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Eye contact and sociability data suggests that Australian dingoes were never domesticated

Current Zoology 2022年第4期68卷 423-431页

作者： j william o ballard Chloe Gardner Lucille Ellem Sonu Yadav Richard I Kemp Department of Ecology Environmentand EvolutionLatrobe UniversityMelbourneVIC 3086Australia Department of BioSciences The University of MelbourneMelbourneVIC 3010Australia School of Life and Environmental Sciences University of SydneyCamperdownNSW 2006Australia Bargo Dingo Sanctuary BargoNSW 2574Australia School of Biotechnology and Biomolecular Sciences UNSW SydneySydneyNSW 2052Australia School of Psychology UNSW SydneySydneyNSW 2052Australia

Dogs were the first animal to become domesticated by humans,and they represent a classic model system for unraveling the processes of *** compare Australian dingo eye contact and socialization with Basenji and German Shepherd dog(GSD)*** dingoes arrived in Australia 5,000–8,000 BP,and there is debate whether they were domesticated before their *** Basenji represents a primitive breed that diverged from the remaining breeds early in the domestication process,while GSDs are a breed dog selected from existing domestic dogs in the late *** conducted a 4-phase study with unfamiliar and familiar investigators either sitting passively or actively calling each *** found 75%of dingoes made eye contact in each *** contrast,86%of Basenjis and 96%of GSDs made eye *** also exhibited shorter eye-gaze duration than breed dogs and did not respond to their name being called ***,quantified as a canid coming within 1m of the experimenter,was lowest for dingoes and highest for *** sociability duration,dingoes spent less time within 1m of the experimenter than either breed *** compared with previous studies,these data show that the dingo is behaviorally intermediate between wild wolves and Basenji dogs and suggest that it was not domesticated before it arrived in ***,it remains possible that the accumulation of mutations since colonization has obscured historical behaviors,and dingoes now exist in a feralized retamed *** morphological and genetic data are required to resolve this conundrum.

关键词： Basenji dingo domestication German Shepherd dog eye gaze sociability

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Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

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Translational Neurodegeneration 2013年第1期2卷 134-142页

作者： Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles j Guillemin Xing-Mai jiang j william o ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan Centre for Healthy Brain Ageing School of PsychiatryUniversity of New South WalesSydneyAustralia Aged Care and Rehabilitation Bankstown-Lidcombe HospitalSydneyAustralia Department of Human Physiology and Centre for Neuroscience Flinders University School of MedicineAdelaideAustralia Faculty of Medicine University of New South WalesSydneyAustralia Neuropsychiatric Institute Prince of Wales HospitalSydneyAustralia School of Medical Sciences University of New South WalesSydneyAustralia St Vincent’s Centre for Applied Medical Research SydneyAustralia St George Clinical School University of New South Wales and St George HospitalSydneyAustralia School of Biotechnology and Biomolecular Sciences University of New South WalesSydneyAustralia Aged Care and Rehabilitation Unit Bankstown-Lidcombe HospitalEldridge RoadBankstown 2031NSWAustralia

The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in *** findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.

关键词： Alpha-synuclein Neurons Astrocytes Fibroblasts Mitochondria

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Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

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Integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo MEjIA Gustavo Lima URBIETA Bruna da Silva XAVIER Isaíjorge de CASTRo joséjúlio DE ToLEDo Gustavo GRACIoLLI Lucio AndréVIANA DIAS william Douglas CARVALHo Programa de Pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

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Development and validation of SuperDEM for non-spherical particulate systems using a superquadric particle method

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Particuology 2022年第2期20卷 74-90页

作者： Xi Gao jia Yu Ricardo j.F.Portal jean-François Dietiker Mehrdad Shahnam william A.Rogers National Energy Technology Laboratory MorgantownWV 26506USA Leidos Research Support Team MorgantownWV 26506USA Centro de Investigação em Modelação e otimização de Sistemas Multifuncionais Instituto Superior de Engenharia de LisboaPolytechnic Institute of Lisbon1959-007 LisboaPortugal Instituto de Engenharia Mecânica–Instituto Superior Técnico Universidade de Lisboa1049-001 LisboaPortugal

This article presents the development and validation of the Superquadric Discrete Element Method(SuperDEM)for non-spherical particle simulation using a superquadric particle method in open-source CFD suite MFiX.A superquadric particle-particle contact algorithm with accelerating and stabilizing strategy was developed.A superquadric particle-arbitrary wall contact algorithm was developed,which enables the simulation in complex *** solver was validated by comparing with experimental data generated in this study or available in the *** include cylinder contacting with a wall,static packing of M&M chocolate candies in a cylindrical container,static packing of cylinders in a cylindrical container,dynamic angle of repose of cylinders in a rotating drum,and discharging of chocolate candies from a ***,MPI parallelization of the solver was implemented and the parallel performance of the solver using MPI was assessed through large-scale simulations of 1 million,10 million,and 100 million particles on up to 6800 cores,which demonstrates that the SuperDEM solver has great potential for industrial-scale systems simulation.

