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World journal of Gastroenterology 2007年第31期13卷 4207-4213页

作者： Nina N Pawlowski Daniela Struck Katja Grollich Anja A Kühl Martin Zeitz Oliver Liesenfeld jrg c hoffmann Medizinische Klinik I Charité-Universittsmedizin Berlin Campus Benjamin Franklin D12200 Berlin Germany Institut für Mikrobiologie und Hygiene Charité-Universittsmedizin Berlin Campus Benjamin Franklin D12203 Berlin Germany

To investigate whether bowel inflammation and/or parasite control is altered in the absence of the T cell adhesion molecule cD2.

关键词： cD2 IL-6 Ileitis Inflammatory bowel dis-ease Interferon-T Toxoplasma gondii

The ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda S.F.Matthees carsten hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-Schiller-Universitat jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied ca^(2+)-sensing,receptor(casR)within the Gprotein-coupled receptor(GPcR)family c,gained attention due to pioneering research led by Georgios Skiniotis ... 详细信息

关键词： Stanford gained Skin

The 5c Model of Linguistic creativity:construction Grammar as a cognitive Theory of Verbal creativity

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journal of Foreign Languages and cultures 2024年第1期8卷 139-154页

作者： Thomas hoffmann catholic University Eichstatt-Ingolstadt

creativity is a design feature of human *** paper presents a cognitive model of verbal creativity that draws on insights from the psychological research into creativity-particularly Glaveanu's 5A model that distinguishes five crucial perspectives on a creative act(actors,audience,artefacts,actions and affordances).The paper will outline a linguistic version of this model that adopts construction Grammar as its theoretical *** resulting"5c model of constructional creativity"argues that the central elements of linguistic creativity are constructors,co-constructors,constructs,constructional blending and the constructional network.

关键词： creativity construction grammar cognitive linguistics blending 5c model of constructional creativity cognition constructional networks

Rapid Identification of Rice Samples Using an Electronic Nose

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journal of Bionic Engineering 2009年第3期6卷 290-297页

作者： john Westbrook W.c.hoffmann R.E.Lacey USDA-ARS College Station Department of Biological and Agricultural Engineering Texas A&M UniversityCollege Station

Four rice samples of long grain type were tested using an electronic nose (cyranose-320).Samples of 5 g of each variety of rice were placed individually in vials and were analyzed with the electronic nose unit consisting of 32 polymer *** cyranose-320 was able to differentiate between varieties of *** chemical composition of the rice odors for differentiating rice samples needs to be *** optimum parameter settings should be considered during the cyranose-320 training process especially for multiple samples,which are helpful for obtaining an accurate training model to improve identification ***,it is necessary to investigate the E-nose sensor selection for obtaining better classification accuracy.A re- duced number of sensors could potentially shorten the data processing time,and could be used to establish an application pro- cedure and reduce the cost for a specific electronic *** research is needed for developing analytical procedures that adapt the cyranose-320 as a tool for testing rice quality.

关键词： rice grain identification electronic nose data analysis pattern recognition

Mortality of Australian alpine grasses (Poa spp.) after drought: species differences and ecological patterns

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journal of Plant Ecology 2012年第2期5卷 121-133页

作者： Philippa c.Griffin Ary A.hoffmann centre for Environmental Stress and Adaptation Research Department of GeneticsBio21 Institute30 Flemington RoadUniversity of MelbourneParkville 3010VictoriaAustralia

Aims Australian alpine ecosystems currently experience high precipitation in the snow-free season,but they are predicted to experience drier conditions under climate *** observed high mortality of the dominant alpine grasses following drought in *** aims were as follows:to test the involvement of plant-available water(PAW)and other environmental variables in grass mortality in the field;to detect possible species differences in drought response and to link soil moisture to precipitation using soil properties and climate *** The dominant tussock grasses of the Australian alpine zone,Poa hothamensis *** ***,Poa hiemata Vickery and Poa phillipsiana Vickery(Poaceae),all exhibited mortality following drought in the Bogong High Plains,Victoria,Australia in *** was calculated using soil water potential measurements,and past drought occurrence was modelled using climate *** then tested the effects of PAW and soil depth on grass survival both at a large spatial scale spanning the elevational range of the alpine zone and at a smaller *** hothamensis and *** were compared in a common-garden experiment to test drought *** Findings Poa hothamensis survival was predicted by dry-season PAW at the small spatial scale;at the large scale,soil depth and elevation were more important predictors of *** survival,but dry-season PAW predicted *** ***-garden experiments supported field observations that *** is more droughtsensitive than is *** also present a simple polynomial relationship between rainfall and field soil moisture,which predicts that the alpine soils dry below wilting point several times a *** suggest the timing of long rain-free periods may be more important than their duration.

