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In-depth analysis of the influence of bio-silica filler(Didymosphenia geminata frustules)on the properties of Mg matrix composites

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Journal of Magnesium and Alloys 2023年第8期11卷 2853-2871页

作者： izabela B.Zgłobicka Anna Dobkowska Aleksandra Zielińska Ewa Borucinska Mirosław J.Kruszewski RafałZybała Tomasz Płociński Joanna Idaszek Jakub Jaroszewicz Krystian Paradowski Bogusława Adamczyk-Cieślak Kostiantyn Nikiforow Bartosz Bucholc WojciechŚwięszkowski Krzysztof J.Kurzydłowski Faculty of Mechanical Engineering Bialystok University of TechnologyWiejska 45C15-351 BialystokPoland Faculty of Materials Science and Engineering Warsaw University of TechnologyWoloska 14102-507 WarsawPoland Lukasiewicz Research Network–Institute of Microelectronics and Photonics Al.Lotnikow 32/4602-668 WarsawPoland Institute of Physical Chemistry Polish Academy of Sciences Kasprzaka 44/5201-224 WarsawPoland Institute of Fundamental Technological Research Polish Academy of Sciences Pawinskiego 5B02-106WarsawPoland

A novel metal matrix composites(MMC)with Mg matrix reinforced with natural filler in the form of Didymosphenia geminata frustules(algae with distinctive siliceous shells)are presented in this *** plasma sintering(PPS)was used to manufacture Mg-based composites with 1,5 and 10 vol.%ceramic *** a reference,pure Mg was *** results show that the addition of 1 vol.%Didymosphenia geminata frustules to the Mg matrix increases its corrosion resistance by supporting passivation reactions,and do not affect the morphology of L929 *** of 5 vol.%the filler does not cause cytotoxic effects,but it supports microgalvanic reactions leading to the greater corrosion *** content than 5 vol.%the filler causes significant microgalvanic corrosion,as well as increases cytotoxicity due to the greater micro-galvanic effect of the composites containing 10 and 15 vol.%*** results of contact angle measurements show the hydrophilic character of the investigated materials,with slightly increase in numerical values with addition of amount of ceramic *** addition of Didymosphenia geminata frustules causes changes in a thermo-elastic properties such as mean apparent value of coefficient of thermal expansion(CTE)and thermal conductivity(λ).The addition of siliceous reinforcement resulted in a linear decrease of CTE and reduction in thermal conductivity over the entire temperature *** the increasing addition of Didymosphenia geminata frustules,an increase in strength with a decrease in compressive strain is *** all composites an increase in microhardness was *** results clearly indicate that filler in the form of Didymosphenia geminata frustules may significantly change the most important properties of pure Mg,indicating its wide potential in the application of Mg-based composites with a special focus on biomedical use.

关键词： Metal-matrix composites(MMCs) Pulse plasma sintering(PPS) Ceramic filler Microstructure Properties

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CDK5 in RNA Biology:New Clues that may Underlie Neuronal and Glial Diseases

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神经药理学报 2019年第Z1期 16-17页

作者： Andrew Bankston izabela Suster Megan Allen LI Wen-qi KU Li YAO Bing FENG Yue Emory University Pharmacology and Chemical Biology

Cyclin-dependent kinase 5(CDK5) plays key roles in governing normal neuronal development and synaptic function though phosphorylation of serine and threonine residues on diverse protein targets. Emerging evidence also revealed that tightly controlled CDK5 activity is also crucial for the development of oligodendrocytes(OLs) and myelinogenesis,which provide protection and trophic support to brain neurons. Aberrant activation of CDK5 contributes to the pathogenesis of an increasing list of brain disorders,including Alzheimer's disease,stroke,schizophrenia,and epilepsy. However,molecular mechanisms that control CDK5 activity and its downstream effectors in neurons and OLs still remain vastly elusive. Activation of CDK5 depends on the available amounts of p35 or p39,two distinct non-cyclin protein activators. Our recent studies identified distinct mechanisms that regulate CDK5 activators in neurons and OLs during brain development. Here we report posttranscriptional mechanisms that control CDK5 activity in postnatal brain neurons and OLs by a functional interplay of RNA-binding proteins and microRNAs implicated in Alzheimer's disease and intellectual disability. Moreover,we discovered that CDK5-dependnent phosphorylation of RNA-binding proteins controls mRNA homeostasis and non-coding RNA biogenesis,including microRNAs and long non-coding RNAs in human neurons and OLs. These results provide the first evidence connecting CDK5 function with regulation of coding and non-coding transcriptome,which revealed new clues for CDK5 pathway function in normal and diseased brains.

