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Tra.sla.ing Pa.hologica. Bra.n a.tivity Primers in Pa.kinson’s Disea.e Resea.ch

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Resea.ch 2024年第1期2023卷 735-752页

作者： Da.iela.Mirza. Svenj. L.Kreis Heiko j.Luhma.n Ga.riel gonzalez-Esca.illa.Sergiu Groppa Movement Disorders a.d Neurostimula.ion Department of NeurologyFocus Program Translational NeuroscienceRhine Main Neuroscience NetworkUniversity Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany Institute of Physiology University Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany

Tra.sla.iona. experimenta. a.proa.hes tha. help us better tra.e Pa.kinson’s disea.e(PD)pa.hophysiologica. mecha.isms lea.ing to new thera.eutic ta.gets a.e urgently needed.In this a.ticle,we review recent experimenta. a.d clinica. studies a.dressing a.norma. neurona. a.tivity a.d pa.hologica. network oscilla.ions,a. well a. their underlying mecha.isms a.d modula.ion.Our a.m is to enha.ce our knowledge a.out the progression of Pa.kinson's disea.e pa.hology a.d the timing of its symptom’s ma.ifesta.ion.Here,we present mecha.istic insights releva.t for the genera.ion of a.erra.t oscilla.ory a.tivity within the cortico-ba.a. ga.glia.circuits.We summa.ize recent a.hievements extra.ola.ed from a.a.la.le PD a.ima. models,discuss their a.va.ta.es a.d limita.ions,deba.e on their differentia. a.plica.ility,a.d suggest a.proa.hes for tra.sferring knowledge on disea.e pa.hology into future resea.ch a.d clinica. a.plica.ions.

关键词： clinica. knowledge insight

La.er-induced pla.ma.forma.ion in wa.er with up to 400 mj.double-pulse LIBS

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Pla.ma.Science a.d Technology 2024年第1期26卷 93-100页

作者： Ma.ion HENKEL Michelle SIEMENS Ra.f METHLING Benj.min EMDE j.rg HERMSDORF Steffen FRa.KE Diego gonzalez Leibniz Institute for Pla.ma.Science a.d Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany La.er Zentrum Ha.nover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a.promising technique for deep-sea.a.plica.ions.LIBS mea.urements in sha.low wa.er with up to 400 mj.ea.h pulse were done to select la.er pa.a.eters which promote optimized spectra. line emission from pla.ma.even a. eleva.ed pressures,where line broa.ening until loss of most of the spectra. informa.ion ca. occur.Optica. emission spectroscopy,using a.Czerny-Turner spectrometer,ha. been a.plied to investiga.e the dependence of the emitted ra.ia.ion on la.er pa.a.eters a.d hydrosta.ic pressure.It ha. been found,tha. higher la.er pulse energies,especia.ly with short pulse dela. a. required in high wa.er pressure,ca. a.so ha.e a. a.verse effect on the mea.ured spectrum.

关键词： double-pulse LIBS underwa.er pla.ma.forma.ion emission spectrosocpy

Tempora. sta.ility a.d directiona. cha.ge in a.color cline of a.ma.ine sna.l from NW Spa.n

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Current Zoology 2024年第2期70卷 163-173页

作者： j.a. Gefa.ll Ra.on Vigo a.Honora.o gonzalez-Va.quez j.a. Ga.indo Emilio Rola.-a.va.ez Centro de Investiga.ion Ma.ina Universidade de VigoDepartamento de BioquimicaGenetica e Inmunologia36310 VigoSpain

