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Risk aspects of dental restoratives: From amalgam to tooth-colored materials

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World journal of Stomatology 2013年第1期2卷 1-11页

作者： Roland Frankenberger Franklin Garcia-Godoy Peter E Murray Albert j Feilzer Norbert kr?mer Department of Operative Dentistry and Endodontics Dental School University of Marburg and University Medical Center Giessen and Marburg Campus Marburg D-35039 Marburg Germany College of Dentistry University of Tennessee Knoxville TN 38163 United States Department of Endodontics College of Dental Medicine Nova Southeastern University Fort Lauderdale FL33328-2018 United States Department of Dental Materials Science Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam NL-1066 EA Amsterdam The Netherlands Department of Pediatric Dentistry Dental School University of Giessen and University Medical Center Giessen and Marburg Campus Giessen D-35392 Giessen Germany

Dental materials' choice of patients has considerably changed. Whereas cast gold and amalgam have been the predominant biomaterials for decades, today toothcolored materials like resin-based composites and ceramics are more and more successful. However, are we going to replace a good but biologically questionable material(amalgam) with an equal material(resin composite) being more esthetic but also biologically questionable? For amalgam, long-term clinical studies reported some significant hints that in single cases amalgam may be a health hazard for patients, finally Norway banned amalgam completely. The main advantage of a resin-based composite over amalgam is its tooth-like appearance and more or less absence of extensive preparation rules. For many years it was believed that resin-based composites may cause pulpal injury. However, pulpal injury associated with the use of resin-based composites is not correlated with their cytotoxic properties. Nevertheless, resin-based composites and other dental materials require rigorous safety evaluation and continuous monitoring to prevent adverse events similar like with amalgam. Because of nonbiocompatible pulp responses to resin-based composites and amalgam, they should not be placed in direct contact with the dental pulp. The less dentin remaining in the floor of preparations between resin-based composites or other dental materials is more likely to cause pulpitis. Percentage of patients and dental practitioners who display allergic reactions is between 0.7% and 2%. The release of cytotoxic monomers from resin-based materials is highest after polymerization and much lower after 1 wk. Substances released from resin-based composites have been shown to be toxic in cytotoxicity tests. Nevertheless, in vitro cytotoxicity assays have shown that amalgam has greater toxic effects than resin-based composites, sometime 100-700-fold higher. Altogether, the risk of side-effects is low, but not zero, especially for dental personnel.

关键词： Exposures Restoratives Amalgam Resinbased composites Adhesives

侵入性脑电图在癫痫手术中的诊断价值:适应证、形式及技术

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癫痫杂志 2017年第1期3卷 80-90页

作者： jayakar P Gotman j Harvey AS Palmini A Tassi L Schomer D Dubeau F Bartolomei F Yu A krek P Velis D Kahane P 吴梦倩慕洁

许多难治性癫痫的患者经过非侵入性检查评估及可成功完成手术,但颅内脑电图(Intracranial electroencephalography,IEEG)在越来越多的复杂病例的手术治疗中有着重要地位。在不同的癫痫中心,IEEG的适应证及应用方式不同,每种方式有其优... 详细信息

许多难治性癫痫的患者经过非侵入性检查评估及可成功完成手术,但颅内脑电图(Intracranial electroencephalography,IEEG)在越来越多的复杂病例的手术治疗中有着重要地位。在不同的癫痫中心,IEEG的适应证及应用方式不同,每种方式有其优势也有其局限性。IEEG可以在相同的术中背景下使用,即术中皮质脑电图,或者通过独立的植入步骤在术后长期记录,后者不仅占用资源而且会带来风险。对IEEG的局限性缺乏认识容易导致信息的错误解读,可能会使有适应证的病例不进行手术或不适当的切除后带来更不利的后果。考虑到IEEG缺乏1级和2级推荐证据,故提出一份关于IEEG诊断价值的专家共识,强调其在特定部位、不同方式的应用,同时考虑它的疗效、安全性、舒适度以及增加的成本效益。这些建议可以规范IEEG的过度利用或利用不足,同时保留灵活性,以符合癫痫中心的大多数实践标准,也可以满足资源匮乏地区的一些需求。

