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Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy

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Light(Science & Applications) 2020年第1期9卷 1455-1469页

作者： Jiao Li Andrei Chekkoury Jaya Prakash Sarah Glasl Paul Vetschera Benno Koberstein-Schwarz ivan olefir Vipul Gujrati Murad Omar Vasilis Ntziachristos School of Precision Instruments and Optoelectronics Engineering Tianjin UniversityNo.92Weijin RoadNankai District300072 TianjinChina Institute of Biological and Medical Imaging Helmholtz Zentrum MunchenIngolstadter Landstr.1D-85764 NeuherbergGermany Chair of Biological Imaging TranslaTUMTechnische Universitat MunchenIsmaningerstr.22D-81675 MunichGermany Department of Instrumentation and Applied Physics Indian Institute of Science BangaloreCV Raman RdBengaluru 560012 KarnatakaIndia

The characteristics of tumour development and metastasis relate not only to genomic heterogeneity but also to spatial heterogeneity,associated with variations in the intratumoural arrangement of cell populations,vascular morphology and oxygen and nutrient *** optical(photonic)microscopy is commonly employed to visualize the tumour microenvironment,it assesses only a few hundred cubic microns of ***,it is not suitable for investigating biological processes at the level of the entire tumour,which can be at least four orders of magnitude *** this study,we aimed to extend optical visualization and resolve spatial heterogeneity throughout the entire tumour *** developed an optoacoustic(photoacoustic)mesoscope adapted to solid tumour imaging and,in a pilot study,offer the first insights into cancer optical contrast heterogeneity in vivo at an unprecedented resolution of<50μm throughout the entire tumour *** spectral methods,we resolve unknown patterns of oxygenation,vasculature and perfusion in three types of breast cancer and showcase different levels of structural and functional *** our knowledge,these results are the most detailed insights of optical signatures reported throughout entire tumours in vivo,and they position optoacoustic mesoscopy as a unique investigational tool linking microscopic and macroscopic observations.

关键词： insight arrangement linking

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Method for passivation of propellant residues in orbital stage tank of launch vehicle

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Chinese Journal of Aeronautics 2024年第1期37卷 64-76页

作者： Valeriy TRUSHLYAKOV ivan LESNYAK Alexey PANICHKIN Department of Aviation and Rocket Building Omsk State Technical UniversityOmsk 644050Russia Sobolev Institute of Mathematics of the Siberian Branch of Russian Academy of Sciences Novosibirsk 630090Russia

The problem of removing unused liquid propellant residues from the tanks of spent spacecraft and orbital stages of Launch Vehicles(LV)leads to their explosion and the formation of space debris in *** provide a solution to this problem,a method for removing liquid propellant residues from the LV tanks after the mission completion is *** method is based on the gasification of liquid propellant residues in the tanks under acoustic-vacuum exposure and the discharge of the gasification products into the surrounding outer *** investigations were carried out on a Ground-based Experimental Installation(GEI)to determine the coefficient of heat transfer from the surface of an acoustic radiator to a *** obtained coefficient was then used to calculate the energy costs for the gasification of *** estimates are given on the example of the tank with kerosene residues from a spent second stage of the LV“Soyuz-2.1 v”.The optimal discharge rate at which kerosene does not freeze is 0.14 m^(3)/***,the acoustic exposure leads to an increase in the mass of evaporated kerosene over a given time by96.1%,and the energy costs are 1756.7 kJ(approximately 50% of the remaining electrical energy).