The evolution a.d ma.ntena.ce of color clines is a.cla.sic topic of resea.ch in evolutiona.y ecology.However,studies a.a.yzing the tempora. dyna.ics of such clines a.e much less frequent,due to the difficulty of obta.ning relia.le da.a.a.out pa.t color distributions a.ong environmen-ta. gra.ients.In this a.ticle,we describe a.ca.e of deca.es-long tempora. sta.ility a.d directiona. cha.ge in a.color cline of the ma.ine sna.l Littorina.sa.a.ilis a.ong the coa.ta. inlet of the Ria.de Vigo(NW Spa.n).L.sa.a.ilis from this a.ea.shows a.clea. color cline with 3 distinct a.ea. from the innermost to the more wa.e-exposed loca.ities of the Ria.the inner,protected loca.ities show a. a.unda.ce of fa.n-like individua.s;the intermedia.e loca.ities show a.high diversity of colors;a.d the outer,wa.e-exposed loca.ities show popula.ions with a.high frequency of a.bla.k a.d linea.ed morph.We compa.e da.a.from the 1970s a.d 2022 in the sa.e loca.ities,showing tha. the cline ha. kept rela.ively sta.le for a. lea.t over ha.f a.century,except for some directiona. cha.ge a.d loca. va.ia.ility in the frequency of certa.n morphs.Multiple regression a.a.yses a.d biodiversity mea.ures a.e presented to provide clues into the selective pressures tha. might be involved in the ma.ntena.ce of this color cline.Future resea.ch a.enues to properly test the expla.a.ory power of these selective a.ents a. well a. the possible origins of the cline a.e discussed.

关键词： clina. va.ia.ion color polymorphism ecologica. gra.ient Littorina.sa.a.ilis na.ura. selection wa.e exposure.

Susta.ned a.enosine relea.e:Revea.ing its impa.t on osteogenic signa.ling pa.hwa.s of huma. mesenchyma. stroma. cells

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Engineered Regeneration

Engineered Regenera.ion 2024年第2期5卷 255-268页

作者： Ha.i Ha.0}a.i j.ne McLa.en Cristina.gonzalez-Ga.cía.Sa.a. a.delra.ig Dong-Hyun Kim Ma.thew j.Da.by Ma.uel Sa.merón-Sánchez Felicity R.a.j.Rose School of Pha.ma.y Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Hea.thca.e Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellula. Microenvironment University of GlasgowGlasgowUK Centre for a.a.ytica. Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Ma.ine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

Non-hea.ing fra.tures,a.globa. hea.th concern a.ising from tra.ma.osteoporosis,a.d tumours,ca. lea. to severe disa.ilities.a.enosine,integra. to cellula. energy meta.olism,ga.ns prominence in bone regenera.ion via.a.eno-sine a. B receptor a.tiva.ion.This study introduces a.controlled-relea.e system for loca.ized a.enosine delivery,fostering huma. mesenchyma. stroma. cell(hMSC)differentia.ion into functiona. bone cells.The study investi-ga.es how the ra.io of la.tic a.id to glycolic a.id in micropa.ticles ca. influence a.enosine relea.e a.d explores the downstrea. effects on gene expression a.d meta.olic profiles of osteogenic differentia.ion in hMSCs cultured in growth a.d osteoinductive media.Insights into a.enosine-modula.ed signa.ling pa.hwa.s during MSC differenti-a.ion,with osteogenic fa.tors,provide a.comprehensive understa.ding of the pa.hwa.s involved.a.a.ysing gene expression a.d meta.olic profiles unra.els a.enosine’s regula.ory mecha.isms in MSC differentia.ion.Susta.ned a.enosine relea.e from micropa.ticles induces minera.iza.ion,synergizing with osteogenic media.supplements,showca.ing the potentia. of a.enosine for trea.ing critica. bone defects a.d meta.olic disorders.This study high-lights the effica.y of a.polymeric micropa.ticle-ba.ed delivery system,offering novel stra.egies for bone repa.r.Unveiling a.enosine’s roles a.d a.socia.ed signa.ling pa.hwa.s a.va.ces our comprehension of molecula. mech-a.isms steering bone regenera.ion,propelling innova.ive bioma.eria.,combined with meta.olites,a.proa.hes for clinica. use.

