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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Why Marginal Pricing?

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journal of Modern Power Systems and Clean Energy 2023年第3期11卷 693-697页

作者： antonio j.Conejo Department of Integrated Systems Engineering and the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOhio 43210USA

Under perfect competition,marginal pricing results in short-term efficiency and the subsequent right short-term price ***,the main reason for the adoption of marginal pricing is not the above,but investment cost *** is,the fact that the profits obtained by infra-marginal technologies(technologies whose production cost is below the marginal price)allow them just to recover their investment *** the other hand,if the perfect competition assumption is removed,investment over-recovery or under-recovery generally occurs for infra-marginal technologies.

关键词： Electricity market marginal pricing investment cost recovery maximum social welfare right spatial and temporal price signals

Storing Freshwater Versus Storing Electricity in Power Systems with High Freshwater Electric Demand

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journal of Modern Power Systems and Clean Energy 2024年第2期12卷 323-333页

作者： Mubarak j.Al-Mubarak antonio j.Conejo Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOHUSA Department of Electrical Engineering Kuwait UniversityP.O.Box 5969Safat 13060Kuwait Department of Integrated Systems Engineering and the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH 43210USA IEEE

We consider a power system whose electric demand pertaining to freshwater production is high(high freshwater electric demand),as in the Middle East,and investigate the tradeoff of storing freshwater in tanks versus storing electricity in batteries at the day-ahead operation *** storing freshwater and storing electricity increase the actual electric demand at valley hours and decrease it at peak hours,which is generally beneficial in term of cost and ***,to what extent?We analyze this question considering three power systems with different generation-mix configurations,i.e.,a thermal-dominated mix,a renewable-dominated one,and a fully renewable *** generation-mix configurations are inspired by how power systems may evolve in different countries in the Middle *** production uncertainty is compactly modeled using chance *** draw conclusions on how both storage facilities(freshwater and electricity)complement each other to render an optimal operation of the power system.

关键词： Power system operation freshwater production and transportation coordination day-ahead scheduling

Equilibria in Interdependent Natural-gas and Electric Power Markets: an Analytical Approach

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journal of Modern Power Systems and Clean Energy 2021年第4期9卷 776-787页

作者： Seyedamirabbas Mousavian Beheshteh Raouf antonio j.Conejo David D.Reh School of Business Clarkson UniversityPotsdamNew York 13699-5790USA Department of Electrical and Computer Engineering Clarkson UniversityPotsdamNew York 13699-5790USA Department of Integrated Systems Engineering and Department of Electrical and Computed Engineering The Ohio State UniversityColumbusOhio 43210USA

Natural-gas and electric power systems and their corresponding markets have evolved over time independently. However, both systems are increasingly interdependent since combined cycle gas turbines that use natural gas to produce electricity increasingly couple them together. Therefore, suitable analysis techniques are most needed to comprehend the consequences on market outcomes of an increasing level of integration of both systems. There is a vast literature on integrated natural-gas and electric power markets assuming that the two markets are operated centrally by a single operator. This assumption is often untrue in the real world, which necessitates developing models for these interdependent yet independent markets. In this vein, this paper addresses the gap in the literature and provides analytical Nash-Cournot equilibrium models to represent the joint operation of natural-gas and electric power markets with the assumption that the market participants in each market make their own decisions independently seeking the maximum profits, as often is the case in the real world. We develop an analytical equilibrium model and apply the Karush-Kuhn-Tucker (KKT) approach to obtain Nash-Cournot equilibria for the interdependent natural-gas and electric power markets. We use a double-duopoly case to study the interaction of both markets and to derive insightful analytical results. Moreover, we derive closed-form analytical expressions for spot-market equilibria in both natural-gas and electric power markets, which are relevant and of practical significance for decision makers. We complement the double-duopoly study with a detailed sensitivity analysis.

关键词： Electric power market natural-gas market Nash-Cournot equilibria analytical equilibrium model

Using electricity options to hedge against financial risks of power producers

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journal of Modern Power Systems and Clean Energy 2013年第2期1卷 101-109页

作者： Salvador PINEDA antonio j.CONEjO Center for Electric Technology Department of Electrical EngineeringTechnical University of DenmarkKgs.LyngbyDenmark University of Castilla-La Mancha Ciudad RealSpain

As a consequence of competition in electricity markets,a wide variety of financial derivatives have emerged to allow market agents to hedge against *** options and forward contracts constitute adequate instruments to manage the financial risks pertaining to price volatility or unexpected unit failures faced by power producers.A multi-stage stochastic model is described in this tutorial paper to determine the optimal forward and option contracting decisions for a risk-averse power *** key features of electricity options to reduce both price and availability risks are illustrated by using two examples.