关键词： Propellant Weightlessness Liquid evaporation Heat and mass transfer Acoustics Vacuum Vapor bubbles

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Mathematical modeling of evolution of cell networks in epithelial tissues

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Quantitative Biology 2024年第3期12卷 286-300页

作者： ivan Krasnyakov Department of Applied Physics Perm National Research Polytechnic UniversityPermRussia

Epithelial cell networks imply a packing geometry characterized by various cell shapes and distributions in terms of number of cell neighbors and *** such simple characteristics describing cell sheets,the formation of bubble-like cells during the morphogenesis of epithelial tissues remains poorly *** study proposes a topological mathematical model of morphogenesis in a squamous *** introduce a new potential that takes into account not only the elasticity of cell perimeter and area but also the elasticity of their internal ***,we incorporate an integral equation for chemical signaling,allowing us to consider chemo-mechanical cell *** addition to the listed factors,the model takes into account essential processes in real epithelial,such as cell proliferation and *** presented mathematical model has yielded novel insights into the packing of epithelial *** has been found that there are two main states:one consists of cells of the same size,and the other consists of“bubble”*** example is provided of the possibility of accounting for chemo-mechanical interactions in a multicellular *** introduction of a parameter determining the flexibility of cell shapes enables the modeling of more complex cell behaviors,such as considering change of cell *** developed mathematical model of morphogenesis of squamous epithelium allows progress in understanding the processes of formation of cell *** results obtained from mathematical modeling are of significant importance for understanding the mechanisms of morphogenesis and development of epithelial ***,the obtained results can be applied in developing methods to influence morphogenetic processes in medical applications.

关键词： bubble-like cells growth epithelial tissue mathematical model tissue modeling vertex model

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Resveratrol as an Anti-inflammatory Agent in Coronary Artery Disease:A Systematic Review,Meta-Analysis and Meta-Regression

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Chinese Journal of Integrative Medicine 2024年第10期30卷 927-937页

作者： Vito A.Damay Ignatius ivan Department of Cardiovascular Medicine Universitas Pelita HarapanTangerangBanten15811Indonesia Jakarta Varices Clinic Jakarta12210Indonesia

Background:Resveratrol is a non-flavonoid polyphenol that shows promise in reducing proinflammatory factors and maintaining endothelial function,which hints at its potential role in slowing atherosclerosis and preventing acute coronary ***:To study the cardioprotective effects of resveratrol on inflammatory mediators and endothelial function in patients with coronary artery disease(CAD).Methods:A thorough search was conducted in databases(Cochrane Library,Pro Quest,Pub Med,LILACS,Science Direct,Springer,Taylor&Francis,CNKI,Wanfang,and Weipu)until September 24,*** vasopro-inflammatory mediators,endothelial function and outcomes related to cardiovascular events were *** and abstracts were assessed,and bias was evaluated with Cochrane Ro B *** of results was explored by metaregression,certainty of evidence was assessed by the GRADE system,and conclusive evidence was enhanced by trial sequence ***:Ten randomized controlled trials and 3 animal studies investigated resveratrol's impact on inflammatory mediators and endothelial *** primary prevention studies,meta-analysis showed a significant reduction(95%CI:–0.73 to–0.20;P=0.0005)in tumor necrosis factor-α(TNF-α)expression with resveratrol,demonstrating a dose-dependent *** significant difference was observed in interleukin-6(IL-6)expression with P=0.58 for primary prevention and P=0.57 for secondary *** endothelial nitric oxide synthase(e NOS)expression was significantly increased after resveratrol pre-treatment following CAD *** prevention studies yielded no significant results;however,meta-regression identified associations between age,hypertension,and lower doses with the extent of TNF-α*** certainty of evidence supported TNF-αreduction,while evidence for IL-6 reduction and e NOS elevation was deemed ***:Resveratrol reduces TNF-αin individuals at risk for CAD,specifically 15 mg per ***

关键词： anti-inflammation coronary artery disease nitric oxide resveratrol systematic review

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Oscillatory Dynamics of a Spherical Solid in a Liquid in an Axisymmetric Variable Cross Section Channel

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1219-1232页

作者： ivan Karpunin Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPerm614990Russia