关键词：癫痫手术颅内脑电图适应证效用

新生儿和婴儿心脏移植——吉森大学小儿心脏中心经验

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德国医学 1999年第5期16卷 300-302页

作者： jrgen Bauer Friedhelm Dapper johannes kroll Christoph Knothe Rainer Maria Bohle josef Thul Karl-jrgen Hagel Barbara Stastny joachim Will Ulrike krmer Ina Michel-Behnke Dietmar Schranz 明长生 Kinderherzzentrum Abteilung Kinderkardiologie der justus-Liebig-Universitt Feulgenst.12D-35392 GieβenGermany 同济医科大学附属同济医院

原位心脏移植(HTX)公认是小儿和成人终末期心脏病的治疗方法。近10年来HTX已成功地应用于新生儿和婴儿。该年龄组HTX数占儿童期HTX总数近一半。少数有经验的移植中心,通过改进术中处理使该年龄组HTX5年生存率高于大龄小儿和成人移植组... 详细信息

原位心脏移植(HTX)公认是小儿和成人终末期心脏病的治疗方法。近10年来HTX已成功地应用于新生儿和婴儿。该年龄组HTX数占儿童期HTX总数近一半。少数有经验的移植中心,通过改进术中处理使该年龄组HTX5年生存率高于大龄小儿和成人移植组。等待供体心脏时间过长仍然是患儿术前死亡原因。供体短缺、术前处理、改善外科替代治疗是影响婴儿移植的主要因素。

关键词：新生儿婴儿心脏移植适应证供体

用马利兰、环磷酰胺、足叶乙甙为预处理方案对急性髓系白血病患者异基因骨髓移植治疗第一次完全缓解时的高剂量化疗

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德国医学 2000年第1期17卷 4-6页

作者： A.R.zander C.Berger N.krger M.Stockschlder W.krǜger M.Horstmann j.Grimm W.zeller Hkabisch R.Erttmann P.Schnrock R.Kuse D.Braumann H.j.Illiger W.Fiedler M.deWitt K.D.Hossfeld H.j.Weh 祁明芳 Bone Marrow Transplantaion Unit Universittskrankenhaus EppendorfD-20246 Hamburg Germany 广州暨南大学医学院第一附属医院

大剂量化疗和全身放疗(TBI)后,组织相合的同胞造血干细胞移植已用于急、慢性白血病的治疗。它对第一次完全缓解(CR1)的急性髓系白血病(AML)患者,长期无病生存率可达50%,而对复发的急性白血病患者,长期无病生存率约为10%～20%。异基因骨... 详细信息

大剂量化疗和全身放疗(TBI)后,组织相合的同胞造血干细胞移植已用于急、慢性白血病的治疗。它对第一次完全缓解(CR1)的急性髓系白血病(AML)患者,长期无病生存率可达50%,而对复发的急性白血病患者,长期无病生存率约为10%～20%。异基因骨髓移植(allo-BMT)预处理方案有 TBI+化疗和单用化疗两种。

关键词：急性白血病骨髓移植马利兰环磷酰胺

白垩纪末期生物大批死亡引起的环境变化及其演化意义

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吉林大学学报（地球科学版） 1982年第1期25卷 1-14页

作者：许靖华何起祥 j.A.Mckenzie H.Weissert K.Perch-Nielsen H.Oberhnsli K.Kelts j.LaBrecque U.krhenbühl S.F.Percival R.Wright R.z.Poore A.M.Gombos K.Pisciotto A.M.Karpoff N.Petersen P.Tucker M.F.Carman E.Schreiber

DSDP 524区中生代最晚期和第三纪最早期的沉积物中,保存着白垩纪末期环境变化和生物演化的详细纪录。我们对该孔进行了加密取样,样品间距大致相当于100年或1000年的时间间隔,同时对样品进行了碳酸盐含量、微量元素成分及碳氧同位素分析... 详细信息

