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Neural regeneration research 2025年第4期20卷 1081-1082页

作者： john Mitrofanis jonathan Stone Michael r.Hamblin Pierre Magistretti Alim-Louis Benabid Glen jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural regeneration research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Anisotropic plastic deformation behavior of as-extruded ZK60 magnesium alloy at room temperature

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Science China(Technological Sciences) 2009年第1期52卷 161-165页

作者： HANS j r Department of Materials Science and Engineering Norwegian University of Science and Technology

The anisotropic plastic deformation behavior of as-extruded ZK60 magnesium alloy at room tempera-ture (rT) was investigated by compressive and tensile testing in different directions, i.e. the loading axis oriented at 0°, 45° and 90° to the extrusion direction. The relationship between texture and plastic deformation behavior were examined. The results show that the extruded ZK60 alloy exhibits a strong ring fiber texture. The mechanical properties are strongly orientation dependent. In tension testing, the 0° specimen exhibited higher yield strength and lower elongation. In compression testing, however, ZK60 alloy exhibited almost the same yield strength in three directions. The anisotropic plastic defor-mation behavior is due to strong fiber texture and the lower symmetry of the hexagonal close packed (hcp) structure of ZK60 alloy. The correlation between texture and mechanical behaviour offers the possibility to improve the mechanical properties of magnesium alloy by optimization of the material production process.

关键词： anisotropic plastic deformation behavior ZK60 Mg alloy texture mechanical property

Stress Analysis of Bolted joints Part II. Contact and Slip Analysis of a Four Bolt joint

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Modern Mechanical Engineering 2014年第1期4卷 46-55页

作者： László Molnár Károly Váradi jános Holubán Andor Tamási Department of Machine and Product Design Budapest University of Technology and Economics Budapest Hungary

For up-to-date bolted joints, first of all in vehicles, high strength bolts of 10.9 or even 12.9 are used, which are preloaded up to 90% or even 100% of the yield strength. The primary aim of this high degree utilization is the weight reduction. For the analytic dimensioning of bolted joints, the VDI 2230 richtlinien German standard [1] provides support. However, the analytic model can mostly consider the true structural characteristics only in a limited way. The analytic modeling is especially uncertain in case of multiple bolted joints when the load distribution among the bolts depends reasonably upon the elastic deformation of the participating elements in the joints over the geometry of the bolted joint. The first part of this paper deals with the problems of numerical modeling and stress analysis, respectively specifying the analytic dimensioning procedure by applying elastic or rather elastic-plastic material law. The error magnitude in bolted joint calculation was examined in case of omitting the existing threaded connection—between the bolt and the nut—in order to simplify the model. The second part of the paper deals with the dimensioning of stands and cantilevers’ multi-bolt fixing problems, first of all, with the load distribution among the bolts keeping in view the analysis of the local slipping relations. For demonstrating the above technique, an elaborated numeric procedure is presented for a four-bolted cantilever, having bolted joints pre-tightened to the yield strength.

关键词： Bolted joints Numerical Modeling Stress Analysis

Multiphysics of multifunctional nanofluids based on different oxides nanoparticles and glycerol fluid

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Particuology 2023年第5期76卷 46-62页

作者： r.j.Sengwa Mukul Saraswat Dielectric research Laboratory Department of PhysicsJai Narain Vyas UniversityJodhpur342005India

Nanofluid(NF)materials consisting of glycerol(Gly)and different inorganic nano oxides(TiO_(2),ZnO,Al_(2)O_(3),and SiO_(2) for the oxides concentration of 0.01 wt%to the weight of Gly base fluid)were prepared by a two-step method through ultrasonic cavitation *** nanofluids were investigated by employing an X-ray diffractometer(XrD),ultraviolet-visible(UV-Vis)spectrophotometer,20 Hz to 1 MHz frequency range dielectric relaxation spectroscopy(DrS),ultrasonic interferometer,and rotational *** multiphysics of these nanofluids includes structural and optical properties,dielectric permittivity,electrical conductivity,conductivity relaxation,ultrasound velocity,adiabatic compress-ibility,acoustic impedance,viscosity,density,thermal conductivity,and viscoacoustic relaxation were *** XrD patterns identified monodispersed and stable suspensions of these different characteristic nanoparticles in the hydrogen-bonded 3D supramolecular structure of ultra-high viscous glycerol fluid which were supported by their UV-Vis absorbance *** energy band gap values of the TiO_(2)and ZnO containing nanofluids were found primarily ruled by the characteristic optical prop-erties of these oxides *** complex dielectric and various electrical functions studied at 25℃revealed that the suspension of different oxide nanoparticles in the glycerol fluid increased the static permittivity whereas reduced the direct current electrical conductivity which showed strong conductivity relaxation process *** rheological measurements of the formulated nanofluids were performed over a shear rate range of 0.4-40 s^(-1)at temperatures of 25-55℃.The linear rela-tionship between shear rate and shear stress and also the shear rate-independent viscosity revealed the Newtonian behaviour of these *** shear viscosity non-linearly decreased with the increase of temperature and exhibited the Arrhenius behaviour for all different oxides contain

关键词： Glycerol Nano oxides Nanofluids Optical properties Dielectric properties Thermophysical parameters

Management of Crohn’s disease in smokers:Is an alternative approach necessary?