关键词： climate change disturbance drought adaptation grassland

On the Simulation of Industrial Gas Dynamic Applications with the Disconti- nuous Galerkin Spectral Element Method

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journal of Thermal Science 2016年第3期25卷 250-257页

作者： F. Hempert M. hoffmann U. Iben c.-D. Munz Robert-Bosch GmbH Robert-Bosch campus 1 71272 Renningen Germany Institute of Aerodynamics and Gas Dynamics Pfaffenwaldring 21 70569 Stuttgart Germany

In the present investigation, we demonstrate the capabilities of the discontinuous Galerkin spectral element method for high order accuracy computation of gas dynamics. The internal flow field of a natural gas injector for bivalent combustion engines is investigated under its operating conditions. The simulations of the flow field and the aeroacoustic noise emissions were in a good agreement with the cxperirnental data. We tested several shockcapturing techniques for the discontinuous Galerkin scheme. Based on the validated framework, we analyzed the development of the supersonic jets during different opening procedures of a compressed natural gas injector. The results suggest that a more gradual injector opening decreases the noise emission.

关键词： Discontinuous Galerkin natural gas injection supersonic under-expanded jet high performance computing

Spectral response of spider mite infested cotton:Mite density and miticide rate study

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International journal of Agricultural and Biological Engineering 2013年第1期6卷 48-52页

作者： Yubin Lan Huihui Zhang W c hoffmann jr.juan D Lopez United States Department of Agriculture Agricultural Research ServiceAreawide Pest Management Research UnitCollege StationTexasUSA United States Department of Agriculture Agricultural Research ServiceWater Management Research UnitParlierCaliforniaUSA

Two-spotted spider mites are important pests in many agricultural *** mites(Acari:Tetranychidae)have been found to cause economic damage in corn,cotton,and *** glass vial bioassays indicate that Temprano™(abamectin)is the most toxic technical miticide for adult two-spotted spider *** an aerial application standpoint,additional research is needed to identify aerial application parameters for this *** objective of this study was to investigate spectral response of spider mite-infested cotton plants with different density levels of mites and treated with different rates of *** showed significantly different spectral signatures of cotton plants infested with different density levels of *** treating mite-infested cotton plants with five different Temprano rate treatments(control,one-eighth,one-fourth,one-half,and full rates),spectral reflectance curves were found to be significantly *** wavelengths of 550 nm,560 nm,680 nm and 740 nm were important for detecting the spectral differences among mite infested cotton plants treated with various rate of *** Difference Vegetative Index imagery was able to detect different levels of cotton plant ***-rate application of Temprano controlled mite-infested plants as effectively as the full-rate *** findings may lead to reduced cost and quantity of miticides used to maintain effective crop production and protection.

关键词： spectral reflectance infested cotton plants crop protection Normalized Difference Vegetative Index(NDVI) Temprano rate treatments

Multisensor Data Fusion for High Quality Data Analysis and Processing in Measurement and Instrumentation

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journal of Bionic Engineering 2007年第1期4卷 53-62页

作者： Yan-bo Huang Yu-bin Lan W. c. hoffmann R. E. Lacey USDA ARS Agricultural Engineer Areawide Pest Management Research Unit Texas 77845 USA Biological and A g ricultural Engineering Department Texas A ＆M University Texas 77843-2117 USA

Multisensor data fusion （MDF） is an emerging technology to fuse data from multiple sensors in order to make a more accurate estimation of the environment through measurement and detection. Applications of MDF cross a wide spectrum in military and civilian areas. With the rapid evolution of computers and the proliferation of micro-mechanical/electrical systems sensors, the utilization of MDF is being popularized in research and applications. This paper focuses on application of MDF for high quality data analysis and processing in measurement and instrumentation. A practical, general data fusion scheme was established on the basis of feature extraction and merge of data from multiple sensors. This scheme integrates artificial neural networks for high performance pattern recognition. A number of successful applications in areas of NDI （Non-Destructive Inspection） corrosion detection, food quality and safety characterization, and precision agriculture are described and discussed in order to motivate new applications in these or other areas. This paper gives an overall picture of using the MDF method to increase the accuracy of data analysis and processing in measurement and instrumentation in different areas of applications.