DSDP 524区中生代最晚期和第三纪最早期的沉积物中,保存着白垩纪末期环境变化和生物演化的详细纪录。我们对该孔进行了加密取样,样品间距大致相当于100年或1000年的时间间隔,同时对样品进行了碳酸盐含量、微量元素成分及碳氧同位素分析。我们所得到的数据可以解释为白垩纪末期生物大批死亡的结果,当时大量远洋地区的生物扫地以尽。养料锐减导致部分从河流带来的溶解CO_2转移到大气圈,致使在长达40,000年的时间内,空气中的CO_2剧增。由此产生的温室效应就是氧同位素所揭示的温度升高的原因。第三纪最早期沉积物中,包括来自“白垩纪生物群”中的化石,有的已经过再沉积作用,有的则是这场灾难的最后幸存者。我们的资料表明,大量远洋生物的灭绝是在第三纪最早期的不利环境中发生的。而这种异常的环境则是生物大批死亡的结果,且持续有几千年之久。恐龙就是因为温度灾难性升高产生的热异常而灭绝的。大洋中生物大批灭绝的原因,与巨大的天外星体的陨落有关,界线附近的铱异常即其标志,我们的资料与许靖华不久前发表的彗星冲击说是不抵触的。

关键词：环境变化碳氧同位素碳同位素碳酸盐含量许靖华大气圈半深海沉积过渡带铱异常有孔虫化石

Search for two-neutrino double-beta decay of 136Xe to the 01+excited state of136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 5-13页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.Daniels L.Darroch S.j.Daugherty j.Davis S.Delaquis A.Der Mesrobian-Kabakian R.De Voe j.Dilling A.Dolgolenko M.j.Dolinski j.Echevers W.Fairbank jr. D.Fairbank j.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen j.Hoessl P.Hufschmidt M.Hughes A.Iverson A.jamil C.jessiman M.j.jewell A.johnson A.Karelin L.j.Kaufman T.Koffas R.krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li z.Li C.Licciardi Y.H.Lin R.Mac Lellan T.Mc Elroy T.Michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson j.Runge S.Schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado j.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel j.-L.Vuilleumier M.Wagenpfeil j.Watkins M.Weber L.j.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne L.Yang Y.-R.Yen O.Ya.zeldovich T.ziegler EXO-200 Collaboration Physics Department McGill University Erlangen Centre for Astroparticle Physics (ECAP) Friedrich-Alexander-University Erlangen-Nürnberg Physics Department Carleton University King Abdulaziz City for Science and Technology Department of Physics Duke University and Triangle Universities Nuclear Laboratory (TUNL) Physics Department University of Illinois Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre “Kurchatov Institute” a division of National Research Center “Kurchatov Institute” Department of Physics University of South Dakota Department of Physics and Astronomy University of Kentucky SLAC National Accelerator Laboratory TRIUMF Institute of High Energy Physics Witmem Technology Co. Ltd. Department of Physics Laurentian University Also at SNOLAB Physics Department Colorado State University Department of Physics and Physical Oceanography University of North Carolina at Wilmington Physics Department and CEEM Indiana University Carleton University Commissariat àl’Energie Atomique et auxénergies alternatives Physics Department Stanford University Department of Physics Drexel University University of California Amherst Center for Fundamental Interactions and Physics Department University of Massachusetts Technische Universit?t München Physikdepartment and Excellence Cluster Universe Qventus Department of Physics University of Virginia Physics Department University of Maryland Department of Physics at the University of California Department of Physics and Astronomy University of Alabama Wright Laboratory Department of Physics Yale University Department of Physics Princeton University IBS Center for Underground Physics Physics Department University of California SNOLAB Department of Physics and Astronomy Stony Brook University SUNY SCIPP University of California Institute for Experimental Physics Hamburg University Department of Physics and Astronomy Iowa State University Kellogg Lab Caltech LHEP Albert Einstein Center University of Ber

A new search for two-neutrino double-beta(2vββ) decay of136Xe to the 01+excited state of136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase Ⅱ dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2vββ decay to the 01+state of136Ba is 2.9 × 1024yr using a total136Xe exposure of 234.1 kg *** statistically significant evidence for 2vββ decay to the 01+state is observed,leading to a lower limit of T1/22v(0+→01+)>1.4×1024yr at 90% confidence level,improved by 70% relative to the current world’s best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

Fungi for future foods

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journal of Future Foods 2021年第1期1卷 25-37页

