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Rabies in a postpandemic world:resilient reservoirs,redoubtable riposte,recurrent roadblocks,and resolute recidivism

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Animal Diseases 2023年第2期3卷 63-89页

作者： Charles E.Rupprecht Philip P.Mshelbwala R.Guy Reeves ivan v.kuzmin College of Forestry Wildlife&EnvironmentCollege of Veterinary MedicineAuburn UniversityAuburnAL 36849USA School of veterinary Science University of QueenslandGattonAustralia Department of veterinary Medicine Faculty of Veterinary MedicineUniversity of AbujaAbujaNigeria Max Planck Institut Fur Evolutionsbiologie 24306 PlonGermany Department of Pathology University of Texas Medical BranchGalvestonTX 77555USA

Rabies is an ancient *** centuries since Pasteur,fundamental progress occurred in virology,vaccinology,and diagnostics—and an understanding of pathobiology and epizootiology of rabies in testament to One Health—before common terminological ***,control,selective elimination,and even the unthinkable—occasional treatment—of this zoonosis dawned by the twenty-first ***,in contrast to smallpox and rinderpest,eradication is a wishful misnomer applied to rabies,particularly post-COvID-19 *** are *** encompasses bats and mesocarnivores,but other mammals represent a diverse spectrum of potential *** rabies virus is the classical member of the genus,other species of lyssaviruses also cause the *** reservoirs remain *** global,this viral encephalitis is untreatable and often *** with other neglected diseases,laboratory-based surveillance falls short of the notifiable ideal,especially in lower-and middleincome *** of actual burden defaults to a flux within broad health economic *** priorities,lack of defined,long-term international donors,and shrinking local champions challenge human prophylaxis and mass dog vaccination toward targets of 2030 for even canine rabies *** prevention,all licensed vaccines are delivered to the individual,whether parenteral or oral–essentially‘one and done’.Exploiting mammalian social behaviors,future‘spreadable vaccines’might increase the proportion of immunized hosts per unit ***,the release of replication-competent,genetically modified organisms selectively engineered to spread intentionally throughout a population raises significant biological,ethical,and regulatory issues in need of broader,transdisciplinary *** this rather curious idea will evolve toward actual unconventional prevention,control,or elimination in the near term remains *** the interim,more precise terminology an

关键词： Diagnosis Epidemiology Lyssavirus Neglected Tropical Diseases Pathogenesis Prophylaxis Rabies Surveillance vaccination Zoonosis

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俄国从蝙蝠分离到新狂犬病病毒

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中国人兽共患病学报 2004年第3期 269-269页

作者： Alexandr D.Botvinkin ,Elena M.Poleschuk ,ivan v.kuzmin ,林春芳

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Expanded Porphyrin Exhibiting Off-Centered Out-of-Plane Coordination to Dysprosium

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CCS Chemistry 2024年第7期6卷 1731-1738页

作者： Dmitry I.Nazarov Jorge Labella Alexey v.kuzmin Maxim A.Faraonov Evgenii N.ivanov Salavat S.Khasanov Tomas Torres Mikhail K.Islyaikin Dmitri v.Konarev Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS 142432 Chernogolovka Department of Organic Chemistry Universidad Autonoma de Madrid28049 Madrid Institute of Solid-State Physics RAS 142432 Chernogolovka Research Institute of Macroheterocycles Ivanovo State University of Chemistry and Technology15300 Ivanovo G.A.Krestov Institute of Solution Chemistry of the Russian Academy of Sciences 153045 Ivanovo Institute for Advanced Research in Chemical Sciences Universidad Autonoma de Madrid28049 Madrid IMDEA-Nanociencia 28049 Madrid

The complexation of high-spin lanthanides to porphyrinoids is a powerful strategy for the development of advanced molecular *** this context,the use of expanded porphyrinoids remains elusive since their coordination chemistry is challenging to ***,taking inspiration from on-surface chemistry,we explored the coordination of Dy^(3+)to a six-membered porphyrinoid,namely,the hemihexaphyrazine ***,we observed the selective formation of a mono-nuclear off-centered,out-of-plane H_(2)Hhp-Dy^(3+)complex when performing the complexation under reductive *** this reaction,the oxidation state of the macrocycle did not *** X-ray diffraction analysis,we found that the coordination number of Dy in this complex was *** macrocycle cocrystallized with decamethylcobaltocene(Cp_(2)^(*)Co)molecules,giving rise to a wellordered solid-state packing,governed byπ-π*** a result of this organization,a small magnetic coupling between the neighboring molecules was *** in all,this work provides key insights into the coordination of magnetically active metals with expanded porphyrinoids,thus motivating the development of advanced spintronic devices.

