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Characterization of Fiber Dust Resulting from Recycling of Carbon Fiber-Reinforced Thermoplastics (CFRP) and Their Cell Toxicity

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journal of Materials Science and Chemical Engineering 2022年第7期10卷 1-16页

作者： Lisa Tölle Christian Monsé Nina Rosenkranz Natalia Haibel Dirk Walter jürgen Bünger Matthias Hopp götz A. Westphal Kunststofftechnik Paderborn University Paderborn Paderborn Germany Institute for Prevention and Occupational Medicine of the german Social Accident Insurance Institute of the Ruhr University Bochum (IPA) Deutsche Gesetzliche Unfallversicherung e.V. (DGUV) Bochum Germany Laboratories of Chemistry and Physics Institute of Occupational and Social Medicine Justus-Liebig-University Giessen Giessen Germany Institute of Inorganic and Analytical Chemistry Justus-Liebig-University Giessen Giessen Germany

Carbon fiber-reinforced thermoplastics (CFRP) have excellent specific strength and rigidity, which has made them a popular material for lightweight construction. The growing demand for fiber-reinforced plastics (FRP) leads to the problem of the sustainable handling of FRP at the end of their life cycle. The aim of the research project was to gain knowledge about the shredding of FRP concerning the optimal machine and process design of the shredding process and the possible formation of harmful, inhalable dust fractions and WHO fibers. Toxicity should be investigated at the cellular level. The investigated shredding parameters influence the amount and length of fiber dust produced, both when shredding with a cutting mill and when shredding with a single-shaft shredder. In all investigations, an increasing rotational speed leads to an increase in the fiber dust mass or the fiber concentration. The proportion of short, respirable fibers increases, but raising the speed does not lead to a further, significant shortening of the fibers. A reduction in feedstock size leads to a slightly reduced mass of fiber dust in the ground material. A reduction in the screen size also leads to an increase in fiber dust mass and concentration. There was no recognizable cytotoxicity in the relevant concentration range up to 500 μg/cm2 and no significant induction of cell migration. This indicates minor flammable effects of the dust formed after inhalation. The biological data indicate that the WHO fibers produced by shredding are only a minor health hazard. Formally, the detected carbon fiber (CF) fragments meet the fiber definition of the legislator. However, carbon fibers currently have no specific limit value.

关键词： Carbon Fibers Fiber Dust Recycling Toxicity

Machine learning in nutrient management:A review

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Artificial Intelligence in Agriculture 2023年第3期9卷 1-11页

作者： Oumnia Ennaji Leonardus Vergütz Achraf El Allali Chair of Soil Science University Mohammed VI PolytechnicLot 660Hay Moulay RachidBenguerir 43150Morocco African genome Center University Mohammed VI PolytechnicLot 660Hay Moulay RachidBenguerir 43150Morocco

In agriculture,precise fertilization and effective nutrient management are *** learning(ML)has recently been increasingly used to develop decision support tools for modern agricultural systems,including nutrient management,to improve yields while reducing expenses and environmental *** based systems require huge amounts of data from different platforms to handle non-linear tasks and build predictive models that can improve agricultural *** study reviews machine learning based techniques for estimating fertilizer and nutrient status that have been developed in the last decade.A thorough investigation of detection and classification approaches was conducted,which served as the basis for a detailed assessment of the key challenges that remain to be *** research findings suggest that rapid improvements in machine learning and sensor technology can provide cost-effective and thorough nutrient assessment and decision-making *** research directions are also recommended to improve the practical application of this technology.

关键词： Fertilization Nutrient management Machine learning

Fever without a source in children:international comparison of guidelines

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World journal of Pediatrics 2023年第2期19卷 120-128页

作者： Sanne graaf Maya Wietske Keuning Dasja Pajkrt Frans Berend Plötz Department of Pediatrics Tergooi HospitalRijksstraatweg 11261 ANBlaricumThe Netherlands Department of Pediatrics Amsterdam University Medical CentersLocation Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Department of Pediatric Infectious Diseases Amsterdam University Medical CentersLocation Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

Background Fever without a source(FWS)in children poses a diagnostic *** distinguish a self-limiting infection from a serious infection,multiple guidelines have been developed to aid physicians in the management of ***,there is no comparison of existing FWS *** This comparative review describes consistencies and differences in guideline definitions and diagnostic and therapeutic recommendations.A literature search was performed to include secondary care FWS guidelines of high-income countries,composed by national or regional pediatric or emergency care associations,available in English or *** Ten guidelines of five high-income countries were included,with varying age ranges of children with *** children younger than one month with FWS,the majority of the guidelines recommended laboratory testing,blood and urine culturing and antibiotic treatment irrespective of the clinical condition of the *** for blood culture and antibiotic treatment varied for children aged 1–3 *** children aged above three months,urine culture recommendations were inconsistent,while all guidelines consistently recommended cerebral spinal fluid testing and antibiotic treatment exclusively for children with a high risk of serious *** We found these guidelines broadly consistent,especially for children with FWS younger than one *** variation was seen most in the targeted age ranges and in recommendations for children aged 1–3 months and above three months of *** findings of the current study can assist in harmonizing guideline development and future research for the management of children with FWS.