作者： Tyler j.Barzee Lin Cao zhongli Pan Ruihong zhang Deparment of Biosytems and Agricuitural Engineering Universiny of Kenucky128 CE Bamhart Building.LexingtonKr40546-0276.USA Deparnment of Biological and Agricultural Engineering Thriversity of Califomnia DanisOme Shields AvemueDarisCA95616USA

The rapid growth of human civilizations has 1ed to imminent pressures to develop new food products with increased nutitiona1 characteristics and decreased environmenta1 *** fungi,a class of microorganisms that have been utilized in a wide variety of foods for thousands of years,have recently gamered widespread attention in research communities and commercia1 ventures seeking to explore new and innovative applications in a diverse aray of food products including,but not 1imited to,their more established applications as alterative *** advances in the cultivation and processing of flamentous fungi have created new frontiers in the control of textures,flavors,and nutritional properties of fungi-based *** review highlights technological advances in the production of fungi-based foods from cultivation to product manufacturing,presents the current state of the ant in fungi-based food products,and offters thoughts on their future *** is given to circular bioprocessing concepts for the sustainable utilization of agricultural and food processing byproducts.

关键词： Filamentous fungi Mycoprotein Fermentation 3D printing Biomanufacturing Nove1 foods

Gaussian Support Vector Machine Algorithm Based Air Pollution Prediction

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Computers, Materials & Continua 2022年第4期71卷 683-695页

作者： K.S.Bhuvaneshwari j.Uma K.Venkatachalam Mehedi Masud Mohamed Abouhawwash T.Logeswaran Department of Computer Sceince and Engineering Karpagam College of EngineeringCoimbatore641032India Department of Electrical and Electronics Engineering M.Kumarasamy College of EngineeringKarur639113India Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA Department of Electrical and Electronics Engineering Kongu Engineering CollegeErode638060India

Air pollution is one of the major concerns considering detriments to human *** type of pollution leads to several health problems for humans,such as asthma,heart issues,skin diseases,bronchitis,lung cancer,and throat and eye *** pollution also poses serious issues to the *** from the vehicle industry is the cause of greenhouse effect and CO2 ***,real-time monitoring of air pollution in these areas will help local authorities to analyze the current situation of the city and take necessary *** monitoring process has become efficient and dynamic with the advancement of the Internet of things and wireless sensor *** is the main issue in WSNs;if the sensor node location is unknown,then coverage and power and routing are not *** study concentrates on localization-based air pollution prediction systems for real-time monitoring of smart *** systems comprise two phases considering the prediction as heavy or light traffic area using the Gaussian support vector machine algorithm based on the air pollutants,such as PM2.5 particulate matter,PM10,nitrogen dioxide(NO2),carbon monoxide(CO),ozone(O3),and sulfur dioxide(SO2).The sensor nodes are localized on the basis of the predicted area using the meta-heuristic algorithms called fast correlation-based elephant herding *** dataset is divided into training and testing parts based on 10 *** evaluation on predicting the air pollutant for localization is performed with the training *** error prediction in localizing nodes is 9.83 which is lesser than existing solutions and accuracy is 95%.

关键词： Air pollution monitoring air pollutant SVM Gaussian EHO fast correlation WSN localization

Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection

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World journal of Gastroenterology 2005年第38期11卷 6031-6037页

作者： C Meiler M Mühlbauer M johann A Hartmann B Schnabl N Wodarz G Schmitz j Schlmerich C Hellerbrand Department of Internal Medicine I Department of Psychiatry Department of Pathology Institute for Clinical Chemistry and Laboratory Medicine

AIM： Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T （-159） polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease （ALD） and chronic hepatitis C virus （HCV） infection. METHODS： CD14 genotyping was performed by PCR-RFLP analysis in （a） 121 HCV patients, （b） 62 patients with alcohol-associated cirrhosis （AIc-Ci）, （c） 118 individuals with heavy alcohol abuse without evidence of advanced liver damage （Alc-w/o Ci）, and （d） 247 healthy controls. Furthermore, serum levels of soluble CD14 （sCD14） and transaminases were determined. RESULTS： The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls （40.3% vs 23.7% or 24.0%, respectively）. In Alc-w/o Ci, serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However, no association was found between CD14 genotypes and histological staging or grading. CONCLUSION： Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease.

关键词： CD14 gene Alcoholic liver disease Chronic hepatitis C infection