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World journal of Clinical Oncology 2014年第5期5卷 800-805页

作者： Milena králí?ková Vaclav Vetvicka Department of Histology and Embryology Faculty of Medicine Charles University Plzen CZ-301 00 Czech Republic Department of Obstetrics and Gynecology University Hospital Faculty of Medicine Charles University Plzen CZ-301 66 Czech Republic Biomedical Centre Faculty of Medicine in Plzen Charles University Plzen CZ-301 66 Czech Republic Department of Pathology University of Louisville Louisville KY 40202 United States

Endometriosis is the leading cause of morbidity among premenopausal women and the complex pathogenesis of this disease remains controversial despite extensive research. This disease represents one of the most common gynecological problems. It is generally believed that this disease is due primarily to retrograde menstruation or transplantation of shed endometrium. Based on overwhelming data, ovarian endometrioma is considered a neoplastic process, since most endometriosis-associated ovarian carcinoma occur in the presence of atypical ovarian endometriosis. A study comparing patients with typical epithelial ovarian cancer with endometriosis-associated ovarian cancer demonstrated that the patients with the latter disease strongly differ in both biological and histological characteristics. The prevelance of this disease is not completely established, but approximately 15 percent of women suffer from this disease. In addition, we know about the possible links between endometriosis and cancer for almost 100 years. Despite clear evidence revealing that endometriosis increases ovariancancer risks, it is possible that it may not affect disease progression after the appearance of ovarian cancer. However, despite clear evidence revealing that endometriosis increases ovarian cancer risk, our knowledge of the risk factors is far from established. In our review, we focused on the most recent approaches including possible biomarkers and genetic approaches.

关键词： Endometriosis Ovarian cancer Biomarkers Cancer Histology

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SHui, an EU-Chinese cooperative project to optimize soil and water management in agricultural areas in the ⅩⅪ century

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International Soil and Water Conservation Research 2020年第1期8卷 1-14页

作者： josé A.Gómez Alon Ben-Gal juan j.Alarcón Gabrielle De Lannoy Shannon de Roos Tomá(s)Dostál Elias Fereres Diego S.Intrigliolo josef krása Andreas Klik Gunther Liebhard Reinhard Nolz Aviva Peeters Elke Plaas john N.Quinton Rui Miao Peter Strauss Weifeng Xu zhiqiang zhang Funing zhong David zumr Ian C.Dodd Institute for Sustainable Agriculture IASCSICAvda Menendez Pidal S/NCordobaSpain Agricultural Research Organization Gilat Research CenterIsrael Centro de Edafología y Biología Aplicada Del Segura(CSIC) Dept.RiegoMurciaSpain Department of Earth and Environmental Sciences KU LeuvenHeverleeBelgium Czech Technical University in Prague Faculty of Civil Engineering.CVUTPragueCzech Republic Agronomy Department University of CordobaCordobaSpain University of Agricultural Sciences Vienna(BOKU) ViennaAustria TerraVision Lab Midreshet Ben-GurionIsrael Georg-August-Universitat Gottingen Germany Centre for Sustainable Agriculture Lancaster Environment CentreLancaster UniversityUK Center for Plant Water-Use and Nutrition Regulation and College of Life Sciences Joint International Research Laboratory of Water and Nutrient in CropsFujian Agriculture and Forestry UniversityFuzhouChina Institute for Land and Water Management Research Federal Agency for Water ManagementPetzenkirchenAustria College of Soil and Water Conservation Beijing Forestry UniversityBeijingChina College of Economics and Management Nanjing Agricultural UniversityNAUNanjingChina

This article outlines the major scientific objectives of the SHui project that seeks to optimize soil and water use in agricultural systems in the EU and China,by considering major current scientific challenges in this ***(for Soil Hydrology research platform underpinning innovation to manage water scarcity in European and Chinese cropping systems)is large cooperative project that aims to provide significant advances through transdisciplinary research at multiple scales(plot,field,catchment and region).This paper explains our research platform of long-term experiments established at plot scale,approaches taken to integrate crop and hydrological models at field scale;coupled crop models and satellite-based observations at regional scales;decision support systems for specific farming situations;and the integration of these technologies to provide policy recommendations through socio-economic analysis of the impact of soil and water saving *** also outlines the training of stake-holders to develop a basic common curriculum despite the subject being distributed across different disciplines and *** such,this article provides a review of major challenges for improving soil and water use in EU and China as well as information about the potential to access information made available by SHui,and to allow others to engage with the project.

