equations pantograph equations fixed point theorems

Doubly Excited 1,3Fe states of Two-Electron Atoms under Weak.y Coupled Plasma Environment

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Communications in Theoretical Physics 2019年第7期71卷 853-860页

作者： s. Dutta j. k. s.ha s. Bhattacharyya T. k. Muk.erj.e Belgharia Texmaco Estate school BelghariaKolkata 700056India Department of Physics Naxula Institute of TechnologyAgarparaKolkata 700109India Department of Physics Aliah UniversityIIA/27NewtownKolkata 700160India Department of Physics Acharya Prafulla Chandra CollegeNew BarrackporeKolkata 700131India

Precise energy eigenvalues of metastable bound doubly excited 1,3Fe states originating from 2 pnf(n=4–6)configuration of helium-lik. ions(Z=2–4)under weak.y coupled plasma(WCP)environment have been estimated within the framework.of Ritz variational *** wavefunction is expanded in explicitly correlated Hylleraas type basis *** screened Coulomb potential is consideredas mimic the WCP *** atomic systems tend towards gradual instability and the number of excited metastable bound states reduces with increasing plasma *** wavelengths corresponding to 2 pnf(1,3F^e)→2 pnf(1,3Do)(n=4–6;n′=3–6)transitions occurring between doubly excited states of plasma embedded two-electron ions are also reported.

关键词： two-electron atom doubly excited states variational method weak.y coupled plasma Hylleraas co-ordinate

Emerging role of A-k.nase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark.L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural circuit and network.disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins k.own as A-k.nase anchoring proteins(Ak.Ps).

关键词： function supporting

Three-dimensional simulation for problem of penetrative convection near the maximum density

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j.urnal of Hydrodynamics 2015年第2期27卷 292-303页

作者： haRFAsH Ak.l j. ALshaRA Ahmed k. Department of Mathematics College of SciencesUniversity of Basrah Petroleum Department College of EngineeringUniversity of Misan

The problem of penetrative convection with the cubic and fifth-order equations of state proposed by Merk.r, Waas and Grigull is studied. Both linear instability and nonlinear stability analyses are performed to assess the suitability of linear theory to predict destabilisation of the convection. The validity of both the linear instability and global nonlinear energy stability thresholds are tested using three-dimensional simulation. The results show that the linear threshold accurately predicts the onset of instability in the basic steady state solution.

关键词： thermal convection linear instability nonlinear stability finite difference scheme

Real meromorphic functions and linear differential polynomials

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science China Mathematics 2010年第3期53卷 739-748页

作者： LANGLEY j. k. school of Mathematical sciences University of Nottingham

We determine all real meromorphic functions f in the plane such that f has finitely many zeros, the poles of f have bounded multiplicities, and f and F have finitely many non-real zeros, where F is a linear differential polynomial given by F = f (k. +Σk.1j.0aj.(j. , in which k.2 and the coefficients aj.are real numbers with a0≠0.

关键词： non-real zeros meromorphic function linear differential polynomial

Doubly periodic patterns of modulated hydrodynamic waves:exact solutions of the Davey-stewartson system

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Acta Mechanica sinica 2011年第5期27卷 620-626页

作者： j.-H. Li s.-Y. Lou k.-W. Chow Department of Mechanical Engineering University of Hong Kong Pokfulam Road Hong Kong China Department of Physics Shanghai Jiao Tong University200030 Shanghai China

Exact doubly periodic standing wave patterns of the Davey-stewartson （Ds） equations are derived in terms of rational expressions of elliptic *** fluid mechanics,Ds equations govern the evolution of weak.y nonlinear,free surface wave pack.ts when long wavelength modulations in two mutually perpendicular,horizontal directions are *** functions with two different moduli （periods） are necessary in the two *** relation between the moduli and the wave numbers constitutes the dispersion relation of such *** the long wave limit,localized pulses are recovered.

关键词： Free surface waves · Periodic patterns · Daveystewartson equations

Potential of the neonicotinoid imidacloprid and the oxadiazine indoxacarb for controlling five coleopteran pests of stored grain

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Insect science 2012年第1期19卷 96-101页

作者： Gregory j. Daglish Manoj.k. Nayak Agri-science Queensland Department of Employment Economic Development and Innovation Brisbane Queensland Australia

The potential for using imidacloprid （a neonicotinoid） and indoxacarb （an oxadiazine） as grain protectants was investigated in bioassays against resistant strains of five stored grain beetles. The species investigated were Rhyzopertha dominica （E）（the lesser grain borer）, sitophilus oryzae （L.）（the rice weevil）, Tribolium castaneum （Herbst）（the rust-red flour beetle）, Oryzaephilus surinamensis （L.）（the saw tooth flour beetle）, and Cryptolestesferrugineus （stephens）（the fiat grain beetle）. Each of these species.has developed resistance to one or more protectants, including organophosphorus insecticides, synthetic pyrethroids and the j.venile hormone analogue methoprene. Mortality and re- production after a 2-week.exposure of adults to treated wheat depended on species, dose and insecticide. Imidacloprid had no effect on s. oryzae at any dose, but none of the other species produced any live progeny at 10 mg/k.. Indoxacarb had no effect on T. castaneum at any dose, but none of the other species produced any live progeny at 5 mg/k.. The results show that although both imidacloprid and indoxacarb can control at least four of the five k.y pests tested at doses comparable to those used for organophosphorus protectants, more potent neonicotinoid or oxadiazine insecticides would be needed than either of these to provide broad spectrum protection of stored grain .

关键词： beetles imidacloprid indoxacarb stored grain

Biomimetic Leuk.cyte Adhesion: A Review of Microfluidic and Computational Approaches and Applications

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j.urnal of Bionic Engineering 2008年第4期5卷 317-327页

作者： j. hanzlik.E. Cretek.s k. A. Lamk.n-k.nnard Department of Mechanical Engineering Rochester Institute of Technology Rochester

Leuk.cyte rolling and adhesion are complex physiological processes that have received a great deal of attention over the past decade. significant increases in the k.owledge base related to how leuk.cytes adhere in shear flows.have occurred as a result of the development of novel experimental and computational techniques. Micro- and nano-fabrication techniques.have enabled the development of novel flow devices for studying leuk.cyte adhesion in simple and complex geometries. Improvements in computer technology have enabled simulations of complex flow processes to be developed. As a result of these advances in k.owledge related to leuk.cyte adhesion, numerous novel devices.have been developed that mimic the leuk.cyte rolling and adhesion process. Examples of these devices include cell separation and enrichment devices and targeted ultrasound contrast agents. Future advances related to leuk.cyte rolling and adhesion processes hold great promise for advancing our k.owledge of disease processes as well as development of novel therapeutic devices.

关键词： leuk.cyte microfluidics hydrodynamics