关键词： Children Fever guideline

The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells

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Science China(Life Sciences) 2014年第4期57卷 412-421,1-3页

作者： CHEN jinYan SUN MengRu WANg XingHua LU jing WEI Yan TAN Yan LIU Ying gtz jürgen HE RongQiao HUA Qian Beijing University of Chinese Medicine Clem jones Centre for Ageing Dementia Research Queensland Brain Institute The University of QueenslandBrisbane Institute of Biophysics Chinese Academy of Sciences

The herbal medicine Tong Luo jiu Nao(TLjN)contains geniposide(gP)and ginsenoside Rg1 at a molar ratio of 10:***1 is the major component of another herbal medicine,panax notoginseng saponin(PNS).TLjN has been shown to strengthen brain function in humans,and in animals it improves learning and *** have previously shown that TLjN reduces amyloidogenic processing in Alzheimer’s disease(AD)mouse *** this suggests TLjN may be a potential treatment for patients with *** chronic damage of the central nervous system by formaldehyde(FA)has been presented as a risk factor for age-associated cognitive dysfunction,in the present study we investigated the protective effect of both TLjN and gP in neuron-like cells exposed to ***-exposed murine N2a neuroblastoma cells were incubated with TLjN,its main ingredient gP,as well as PNS,to measure cell viability and morphology,the rate of apoptosis and expression of genes encoding Akt,FOXO3,Bcl2 and *** CCK-8 assay,cytoskeletal staining and flow cytometry were used to test cell viability,morphology and apoptosis,*** quantitative real-time PCR(qRT-PCR)was used to monitor changes in gene expression,and HPLC to determine the rate of FA *** of N2a cells with 0.09 mmol L?1 FA for 24 h significantly reduced cell viability,changed cell morphology and promoted *** TLjN and gP conferred neuroprotection to FA-treated N2a cells,whereas PNS,which had to be used at lower concentrations because of its toxicity,did *** data demonstrate that TLjN can rescue neuronal damage caused by FA and that its main ingredient,gP,has a major role in this *** presents purified gP as a drug or lead compound for the treatment of AD.

关键词：神经母细胞瘤细胞凋亡中药复方栀子苷甲醛定量RT-PCR 神经保护作用阿尔茨海默氏病

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Breast reconstruction:Review of current autologous and implantbased techniques and long-term oncologic outcome

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World journal of Clinical Cases 2023年第10期11卷 2201-2212页

作者： Mahdi Malekpour Fatemeh Malekpour Howard tz-Ho Wang Department of Plastic and Reconstructive Surgery University of Texas Health San AntonioSan AntonioTX 78229United States

Implant-based reconstruction is the most common method of breast *** breast reconstruction is an indispensable option for breast reconstruction demanding keen microsurgical skills and robust anatomical *** reconstructive choice is made by the patient after a discussion with the plastic surgeon covering all the available *** and disadvantages of each technique along with long-term oncologic outcome are reviewed.

关键词： Breast Reconstruction Mammaplasty Breast Implant Autologous Reconstruction Oncologic Outcome Breast Neoplasms

Design of metal-organic frameworks for improving pseudo-solid-state magnesium-ion electrolytes:Open metal sites,isoreticular expansion,and framework topology

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journal of Materials Science & Technology 2023年第13期144卷 15-27页

作者： Yun Zheng junpo guo De Ning Yike Huang Wen Lei jing Li jianding Li götz Schuck jingjun Shen Yan guo Qi Zhang Hao Tian Hou Ian Huaiyu Shao guangdong-Hong Kong-Macao joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeMacao 999078China Centre for Photonics Information and Energy Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China School of Science Huzhou UniversityHuzhou 313000China Helmholtz-Center Berlin for Materials and Energy Albert-Einstein-StreetBerlin 1512489Germany Cancer Center and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China

