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Design multifunctional Mg–Zr coatings regulating Mg alloy bioabsorption

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Journal of Magnesium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Benzarti sandesh Itani JoséDavid Castro sandra carvalho Ana sofia Ramos University of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Materials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magnesium(Mg)alloys are widely used for temporary bone implants due to their favorable biodegradability,cytocompatibility,hemocompatibility,and close mechanical properties to ***,rapid degradation and inadequate strength limit their *** overcome this,the direct current magnetron sputtering technique is employed for surface coating in Mg-based alloys using various zirconium(Zr)*** approach presents a promising strategy for simultaneously improving corrosion resistance,maintaining biocompatibility,and enhancing strength without compromising *** leveraging Mg’s inherent biodegradability,it has the potential to minimize the need for secondary surgeries,thereby reducing costs and *** paper is a systematic study aimed at understanding the corrosion mechanisms of Mg–Zr coatings,denoted Mg-xZr(x=0–5 at.%).Zr-doped coatings exhibited columnar growth leading to denser and refined structures with increasing Zr *** analysis confirmed the presence of the Mg(00.2)basal plane,shifting towards higher angles(1.15°)with 5 at.%Zr doping due to lattice parameter changes(i.e.,decrease and increase of“c”and“a”lattice parameters,respectively).Mg–Zr coatings exhibited“liquidphilic”behavior,while Young’s modulus retained a steady value around 80 GPa across all ***,the hardness has significantly improved across all samples’coating,reaching the highest value of(2.2±0.3)GPa for 5 at.%*** testing in simulated body fluid(sBF)at 37℃ revealed a significant enhancement in corrosion resistance for Mg–Zr coatings containing 1.0–3.4 at.%*** with the 5 at.%Zr coating which exhibited a corrosion rate of 32 mm/year,these coatings displayed lower corrosion rates,ranging from 1 to 12 mm/*** synergistic enhancement in mechanical properties and corrosion resistance,achieved with 2.0–3.4 at.%Zr,suggests potential ability for reducing stress shielding and controlled degradation performance,and consequentl

关键词： Mg-Zr coatings Magnetron sputtering Nanoindentation Corrosion resistance Bone implants

Determination of critical state line(CsL)for silty-sandy iron ore tailings subjected to low-high confining pressures

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1684-1695页

作者： Nilo Cesar Consoli João Vítor de Azambuja carvalho Alexia Cindy Wagner Hugo Carlos scheuermann Filho Inácio carvalho Pedro Pazzoto Cacciari João Paulo de sousa silva Civil Engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil Exploration and Mineral Projects-Mineral Development Centre VALE S.A.Santa LuziaMG33040-900Brazil Department of Civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The disposal of filtered tailings in high dry stacks can induce particle breakage,changing the material's behaviour during the structure's *** grading changes influence material properties at the critical state,and this is not mature for intermediate artificial soils(tailings)in a broad range of confining *** this paper,it aims to describe the behaviour of iron ore tailings in a spectrum of confining pressures broader than the reported in previous studies.A series of consolidated drained(CD)triaxial tests was carried out with confining pressures ranging from 0.075 MPa to 120 *** results show that the amount of breakage plays an essential role in the response of iron ore *** existence of curved critical state line(CsL)in both specific volume(ν)-logarithm of mean effective stress(p′)and deviatoric stress(q)-mean effective stress(p′)planes,and different responses in the deviatoric stress-axial strain-volumetric strain curves were *** inverse s-shaped equation was proposed to represent the silty-sandy tailings'behaviour up to high pressures onν-lnp′*** proposed equation provides a basis for enhancing constitutive models and considers the evolution of the grading up to severe loading *** adjustment considered three regions with different responses associated with particle breakage at different pressure levels.