关键词： CDK5 in RNA Biology:New Clues that may Underlie Neuronal and Glial Diseases RNA

Understanding of Socially Vulnerable Individuals on Oral Health and Access to Dentist: A Brazilian Study

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Open Journal of Preventive Medicine 2014年第11期4卷 868-875页

作者： Cristina Berger Fadel Jean Erick Langoski Marina izabela Machado Juliana Maria Stremel Danielle Bordin Joao Alfredo Madalozo Departament of Dentistry State University of Ponta GrossaPonta GrossaBrazil Paulist State University AraçatubaBrazil Departament of Geography State University of Ponta GrossaPonta GrossaBrazil

Social vulnerability experienced by collectors of recyclable materials has a strong influence on their understanding and confrontations health. This research aimed to explore the relationship between oral health and perception of subjects in a context of social disadvantage, in order to support concrete alternatives for action on (oral) health conference. This was a qualitative study carried out with representatives of an autonomous community of Brazilian collectors of recyclable materials. Data were collected through interviews and focus group treated with the technique of qualitative analysis. Respondents showed perceptions of etiology and care practices on oral health promoted beliefs and values collectively instituted in a social risk territory. Also, they associate the quality of their oral health and their difficulty of public access to the context of social vulnerability. This study suggests the adoption of protective, educational and interceptive in oral health practice in order to improve and enable the oral health status of this population.

关键词： Health Care Vulnerable Populations Oral Health

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提高薄膜太阳能电池的效率

集成电路应用 2008年第9期25卷 32-33页

作者： izabela Kuzma Guy Beaucarne Jef Poortmans IMEC

降低硅太阳能电池成本的方法之一是尽量减少高质量硅材料的使用量,如薄膜太阳能电池。不过这种太阳能电池的效率只达到了约11-12%。研究人员们正在寻求提升其效率的方法。

关键词：薄膜太阳能电池硅太阳能电池研究人员使用量硅材料

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Mutations of TP53 Gene and Oxidative Stress in Alzheimer’s Disease Patients

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Advances in Alzheimer's Disease 2014年第1期3卷 24-32页

作者： Jolanta Dorszewska Agata Rozycka Anna Oczkowska Jolanta Florczak-Wyspianska Michal Prendecki Mateusz Dezor izabela Postrach Pawel P.Jagodzinski Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Department of Biochemistry and Molecular Biology Poznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical Sciences10Fredry Str.61-701 PoznanPoland

Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p TP53 (p TP53 (C748A, C708T) may be associated with pathogenesis of AD.

关键词： TP53 8-oxo2dG p53 OGG1 AD

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三亚阜外心血管康复中心

城市环境设计 2011年第Z3期 244-247页

作者：谷建 Jonny Hofmann 李莎 izabela Langner 杜里根中国中元国际工程公司医疗建筑设计研究院IG工作室

"三亚阜外心血管康复中心"依托中国医学科学院阜外心血管病医院一流的专家资源和雄厚的技术实力,结合国家心血管疾病防治研究中心等丰富的专业资源与网络平台.围绕"预防—治疗—康复"这条主线,举办方将为岛内居民和海内外游客以及来岛... 详细信息

"三亚阜外心血管康复中心"依托中国医学科学院阜外心血管病医院一流的专家资源和雄厚的技术实力,结合国家心血管疾病防治研究中心等丰富的专业资源与网络平台.围绕"预防—治疗—康复"这条主线,举办方将为岛内居民和海内外游客以及来岛从事政商经贸活动的各界人士,提供高水平的医疗护理、紧急救护、慢病干预、保健养生和健康教育等全面健康服务。"三亚阜外心血管康复中心"以心血管病诊治和康复疗养为主要特色,力图打造技术、管理、服务、环境达国际一流水准的国际化高端医疗服务机构。

关键词：康复中心三亚心血管病心脏血管疾病中国医学科学院阜外心血管病医院内院保健养生鹿回头医疗护理康复疗养紧急救护举办方

Arabidopsis Protein Phosphatase 2C ABI1 Interacts with Type I ACC Synthases and Is Involved in the Regulation of Ozone-Induced Ethylene Biosynthesis

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Molecular Plant 2014年第6期7卷 960-976页

作者： Agnieszka Ludwikow Agata Ciesla Anna Kasprowicz-Malusk Filip Mitula Malgorzata Tajdel lukasz Gaigarnski Piotr A. Ziolkowski Piotr Kubiak Arleta Malecka Aneta Piechalak Marta Szabat Alicja Gorska Maciej Dabrowskia izabela Ibragimow Jan Sadowski Department of Biotechnology Institute of Molecular Biology and Biotechnology Faculty of Biology Adam Mickiewicz University inPoznan Umultowska 89 61-614 Poznan Poland Institute of Plant Genetics Polish Academy of Science Strzeszynska 34 60-479 Poznan Poland Department of Molecular and Cellular Biology Institute of Molecular Biology and Biotechnology Faculty of Biology Adam MickiewiczUniversity in Poznan Umultowska 89 61-614 Poznan Poland Department of Biotechnology and Food Microbiology University of Life Sciences Wojska Polskiego 48 60-627 Poznan Poland Department of Biochemistry Institute of Molecular Bioloqy and Biotechnology Faculty of Bioloqy Adam Mickiewicz University inPoznan Umultowska 89 61-614 Poznan Poland