关键词： a.enosine relea.e Osteogenic signa.ling pa.hwa.s Huma. mesenchyma. stroma. cells Bone regenera.ion

Beyond cotton a.d polyester: a. eva.ua.ion of emerging feedstocks a.d conversion methods for the future of fa.hion industry

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j.urna. of Bioresources a.d Bioproducts 2024年第2期9卷 130-159页

作者： Ryen M.Fra.ier Keren a.Viva. Iva.a.a.ua.0} Ra.on Vera.a.onzo Pifa.o Na.ca.i Forfora.Ha.a. j.meel Ericka.Ford j.el j.Pa.la. Richa.d Venditti Rona.ds gonzalez Depa.tment of Forest Bioma.eria.s North Carolina State UniversityRaleighNC 27695USA Depa.tment of Textile Engineering Chemistry and ScienceThe Nonwovens InstituteNorth Carolina State UniversityRaleighNC 27695USA

a. the globa. popula.ion grows,the dema.d for textiles is increa.ing ra.idly.However,this puts immense pressure on ma.ufa.turers to produce more fiber.While synthetic fibers ca. be pro-duced chea.ly,they ha.e a.nega.ive impa.t on the environment.On the other ha.d,fibers from wool,sisa.,fique,wood pulp(viscose),a.d ma.-ma.e cellulose fibers(MMCFs)from cotton ca.-not a.one meet the growing fiber dema.d without ma.0}r stresses on la.d,wa.er,a.d existing ma.kets using these ma.eria.s.With a.grea.er empha.is on tra.spa.ency a.d circula. economy pra.tices,there is a.need to consider na.ura. non-wood a.terna.ive sources for MMCFs to supple-ment other fiber types.However,introducing new feedstocks with different compositions ma. require different bioma.s conversion methods.Therefore,ba.ed on existing work,this review a.-dresses the technica. fea.ibility of va.ious a.terna.ive feedstocks for conversion to textile-gra.e fibers.First,a.terna.ive feedstocks a.e introduced,a.d then conventiona.(dissolving pulp)a.d emerging(fibrilla.ed cellulose a.d recycled ma.eria.)conversion technologies a.e eva.ua.ed to help select the most suita.le a.d promising processes for these emerging a.terna.ive sources of cellulose.It is importa.t to note tha. for a.terna.ive feedstocks to be a.opted on a.mea.ingful sca.e,high bioma.s a.a.la.ility a.d proximity of conversion fa.ilities a.e critica. fa.tors.In North a.erica.soybea.,whea.,rice,sorghum,a.d suga.ca.e residues a.e widely a.a.la.le a.d most suita.le for conventiona. conversion through va.ious dissolving pulp production methods(pre-hydrolysis kra.t,a.id sulfite,soda.SO2-etha.ol-wa.er,a.d pota.sium hydroxide)or by emerging cellulose fibrilla.ion methods.While dissolving pulp conversion is well-esta.lished,fibrilla.ed cel-lulose methods could be beneficia. from cost,efficiency,a.d environmenta. perspectives.Thus,the a.thors strongly encoura.e more work in this growing resea.ch a.ea.However,conducting thorough cost a.d susta.na.ility a.sessments is importa.t to determine the best feedstock a

关键词： Non-wood Residue Regenera.ed cellulose Dissolving pulp Ma.-ma.e cellulose fiber a.pa.el textile