关键词： DEM Particle Non-spherical Superquadric Parallelization MFiX

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Evaluating the performance of nanostructured materials as lithium-ion battery electrodes

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Nano Research 2014年第1期7卷 1-62页

作者： Mark j. Armstrong Colm o'Dwyer william j. Macklin justin. D. Holmes Materials Chemistry & Analysis Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Applied Nanoscience Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin 2 Ireland Nexeon Limited Abingdon Oxfordshire UK.

锂离子房间的性能重重地依赖于主机电极的能力从本地结构提供并且释放 Li+ 离子。当电极材料的选择可以定义象房间潜力和能力那样的参数时，置闰的过程可以被率身体上限制固态 Li+ 散开。在锂离子电极的增加的散开率可以在散开路径通过... 详细信息

锂离子房间的性能重重地依赖于主机电极的能力从本地结构提供并且释放 Li+ 离子。当电极材料的选择可以定义象房间潜力和能力那样的参数时，置闰的过程可以被率身体上限制固态 Li+ 散开。在锂离子电极的增加的散开率可以在散开路径通过减小被完成，由一可伸缩各自的电极尺寸完成了。另外，一些电极可以经历与收费并且排出联系的大体积变化，的紧张，可以更好通过 nanostructuring 被提供。主机的失败可以导致本地结构的 pulverisation 和能力的快速的损失提供如此的卷变化。在这篇评论文章，我们寻求在 nanostructured 锂离子电池体系结构(阳极和阴极) 的开发加亮很多重要获得，作为潜在的下一代的电气化学的精力存储设备的驱动程序。

关键词：纳米结构材料锂离子电池电极材料性能评价局部结构扩散速率离子电极

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Genetic Improvement of Willow for Bioenergy and Biofuels

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journal of Integrative Plant Biology 2011年第2期53卷 151-165页

作者： Angela Karp Steve j.Hanley Sviatlana o.Trybush william Macalpine Ian Shield Centre for Bioenergy and Climate Change Plant and Invertebrate Ecology DepartmentRothamsted Research

Willows （Salix spp.） are a very diverse group of catkin-bearing trees and shrubs that are widely distributed across temperate regions of the globe. Some species respond well to being grown in short rotation coppice （SRC） cycles, which are much shorter than conventional forestry. Cop- picing reinvigorates growth and the biomass rapidly accumulated can be used as a source of renewable carbon for bioenergy and biofuels. As SRC willows re-distribute nutrients during the perennial cycle they require only minimal nitrogen fertilizer for growth. This results in fuel chains with potentially high greenhouse gas reductions. To exploit their potential for renewable energy, willows need to be kept free of pests and diseases and yields need to be improved without significantly increasing the requirements for fertilizers and water. The biomass composition needs to be optimized for different end-uses. Yields also need to be sustainable on land less productive for food crops to reduce conflicts over land use. Advances in understanding the physiology and growth of willow, and in the identification of genes underlying key traits, are now at the stage where they can start to be used in breeding programs to help achieve these goals.

关键词： Genetic Improvement of Willow for Bioenergy and Biofuels QTLs SRC

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The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency Special Issue:Emerging Investigators

聚集体(英文)

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聚集体(英文) 2023年第4期4卷 195-209页

作者： Bruce Lin Andrew Hung william Singleton Kevion K.Darmawan Rachael Moses Bicheng Yao Hongkang Wu Anders Barlow Marc-Antoine Sani Alastair j.Sloan Mohammed Akhter Hossain john D.Wade Yuning Hong Neil M.o’Brien-Simpson Wenyi Li The Bio21 Institute of Molecular Science and Biotechnology University of MelbourneMelbourneVictoriaAustralia ACTV Research group Melbourne Dental SchoolCentre for Oral Health ResearchUniversity of MelbourneMelbourneVictoriaAustralia School of Science RMIT UniversityMelbourneVictoriaAustralia Melbourne Dental School Division of Basic and Clinical Oral SciencesUniversity of MelbourneMelbourneVictoriaAustralia Department of Biochemistry and Chemistry La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVictoriaAustralia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoriaAustralia School of Chemistry University of MelbourneMelbourneVictoriaAustralia Materials Characterisation and Fabrication Platform University of MelbourneMelbourneVictoriaAustralia