关键词： multisensor data fusion artificial neural networks NDI food quality and safety characterization precision agriculture

In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines

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World journal of Gastroenterology 2007年第22期13卷 3063-3070页

作者： Dennis hoffmann Wibke Bayer Oliver Wildner Department of Molecular and Medical Virology Institute of Microbiology and Hygiene Ruhr-University Bochum Bldg. MA Rm. 6/40 D-44801 Bochum Germany

AIM： To evaluate whether intratumoral expression of measles virus fusogenic membrane glycoproteins H and F （MV-FMG）, encoded by an adenovirus vector ***-HI F, alone or in combination with local coexpression of cytokines （IL-2, IL-12, IL-18, IL-21 or GM-cSF）, can serve as a platform for inducing tumor-specific immune responses in colon cancer.METHODS： We used confocal laser scanning microscopy and flow cytometry to analyze cell-cell fusion after expression of MV-FMG by dye colocalization. In a syngeneic bilateral subcutaneous Mc38 and colon26 colon cancer model in c57BL/6 and BALB/c mice, we assessed the effect on both the directly vector-treated tumor as well as the contralateral, not directly vector- treated tumor. We assessed the induction of a tumorspecific cytotoxic T lymphocyte （cTL） response with a lactate dehydrogenase （LDH） release assay.RESULTS： We demonstrated in vitro that transduction of Mc38 and colon26 cells with ***-H/F resulted in dye colocalization, indicative of cell-cell fusion, in addition, in the syngeneic bilateral tumor model we demonstrated a significant regression of the directly vector-inoculated tumor upon intratumoral expression of MV-FMG alone or in combination with the tested cytokines. We observed the highest anti-neoplastic efficacy with MV-FMG and lL-21 coexpression. The degree of tumor regression of the not directly vector-treated tumor correlated with the anti-neoplastic response of the directly vector-treated tumor. This regression was mediated by a tumor-specific cTL response.cONcLUSION： Our data indicate that intratumoral expression of measles virus fusogenic membrane glycoproteins is a promising tool both for direct tumor treatment as well as for tumor vaccination approaches that can be further enhanced by cytokine coexpression.

关键词： Adenovirus vectors Measles virus fusogenic membrane glycoproteins colorectal cancer Interleukins

Fusing MEMS technology with lab-on-chip: nanoliter-scale silicon microcavity arrays for digital DNA quantification and multiplex testing

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Microsystems & Nanoengineering 2020年第1期6卷 345-356页

作者： Daniel Podbiel Franz Laermer Roland Zengerle jochen hoffmann Robert Bosch GmbH Corporate Sector ResearchMicrosystems and NanotechnologiesRobert-Bosch-Campus 171272 RenningenGermany IMTEK-Department of Microsystems Engineering University of Freiburg Georges-Koehler-Allee 10379110 FreiburgGermany

We report on the development of a microfluidic multiplexing technology for highly parallelized sample analysis via quantitative polymerase chain reaction(PcR)in an array of 96 nanoliter-scale microcavities made from *** PcR array technology features fully automatable aliquoting microfluidics,a robust sample compartmentalization up to temperatures of 95°c,and an application-specific prestorage of reagents within the 25nl *** here presented hybrid silicon–polymer microfluidic chip allows both a rapid thermal cycling of the liquid compartments and a real-time fluorescence read-out for a tracking of the individual amplification reactions taking place inside the *** demonstrate that the technology provides very low reagent carryover of prestored reagentscross talk ratecR cycle,which facilitate a multi-targeted sample analysis via geometric ***,we apply this PcR array technology to introduce a novel digital PcR-based DNA quantification method:by taking the assay-specific amplification characteristics like the limit of detection into account,the method allows for an absolute gene target quantification by means of a statistical analysis of the amplification results.

关键词： liter testing apply