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An artificial neuronal network coupled with a genetic algorithm to optimise the production of unsaturated fatty acids in Parachlorella kessleri

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Artificial Intelligence in Agriculture 2024年第3期13卷 32-44页

作者： Pablo Fernández Izquierdo Leslie cerón Delagado Fedra Ortiz Benavides Department of Biology University of NariñoPastoColombia School of Basic Sciences Technology and EngineeringNational Open and Distance UniversityColombia

In this study,an Artificial Neural Network-Genetic Algorithm(ANN-GA)approachwas successfully applied to optimise the physicochemical factors influencing the synthesis of unsaturated fatty acids(UFAs)in the microalgae *** UCM *** optimized model recommended specific cultivation conditions,including glucose at 29 g/L,NaNO_(3)at 2.4 g/L,K_(2)HPO_(4)at 0.4 g/L,red LED light,an intensity of 1000 lx,and an 8:16-h light-dark *** ANN-GA optimisation,a remarkable 66.79%increase in UFAs production in *** UCM 001 was achieved,compared to previous *** underscores the potential of this technology for enhancing valuable lipid *** variations in the application of physicochemical factors during microalgae culture under mixotrophic conditions,as optimized by ANN-GA,induced alterations in UFAs production and composition in *** UCM *** suggests the feasibility of tailoring the lipid profile of microalgae to obtain specific lipids for diverse industrial *** isolated froma high-mountain lake in Colombia,highlighting their adaptation to extreme *** underscores their potential for sustainable lipid and biomaterial *** study demonstrates the effectiveness of using ANN-GA technology to optimise UFAs production in microalgae,offering a promising avenue for obtaining valuable ***'s unique origin in a high-mountain environment in Colombia emphasises the importance of exploring and harnessing microbial resources in distinctive geographical regions for biotechnological applications.

关键词： Artificial neural network(ANN) Genetic algorithm(GA) Microalgae Unsaturated fatty acids(UFAs) Mixotrophy

Atmospheric Dry Deposition in the Proximity of Oil-Fired Power Plants at Mexican Pacific Coast

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j.urnal of Environmental Protection 2012年第9期3卷 1228-1237页

作者： R. M. cerón j. G. cerón C. Aguilar C. Montalvo C. Carballo B. Cárdenas A. Ortinez M. Cocom j. Carrillo National Center for Training and Environmental Research National Institute of Ecology Mexico City Mexico Research Center on Environmental Sciences Autonomous University of Carmen Carmen City Mexico

Dry deposition samples were collected in a weekly basis during 2010 in a site located at the Mexican Pacific Coast: Manzanillo, Colima. Samples were collected with an automatic wet/dry deposition sampler using nylon filters as surrogate surfaces. Samples were extracted with deionized water and analyzed for pH, conductivity, Na+, K+, Ca2+, Mg2+, NH4-, NO3-, SO42- and Cl-. Nitrate and sulfate were the most abundant ions, contributing with 53% to the total ionic mass;and their levels exceeded the hemispheric background concentrations proposed for marine remote sites. The influence of the power plants burning combustoleo located upwind the sampling site was completely evident. From meteorological analysis, it could be observed that the sampling site was all time under the influence of power plants as a result of the effect of breezes. However, in spite of the high levels of NO3- and SO42- found in the samples collected, pH value average was almost neutral, with 28% of samples slightly acid. Potassium was the most abundant cation and from the quantification of the neutralization effect of the main alkaline components, the prevalence role of K+ was completely evident, suggesting the influence of the mining complex Pe?a Colorada located upwind the sampling site, where amyl xanthate potassium is used as collector in tailing dams. Dry deposition fluxes were estimated for all ions measured. Nitrogen dry deposition at Manzanillo is already in the upper extreme of the threshold value reported for sensible ecosystems. On the other hand, sulfur deposition exceeded slightly the critical load value reported for some ecosystems in Europe. Even at this moment, nitrogen and sulfur deposition is not a problem, it is necessary to take steps to avoid that total deposition of these elements exceeds critical loads, considering that results reported in this study not include the wet deposition fluxes.