Vertica. Displa.ement Mea.urement in a.Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pa.cua. SEVILLa.O j.vier PRECIa.O-Ga.Ba.O j.rge SEVIL Fra.cisco GUTIERREZ j.a. j.a.TiNEZ Sonia.Ma.TiN-LOPEZ Miguel gonzalez-HERRa.Z a.a.on Institute of Engineering Resea.ch(I3a. Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering a.d Communica.on Dpa.tment EINAUniversidad de ZaragzaZaragza 50018Spain a.a.on Photonics La.s. Zaragoza 50009Spain Depa.tment of Ea.th Sciences Universidad de ZaragozaZaragoza 50009Spain Depa.tment of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring a.d ea.ly-wa.ning systems for ground deforma.ion phenomena.such a. sinkholes,depends on their a.ility to a.cura.ely resolve the ongoing ground displa.ement a.d detect the subtle deforma.ion preceding ca.a.trophic fa.lures.Sa.ging sinkholes with a.slow subsidence ra.e a.d diffuse edges pose a.significa.t cha.lenge for subsidence monitoring due to the low deforma.ion ra.es a.d limited la.era. stra.n gra.ients.In this work,we sa.isfa.torily illustra.e the pra.tica.ity of the Brillouin optica. time doma.n a.a.ysis(BOTDa.to mea.ure the spa.ia.-tempora. pa.terns of the vertica. displa.ement in such cha.lenging slow-moving sa.ging sinkholes.To a.sess the performa.ce of the a.proa.h,we compa.e the stra.n recorded by the distributed optica. fiber sensor with the vertica. displa.ement mea.ured by high-precision leveling.The results show a.good spa.ia. correla.ion with the a.ility to identify the ma.imum subsidence point.There is a.so a.good tempora. correla.ion with the detection of a. a.celera.ion pha.e in the subsidence a.socia.ed with a.flood event.

关键词： Distributed fiber optic sensing(DFOS) vertica. displa.ement mea.urement slow subsidence ra.e sinkhole ha.a.d ea.ly-wa.ning system

重症监护室护士限制治疗努力的能力:整合性综述

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Interna.iona. j.urna. of Nursing Sciences 2024年第1期11卷 143-154,I0003页

作者： Elvia.R.Lopez-Pa.za.Va.essa.C.Pa.heco-Roys Kelly j.Ferna.dez-a.uma.a.Dia.a.C.Día.-Ma.s Ma.ía.Y.Exposito-Concepcion Eliza.eth Villa.rea.-Ca.tillo Cesa. I.a.iles gonzalez Nursing Depa.tment Universidad del NorteBarranquillaColombia Nursing Progra. Faculty of Health SciencesUniversidad Popular del CesarValleduparColombia Clínica.Va.ledupa. ValleduparColombia Hospita. Universida. del Norte SoledadColombia Depa.tment of Medica. Sciences a.d Public Hea.th University of CagliariCittadella Universitaria di MonserratoCagliariItaly

目的在重症监护病房(IntensiveCa.eUnit,ICU),护土难免会遇到需要限制治疗努力(limiting thera.eutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对... 详细信息

目的在重症监护病房(IntensiveCa.eUnit,ICU),护土难免会遇到需要限制治疗努力(limiting thera.eutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对2010年--2023年发表的文献进行综述。系统检索了5个数据库:Medline、Wiley Online Libra.y、SciELO、ScienceDirect和Web of Science。使用关键评估项目工具西班牙语版(Critica. a.pra.sa. Skills Progra.me in Spa.ish,Ca.Pe)作为评判性阅读工具。使用牛津循证医学中心(Center for Evidence-Ba.ed Medicine.,CEBM)评估工具确定证据级别和推荐强度。结果共纳入25篇文献。ICU护士LTE护理的能力包括对患者的直接护理、以家庭为中心的护理以及护士在团队中的作用。该综述确定了3个类别的能力:作为患者、家庭与跨学科团队之间维护者的能力,在LTE方面的决策能力,在患者生命末期治疗和护理干预的能力。结论ICU护士在LTE方面需要具备相应的能力,这对患者的生活质量死亡尊严以及患者家庭应对悲伤的全面支持至关重要。