The dynamics of a solid spherical body in an oscillating liquid flow in a vertical axisymmetric channel of variable cross section is experimentally *** is shown that the oscillating liquid leads to the generation of intense averaged flows in each of the channel *** intensity and direction of these flows depend on the dimensionless oscillating *** the region of studied frequencies,the dynamics of the considered body is examined when the primary vortices emerging in the flow occupy the whole region in each *** a fixed frequency,an increase in the oscillation amplitude leads to a phase-inclusion holding effect,i.e.,the body occupies a quasi-stationary position in one of the cells of the vertical channel,while oscillating around its average *** is also shown that the oscillating motion of a liquid column generates an averaged force acting on the body,the magnitude of which depends on the properties of the body and its position in the *** quasi-stationary position is determined by the relative density and size of the body,as well as the dimensionless *** behavior of the body as a function of the amplitude and frequency of fluid oscillation and relative size is discussed in *** findings may be used in the future to control the position of a phase inclusion and/or to strengthen mass transfer effects in a channel of variable cross section by means of fluid oscillations.

关键词： Phase inclusion axisymmetric channel variable cross section oscillations dimensionless frequency averaged force viscous boundary layer

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Applying the Shearlet-Based Complexity Measure for Analyzing Mass Transfer in Continuous-Flow Microchannels

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1743-1758页

作者： Elena Mosheva ivan Krasnyakov Institute of Continuous Media Mechanics UB RAS Perm614013Russia Department of Applied Physics Perm National Research Polytechnic UniversityPerm614990Russia

Continuous-flow microchannels are widely employed for synthesizing various materials,including nanoparticles,polymers,and metal-organic frameworks(MOFs),to name a *** technology allows precise control over reaction parameters,resulting in purer,more uniform,and structurally stable products due to more effective mass transfer ***,continuous-flow synthesis processes may be accompanied by the emergence of spatial convective structures initiating convective *** the one hand,convection can accelerate reactions by intensifying mass *** the other hand,it may lead to non-uniformity in the final product or defects,especially in MOF microcrystal *** ability to distinguish regions of convective and diffusive mass transfer may be the key to performing higher-quality reactions and obtaining purer *** this study,we investigate,for the first time,the possibility of using the information complexity measure as a criterion for assessing the intensity of mass transfer in microchannels,considering both spatial and temporal non-uniformities of liquid’s distributions resulting from convection *** calculate the complexity using shearlet transform based on a local *** contrast to existing methods for calculating complexity,the shearlet transform based approach provides a more detailed representation of local *** analysis involves experimental images illustrating the mixing process of two non-reactive liquids in a Y-type continuous-flow microchannel under conditions of double-diffusive convection *** obtained complexity fields characterize the mixing process and structure formation,revealing variations in mass transfer intensity along the *** compare the results with cases of liquid mixing via a pure diffusive *** analysis,it was revealed that the complexity measure exhibits sensitivity to variations in the type of mass transfer,establishing its feasibility as an ind

关键词： Shearlet analysis complexity measure entropy measure convection microchannels double-diffusive instability

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Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČEK Petr ŠPERKA ivan KŘUPKA Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(EHL)films by water-based lubricants(glycerol and polyethylene glycol(PEG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PEG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(EHL) film thickness

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Three-Dimensional Convection in an Inclined Porous Layer Subjected to a Vertical Temperature Gradient

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Fluid Dynamics & Materials Processing 2024年第9期20卷 1957-1970页

作者： ivan Shubenkov Tatyana Lyubimova Evgeny Sadilov Computational Fluid Dynamics Laboratory Institute of Continuous Media Mechanics UB RASPerm614068Russia Theoretical Physics Department Perm State UniversityPerm614990Russia

In this paper,we study the onset and development of three-dimensional convection in a tilted porous layer saturated with a *** layer is subjected to a gravitational field and a strictly vertical temperature ***,problems of thermal convection in tilted porous media saturated with a liquid are studied by assuming constant different temperatures at the boundaries of the layer,which prevent these systems from supporting conductive(non-convective)*** boundary conditions considered in the present work allow a conductive state and are representative of typical geological *** an earlier work,we carried out a linear stability analysis of the conductive *** was shown that at any layer tilt angles,the most dangerous type of disturbances are longitudinal ***,a non-zero velocity component exists in *** the present work,threedimensional non-linear convection regimes are *** original three-dimensional problem is reduced to two-dimensional one with an analytical expression for the velocity z-component v_(z)=v_(z)(x,y).It is shown that the critical Rayleigh number values obtained through numerical solutions of the obtained 2D problem by a finite difference method for different layer inclination angles,are in a good agreement with those predicted by the linear *** number of convective rolls realized in nonlinear calculations also fits the linear theory predictions for a given cavity *** carried out at low supercriticalities show that a direct bifurcation takes *** increasing supercriticality,no transitions to other convective regimes are *** situation studied in this problem can be observed in oil-bearing rock formations under the influence of a geothermal temperature gradient,where the ensuing fluid convection can affect the distribution of oil throughout the layer.