关键词： Dry Deposition Dry Fluxes Oil-Fired Power Plants Combustoleo Mexico

Chemical Composition, Fluxes and Seasonal Variation of Acid Deposition in Carmen Island, Campeche, Mexico

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j.urnal of Environmental Protection 2013年第8期4卷 50-56页

作者： R. M. cerón j. G. cerón C. G. Carballo C. A. Aguilar C. Montalvo j. A. Benítez Y. j. Villareal M. M. Gómez EPOMEX Institute Autonomous University of Campeche San Francisco de Campeche Mexico Research Center on Environmental Sciences Autonomous University of Carmen Carmen City Mexico

Two hundred and seven rain events from April to October 2012 were collected in Carmen Island, Campeche, Mexico, and the concentration of 8 maj.r ions with the pH of the rainwater was analyzed. Chemical composition variations as a result of seasonal patterns, meteorological conditions, and mixed local and regional sources contribution were assessed. In spite of the fact that nitrate and sulfate levels were higher than background hemispheric values, the average pH values were almost neutral. Carmen Island was under the influence of both, local and long-range transported emissions. Chemical composition showed a dilution effect as a result of the monthly rainfall amount. Ca2+ and Na+ were the most abundant ions, and these ions acted as acid neutralizers and buffered the acidity of the rain, suggesting that marine and crustal aerosols played an important role in the acid-base interactions. Wet deposition fluxes obtained were compared with reference values proposed as critical loads, fluxes obtained in this study did not exceed the critical values reported for sensitive ecosystems in Europe, indicating that this site has yet enough capacity to support acidity, nitrogen and sulfur deposition. However, it is necessary to obtain reference values characteristics for tropical regions.

关键词： Trace Elements Acid Deposition Deposition Fluxes Critical Loads Acid Rain Campeche Mexico

Diurnal and Seasonal Variation of BTX in Ambient air of One Urban Site in Carmen City, Campeche, Mexico

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j.urnal of Environmental Protection 2013年第8期4卷 40-49页

作者： j. G. cerón E. Ramírez R. M. cerón C. Carballo C. Aguilar U. López A. Ramírez Y. Gracia D. Naal A. Campero j. Guerra E. Guevara Facultad de Ciencias Químicas Universidad Autónoma de Nuevo León (UANL) San Nicolás de los Garza Mexico Universidad Autónoma del Carmen Ciudad del Carmen Mexico

BTX (benzene, ethylbenzene, toluene and p-xylene) and meteorological parameters were measured in ambient air of an urban site located in Carmen City, Campeche, Mexico. A total of 412 samples were collected for BTX and analyzed by Gas Chromatography with Flame Ionization Detection (GC-FID). Meteorological parameters were measured by a portable station. A marked diurnal variation was found for all measured BTX. The highest concentrations occurred during midday (13:00-14:30 h). A clear seasonal pattern was observed too for all compounds registering their highest levels during summer sampling period. Mean concentrations for benzene, ethylbenzene, toluene and p-xylene were: 5.42, 3.97, 11.24 and 8.32 ppbv, respectively. BTX abundance showed the following order: toluene > p-xylene > benzene > ethylbenzene. BTX maximum concentrations were found when winds blowed from E and NE. Important oil industry sources and avenues are located at these directions. These sources could contribute to the levels of BTX in this site.

关键词： BTX Carbonyls Volatile Organic Compounds Air Pollution Carmen City Mexico

Can inhibition of telomerase increase pancreatic cancer cell's susceptibility to chemotherapeutic reagents?

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 155-160页

作者： Thomas j.Ⅲ Fahey Department of Surgery Cornell University Medical College New York NY USA

Obj.ctives: To clarify the inhibition of pancreatic can-cer cells by interference with the hTR component of thetelomerase reverse transcriptase enzymatic complexand evaluate susceptibility of antisense hTR pancreaticcancer cells to chemotherapeutic ***: A 593 bp of full length hTR cDNA was sub-cloned into a mammalian expression vector pcDNA3.1(-) in antisense orientation to construct an antisensehTR expression plasmid. The plasmids were introducedinto Pancl cells, a human pancreatic carcinoma cellline, by lipofectin, and G418-resistant stable trans-formants were expanded. Resulting stable clones werescreened for the presence of hTR insert by PCR withT7 and BGH reverse primers located on the flanks ofthe multiclonal site of pcDNA3.1 vector. Cell growth rate,hTR expression, telomerase activity, and anchorage-in-dependent growth property were analyzed. Finally, sus-ceptibility of antisense hTR cells to chemotherapeuticreagents was ***: Significant downregulation of endogenous hTRwas evident in the antisense-hTR transformed cells,and telomerase activity was markedly decreased com-pared to control cells in standard TRAP assays. Fur-thermore, the proliferation and the anchorage-inde-pendent growth ability in antisense-hTR expressingcells were significantly decreased compared with thecontrol parental cells. However, no crisis or senescencephenomena was observed. Antisense hTR appears toincrease Pancl cell's susceptibility to chemotherapeuticreagent cDDP, but not to differentiation reagent DM-SO, COX2 inhibitor sulinbac, NS-398, curcumin, andchemotherapeutic reagent adriamycin(ADM).Conclusions: These data indicate that hTR is probablya critical component of human telomerase activity andthat downregulation of the RNA component of humantelomerase is an effective target for anticancer strategyand antisense hTR can increase Pancl cell's susceptibilityto cDDP.

