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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A systemic look at pancreatic cancer patients: Predicting metastasis by studying the liver

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4170-4171页

作者： Susanne Roth Christoph Michalski jörg D.Hoheisel Department of General Surgery University Hospital HeidelbergHeidelbergGermany Division of Functional Genome Analysis German Cancer Research Center(DKFZ)HeidelbergGermany

In a recent paper published in Nature Medicine,Bojmar et *** an elaborate effort toward predicting the metastatic progress of pancreatic ductal adenocarcinoma(PDAC)after primary tumour resection.1 Instead of investigating the tumour,however,they studied several molecular,cellular,and metabolic features in biopsy samples from the seemingly still unaffected liver,which were collected during resection of the primary tumour,demonstrating the large and still neglected biomedical potential of looking at cancer in a systemic manner.

关键词： tumour metastasis al.

Toddy Palm (Borassus Flabellifer) Fruit Fibre Bundles as Reinforcement in Polylactide (PLA) Composites: An Overview About Fibre and Composite Characteristics

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journal of Renewable Materials 2019年第8期7卷 693-711页

作者： Nina Graupner Koranat Narkpiban Thiprada Poonsawat Porntip Tooptompong jörg Müssig The Biological Materials Group Department of BiomimeticsHSB-City University of Applied SciencesBremenGermanyNeustadtswall 30D-28199 BremenGermany Bioproduct Science Department of ScienceFaculty of Liberal Arts and ScienceKasetsart University1 Malaiman RdKamphaeng SaenNakhon Pathom 73140Thailand Department of Botany Faculty of Liberal Arts and ScienceKasetsart University1 Malaiman RdKamphaeng SaenNakhon Pathom 73140Thailand Textile Technology and Innovation Research Unit Department of Textile ScienceFaculty of Agro-IndustryKasetsart University50 Thanon Ngam Wong WanKhwaeng Lat YaoKhet ChatuchukBangkok 10900Thailand Department of Science and Mathematics Faculty of Science and TechnologyRajamangala University of Technology Tawan-OkChonburi 20110Thailand

Toddy palm fruit have an apparent density below 0.8 g/cm³and offer an interesting lightweight construction potential in polylactide(PLA)composites reinforced with 37 mass-%*** fibre bundles show similar mechanical properties compared with coir:tensile strength of 240 MPa,Young´s modulus of 3.8 GPa and an elongation at break of 31%.However,density and diameter(~50μm)of fruit fibre bundles are significantly *** compression moulded composites have a density of 0.9 g/cm³and achieved an unnotched Charpy impact strength of 12 kj/m^(2),a tensile strength of 25 MPa,Young’s modulus of 1.9 GPa and an elongation at break of 9%.Due to the high porosity of the composites and the different stress-strain behaviour of fibre and matrix the fibre-reinforcement potential could not be fully *** stress of the composite was reached at the elongation at break of the PLA-matrix(~2%)while the fibre achieved its maximum stress at an elongation of~31%.After reaching the maximum stress of the composite,the fibres were pulled out from the matrix with low energy absorption,resulting in a decrease in stress and a limited reinforcement ***,the study investigates whether an insect attack by the Asian fruit fly on the mesocarp has a significant influence on the mechanical fibre *** results have shown that only the rough surface of the fibre bundles is smoothed by insect *** mechanical properties were not significantly *** this reason insect-infested fruits of the toddy palm,which are no longer suitable for food production,can be used for the production of sustainable composite materials.

