检索结果-南通市图书馆

Intracranial pressure is elevated at 24h post-stroke inmice

在线全文

学校读者我要写书评

暂无评论

Neuroprotection 2024年第1期2卷 60-64页

作者： Kirby E.Warren Rebecca j.hood Fredrick R.Walker Neil j.Spratt School of Biomedical Sciences and Pharmacy University of NewcastleCallaghanAustralia Hunter Medical Research Institute NewLambton HeightsAustralia School of Biomedicine Discipline of Anatomy and PathologyFaculty of Health and Medical SciencesThe University of AdelaideAdelaideAustralia Department of Neurology John Hunter HospitalNewLambton HeightsAustralia

Background:It has long been assumed that post-stroke intracranial pressure(ICP)elevation occurs because of large infarct and edema ***,we have repeatedly shown IcP elevation at 24 h post-stroke in the presence of little to no edema in *** processes are often conserved across species and types of ***,we aimed to determine if an ICP rise occurs at 24 h post-stroke in the presence of small infarct and edema volumes in ***:Mice were randomized by random number table to either photothrombotic stroke or sham surgery(n=15).Epidural ICP was recorded using a fiber optic catheter at 1 h post-stroke(baseline)and between 23 and ***:ICP was significantly higher at 24 h compared to baseline in stroke animals(n=6;10.71±6.45mmHg vs.3.74±2.20mmHg,respec-tively;p=0.03).ICP at 24 h was also significantly higher in stroke mice compared to sham(n=6;3.45±1.43mmHg;p=0.02).There was no change in ICP in sham mice(p=0.9).Edema volumes in stroke animals were small(0.04±0.04 mm3)and unlikely to have caused significant ICP ***:This study provides evidence of an edema-independent ICP elevation following small ischemic stroke in *** occurrence of this rise supports our findings in other species and suggests it is caused by a previously undescribed mechanism.

关键词： cerebraledema intracranial pressure ischemic stroke

Lessons Learned as President of the Institute for Systems Biology(2000–2018)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2018年第1期16卷 1-9页

作者： Leroy E. hood Providence St. j.seph Health Seattle WA 98057 USA Institute for Systems Biology Seattle WA 98109 USA

I stepped down as president of the Institute for Systems Biol- ogy （ISB） on j.n 1, 2018. As I think about my 17-year term as President, I am astounded at how much I have learned, not only about science but also abou... 详细信息

关键词： 21st-Century medicine Systems medicine Scientific wellness P4 healthcare Systems biology Personal, dense, dynamic data clouds

Systems Approaches to Biology and Disease Enable Translational Systems Medicine

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2012年第4期10卷 181-185页

作者： Leroy hood Qiang Tian Institute for Systems Biology SeattleWA 98109-5234USA

The development and application of systems strategies to biology and disease are transforming medical research and clinical practice in an unprecedented rate. In the foreseeable future, clinicians, medical researchers, and ultimately the consumers and patients will be increasingly equipped with a deluge of personal health information, e.g., whole genome sequences, molecular profiling of diseased tissues, and periodic multi-analyte blood testing of biomarker panels for disease and wellness. The convergence of these practices will enable accurate prediction of disease susceptibility and early diagnosis for actionable preventive schema and personalized treatment regimes tailored to each individual. It will also entail proactive participation from all maj.r stakeholders in the health care system. We are at the dawn of predictive, preventive, personalized, and participatory （P4） medicine, the fully implementation of which requires marrying basic and clinical researches through advanced systems thinking and the employment of high-throughput technologies in genomics, pro- teomics, nanofluidics, single-cell analysis, and computation strategies in a highly-orchestrated discipline we termed translational systems medicine.

关键词： Systems biology P4 medicine Family genome sequencing Targeted proteomics Single-cell analysis

Mitophagy Regulation in Skeletal Muscle:Effect of Endurance Exercise and Age

在线全文

学校读者我要写书评

暂无评论

j.urnal of Science in Sport and Exercise 2019年第3期1卷 228-236页

作者： Avigail T.Erlich David A.hood Muscle Health Research Centre School of Kinesiology and Health ScienceYork University4700 Keele StTorontoON M3J 1P3Canada

Mitochondria are essential energy-providing organelles that are required in the maintenance of healthy skeletal *** such,the removal of damaged mitochondria,through mitophagy,is necessary to maintain mitochondrial *** aging muscle,mitochondrial content and function are often found to be reduced compared to young *** occurs despite the fact that measures of mitophagy are elevated,suggesting that mitophagy is insufficiently high to remove all of the dysfunctional organelles in aging *** evidence has shown that acute exercise promotes mitophagic signaling,leading to organelle *** exercise-induced signaling is attenuated in aging muscle,suggesting that aging muscle loses its capacity for mitochondrial turnover in response to *** contributes to the reduction in muscle health in elderly *** exercise training improves mitochondrial content and function,even in aging muscle,leading to reduced mitophagy ***,exercise training should be prescribed for both young and elderly populations to pro-mote the maintenance of a healthy mitochondrial pool,through the stimulation of both organelle biogenesis and mitophagy.