关键词： Telomerase hTR Antisense Pancreatic carcinoma cellline chemotherapeutic reagents

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耳鸣评价量表的临床应用价值研究

听力学及言语疾病杂志 2017年第3期25卷 242-246页

作者：陈知己郑芸钟萍李刚 Sigfrid D soli 四川大学华西医院耳鼻咽喉头颈外科听力中心/听觉言语科学实验室成都610041 美国House临床医学中心

目的探讨耳鸣评价量表(tinnitus evaluation questionnaire,TEQ)的临床应用价值。方法以耳鸣为第一主诉初诊的187例患者(13~80岁,平均42.5±13.5岁)为研究对象,由专业医务人员进行TEQ评估,以患者自填的耳鸣残疾量表(tinnitus handicap i... 详细信息

目的探讨耳鸣评价量表(tinnitus evaluation questionnaire,TEQ)的临床应用价值。方法以耳鸣为第一主诉初诊的187例患者(13~80岁,平均42.5±13.5岁)为研究对象,由专业医务人员进行TEQ评估,以患者自填的耳鸣残疾量表(tinnitus handicap inventory,THI)作为对照,研究TEQ的汇聚效度;从中抽取96例患者由两名专业医务人员在半天内对同一患者进行2次TEQ评估,评估耳鸣严重程度,以比较不同测试者间的重测信度;抽取57例患者给予治疗一个月,根据治疗前后患者主观感觉耳鸣有无变化,应用效应量(effect size,ES)计算公式评估TEQ反应度(responsiveness);记录TEQ评估每位患者的测试用时及患者自填THI的时间,以比较测试时效。结果 187例患者TEQ、THI总分分别为10.69±2.88和43.12±19.40,相关系数r=0.79(P<0.01),TEQ与THI汇聚效度好;接受两名测试者评估的96例患者不同测试者间TEQ重测信度为0.94(P<0.01),TEQ的重测信度良好;57例患者治疗一个月后自觉耳鸣症状改善组(36例)治疗前TEQ得分10.69±2.74分,治疗后为7.83±2.74分,效应量为1.04,为较大效应量;说明TEQ能敏感反映患者症状变化,反应度良好。TEQ评估时间(3.27±1.01分钟)显著短于THI评估时间(11.17±3.11分钟)(P<0.01)。结论 TEQ的准确性、可靠性、敏感性及可操作性均较理想,且费时少,具有良好的临床实用价值,适用于对耳鸣严重程度和疗效的评估。

关键词：耳鸣评价量表耳鸣残疾量表信度效度反应度

预测非ST段抬高急性冠状动脉综合征患者1个月和1年发生主要事件风险的多指标方法

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 22-23页

作者： Bod V. Sanchis j. Llàcer .  郝广华 Servei de Cardiologa Hosp. Clnic I Universitari Avda Blasco Ibáez 17 46010 Valè ncia Spain

Background: The aim of this study was to define the utility of the combined measurement of troponin I, myoglobin, C- reactive protein, fibrinogen, and homocysteine to predict risk in non- ST elevation acute coronary syndromes. Methods: Troponin I, myoglobin, high- sensitivity C- reactive protein, fibrinogen, and homocysteine were measured in 557 consecutive patients admitted to our institution for non- ST elevation acute coronary syndrome. The risk for maj.r events(death or nonfatal myocardial infarction) at first month and at first year follow- up was analyzed. Results: In a multivariate model adj.sting for baseline characteristics and electrocardiographic changes, the only biomarkers related to maj.r events at first month were C- reactive protein(P=.007) and myoglobin(P=.02), and at first year troponin I(P=.02), C- reactive protein(P=.03), and homocysteine(P=.04). The rate of maj.r events depending on the number(0- 5) of elevated biomarkers were at first month: 4.1% , 3.7% , 5.7% , 6.1% , 6.5% , and 30.8% (Pj.sted risk of maj.r events of 1.6[1.3- 1.9] at first month and of 1.4[1.2- 1.7] at first year. Conclusions: Markers of myocardial damage, inflammation, and homocysteine analyzed separately provide prognostic information. The number of elevated biomarkers is an independent risk predictor of maj.r events.