关键词： Yield Sustainability Cropping Cooperation

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压力性尿失禁妇女I型胶原α1链Sp1结合位点的多态性

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 5-6页

作者： Skorupski P. król j. Stareega j. 张旸 Second Department of Gynecological Surgery Skubiszewski Medical University of Lublin Jaczewski str. 820-954 Lublin Poland Dr

Objective: We examined the possible influence of G→ T substitution in transcription factor Sp1- binding site in the gene encoding α - 1 chain of type I collagen on the risk of stress urinary incontinence. Study design: The study group consisted of 50 women reporting symptoms of stress urinary incontinence. Fifty control subjects were treated for benign gynecological conditions other then stress urinary incontinence. DNA was obtained from peripheral blood leukocytes. The fragment of the first intron of the gene encoding the α - 1 chain of type I collagen containing the Sp1- binding site was amplified by polymerase chain reaction. The analysis of restriction fragment length polymorphism was performed. Results: We found association between the GT and TT genotype and stress urinary incontinence (P = .019). The odds ratio for developing stress urinary incontinence is 4.98 (95% confidence interval 1.97 to 12.56) in subjects presenting the GT genotype and 2.23 (95% confidence interval 0.69 to 7.25) for the TT genotype. Conclusion: The G- T polymorphismat the Sp1 binding site of the gene encoding α - 1 chain of type 1 collagen is associated with increased risk of stress urinary incontinence in women.

关键词：限制性片段长度多态性 Sp1结合位点压力性尿失禁 Ⅰ型胶原妇女 α1链第一内含子 PCR扩增

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通过模拟缩短过程

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现代制造 2006年第27期 73-74页

作者： Daniel Trebes Frank krüger Klaus-jürgen Meier

西门子Optical Solutions的例子表明．功能强大的供应链管理能够改进工作和改善结果．业务摸拟拓展了精确的相互作用。

关键词： Solutions Optical 模拟供应链管理相互作用西门子

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Neurocognitive and mental health outcomes in children with tungiasis:a cross-sectional study in rural Kenya and Uganda

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Infectious Diseases of Poverty 2023年第6期12卷 98-98页

作者： Berrick Otieno Lynne Elson Abneel K.Matharu Naomi Riithi Esther Chongwo Khamis Katana Carophine Nasambu Francis Mutebi Herman Feldmeier jürgen krücken Ulrike Fillinger Amina Abubakar Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme Hospital Road Kilifi Kenya Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK International Centre of Insect Physiology and Ecology (ICIE) Human Health Theme Nairobi Kenya Institute for Parasitology and Tropical Veterinary Medicine Freie Universität Berlin Berlin Germany Institute for Human Development Aga Khan University Nairobi Kenya School of Veterinary Medicine and Animal Resources College of Veterinary Medicine Animal Resources and Biosecurity Makerere University Kampala Uganda Charité University Medicine Berlin Germany