关键词： Mitochondria Mitophagy Exercise Aging Lysosomes

Exercise is mitochondrial medicine for muscle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2019年第1期1卷 11-18页

作者： Ashley N.Oliveira David A.hood Muscle Health Research Centre School of Kinesiology and Health ScienceYork UniversityTorontoOntarioCanada

Mitochondria are vital organelles that provide energy for muscle *** these organelles become dysfunctional,they produce less energy as well as excessive levels of reactive oxygen species which can trigger muscle atrophy,weakness and loss of *** this review,molecular evidence is provided to show that exercise serves as a useful therapeutic countermeasure to overcome mitochondrial dysfunction,even when key regulators of organelle biogenesis are *** findings illustrate the complexity and compensatory nature of exercise-induced molecular signaling to transcription,as well as to post-transcriptional events within the mitochondrial synthesis and degradation(***)*** with the first bout of contractile activity,exercise exerts a medicinal effect to improve mitochondrial health and whole muscle function.

关键词： Mitochondria Muscle Exercise Health Aging Metabolism Training

Human Gut Microbiota and Gastrointestinal Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2018年第1期16卷 33-49页

作者： Changting Meng Chunmei Bai Thomas D. Brown Leroy E. hood Qiang Tian Institute for Systems Biology Seattle WA 98109 USA Department of Oncology Peking Union Medical College Hospital Beijing 100730 China Swedish Cancer Institute Seattle WA 98104 USA P4 Medicine Institute Seattle WA 98109 USA

Human gut microbiota play an essential role in both healthy and diseased states of humans. In the past decade, the interactions between microorganisms and tumors have attracted much attention in the efforts to understand various features of the complex microbial communities, as well as the possible mechanisms through which the microbiota are involved in cancer prevention, carcinogenesis, and anti-cancer therapy. A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways. Further studies have suggested that the microbiota and their associated metabolites are not only closely related to carcinogenesis by inducing inflammation and immune dysregulation, which lead to genetic instability, but also inter- fere with the pharmacodynamics of anticancer agents. In this article, we mainly reviewed the influ- ence of gut microbiota on cancers in the gastrointestinal （GI） tract （including esophageal, gastric, colorectal, liver, and pancreatic cancers） and the regulation of microbiota by diet, prebiotics, pro- biotics, synbiotics, antibiotics, or the Traditional Chinese Medicine. We also proposed some new strategies in the prevention and treatment of GI cancers that could be explored in the future. We hope that this review could provide a comprehensive overview of the studies on the interactions between the gut microbiota and GI cancers, which are likely to yield translational opportunities to reduce cancer morbidity and mortality by improving prevention, diagnosis, and treatment.

关键词： Inflammation Immune regulation Microbial metabolites Carcinogenesis Traditional ChineseMedicine

截断式脉冲射流流场结构模拟与冲蚀硬岩能力分析

在线全文

学校读者我要写书评

暂无评论

振动与冲击 2017年第19期36卷 180-185页

作者：陆朝晖卢义玉 Michael hood 潘林华贺培重庆地质矿产研究院国土资源部页岩气资源勘查重点实验室重庆400042 重庆大学煤矿灾害动力学与控制国家重点实验室重庆400044 昆士兰大学采矿合作研究中心

孔盘截断式脉冲射流能够充分利用水锤压力、高速侧向流、循环载荷等效应,破岩效率高,在硬岩破碎中具有较高的开发潜力。基于VOF模型和动网格技术,建立与截断式脉冲射流生成装置几何及运动过程一致的两相流瞬态计算模型,结合高速摄像技术... 详细信息