关键词：重症监护家庭支持重症监护病房护士的作用安宁疗护专业能力

Performa.ce a.d ca.ibra.ion of qua.k/gluon-j.t ta.gers using 140 fb^(-1) of pp collisions a. √s=13 TeV with the a.La. detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. a.d B. a.bott K. a.eling N.j. a.icht S.H. a.idi a. a.oulhorma.H. a.ra.owicz H. a.reu Y. a.ula.ti B.S. a.ha.ya.C. a.a. Bourda.ios L. a.a.czyk S.V. a.depa.li M.j. a.dison j. a.elma. a. a.iguzel T. a.ye a.a. a.folder Y. a.ik M.N. a.a.a. j. a.a.wa.a.a. a.ga.wa. C. a.heorghiesei a. a.ma. F. a.ma.ov W.S. a.med S. a.uj. X. a. G. a.elli a. a.kot M. a.t Ta.liha. B. a.tbenchikh I. a.zenberg M. a.biyik T.P.a. Åkesson a.V. a.imov D. a.iya.a.N.N. a.olka. K. a. Khoury G.L. a.berghi j. a.bert P. a.bicocco G.L. a.bouy S. a.derweireldt M. a.eksa.I.N. a.eksa.drov C. a.exa.T. a.exopoulos F. a.fonsi M. a.gren M. a.hroob B. a.i H.M.j. a.i S. a.i S.W. a.ibocus M. a.iev G. a.imonti W. a.ka.hi C. a.la.re B.M.M. a.lbrooke j.F. a.len C.a. a.lendes Flores P.P. a.lport a. a.oisio F. a.onso C. a.pigia.i M. a.va.ez Estevez a. a.va.ez Ferna.dez M. a.ves Ca.doso M.G. a.viggi M. a.y Y. a.a.a. Coutinho a. a.bler C. a.elung M. a.erl C.G. a.es D. a.idei S.P. a.or Dos Sa.tos K.R. a.os V. a.a.iev C. a.a.topoulos T. a.deen j.K. a.ders S.Y. a.drea. a. a.drea.za.S. a.gelida.is a. a.gera.i a.V. a.isenkov a. a.novi C. a.tel M.T. a.thony E. a.tipov M. a.tonelli F. a.ulli M. a.ki T. a.ki j.a. a.a.isi Pozo M.a. a.a.o L. a.erio Bella.C. a.pelt a. a.ya. N. a.a.za.a. S.j. a.biol Va. C. a.ca.geletti a.T.H. a.ce E. a.ena.j.F. a.guin S. a.gyropoulos j.-H. a.ling O. a.na.z H. a.nold G. a.toni H. a.a.a.K. a.a. S. a.a. N.a. a.ba. j. a.sa.sa. K. a.sa.a.a. R. a.ta.os S. a.a.hi R.j. a.kin M. a.kinson H. a.ma.i P.a. a.ma.iddha.K. a.gsten S. a.ricchio a.D. a.riol V.a. a.strup G. a.olio K. a.iotis G. a.uelos D. Ba.a. H. Ba.ha.ou K. Ba.ha. a. Ba.hiu F. Ba.kma. a. Ba.ea.P. Ba.na.a.M. Ba.ma.i a.j. Ba.ley V.R. Ba.ley j.T. Ba.nes L. Ba.nes O.K. Ba.er E. Ba.os D. Ba.shi Gupta.V. Ba.a.rishna. R. Ba.a.ubra.a.ia. E.M. Ba.din P. Ba.ek E. Ba.la.ene F. Ba.li L.M. Ba.tes W.K. Ba.una. j. Ba.z E. Ba.a. M. Ba.diera.onte a. Ba.dyopa.hya. S. Ba.sa. L. Ba.a. M. Ba.a.a. E.L. Ba.berio D. Ba.beris M. Ba.bero M.Z. Ba.el K.N. Ba.ends T. Ba.illa.i M-S. Ba.isits T. Ba.klow P. Ba.on D.a. Ba.on Mo The a.La. Colla.ora.ion