Antimicrobial peptides(AMPs)are potentially powerful alternatives to conven-tional antibiotics in combating multidrug resistance,given their broad spectrum of *** mainly interact with cell membranes through surface electrostatic potentials and the formation of secondary structures,resulting in permeability and destruction of target microorganism *** earlier work showed that two leading AMPs,MSI-78(4–20)and pardaxin(1–22),had potent antimicrobial activ-ity against a range of *** is known that the attachment of moderate-length lipid carbon chains to cationic peptides can further improve the functionality of these peptides through enhanced interactions with the membrane lipid bilayer,inducing membrane curvature,destabilization,and potential ***,in this work,we aimed to investigate the antimicrobial activity,oligomerization propensity,and lipid-membrane binding interactions of a range of N-terminal lipidated analogs of MSI-78(4–20)and pardaxin(1–22).Molecular modeling results suggest that aggregation of the N-lipidated AMPs may impart greater structural stability to the peptides in solu-tion and a greater depth of lipid bilayer insertion for the N-lipidated AMPs over the parental *** experimental and computationalfindings provide insights into how N-terminal lipidation of AMPs may alter their conformations,with subsequent effects on their functional properties in regard to their self-aggregation behavior,membrane interactions,and antimicrobial activity.

关键词： aggregation antimicrobial peptide lipidation membrane active peptide

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Higher testosterone levels are associated with increased highdensity lipoprotein cholesterol in men with cardiovascular disease： results from the Massachusetts Male Aging Study

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Asian journal of Andrology 2008年第2期10卷 193-200页

作者： Stephanie T. Page Beth A. Mohr Carol L. Link Amy B. o＇oonnell william j. Bremner john B. McKinlay Department of Medicine University of Washington Seattle 98195 USA New England Research Institutes Watertown 02472 USA

Aim： To study the relationship between circulating androgens （total testosterone [TT], free testosterone [IT] and dihydrotestosterone [DHT]） and high-density lipoprotein cholesterol （HDL-C） in men with and without cardiovascular disease （CVD）. Methods： Cross-sectional analyses included 1 661 baseline samples from the Massachusetts Male Aging Study （MMAS）, a population-based cohort of men ages 40-70 years. Serum hormones were measured by radioimmunoassay and HDL-C was determined following precipitation of the lower density lipoproteins. CVD was determined by self-report. Analyses were performed using multiple linear regression. Results： TT and HDL-C were positively correlated in the entire sample （r = 0.11, P = 0.0001）. After adjusting for confounders, we found this relationship was mostly limited to the 209 men with CVD. Among men with CVD, TT （P = 0.0004）, iT （P = 0.0172） and DHT （P = 0.0128） were all positively correlated with HDL-C, whereas in men without CVD only TT correlated with HDL-C （P = 0.0099）. Conclusion： our results suggest that if androgens contribute to CVD in middle-aged men, the effect is not related to a suppressive effect of endogenous T on HDL-C. （Asian jAndrol 2008 Mar; 10： 193-200）

关键词： testosterone high-density lipoprotein cholesterol androgens epidemiology

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Macrophage-specific inhibition of the histone demethylase jMjD3 decreases STING and pathologic inflammation in diabetic wound repair

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Cellular & Molecular Immunology 2022年第11期19卷 1251-1262页

作者： Christopher o.Audu william j.Melvin Amrita D.joshi Sonya j.Wolf jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer james Shadiow Matthew A.Corriere Andrea Tobi Steven LKunkel Benjamin Levi Bethany BMoore johann EGudjonsson Andrew MSmith Katherine A.Gallagher Department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA Department of Microbiology and Immunology University of MichiganAnn ArborMIUSA Department of Medicinal Chemistry University of MichiganAnn ArborMIUSA Department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA Department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

Macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic wounds,we identified increased jMjD3 in diabetic wound macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,jMjD3 directs early macrophage-mediated inflammation via jAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates jMjD3 expression in diabetic wound macrophages via the jAK1,3/STAT3 pathway and that this late increase in jMjD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with jMjD3-deficient myeloid cells(jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by jMjD3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of jMjD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of jMjD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.

关键词： wound healing epigenetics diabetes jMjD3 STING

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Plant mineral nutrient sensing and signaling

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journal of Integrative Plant Biology 2014年第3期56卷 190-191页

作者： Leon V.Kochian william j.Lucas Robert W.Holley Center for Agriculture and Health USDA‐ARS Cornell University Department of Plant Biology College of Biological Sciences University of California

As terrestrial plants are sessile organisms and therefore must directly deal with an often complex and changing environment, they have had to develop complex and elegant strategies to survive and thrive in the face of environmental stress. This is particularly true for plant adaptation to the soil environment, where essential mineral nutrients often are found at sub- optimal levels and their concentrations can vary significantly, both spatially and temporally. Furthermore, plants also at times have to respond to excessively high and potentially toxic levels of essential nutrients, as well as toxic levels of non- essential metals and metalloids in the soil. Although plant mineral nutrition as a bona ~ide research discipline has a history of over 15o years, beginning with the pioneering work of justus Von Liebieg and others in the mid-1800＇s, it is only very recently that researchers have begun to truly appreciate how sophisticated plants are with regards to the sensing of their mineral status and the maintaining of mineral homeostasis in the plant.

关键词： Plant mineral nutrient sensing and signaling root

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