关键词： Toddy palm fibre Borassus flabellifer fibre polylactide(PLA)composite impact strength fibre/matrix adhesion

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基于优化算法的串联体系可靠度分析(英文)

计算力学学报 2004年第6期21卷 665-670页

作者：李刚 meyer j 大连理工大学工业装备结构分析国家重点实验室辽宁大连116024 科罗拉多州立大学化学工程系

结构体系的失效概率数学上可以表示为结构体系失效域上联合概率密度函数的积分,一般情况下很难直接积分求解。近几十年来,结构体系可靠度分析一直是可靠度领域的一个研究热点,人们提出许多方法,如:Monte-Carlo法、重要性抽样法与界限法... 详细信息

结构体系的失效概率数学上可以表示为结构体系失效域上联合概率密度函数的积分,一般情况下很难直接积分求解。近几十年来,结构体系可靠度分析一直是可靠度领域的一个研究热点,人们提出许多方法,如:Monte-Carlo法、重要性抽样法与界限法和概率网络估算技术等,这些算法在求解精度、计算效率、收敛性和易使用性等方面是不同的。本文采用优化算法(改进的可行方向法、序列线性规划和序列二次规划法)进行串联体系可靠度分析,并且与其他算法(HL-RF法、Monte-Carlo法和重要性抽样法)的结果以及一些精确解进行了比较。结果表明,相对于其他算法,基于优化算法的可靠度分析适用性广,在收敛性和健实性等方面具有明显的优势。

关键词：体系可靠度一次二阶矩法优化算法 Monte—Carlo法重要性抽样法

The impact of salps(Salpa thompsoni)on the Antarctic krill population(Euphausia superba):an individual-based modelling study

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Ecological Processes 2023年第1期12卷 680-695页

作者： Bruno Walter Pietzsch Aaron Schmidt jürgen Groeneveld Dominik Bahlburg Bettina meyer Uta Berger Faculty of Environmental Sciences Institute of Forest Growth and Forest Computer SciencesTechnische Universität Dresden01062 DresdenGermany Department of Ecological Modelling Helmholtz Centre for Environmental Research-UFZLeipzigGermany Section Polar Biological Oceanography Alfred Wegener Institute Helmholtz Centre for Polar and Marine ResearchBremerhavenGermany Institute for Chemistry and Biology of the Marine Environment(ICBM) Carl-Von-Ossietzky UniversityOldenburgGermany Helmholtz Institute for Marine Functional Biodiversity(HIFMB) OldenburgGermany

Background Krill(Euphausia superba)and salps(Salpa thompsoni)are key macrozooplankton grazers in the Southern Ocean ***,due to differing habitat requirements,both species previously exhibited little spatial *** ongoing climate change-induced seawater temperature increase and regional sea ice loss,salps can now extend their spatial distribution into historically krill-dominated areas and increase rapidly due to asexual reproduction when environmental conditions are *** the potential effects on krill is crucial,since krill is a species of exceptional trophic significance in the Southern Ocean food *** impacts on krill could trigger cascading effects on its predators and *** address this question,we combined two individual-based models on salps and krill,which describe the whole life cycle of salp individuals and the dynamic energy budget of individual *** resulting new model PEKRIS(PErformance of KRIll ***)simulates a krill population for 100 years under varying chlorophyll-a concentrations in the presence or absence of *** All of the investigated krill population properties(abundance,mean length,and yearly egg production)were significantly impacted by the presence of *** the other hand,salp density was not impacted if krill were *** medians of krill population properties deviated during variable maximum chlorophyll-a density per year when salps were introduced by−99.9%(−234 individuals per 1000 m3)for krill density,−100%(−22,062 eggs per 1000 m3)for krill eggs and−0.9%(−0.3 mm)for mean length of *** If both species compete for the same food resource in a closed space,salps seem to inhibit krill *** simulation studies should investigate whether this effect prevails if different phytoplankton sizes and consumption preferences of krill are ***,direct predation of the two species or consumption of krill fecal pellets by salps could c

关键词： Euphausia superba Salpa thompsoni Individual-based model Food competition Population dynamics DEB theory

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STABILIZED FEM FOR CONVECTION-DIFFUSION PROBLEMS ON LAYER-ADAPTED MESHES

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journal of Computational Mathematics 2009年第2期27卷 266-279页

作者： Hans-Grg Roos TU Dresden Germany

The application of a standard Galerkin finite element method for convection-diffusion problems leads to oscillations in the discrete solution, therefore stabilization seems to be necessary. We discuss several recent stabilization methods, especially its combination with a Galerkin method on layer-adapted meshes. Supercloseness results obtained allow an improvement of the discrete solution using recovery techniques.