关键词：事件风险指标方法致命性心肌梗死预后信息炎症标记物高半胱氨酸事件相关心电图改变多变量模型综合测量

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普通话儿童言语理解力测试（MPSI）

中国听力语言康复科学杂志 2011年第6期40卷 29-34页

作者：李刚郑芸王恺 Sigfrid D.soli （美国）四川大学华西医院耳鼻咽喉一头颈外科听力中心／听觉言语科学实验室成都610041 美国HOUSE耳研所洛杉矶90057

1研发背景随着科学技术的飞速发展和政府对听障儿童的日益重视，越来越多的听障儿童在出生后不久即能得到及时发现、诊断和干预。但这只是听障儿童成功康复的第一步，因为它只是让听障儿童有机会去聆听声音。听力康复的最终目标是让听... 详细信息

1研发背景随着科学技术的飞速发展和政府对听障儿童的日益重视，越来越多的听障儿童在出生后不久即能得到及时发现、诊断和干预。但这只是听障儿童成功康复的第一步，因为它只是让听障儿童有机会去聆听声音。听力康复的最终目标是让听障儿童能像健听儿童一样在日常生活的各种复杂环境中自如地与人沟通交流，要实现这一步必须在听力问题的早期发现、早期诊断和早期干预后．定期随访听觉言语发育情况。

关键词：听障儿童言语理解力普通话听觉言语康复早期诊断测试听力康复科学技术

9月龄内听力损失婴儿助听器干预后的早期语前听能发育规律初步研究

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中国听力语言康复科学杂志 2015年第6期13卷 427-430页

作者：张圆郑芸李刚 Sigfrid D.soli 四川大学华西医院耳鼻咽喉一头颈外科听力中心/听觉言语科学实验室成都610041 美国Housel临床医学中心洛杉矶90057

目的了解9月龄内听力损失婴儿助听器干预后的早期语前听能发育规律。方法采用前瞻性纵向研究方法，共纳入43例患儿，根据听力损失程度分为中度、重度、极重度三组，分别有10、9、24例。使用婴幼儿有意义听觉整合量表（infanttoddler mea... 详细信息

目的了解9月龄内听力损失婴儿助听器干预后的早期语前听能发育规律。方法采用前瞻性纵向研究方法，共纳入43例患儿，根据听力损失程度分为中度、重度、极重度三组，分别有10、9、24例。使用婴幼儿有意义听觉整合量表（infanttoddler meaningful auditory integrationscale，IT-MAIS），对43例9个月内双耳中度及以上感音神经性听力损失的婴儿，在其双耳配戴助听器前及配戴后l、3、6、12个月进行语前听能评估。结果三组患儿的平均IT—MAIS得分均随助听器配戴时间的延长而显著提高（P〈0．05）。采用单因素方差分析，三组患儿之间的IT—MAIS得分在配戴前及配戴后1、3、6个月均具有显著性差异（P〈0．05），在12个月时无显著性差异（P〉O．05）。对配戴前及配戴后1、3、6个月的IT-MAIS得分分别进行两两比较显示，中度组与重度组在6个月前均无显著性差异（P〉0．05）；中度组与极重度组在6个月前均具有显著性差异（P〈0．05）；重度与极重度组除在配戴1个月时无显著性差异（P〉0．05）外，其余均有显著性差异（P〈0．05）。结论听力损失婴儿助听后的早期语前听觉能力随助听器配戴时间延长而提高，早期语前听能发育主要受助听器配戴时间的影响。IT—MAIs可提供常规测听方法不能反映的重要听能发育信息，应作为听力损失患儿康复效果评估的常规测试方法在临床上应用。

关键词：婴幼儿有意义听觉整合量表早期语前听能发育听力损失婴儿早期干预助听器验配