The identifica.ion of j.ts origina.ing from qua.ks a.d gluons,often referred to a. qua.k/gluon ta.ging,pla.s a. importa.t role in va.ious a.a.yses performed a. the La.ge Ha.ron Collider,a. Sta.da.d Model mea.urements a.d sea.ches for new pa.ticles deca.ing to qua.ks often rely on suppressing a.la.ge gluon-induced ba.kground.This pa.er describes the mea.urement of the efficiencies of qua.k/gluon ta.gers developed within the a.La. Colla.ora.ion,using √s=13 TeV proton–proton collision da.a.with a. integra.ed luminosity of 140 fb^(-1) collected by the a.La. experiment.Two ta.gers with high performa.ces in rej.cting j.ts from gluon over j.ts from qua.ks a.e studied:one ta.ger is ba.ed on requirements on the number of inner-detector tra.ks a.socia.ed with the j.t,a.d the other combines severa. j.t substructure observa.les using a.boosted decision tree.a.method is esta.lished to determine the qua.k/gluon fra.tion in da.a.by using qua.k/gluon-enriched subsa.ples defined by the j.t pseudora.idity.Differences in ta.ging efficiency between da.a.a.d simula.ion a.e provided for j.ts with tra.sverse momentum between 500 GeV a.d 2 TeV a.d for multiple ta.ger working points.

关键词： a.La. j.T QUa.K GLUON Ta.GING

Declining meta.olic sca.ing pa.a.lels a. ontogenetic cha.ge from elonga.e to deep-bodied sha.es in j.venile Brown trout

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Current Zoology 2023年第3期69卷 294-303页

作者： j.rge-Ruben Sa.chez-gonzalez a.fredo G.Nicieza Depa.tment of Orga.isms a.dSystems Biology University of Oviedo33006O OviedoSpain Biodiversity Resea.ch Institute(IMIB) University of Oviedo-Principality of Asturias-CSIC33600 MieresSpain Depa.tment of a.ima. Science-Wildlife Section University of Lleida25006 LleidaSpain

Body sha.e a.d meta.olic ra.e ca. be importa.t determina.ts of a.ima. performa.ce,yet often their effects on influentia. tra.ts a.e eva.ua.ed in a.non-integra.ed wa..This crea.es a. importa.t ga. beca.se the integra.ion between sha.e a.d meta.olism ma. be crucia. to eva.ua.e meta.olic sca.ing theories.Here,we mea.ured sta.da.d meta.olic ra.e in 1-a.d 2-yea.s old j.venile brown trout Sa.mo trutta.a.d used a.geometric morphometrics a.proa.h to extrica.e the effects of ontogeny a.d size on the link between sha.e a.d meta.olic sca.ing.We evidenced nea.-isometric ontogenetic sca.ing of meta.olic ra.e with size,but a.so a.bipha.ic pa.tern driven by a.significa.t cha.ge in meta.olic sca.ing,from positive to nega.ive a.lometry.Moreover,the cha.ge in meta.olic a.lometry pa.a.lels a. ontogenetic cha.ge from elonga.e to deep-bodied sha.es.This is consistent with the dyna.ic energy budget(DEB)a.d surfa.e a.ea.Sa.theories,but not with the resource tra.sport network theory which predicts increa.ing a.lometric exponents for trends towa.ds more robust,three-dimensiona. bodies.In a.dition,we found a.rela.ionship between body sha.e a.d size independent meta.olic ra.e,with a.positive correla.ion between robustness a.d meta.olic ra.e,which fits well within the view of Pa.e-of-Life Syndromes(POLS).Fina.ly,our results a.ign with previous studies tha. question the universa.ity of meta.olic sca.ing exponents a.d propose other mecha.istic models expla.ning the diversity of meta.olic sca.ing rela.ionships or empha.izing the potentia. contribution of ecologica. fa.tors.

关键词： bipha.ic a.lometric sca.ing meta.olic ra.e ontogenetic a.lometry sha.e surfa.e-a.ea trout