关键词： Singular perturbations Convection-diffusion Finite element method Stabi-lization Layer-adapted mesh Superconvergenee Recovery

“When you’re down, stay down”:A lesson for all competitive alpine skiers supported by an ACL rupture measured in vivo

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journal of Sport and Health Science 2022年第1期11卷 14-20页

作者： jörg Spöorri Erich Müller josef Kröoll Sports Medical Research Group Department of OrthopaedicsBalgrist University HospitalUniversity of ZurichZurich 8008Switzerland University Centre for Prevention and Sports Medicine Department of OrthopaedicsBalgrist University HospitalUniversity of ZurichZurich 8008Switzerland Department of Sport Science and Kinesiology University of SalzburgHallein-Ri 5400Austria

Background:During an experiment,a ski racer equipped with various measurement devices suffered an anterior cruciate ligament(ACL)rupture in his right *** aim of this study was to describe the underlying injury mechanism from a functional ***:Eight giant slalom turns(i.e.,4 left turns),followed by 1 left turn at which the ACL injury occurred,were recorded by 2 video cameras,electromyography of 4 relevant muscle groups,inertial measurement units to measure knee and hip angles,and pressure insoles to determine ground reaction ***:Due to a loss of balance,the ski racer began to slide sideways at the apex of a left *** sliding,his right(outside)leg was actively abducted upward without touching the *** ski racer then attempted to stand up again by dropping his leg back towards the snow *** end of this dropping was accompanied by a decrease in electromyographic activity in the knee stabilizing *** the inside edge of the outer ski caught the snow surface,a rapidly increasing peak force,knee flexion,and an aggressive sudden activation of the vastus medialis muscle were observed,while biceps femoris and rectus femoris further decreased their activation *** likely resulted in excessive anterior translation of the tibia relative to the femur,causing damage to the ***:Our example emphasizes that ski racers should not get up until they stop ***:“When you’re down,stay down.”

关键词： Alpine skiing Athletes Injury mechanism Injury prevention Knee injuries

Interference screws *** anchors for isolated medial patellofemoral ligament femoral fixation:A systematic review

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journal of Sport and Health Science 2022年第1期11卷 123-129页

作者： Filippo Migliorini Alice Baroncini jörg Eschweiler Markus Tingart Nicola Maffulli Department of Orthopaedics University Clinic AachenRheinisch-Westfälische Technische Hochschule(RWTH)Aachen University ClinicAachen 52074Germany Department of Medicine Surgery and DentistryUniversity of SalernoBaronissi 84081Italy School of Pharmacy and Bioengineering School of MedicineKeele UniversityStoke on Trent ST47QBUK Centre for Sports and Exercise Medicine Barts and the London School of Medicine and DentistryMile End HospitalQueen Mary University of LondonLondon E14DGUK

Purpose:The present study aimed to systematically review and compare 2 femoral autograft fixation techniques,namely,interference screws and suture anchors,for isolated medial patellofemoral ligament reconstruction in patients with recurrent patellofemoral instability at mid-to long-term ***:A literature search was performed in September *** studies reporting the outcomes of primary isolated medial patellofemoral ligament reconstruction for recurrent patellofemoral instability were considered for *** studies reporting the type of femoral autograft fixation under examination were *** reporting data from patients with elevated tibial tuberosity-tibial groove,patella alta,and/or Dejour’s trochlear dysplasia types C and D,were not *** articles reporting data with a minimum follow-up period of 18 months were ***:Data from 19 studies(615 patients)were *** overall age was 24.4±6.7 years(mean±SD).The mean follow-up was 46.5±20.9 *** were 76 patients in the anchor group and 539 in the screw *** was found with regard to age and follow-up duration between the 2 study *** was comparability between the Kujala,Lysholm,and Tegner scores at *** the last follow-up,no worthy differences were found in terms of mean Kujala(+2.1%;p=0.04),Lysholm(+1.7%;p=0.05),and Tegner(+15.8%;p=0.05)*** complications occurred almost exclusively in the screw cohort,no statistically significant difference was ***:Femoral autograft fixation through interference screws or suture anchors report similar clinical scores and rate of apprehension test,persistent joint instability,re-dislocations,and *** results must be interpreted within the limitations of the present study.