关键词： Thermal convection inclined layer porous media vertical temperature gradient

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Multi-criteria decision-making method for evaluation of investment in enhanced geothermal systems projects

Energy and AI

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Energy and AI 2024年第3期17卷 143-167页

作者： Sara Raos Josipa Hranić ivan Rajšl University of Zagreb Faculty of Electrical Engineering and Computing Unska 310000 ZagrebCroatia GE Vernova 58 Charles StreetCambridgeMassachusettsUSA

Deep geothermal energy presents large untapped renewable energy potential could significantly contribute to global energy needs. However, developing geothermal projects involves uncertainties regarding adequate geothermal brine extraction and huge costs related to preparation phases and consequently drilling and stimulation activities. Therefore, evaluating utilization alternatives of such projects is a complex decision-making problem effectively addressed using multi-criteria decision-making (MCDM) methods. This study introduces the MCDM method utilizing analytic hierarchy process (AHP) and weighted decision matrix (WDM) to assess different utilization alternatives (electricity generation, direct heat use and cogeneration). The AHP method determines the weight of each criterion and sub-criterion, while the WDM calculates the final project grade. Five criteria groups - technological, geological, economic, societal and environmental – comprising twenty-eight influencing factors were selected and used for the assessment of investment in Enhanced Geothermal Systems (EGS) projects. The AHP-WDM method was used by 38 experts from six categories: industry, educational institution, research and technology organization (RTO), small- and medium-sized enterprises (SME), local community and other. These diverse expert inputs aimed to capture varying perspectives and knowledge influence investment decisions in geothermal energy. The results were analysed accordingly. The results underscore the importance of incorporating different viewpoints to develop robust, credible, and effective investment strategies for EGS projects. Therefore, this method will contribute to more efficient EGS project development, enabling thus a greater penetration of the EGS into the market. Additionally, the proposed AHP-WDM method was implemented for a case study examining two locations. Locations were assessed and compared on scenario-based evaluation. The results confirmed the method's adequacy for a

关键词： Deep geothermal energy Enhanced geothermal systems(EGS) Multi-criteria decision-making(MCDM)method Analytic hierarchy process(AHP) Weighted decision matrix(WDM)

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Products of Commutator Ideals of Some Lie-admissible Algebras

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1875-1892页

作者： ivan KAYGORODOV Farukh MASHUROV Tran Giang NAM Ze Rui ZHANG CMA-UBI Universidade da Beira InteriorCovilhaPortugal Shenzhen International Center for Mathematics(SICM) Southern University of Science and TechnologyShenzhen 518055P.R.China Institute of Mathematics VAST18 Hoang Quoc VietCau GiayHanoiVietnam School of Mathematical Sciences South China Normal UniversityGuangzhou 510631P.R.China

In this article,we mainly study the products of commutator ideals of Lie-admissible algebras such as Novikov algebras,bicommutative algebras,and assosymmetric *** precisely,we first study the properties of the lower central chains for Novikov algebras and bicommutative *** we show that for every Lie nilpotent Novikov algebra or Lie nilpotent bicommutative algebra A,the ideal of A generated by the set{ab−ba|a,b∈A}is ***,we study properties of the lower central chains for assosymmetric algebras,study the products of commutator ideals of assosymmetric algebras and show that the products of commutator ideals have a similar property as that for associative algebras.

关键词： Novikov algebra bicommutative algebra assosymmetric algebra Lie nilpotent algebra

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