Ethylene plays a crucial role in various biological processes and therefore its biosynthesis is strictly regu- lated by multiple mechanisms. Posttranslational regulation, which is pivotal in controlling ethylene biosynthesis, impacts 1-aminocyclopropane 1-carboxylate synthase （ACS） protein stability via the complex interplay of specific factors. Here, we show that the Arabidopsis thaliana protein phosphatase type 2C, ABI1, a negative regulator of abscisic acid signaling, is involved in the regulation of ethylene biosynthesis under oxidative stress conditions. We found that ABI1 interacts with ACS6 and dephosphorylates its C-terminal fragment, a target of the stress-responsive mitogen-activated protein kinase, MPK6. In addition, ABI1 controls MPK6 activity directly and by this means also affects the ACS6 phosphorylation level. Consistently with this, ozone-induced ethylene production was significantly higher in an ABI1 knockout strain （abiltd） than in wild-type plants. Importantly, an increase in stress-induced ethylene production in the abiltd mutant was compen- sated by a higher ascorbate redox state and elevated antioxidant activities. Overall, the results of this study provide evi- dence that ABI1 restricts ethylene synthesis by affecting the activity of ACS6. The ABI1 contribution to stress phenotype underpins its role in the interplay between the abscisic acid （ABA） and ethylene signaling pathways.

关键词： hormonal regulation protein phosphorylation/dephosphorylation signal transduction Arabidopsis.

Epidemiological Profile of Breast Neoplasia in the Municipality of Valença (RJ Brazil): Study from 2009 to 2017

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Journal of Biosciences and Medicines 2020年第6期8卷 179-187页

作者： Catharina Ferrari Salgado Fernandes Helena Torres Passos izabela Cristina Ferreira Marina Coelho de Paulo Raquel Alencar Sampaio Ferraz Filomena Aste Silveira João Alfredo Seixas Daniel Almeida da Costa Faculty of Medicine of Valenç a UNIFAA Valen&ccedil a Brazil

Breast neoplasms are the main oncological pathology in Gynecology and Obstetrics, with increasing rates of incidence and mortality in the female population. According to the World Health Organization (WHO), more than 1 million new cases of breast cancer are diagnosed worldwide every year. This study aims to understand and analyze the epidemiological profile of patients diagnosed with breast cancer in the last nine years in the city of Valença—RJ, Brazil. A descriptive, documentary-retrospective analysis was carried out from January 2009 to December 2017, on 96 records of women who underwent breast biopsy at the Escola Escola de Valença (HEV), referred by the HEV Gynecology outpatient clinic. The results compared the variables age, race, parity, alcoholism, smoking, comorbidities, histological type, family history and screening performed with the scenario of breast cancer in the world, concluding that it is essential to identify patients at risk development of breast cancer to guide prevention, screening and early detection of pathology. The cases in the municipality are similar to other studies in relation to smoking, alcohol consumption, associated comorbidities, histological type and family history. However, the prevalence in younger people stands out, as well as the high percentage of women who have not had previous screening, which highlights the importance of the development and spread of women’s health in this city in the south of the state.

关键词： Breast Neoplasia Epidemiological Profile Comorbidity

ID7 Isolated from Bauhinia variegata Stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative Breast Cancer in Vivo

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 368-384页

作者： Kamilla Monteiro dos Santos izabela Natalia Faria Gomes Renato JoséSilva Oliveira Fernanda E.Pinto Bruno Oliveira Fabrício P.Batista Rafael Cesar Russo Chagas Hélio B.Santos Ralph G.Thomé Wanderson Romao Rui Manuel Reis Maria Luiza Vilela Oliva Rosy Iara Maciel de Azambuja Ribeiro Laboratory of Experimental Pathology Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Josédo Rosário Vellano University UnifenasDivinópolisMGBrazil Molecular Oncology Research Center(CPOM) Barretos Cancer HospitalBarretosSPBrazil Petroleomic and Forensic Chemistry Laboratory Department of ChemistryFederal Institute of Espírito Santo(IFES)VitóriaESBrazil Chemistry Department Federal University of Sao PauloBrazil Tissue Processing Laboratory Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Life and Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoBragaPortugal 3ICVS/3B’s-PT Government Associate Laboratory GuimaraesBragaPortugal

Background:The breast cancer has been the most common form of cancer among *** triple negative subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being *** main cause of death of patients with cancer is due to metastasis,which can reach the liver and ***:The activities of ID7 fraction of the stems of Bauhinia variegata *** breast cancer,lung metastasis and liver inflammatory process were ***:ID7 was characterized by *** viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue and fluorescence assay and viability of BT-20,MDA-MB-231 and MCF-7 human breast cancer tumor lines by *** cell migration,invasion using matrigel and adhesion were *** expression of cell death proteins was quanitified by western blot and the gelatinases by *** ID7 activity of the tumor(4T1)and metastatic progession in vivo was ***:ID7 reduced the 4T1 and MDA-MB-231viability and increased the late apoptosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active ***7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and *** vivo,the ID7 decreased the volume and weight of the tumors and decreased lung metastasis and inflammation in the *** characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ***:Thus,it was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity,preventing lung metastasis and inflammation in the *** is suggested that fatty acids and flavonoids are correlated with such activities.

关键词： 4T1 cells MDA-MB-231 medicinal plants kaempferol gelatinases apoptosis cell viabilty in vivo