关键词： porphyrins dysprosium macrocycle coordination chemistry magnetism

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On the Modeling of Non-Classical Problems Involving Liquid Jets and Films and Related Heat Transfer Processes

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Fluid Dynamics & Materials Processing 2019年第5期15卷 491-507页

作者： ivan v.Kazachkov Division of Information Technology and Data Analysis Nizhyn Gogol State UniversityNizhyn16600Ukraine Division of Heat and Power Royal Institute of TechnologyBrinellvägen 6810044StockholmSweden

Non-classical subjects relating to the dynamics of jet and film flow and related heat transfer processes are *** problems,which are relevant to several technological applications,cannot completely be addressed in the frame of the canonical Navier-Stokes *** first example deals with the formation of a film flow as a result of the hydraulic shock of a vertical jet impinging on a horizontal *** effective thickness of the film resulting from the hydraulic shock is much less than the value obtained using the conventional approach(relying on the assumption of smooth flow),while the corresponding speed is much *** next case is a jet penetrating into a pool of another liquid,which under certain conditions can form a jet head of a fungoid *** the jet penetrates the pool,it expands sharply,and this situation is another example of circumstances where classical models are ***,by virtue of the intense radiating heat transfer taking place at the front of the jet,a high-temperature jet can penetrate a pool of evaporating coolant,like a“jet in a bag of steam”.These exotic problems are modeled and explained in the present article along with experimental data used for model *** new hydrodynamic phenomena discovered over recent years are presented together with their practical applications,in particular,the modes of soliton-like and shock-wave decay of jets during vibration and electromagnetic resonant decomposition of the jet into droplets of a given *** phenomena are relevant to the areas of granulation of metal melts,cooling of molten corium during postulated severe accidents in nuclear power plants and in other industrial and technological devices and processes.

关键词： Jet film thickness flow hydraulic shock penetration pool vapor mushroom

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Semen microbiota and cytokines of healthy and infertile men

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Asian Journal of Andrology 2022年第4期24卷 353-358页

作者： Oleg v Bukharin Natalya B Perunova Elena v ivanova Irina N Chaynikova Anastasia v Bekpergenova Taisiya A Bondarenko Michael D kuzmin Institute of Cellular and Intracellular Symbiosis Ural Department of the Russian Academy of SciencesOrenburg Federal Research Center UD of RASOrenburg 460014Russia

In this study,we determined the levels of cytokine secretory inhibitors and the microbiota biofilms of semen from healthy and infertile subjects.A total of 118 clinical bacterial isolates were isolated and *** secretory inhibitors were determined based on the difference in cytokine content between the control and experimental samples of cell-free supernatants of isolated *** formation was studied by determining the adhesion of microorganisms to the surface of a 96-well sterile plate and expressed as the optical density at 630 nm(OD_(630)).Cell-free supernatants of Staphylococcus contained higher levels of secretory inhibitor of cytokines in conditionally healthy than in infertile *** contrast,in infertile men,the ability to reduce cytokine levels was more characteristic of Enterococcus and *** Staphylococcus,Corynebacterium,and Enterococcus isolated from infertile subjects showed a greater ability to form biofilms than the same bacteria isolated from healthy *** research is needed on this topic,since it is necessary to determine the relationships between decreased secretory inhibitors of cytokines,production of biofilms by bacteria in semen,and *** is likely that the ability of microorganisms to change the concentration of cytokines and increase the level of biofilm formation in semen may be associated with minimal impairments of fertilizing ability,which are not detected using other methods.

关键词： biofilms infertility microbiota secretory inhibitor of cytokines semen

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Chemotactic signaling in mesenchymal cells compared to amoeboid cells

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Genes & Diseases 2014年第2期1卷 162-173页

作者： Alexander v.vorotnikov Pyotr A.Tyurin-kuzmin Faculty of Fundamental Medicine M.V.Lomonosov Moscow State UniversityMoscowRussian Federation Institute of Experimental Cardiology Russian Cardiology Research and Production ComplexMoscowRussian Federation

Cell chemotaxis plays a pivotal role in normal development,inflammatory response,injury repair and tissue regeneration in all *** is also a critical contributor to cancer metastasis,altered angiogenesis and neurite growth in *** molecular mechanisms regulating chemotaxis are currently being identified and key components may be pertinent therapeutic *** these components appear to be mostly common in various cells,there are important differences in chemotactic signaling networks and signal processing that result in the distinct chemotactic behavior of mesenchymal cells compared to much better studied amoeboid blood *** differences are not necessarily predetermined based on cell type,but are rather chosen and exploited by cells to modify their chemotactic behavior based on physical constraints and/or environmental *** results in a specific type of chemotactic migration in mesenchymal cells that can be selectively targeted in ***,we compare the chemotactic behavior,signaling and motility of mesenchymal and amoeboid *** suggest that the current model of chemotaxis is applicable for small amoeboid cells but needs to be reconsidered for large mesenchymal *** focus on new candidate regulatory molecules and feedback mechanisms that may account for mesenchymal cell type-specific chemotaxis.