关键词： Tailings Iron ore tailings dry stacking silty-sandy material Critical state soil mechanics High confining pressures Particle breakage

How far have we come?Review of main public policies to reduce landslide impacts in Brazil

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Journal of Mountain science 2024年第9期21卷 2891-2904页

作者： Bianca carvalho VIEIRA Tiago Damas MARTINs Telma Mendes da sILVA JoséEduardo BONINI Department of Geography University of São PauloAvenida Professor Lineu Prestes 05508-000Brazil Cities Institute Federal University of São PauloAvenida Jacu-Pêssego 08260-001Brazil Department of Geography Federal University of Rio de JaneiroAvenida Athos da Silveira Ramos 21941-916Brazil

During the rainy season in Brazil,landslides can have catastrophic consequences,including loss of life,damage to urban infrastructure and significant economic ***,more than eight million people in Brazil live in disaster-prone *** objective of this article is to present a chronological review of the principal policies and programmes at the national,state,and municipal levels,with an emphasis on their key actions aimed at mitigating the impact of disasters related to natural hazards,particularly *** analysis was based on official records of public policies from the national,state,and municipal *** results show that several initiatives were initially developed at the local and regional ***,it was not until the late 1980s that a comprehensive organisation of civil protection at the national level emerged as a response *** is possible to highlight three phases(understanding,coexistence,and prevention)of institutional action focused on risk management in the face of *** the growing knowledge of risk scenarios,disasters continue to occur in Brazil on an annual basis,revealing several obstacles to reducing their impact,particularly given the social and economic disparities between Brazilian regions and the applicability of public policies that must overcome the limitations of each municipality.

关键词： Disasters Risk Mitigation Prevention Legislation Civil Defense Natural Hazards

Lipedema:A common though often unrecognized condition

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Chinese Journal of Plastic and Reconstructive surgery 2024年第3期6卷 149-153页

作者： Rafael carvalho Private Practice R.Iolanda del Nero Barco101PirassunungaSao Paulo13631-064Brazil

Lipedema is a chronic disorder primarily affecting women,characterized by abnormal fat deposition in the extremities,leading to pain,mobility issues,and psychological *** fat deposits are clear-cut and spare hands and *** misdiagnosed as lymphedema,its prevalence remains uncertain due to a lack of universally accepted diagnostic criteria and difficulty in differentiating it from obesity or *** factors and hormonal influences are likely related to the pathophysiology of the disease,though the specific causes remain *** techniques may aid evaluation,but no definitive test exists,and diagnosis is made *** treatments such as lifestyle modifications and compression garments are considered first-line treatments,while surgical options such as liposuction and lipectomy are reserved for severe or refractory *** support may be recommended,given lipedema’s impact on quality of life and *** review aims to present the current understanding of this condition,including challenges in diagnosis,current guideline recommendations for clinical care,and associated comorbid conditions.

关键词： Lipedema Obesity Lymphedema Liposuction Lipectomy

starch Orodispersible Film Loaded with Melatonin for Human supplementation

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Journal of Renewable Materials 2024年第7期12卷 1343-1354页

作者： Fabio Tamanini Tatiane Zucchini de souza Creusa sayuri Tahara Amaral Antônio JoséFelix carvalho Eliane Trovatti Department of Health and Biological sciences University of Araraquara(UNIARA)São Paulo14801-340Brazil Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloSão Paulo13563-120Brazil

An innovative pharmaceutical form for administering melatonin,based on starch orodispersibleﬁlm(ODF),was designed and *** composition of the ODF included starch as the polymer matrix,the active drug melatonin,and a ***,a natural hormone produced by the pineal gland in the brain,can be absorbed by passive diffusion across the mucous membrane,resulting in improved bioavailability when compared to conventional oral *** study shows a simple and efﬁcient method for preparing melatonin-loaded orodispersibleﬁlms with a physically stable and commercially viable matrix,suitable for use in the pharmaceutical ***ﬁlms were prepared by treating the starch with microwave irradiation,followed by plasticization with glycerol,melatonin loading and drying by solvent *** tests showed theﬁlms’robustness,with a modulus of approximately 97 MPa,indicating good handling *** uptake analysis showed fast water absorption,reaching about 150%within 2 min,indicating its fast oral disintegration *** tests in artiﬁcial saliva and dissolution studies indicated the release of the drug in min-utes,indicating the potential properties of theﬁlm for oral drug *** the best of our knowledge,there is no melatonin ODF based on starch described in the literature.