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World journal of Gastroenterology 2011年第31期17卷 3567-3574页

作者： Pilar nos Eugeni Domènech Gastroenterology Unit La Fe University Hospital Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas(CI-BErEHD) MadridSpain Digestive Disease Department Germans Trias i Pujol Hospital

Inflammatory bowel disease(IBD) is a chronic condition with a pathogenic background that involves both genetic and environmental *** important progress has been made regarding the former in the last decade,scarce knowledge is available for the *** this sense,smoking remains the most important environmental factor in *** smoking increases the risk of developing Crohn's disease(CD).Moreover,CD patients who start or continue smoking after disease diagnosis are at risk for poorer outcomes such as higher therapeutic requirements and disease-related complications,as compared to those patients who quit smoking or who never ***,the harmful effect of active smoking is not uniform in all patients or in all clinical *** designed to facilitate smoking cessation may impact the course of the *** this article,the available evidence of the deleterious effects of smoking on CD is reviewed in detail,and alternative therapeutic approaches to CD in smokers are proposed.

关键词： Tobacco Crohn's disease Therapy Smoking cessation recurrence Complications

Laser induced photo-detachment of O2 in DC discharge

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Plasma Science and Technology 2018年第7期20卷 98-105页

作者： j r legorreta j l patiNo f b yousif Centro de Investigacion en Ciencias Universidad Autonoma del Estado de Morelos.Av.UniversidadNo.1001 Col.Chamilpa Cuemavaca MorelosMexico

Determination of the negative ion number density of O2 and O in a DC discharge of oxygen plasma was made employing Langmuir probe in conjunction with eclipse laser photo- detachment technique. The temporal evolution of the extra electrons resulting from the photo- detachment of O2- and O- were used to evaluate the negative ion number density. The ratio of O2 number density to O varied from 0.03 to 0.22. Number density of both O~ and O increased with increasing power and decreased as the pressure was increased. Electron number density was evaluated from the electron energy distribution function （EEDF） using the I-V recorded characteristic curves. Electron temperature between 2 and 2.7 eV were obtained. Influence of the 02（al△g） metastable state is discussed.

关键词： electronegative plasma electron temperature Langmuir probe negative ion number density

Made-to-measure galaxy modelling utilising absorption line strength data

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research in Astronomy and Astrophysics 2016年第12期16卷 89-100页

作者： r.j.Long National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China jodrell Bank Centre for Astrophysics School of Physics and Astronomythe University of ManchesterOxford RoadManchester M13 9PLUK

We enhance the Syer ＆ Tremaine made-to-measure （M2M） particle method of stellar dynamical modelling to model simultaneously both kinematic data and absorption line strength data, thus creating a ＇chemo-M2M＇ modelling scheme. We apply the enhanced method to four galaxies （NGC 1248, NGC 3838, NGC 4452, NGC 4551） observed using the SAUrON integral-field spectrograph as part of the ATLAS3D programme. We are able to reproduce successfully the 2D line strength data achieving mean X2 per bin values of ≈ 1 with 〉 95% of particles having converged weights. Because M2M uses a 3D particle system, we are also able to examine the underlying 3D line strength distributions. The extent to which these dis- tributions are plausible representations of real galaxies requires further consideration. Overall, we consider the modelling exercise to be a promising first step in developing a ＇chemo-M2M＇ modelling system and in understanding some of the issues to be addressed. While the made-to-measure techniques developed have been applied to absorption line strength data, they are in fact general and may be of value in modelling other aspects of galaxies.

关键词： galaxies: abundances --galaxies: formation- galaxies: individual (NGC 1248 NGC 3838,NGC 4452 NGC 4551) -- galaxies: kinematics and dynamics -- galaxies: structure -- methods: numerical

Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural regeneration research 2025年第8期20卷 2218-2230页

作者： rahul Mittal Keelin McKenna Grant Keith Evan McKenna joana r.N.Lemos jeenu Mittal Khemraj Hirani Diabetes research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

revealing the topological phase diagram of ZrTe_(5) using the complex strain fields of microbubbles

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npj Computational Materials 2022年第1期8卷 1685-1691页

作者： Zoltán Tajkov Dániel Nagy Konrád Kandrai jános kol.ai LászlóOroszlány Péter Süle Zsolt EHorváth Péter Vancsó Levente Tapasztó Péter Nemes-Incze Centre for Energy research Institute of Technical Physics and Materials Science1121BudapestHungary Department of Physics of Complex Systems ELTE Eötvös Loránd University1117BudapestHungary ELTE Eötvös Loránd University Department of Biological Physics1117BudapestHungary Budapest University of Technology and Economics 1111BudapestHungary

Topological materials host robust properties,unaffected by microscopic perturbations,owing to the global topological properties of the bulk electron *** in which the topological invariant can be changed by easily tuning external parameters are especially sought *** pentatelluride(ZrTe_(5))is one of a few experimentally available materials that reside close to the boundary of a topological phase transition,allowing the switching of its invariant by mechanical ***,we unambiguously identify a topological insulator–metal transition as a function of strain,by a combination of ab initio calculations and direct measurements of the local charge *** model quantitatively describes the response to complex strain patterns found in bubbles of few layer ZrTe_(5) without fitting parameters,reproducing the mechanical deformation-dependent closing of the band gap observed using scanning tunneling *** calculate the topological phase diagram of ZrTe_(5) and identify the phase at equilibrium,enabling the design of device architectures,which exploit the topological switching characteristics of the system.

关键词： density topological invariant