关键词： Price risk Availability risk Stochastic programming Forward contracts Electricity options

A SHORT NOTE ABOUT EXPOSED POINTS IN REAL BANACH SPACES

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Acta Mathematica Scientia 2008年第4期28卷 797-800页

作者： antonio Aizpuru Francisco j Garcia-Pacheco Departamento de Matemá ticas Universidad de Cá diz Department of Mathematical Sciences Kent State University

We express the set of exposed points in terms of rotund points and non-smooth *** long as we have Banach spaces each time＂bigger＂,we consider sets of non-smooth points each time＂smaller＂.

关键词： Exposed point exposed face rotund point smooth point

Comprehensive Survey and Critical Evaluation of the Performance of State-of-the-art LED Drivers for Lighting Systems

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Chinese journal of Electrical Engineering 2021年第2期7卷 21-36页

作者： Fernando Bento antonio j.Marques Cardoso CISE-Electromechatronic Systems Research Centre University of Beira InteriorCovilhã6201-001Portugal

The adoption of light-emitting diodes(LEDs)for lighting applications is becoming increasingly relevant as this recent technology is *** the recent uptake of LED lighting technologies for distinctive end-uses,the research community has also committed to the development of an ever-increasing range of power electronic converters that are suitable for yielding maximum quality lighting,high efficiency,and long *** one of the most recent and promising technologies of the moment,it is vital to fully understand the performance and merits of each state-of-the-art LED lighting ***,this paper compiles essential information about a broad range of state-of-the-art LED lighting systems,aiming to compare their performances in terms of *** on the comparative analysis,the main merits and drawbacks of each LED lighting system architecture are ***,a detailed evaluation of the performance of a particular LED lighting system and the corresponding control strategy is developed,thereby enabling a clear view of the evolution of the performance of the system as a function of parameters like supply voltage and number of driver channels.

关键词： Efficiency analysis LED lighting AC-DC converters DC-DC converters

Benefits of Stochastic Optimization for Scheduling Energy Storage in Wholesale Electricity Markets

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journal of Modern Power Systems and Clean Energy 2021年第1期9卷 181-189页

作者： Hyeong jun Kim Ramteen Sioshansi antonio j.Conejo the Department of Integrated Systems Engineering The Ohio State UniversityColumbusOhioUSA the Department of Electrical and Computer Engineering The Ohio State UniversityColumbus.OhioUSA

We propose a two-stage stochastic model for optimizing the operation of energy storage. The model captures two important features: uncertain real-time prices when day-ahead operational commitments are made;and the price impact of charging and discharging energy storage. We demonstrate that if energy storage has full flexibility to make real-time adjustments to its day-ahead commitment and market prices do not respond to charging and discharging decisions, there is no value in using a stochastic modeling framework, i.e., the value of stochastic solution is always zero. This is because in such a case the energy storage behaves purely as a financial arbitrageur day ahead, which can be captured using a deterministic *** show also that prices responding to its operation can make it profitable for energy storage to "waste" energy, for instance by charging and discharging simultaneously, which is normally sub-optimal. We demonstrate our model and how to calibrate the price-response functions from historical data with a practical case study.

关键词： Energy storage stochastic optimization value of stochastic solution electricity market

Expansion Planning for Renewable Integration in Power System of Regions with Very High Solar Irradiation

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journal of Modern Power Systems and Clean Energy 2021年第3期9卷 485-494页

作者： Musfer Alraddadi antonio j.Conejo Ricardo M.Lima the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH 43210USA the Department of Integrated Systems Engineering and the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH 43210USA King Abdullah University of Science and Technology Thuwal 23955-6900Kingdom of Saudi Arabia

In this paper,we address the long-term generation and transmission expansion planning for power systems of regions with very high solar *** target the power systems that currently rely mainly on thermal generators and that aim to adopt high shares of renewable *** propose a stochastic programming model with expansion alternatives including transmission lines,solar power plants(photovoltaic and concentrated solar),wind farms,energy storage,and flexible combined cycle gas *** model represents the longterm uncertainty to characterize the demand growth,and the short-term uncertainty to characterize daily solar,wind,and demand *** use the Saudi Arabian power system to illustrate the functioning of the proposed model for several cases with different renewable integration *** results show that a strong dependence on solar power for high shares of renewable sources requires high generation capacity and storage to meet the night demand.

关键词： Generation and transmission expansion planning uncertainty solar power wind power