Background Tungiasis,a neglected tropical parasitosis,disproportionately afects *** empirical studies have reported neurocognitive and mental health outcomes of children with ectoparasitic skin diseases like *** of tungiasis suggests it could detrimentally afect cognition and *** study pioneered the investigation of neurocognitive and mental health outcomes in children with *** This was a multi-site cross-sectional study including 454 quasi-randomly sampled school-children aged 8-14 from 48 randomly selected schools in two counties in Kenya and a district in *** participants were stratifed into infected and uninfected based on the presence of *** infected were further classifed into mild and severe infection groups based on the intensity of the ***,validated,and standardized measures of cognition and mental health such as Raven Matrices and Child Behaviour Checklist were used to collect *** tests including a multilevel,generalized mixed-efects linear models with family link set to identity were used to compare the scores of uninfected and infected children and to identify other potential risk factors for neurocognitive and behavioural *** When adjusted for covariates,mild infection was associated with lower scores in literacy[adjustedβ(aβ)=−8.9;95%confdence interval(CI)−17.2,−0.6],language(aβ=−1.7;95%CI−3.2,−0.3),cognitive fexibility(aβ=−6.1;95%CI−10.4,−1.7)and working memory(aβ=−0.3;95%CI−0.6,−0.1).Severe infection was associated with lower scores in literacy(aβ=−11.0;95%CI−19.3,−2.8),response inhibition,(aβ=−2.2;95%CI−4.2,−0.2),fne motor control(aβ=−0.7;95%CI−1.1,−0.4)and numeracy(aβ=−3;95%CI−5.5,−0.4).Conclusions This study provides frst evidence that tungiasis is associated with poor neurocognitive functioning in *** tungiasis is a chronic disease with frequent reinfections,such negative efects may potentially impair their development and l

关键词： Tungiasis Tunga penetrans Neglected tropical disease Neurocognition Mental health School-aged children Africa

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Efficacy of Bacillus subtilis MBI 600 Against Sheath Blight Caused by Rhizoctonia solani and on Growth and Yield of Rice

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Rice science 2012年第1期19卷 55-63页

作者： K. VIjAY krISHNA KUMAR S. kr. YELLAREDDYGARI M. S. REDDY j. W. KLOEPPER K. S. LAWRENCE X. G. zHOU H. SUDINI D. E. GROTH S. krISHNAM RAjU M. E. MILLER Department of Entomology ＆ Plant Pathology Auburn University Auburn Alabama 36849 USA ＆ Acharya N G Ranga Agricultural University Hyderabad 500030 India Department of Entomology ＆ Plant Pathology Auburn University Auburn Alabama 36849 USA Texas A ＆ M University Agri-Life Research ＆ Extension Center Texas 77713 USA International Crops Research Institute fo)r the Semi-Arid Tropics (ICRISAT) Hyderabad 502324 India Rice Research Station LSU AgCenter LA 70578 USA Andhra Pradesh Rice Research Institute Maruteru AP 534122 India Department of Biological Sciences Auburn University Auburn Alabama 36849 USA

Rice sheath blight disease （ShB）, caused by Rhizoctonia solani, gives rise to significant grain yield losses. The present study evaluated the efficacy of Integral, the commercial liquid formulation of Bacillus subtilis strain MBI 600, against rice ShB and for plant growth promotion. In greenhouse studies, four log concentrations of Integral （from 2.2×10^6 to 2.2×10^9 cfu/mL） were used as seed treatment （ST）. After 25 d, seedlings were dipped （SD） into Integral prior to transplanting. At 30 d after transplanting （DAT）, leaf sheaths were inoculated with immature sclerotia of the pathogen. At 45 DAT, a foliar spray （FS） with Integral was applied to some treatments. The fungicide control was 50% carbendazim at 1.0 g/L, and a nontreated control was also included. Overall, there were 10 treatments, each with five replications. ShB severity was rated at 52 DAT, and seedling height and number of tillers per plant were rated at 60 DAT. In 2009, two field trials evaluated Integral at 2.2×10^8 and 2.2×10^9 cfu/mL. Integral was applied as ST, and seedlings were produced in a nursery bed. After 32 d, seedlings were treated with Integral as SD and transplanted into 10 m^2 blocks. Foliar sprays were given at 45 and 60 DAT. There were seven treatments, each with eight replications arranged as a factorial randomized complete block design. At 20 DAT, the plots were broadcast inoculated with R. solani produced on rice grains. Seedling height before transplanting, ShB severity at 90 DAT, and grain yield at harvest were recorded. Integral at 2.2×10^9 cfu/mL provided significant increase of seedling heights over other treatments under greenhouse conditions. The Integral treatments of ST ＋ SD ＋ FS at 2.2×10^9 cfu/mL significantly suppressed ShB over other treatments. In field studies, Integral provided significant increase of seedling height in nursery, and number of tillers per plant, compared with the control. ShB severity was significantly suppressed with higher concentrations of Integ