孔盘截断式脉冲射流能够充分利用水锤压力、高速侧向流、循环载荷等效应,破岩效率高,在硬岩破碎中具有较高的开发潜力。基于VOF模型和动网格技术,建立与截断式脉冲射流生成装置几何及运动过程一致的两相流瞬态计算模型,结合高速摄像技术,研究了截断式脉冲水射流的流体结构的动态演变动力特征,测试了截断式脉冲水射流的破岩能力,并分别从流畅结构和破岩能力上与常规圆柱水射流进行了对比分析。研究结果表明:截断式脉冲射流有助于在射流末端形成偏转的瓦状尖体结构,可有效减弱或避免激波阻力的影响;截断式脉冲水射流在破岩过程中,岩石靶物冲蚀孔口呈现非轴对称形态,与常规圆柱射流相比,截断式脉冲射流能够大幅度提升破岩速度,增大破岩体积。

关键词：孔盘截断式脉冲射流流场结构动网格技术硬岩冲蚀

Petrology, physicochemical and thermal analyses of selected cretaceous coals from the Benue Trough Basin in Nigeria

在线全文

学校读者我要写书评

暂无评论

International j.urnal of Coal Science & Technology 2020年第1期7卷 26-42页

作者： S.A.Akinyemi O.F.Adebayo B.B.Nyakuma A.K.Adegoke O.A.Aturamu O.A.OlaOlorun A.Adetunj. j.C.Hower M.M.hood A.j.uro Department of Geology Ekiti State University.P.M.B 5363Ado EkitiEkiti StateNigeria School of Chemical and Energy Engineering Universiti Teknologi MalaysiaSkudaiMalaysia Department of Geology Obafemi Awolowo UniversityP.M.BOB.lie IfeOsun StateNigeria Centre for Applied Energy Research University of KentuckyKentuckyUSA National Centre for Petroleum Research and Development(NCPRD) Abubakar Tafawa Balewa UniversityBauchiNigeria

Abundant coal resources that were previously neglected due to a crude oil boom need revitalisation and integration into the national electricity mix to address the energy demands of the Nigerian *** coal samples from the Benue Trough sedimentary basin in Nigeria were examined by various techniques,including proximate and ultimate analyses,organic petrography,Fourier transform infrared ray spectroscopy,and thermogravimetric *** on vitrinite reflectance,the Lafia-Obi(OLB),Garin Maiganga(GMG),Imiegba(IMG),and Okaba(OKB)coals are classified as subbituminous,while the Lamj.1(LMj.),Lamj.2(LMj.)and Chikila(CHK)coals are high volatile B *** Enugu(ENG)coal is on the boundary between subbituminous and high volatile C *** petrographic results indicate vitrinite and fusinite contents steadily increase from the Lower Benue Trough coals to the Upper Benue Trough coals,while semifusinite and total mineral contents follow a reverse *** decomposition occurred in three stages,i.e.,drying,devolatilization,and coke formation above 700°C;and the coal reactivity follows the following order,ENG>IMG>IGH>CHK>LMj.OKB>GMG>*** higher temperatures(above 900°C)are required to decompose the coals for efficient energy *** LMj.,LMj.,OLB,CHK,GMG,and OKB coals can be exploited for electricity power ***,the Imeagha and Enugu coals are best suitable for both cement and power generation.

关键词： Petrology Thermal analysis Cretaceous coal Benue Trough Nigeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

冲击挤压式脉冲射流生成过程的简化差分模型

应用基础与工程科学学报 2013年第6期21卷 1086-1093页

作者：陆朝晖王洁卢义玉 hood M 秦宗义重庆地质矿产研究院重庆市页岩气资源与勘查工程技术研究中心重庆400042 重庆大学煤矿灾害动力学与控制国家重点实验室重庆400030 昆士兰大学采矿合作研究中心

冲击挤压式脉冲射流在高强度物料破碎领域具有较高的应用前景,其形成过程相对复杂,设计加工难度大,限制了该类型射流的发展.针对这一问题,建立了活塞的多碰撞方程,结合有限差分方法提出了用于描述冲击挤压式脉冲射流形成过程的简化数学... 详细信息

冲击挤压式脉冲射流在高强度物料破碎领域具有较高的应用前景,其形成过程相对复杂,设计加工难度大,限制了该类型射流的发展.针对这一问题,建立了活塞的多碰撞方程,结合有限差分方法提出了用于描述冲击挤压式脉冲射流形成过程的简化数学模型.应用所建模型预测了一定工作参数下的射流压力、射流出口速度以及活塞的运动状态等随时间的变化.设计以重锤为冲击动力源的冲击挤压式射流装置,实验验证了模型的合理性.应用此模型进行数值实验,可为冲击挤压式脉冲射流装置的设计与优化提供重要参考依据.

关键词：脉冲射流差分方法数值模拟实验验证