The design criteria for metal-organic frameworks(MOFs)have been established by evaluating the rela-tionship between their key characteristics and magnesium-ion conductivity based on three types of sec-ondary building blocks(Zn_(4)O(CO_(2))_(6):MOF-5 and MOF-177;Cu_(2)(CO_(2))4:MOF-199,MOF-143,MOF-14,and MOF-399;Cu_(2)O_(2)(CO_(2))2:Cu-MOF-74)to achieve pseudo-solid-state magnesium-ion *** found that open-metal sites and channel layouts play a pivotal role in promoting magnesium-ion transport dy-namics at reduced activation energy,transforming MOF scaffolds into ionic-channel analogs.X-ray ab-sorption spectroscopy combined with Raman and Fourier-transform infrared spectroscopy predicted the chemical environment,solvents,and anions that occupied coordinatively unsaturated metal *** chemical compositions of electrolytes determined by^(1)H-NMR(nuclear magnetic resonance)and organic elemental analysis confirmed that isoreticular expansion increases the molar percentage of charge carri-ers,providing high *** current research systematically reveals the impacts of different MOF characteristics on ionic conduction performance,paving the way for the construction of a new class of fast and selective multivalent-ion pseudo-solid electrolytes.

关键词： Magnesium conduction Magnesium battery Metal-organic frameworks Solid-state electrolytes Reticular chemistry

Oligomeric and fibrillar species of β-amyloid(Aβ42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2015年第A期 8-8页

作者： Anne Eckert Susanne Hauptmann Isabel Scherping jessica Meinhardt Virginie Rhein Stefan Dr?se Ulrich Brandt Marcus F?ndrich Walter E.Müller jürgen g?tz

We recently provided evidence for a mitochondrial dysfunction in P301 l tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease(ad) and frontotemporal dementia(ftd). in addition to tau aggregates, the ad brain is further characterized by Aβ peptide-containing plaques. When we addressed the role of Aβ, this indicated a synergistic action of tau and Aβ pathology on the mitochondria. In the present study, we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβ might be the actual toxic species. Interestingly, both oligomeric and fibrillar, but not disaggregated(mainly monomeric) Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301 L tau transgenic mice. This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons. Furthermore, we found reductions in state 3 respiration, the respiratory control ratio, and uncoupled respiration when incubating P301 L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42. Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic, but exert different degrees of toxicity.

关键词： Alzheimer’s disease Amyloid aggregates Amyloid β-peptide Amyloid toxicity Fibrils Frontotemporal dementia globulomer Mitochondria oligomer Protein aggregation respiration tau transgenic mice

Oligomeric and fibrillar species of β-amyloid(A β 42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2015年第99期 1-1页

作者： Anne Eckert Susanne Hauptmann Isabel Scherping jessica Meinhardt Virginie Rhein Stefan Dr?se Ulrich Brandt Marcus F?ndrich Walter E.Müller jürgen g?tz

We recently provided evidence for a mitochondrial dysfunction in P301L tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease(ad) and frontotemporal dementia(ftd). in addition to tau aggregates, the ad brain is further characterized by Aβ peptide-containing plaques. When we addressed the role of Aβ, this indicated a synergistic action of tau and Aβ pathology on the mitochondria. In the present study, we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβ might be the actual toxic species. Interestingly, both oligomeric and fibrillar, but not disaggregated(mainly monomeric) Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301L tau transgenic mice. This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons. Furthermore, we found reductions in state 3 respiration, the respiratory control ratio, and uncoupled respiration when incubating P301L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42. Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic, but exert different degrees of toxicity.

Feature Fusion-Based Deep Learning Network to Recognize Table Tennis Actions

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Computers, Materials & Continua 2023年第1期74卷 83-99页

作者： Chih-Ta Yen tz-Yun Chen Un-Hung Chen guo-Chang WangZong-Xian Chen Department of Electrical Engineering Taiwan Ocean UniversityKeelung City202301Taiwanchina Office of Physical Education National Formosa UniversityYunlin County632Taiwan Department of Electrical Engineering National Formosa UniversityYunlin County 632Taiwan

A system for classifying four basic table tennis strokes using wearable devices and deep learning networks is proposed in this *** wearable device consisted of a six-axis sensor,Raspberry Pi 3,and a power *** kernel sizes were used in convolutional neural network(CNN)to evaluate their performance for extracting ***,a multiscale CNN with two kernel sizes was used to perform feature fusion at different scales in a concatenated *** CNN achieved recognition of the four table tennis *** data were obtained from20 research participants who wore sensors on the back of their hands while performing the four table tennis strokes in a laboratory *** data were collected to verify the performance of the proposed models for wearable ***,the sensor and multi-scale CNN designed in this study achieved accuracy and F1 scores of 99.58%and 99.16%,respectively,for the four *** accuracy for five-fold cross validation was 99.87%.This result also shows that the multi-scale convolutional neural network has better robustness after fivefold cross validation.

关键词： Wearable devices deep learning six-axis sensor feature fusion multi-scale convolutional neural networks action recognit