关键词： rice sheath blight Rhizoctonia solani plant growth-promoting rhizobacterium Bacillus subtilis

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关于铝熔体除气工艺的报告

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轻合金加工技术 1984年第4期 10-13+43页

作者： S.Kastner j.krüger 张正国

随着环境保护在生产技术和社会上所占地位的越来越高,现行铝熔体除气工艺的某些部分对社会公害日趋明显,恐怕将来几乎都不能再继续采用.因此,铝熔炼厂及铸造行业的企业家们积极大量投资,以便继续能用氯气或氯分裂剂对铝熔体处理.迄今能... 详细信息

随着环境保护在生产技术和社会上所占地位的越来越高,现行铝熔体除气工艺的某些部分对社会公害日趋明显,恐怕将来几乎都不能再继续采用.因此,铝熔炼厂及铸造行业的企业家们积极大量投资,以便继续能用氯气或氯分裂剂对铝熔体处理.迄今能够取代氯气处理的、并对环境无妨害的要算是铝熔体的真空精炼处理了.铝熔体真空精炼工艺是通过减低熔体上的压力以降低液相的含气量.从试验数据来看,气体在铝里的扩散速度、溶解度等,决定了除气的极限值.但要实现这些极限值,还需用相当长的处理时间.所以,铝工业里尽量努力采取经改善了的动态工艺参数,来

关键词：高速喷嘴多孔砖空心砖铝熔体除气

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Daimler公司满足欧6和第4阶段排放标准的10.7L商用车柴油机

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汽车与新动力 2013年第6期45卷 5-9页

作者： krger W Kleffel j Dietrich P Koch D 范明强

OM 470型10.7 L柴油机是Daimler公司15.6 L以下排量的新型重载商用车柴油机系列的代表机型,已被投放市场。该机型通过了载货车和公交车用欧6柴油机的认证,能用作欧4和第4阶段(Tier 4)排放标准等级的工业用柴油机,而且适用于全球市场。... 详细信息

OM 470型10.7 L柴油机是Daimler公司15.6 L以下排量的新型重载商用车柴油机系列的代表机型,已被投放市场。该机型通过了载货车和公交车用欧6柴油机的认证,能用作欧4和第4阶段(Tier 4)排放标准等级的工业用柴油机,而且适用于全球市场。鉴于未来柴油机小型化,以及降低二氧化碳排放和燃油耗的要求,这种机型在Daimler公司重载商用车柴油机系列中起着越来越重要的作用。详细介绍了OM 470型柴油机为达到欧6排放标准的热力学开发,以及为达到欧4和Tier 4排放标准的配套情况。

关键词：柴油机重载商用车欧6排放标准试验循环

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Investigation of turbulence rotation in the SOL and plasma edge of W7-X for different magnetic configurations

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Plasma Science and Technology 2020年第6期22卷 21-31页

作者： A krÄMER-FLECKEN X HAN M OTTE G ANDA S A BOzHENKOV D DUNAI G FUCHERT j GEIGER O GRULKE E PASCH E R SCOTT E TRIER M VÉCSEI T WINDISCH S zOLETNIK W7-X Team Institute for Energy-and Climate Research/Plasma Physics Forschungszentrum Jülich GmbH52425 JülichGermany Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China Max Planck Institut für Plasmaphysik 17491 GreifswaldGermany Wigner Research Centre for Physics 1525 BudapestHungary Max Planck Institut für Plasmaphysik 85748 GarchingGermany 不详