关键词： Femoral fixation Medial patellofemoral ligament reconstruction Patellofemoral instability

Dynamics and functions of E‑cadherin complexes in epithelial cell and tissue morphogenesis

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Marine Life Science & Technology 2023年第4期5卷 585-601页

作者： Na Zhang Matthias Häring Fred Wolf jörg Großhans Deqing Kong Department of Biology Philipps University35043 MarburgGermany Göttingen Campus Institute for Dynamics of Biological Networks(CIDBN) Georg August University Göttingen37073 GöttingenGermany

Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue.E-cadherin–catenin complexes mediate Ca^(2+)-dependent trans-homodimerization and constitute the kernel of adherens *** the basic function of cell–cell adhesion,recent progress sheds light the dynamics and interwind interactions of individual E-cadherin–catenin complex with E-cadherin superclusters,contractile actomyosin and mechanics of the cortex and *** nanoscale architecture of E-cadherin complexes together with cis-interactions and interactions with cortical actomyosin adjust to junctional tension and mechano-transduction by reinforcement or weakening of specific features of the *** post-translational modifications such as phosphorylation and glycosylation have been implicated,their role for specific aspects of in E-cadherin function has remained ***,we provide an overview of the E-cadherin complex in epithelial cell and tissue morphogenesis focusing on nanoscale architectures by super-resolution approaches and post-translational modifications from recent,in particular in vivo,***,we review the computational modelling in E-cadherin complexes and highlight how computational modelling has contributed to a deeper understanding of the E-cadherin complexes.

关键词： Nanoscale architectures Phosphorylation Glycosylation Computational modelling

Promoting electrochemical reduction of CO_(2) to ethanol by B/N-doped sp^(3)/sp^(2) nanocarbon electrode

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Chinese Chemical Letters 2022年第10期33卷 4691-4694页

作者： Yanming Liu Haolei Yang Xinfei Fan Bing Shan Thomas j.meyer Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China Department of Chemistry University of North Carolina at Chapel HillChapel HillNorth Carolina 27599United States College of Environmental Science and Engineering Dalian Maritime UniversityDalian 116026China

Electrochemical reduction of CO_(2) to value-added chemicals holds promise for carbon utilization and renewable electricity ***,selective CO_(2) reduction to multi-carbon fuels remains a significant ***,we report that B/N-doped sp^(3)/sp^(2) hybridized nanocarbon(BNHC),consisting of ultra-small nanoparticles with a sp^(3) carbon core covered by a sp^(2) carbon shell,is an efficient electrocatalyst for electrochemical reduction of CO_(2) to ethanol at relatively low ***_(2) reduction occurs with a Faradaic efficiency of 58.8%-69.1% for ethanol and acetate production at -0.5∼-0.6 V(***),among which 51.6%-56.0% is for *** high selectivity for ethanol is due to the integrated effect of sp^(3)/sp^(2) carbon and B/N *** sp^(3) carbon and B/N doping contribute to enhanced ethanol production with sp^(2) carbon reducing the overpotential for CO_(2) reduction to ethanol.

关键词： CO_(2)reduction Ethanol B/N-doped sp^(3)/sp^(2)hybridized nanocarbon Electrocatalysis multi-carbon product