关键词： starch orodispersibleﬁlm melatonin drug delivery

Impact of Paenibacillus elgii supernatant on screening bacterial strains with potential for biotechnological applications

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Engineering Microbiology 2024年第3期4卷 1-15页

作者： I.C.Cunha-Ferreira C.s.Vizzotto T.D.Frederico J.Peixoto L.s carvalho M.R.Tótola R.H.Krüger Laboratory of Enzymology Department of Cellular BiologyUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratory of Environmental sanitation Department of Civil and Environmental EngineeringUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratório de Biotecnologia e Biodiversidade para o Meio Ambiente Universidade Federal de Viçosa(UFV)Viçosa36570-900Brazil

The biotechnological industry faces a crucial demand for novel bioactive compounds,particularly antimicrobial agents,to address the rising challenge of bacterial resistance to current available *** strate-gies for cultivating naturally occurring microorganisms often limit the discovery of novel antimicrobial *** study presents a protocol for targeted selection of bacterial strains using the supernatant of Paenibacillus el-gii,which produces abundant signal molecules and antimicrobial *** samples were inoculated in these enriched culture media to selectively cultivate bacteria resistant to the supernatant,indicating their potential to produce similar *** bacterial strains isolated through this method were assessed for their antibac-terial *** addition,the functional annotation of the genome of one of these strains revealed several gene clusters of biotechnological *** study highlights the effectiveness of using this approach for selective cultivation of microorganisms with potential for biotechnological applications.

关键词： Prospecting supernatant Antibacterial activity

Effect of biochar on the metabolome of soybean seedlings

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Oil Crop science 2024年第1期9卷 60-68页

作者： Nathalia E.silva Mariana G.Aguilar Osania E.Ferreira Gleicia M.Paulino Jaqueline C.L.carvalho Lúcia P.s.Pimenta Alan R.T.Machado Programa de Pos-graduaçao em Ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de Engenharia Aplicada e Tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de Ciencias Exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biochar can have several effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(sCB300),400℃(sCB400)and 600℃(sCB600).Then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the number of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).The extracts were submitted to metabolomics analysis by Proton Nuclear Magnetic *** Relative Germination,Relative Average Radicle Growth and Germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for sCB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most influential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： Germination Metabolomics 1H NMR Pyrolysis sugarcane bagasse

Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveira Vidal Luiz Fernando Alvarenga Ribeiro Marco Antonio de carvalho-Filho Fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil surgical specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

Plasma Lysophosphatidylcholine and Phospholipase A2 Activity in Chagas Disease Patients: A Comparative Analysis

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Advances in Bioscience and Biotechnology 2024年第8期15卷 462-473页

作者： Maria Fernanda carvalho de Araujo Bruna Maria Ferreira Iaciura Fillipe Araujo de sá Georgia Correa Atella Laboratrio de Bioqumica de Lipdios e Lipoprotenas Instituto de Bioqumica Mdica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Nacional de Cincia e Tecnologia em Entomologia Molecular (INCT-EM) Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Laboratrio de sinalizao Celular Instituto de Bioqumica Mdica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

Chagas disease (CD) affects 21 countries in the Americas and is caused by the parasite Trypanosoma cruzi. A key molecule involved in CD is lysophosphatidylcholine (LPC), which has been studied in various contexts: in the saliva of insect vectors, during the establishment of infection in the vertebrate host, and for the parasite itself. This lipid can be produced by the action of phospholipases A2 (PLA2), enzymes that catalyze the hydrolysis of phospholipids releasing fatty acids and lysophospholipids, such as LPC. This study investigates LPC levels and PLA2 activities in the plasma of CD patients and compares these levels with those in healthy individuals and patients with idiopathic dilated cardiomyopathy (IDCM). Plasma from 64 CD patients, 54 healthy individuals, and 16 IDCM patients were analyzed. LPC levels and the activity of two types of phospholipase A2: secreted (sPLA2) and lipoprotein-associated (Lp-PLA2) were measured. LPC levels and sPLA2 activity were similar between CD patients and the control groups. However, there were notable differences in LPC levels and sPLA2 activity between subgroups of CD patients and IDCM patients. This study is the first to identify LPC in patients with CD across various stages of the disease. It also offers new insights into the biochemical changes observed in the plasma of patients with IDCM.

关键词： Lysophosphatidylcholine Phospholipase A2 Plasma Chagas Disease Idiopathic Dilated Cardiomyopathy