The W7-X stellarator is optimized with respect to neoclassical *** turbulent transport plays an important *** is equipped with an inertial cooled graphite divertor which intersects the island chain at the plasma edge depending on the magnetic *** control coils and the plasma current modify the iota profile at the plasma edge and shift the position of the island *** monitor the effects on the poloidal propagation velocity in the scrape-off layer(SOL)and the plasma edge,an O-mode Poloidal Correlation Reflectometer(PCR)is used which simultaneously monitors the propagation of low-k *** in the density range of 0.6?×?1019 m-3 to2?×?1019 m-3 it covers a large part of the SOL and the plasma edge and allows for the experimental determination in the last closed flux surface(LCFS)and the associated shear layer in low to middensity *** this paper it is shown that the propagation in the shear layer and its vicinity is determined best,when based on an elliptical *** magnetic configurations with magnetic edge topology of five independent islands forι?=?1 and six linked islands forι?=?0.81 are *** the effects of the plasma current and additional control coils on the edge magnetic topology are *** coherence spectra of antenna pairs for different poloidal separations is *** a decomposition method for the measured coherence spectra the characterization of turbulence spectra is possible with respect to *** band turbulence and quasi coherent modes.A strong reduction of the broad band turbulence is observed in the vicinity of the LCFS which is evidence for the suppression of low-k turbulence at the shear layer.

关键词： stellarator correlation reflectometer turbulence rotation scrape-off layer island divertor

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Differential effects of d,l-sotalol and d-sotalol on isoproterenol increased delayed rectifier outward potassium current in guinea pig myocytes

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Chinese Medical journal 1997年第12期 51-51页

作者： X.z. Yao, N.C. Yannoulis, j.Kiehn and j.Brachmann

Objective Catecholamines antagonize the clinical efficacy of pure class Ⅲ antiarrhythmic agents in vivo. The antiarrhythmic agent d, l sotalol has β adrenergic blocking properties and class Ⅲ activity. However, its d isomer without β blockade has been shown to exert significant proarrhythmia. To determine the role of β adrenergic blocking properties of d, l sotalol on its antiarrhythmic effect, we compared the effects of d, l sotalol and d sotalol on delayed rectifier K + outward current in the presence of isoproterenol at different concentrations. Methods Time dependent delayed rectifier K + outward currents, I K (I kr and I Ks ) and tail current (I K tail ) were measured in isolated guinea pig myocytes using the whole cell configuration of the patch clamp technique. Currents were measured in response to 300 ms depolarizing pulses from a holding potential of Department of Cardiology, University Hospital Heidelberg, Germany (Yao Xz, Yannoulis NC, Kiehn j and Brachmann j) 40 mV in three experimental protocols [control, isoproterenol (10 9 -10 6 mol/L), and isoproterenol (10 9 -10 6 mol/L) plus either d, l sotalol (10 4 mol/L) or d sotalol (10 4 mol/L)]. I K tail currents were measured upon repolarization to 40 mV. Results Isoproterenol significantly inreased I K and I K tail in a concentration dependent manner. I K was significantly amplified in the presence of isoproterenol (10 9 -10 6 mol/L) plus d sotalol. At 10 8 mol/L isoproterenol, I K was increased by 92.3%±23.7% before and 54.3%±13.4% after d sotalol. In contrast, d, l sotalol strongly suppressed the effect of isoproterenol on I K, and compared to control, I K was decreased by 35.6%±8.1% at 10 8 mol/L isoproterenol. Conclusions The β adrenergic blocking property of d, l sotalol maintains delayed rectifier K + outward current block in the presence of isoprotere

关键词： Differential effects of d l-sotalol and d-sotalol on isoproterenol increased delayed rectifier outward potassium current in guinea pig myocytes

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