关键词： Chemotaxis Feedback regulation Fibroblasts Hydrogen peroxide Signaling

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MULTIWAvE MEDICAL DEvICE ON THE DIODE PUMPED SOLID STATE LASER FOR THE MICROBE NATURE DISEASE TREATMENT

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Journal of Innovative Optical Health Sciences 2012年第2期5卷 58-62页

作者： G.P.kuzmin A.G.kuzminA O.v.LOvACHEvA A.A.SIROTKIN Prokhorov General Physics Institute of the Russian Academy of Sciences 119991 Vavilov 38Moscow First Moscow State Medical University by I.M.Sechenov 119992 Mochovaya11Moscow Central TB Research Institute of the Russian Academy of Medical Sciences 107564 Yauzskaya Alley2Moscow

Multiwave laser medical device"Livadia"has been developed for bactericidal and therapeutic impact on the affected organism *** device is on the diode pumped solid-state laser and main wavelength radiation conversion 1064 nm into the second harmonic 532 nm and fourth harmonic 266 *** has been shown that Uv radiation on the wavelength 266 nm on bronchia mucosa with various inflammation types improves regenerative processes in bronchia tissues which decreases treatment deadline.

关键词： Ultraviolet radiation bactericidal action solid-state laser harmonics

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Electrofishing method improves evaluation of amphibian larvae abundance:a case of“beaver rivers”

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Integrative Zoology 2017年第4期12卷 345-350页

作者： Yury Y.DGEBUADZE ivan v.BASHINSKIY Severtsov Institute of Ecology&Evolution Leninsky ProspectMoscowRussia

There are many locations in Russia where Eurasian beaver(Castor fiber)populations have been *** a keystone species,beavers provide wide-ranging direct and indirect impacts on aquatic *** particular,beaver-created ponds are sites for spawning and nursery places for tadpoles of the brown frogs(genus Rana).Because of such impacts,study techniques for assessing aquatic organism abundance are being *** compared two methods for estimating tadpole abundance:traditional catches by dipnet and *** results show that the dipnet catch data for the shallower ponds with larger water surface area were five times lower than that obtained by ***,we conclude that dipnet catches are not suitable for comparing the relative abundance of tadpoles in the two beaver ponds that were studied.

关键词： abundance of tadpoles beaver ponds Rana

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特约小编之当坦克开进校园

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小哥白尼（军事科学） 2015年第5期 26-28页

作者：里德 vitaly v.kuzmin

装甲车改装的出租车、横穿公路的坦克、停车场里的步兵战车……在兵器大国俄罗斯,这些可都不算稀罕事。听说,坦克还能进校园呢。这到底是怎么回事?快随特约小编走进这所不一样的中学,去当一天"体验生"吧。早上好!来逛校史馆还不到早晨8... 详细信息

装甲车改装的出租车、横穿公路的坦克、停车场里的步兵战车……在兵器大国俄罗斯,这些可都不算稀罕事。听说,坦克还能进校园呢。这到底是怎么回事?快随特约小编走进这所不一样的中学,去当一天"体验生"吧。早上好!来逛校史馆还不到早晨8点,当我抵达苏沃洛夫军校时却发现,今天约定陪我上课的同学们都已经整装待发,在校门口迎接我啦。他们每天早晨都会7点起床,操练结束,吃个早饭,就要开始一天紧张的学习了。我到的时间距离上课还有一会儿,他们急忙先带我去了学校的校史馆,为今天的体验打打基础。

关键词：早上好校史馆时间距离步兵战车校门口小编洛夫小哥白尼航空飞行柳车

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Solar flares with similar soft but different hard X-ray emissions： case and statistical studies

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Research in Astronomy and Astrophysics 2016年第1期16卷 39-50页

作者： ivan N.Sharykin Alexei B.Struminsky ivan v.Zimovets Wei-Qun Gan Space Research Institute Russian Academy of Sciences Moscow 117997 Russia Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China

From the Reuven Ramaty High Energy Solar Spectroscopic Imager （RHESS1） catalog we select events which have approximately the same GOES class （high C - low M or 500-1200 counts s-1 within the RHESSI 6-12 kev energy band）, but with different maximal energies of detected hard X-rays. The selected events are subdivided into two groups：（1） flares with X-ray emissions observed by RHESSI up to only 50 kev and （2） flares with hard X-ray emission observed also above 50 kev. The main task is to understand observational peculiarities of these two flare groups. We use RHESSIX-ray data to obtain spectral and spa- tial information in order to find differences between selected groups. Spectra and images are analyzed in detail for six events （case study）. For a larger number of samples （85 and 28 flares in the low-energy and high-energy groups respectively） we only make some generalizations. In spectral analysis we use the thick- target model for hard X-ray emission and one temperature assumption for thermal soft X-ray emission. RHESSI X-ray images are used for determination of flare region sizes. Although thermal and spatial prop- erties of these two groups of flares are not easily distinguishable, power law indices of hard X-rays show significant differences. Events from the high-energy group generally have a harder spectrum. Therefore, the efficiency of chromospheric evaporation is not sensitive to the hardness of nonthermal electron spectra but rather depends on the total energy flux of nonthermal electrons.

关键词： Sun: flares -- Sun: X-rays -- gamma rays

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