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observation of nonlinear fractal higher order topological insulator

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Light(Science & Applications) 2024年第11期13卷 2699-2714页

作者： Hua Zhong Victor o.Kompanets Yiqi Zhang Yaroslav V.Kartashov Meng Cao Yongdong Li Sergei A.Zhuravitskii Nikolay N.Skryabin ivan V.Dyakonov Alexander A.Kalinkin Sergei P.Kulik Sergey V.Chekalin Victor N.Zadkov Key Laboratory for Physical Electronics and Devices Ministry of EducationSchool of Electronic Science and EngineeringXi’an Jiaotong University710049 Xi’anChina Institute of Spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Quantum Technology Centre Faculty of PhysicsM.V.Lomonosov Moscow State UniversityMoscow 119991Russia Faculty of Physics Higher School of EconomicsMoscow 105066Russia

Higher-order topological insulators(HoTIs)are unique materials hosting topologically protected states,whose dimensionality is at least by 2 lower than that of the *** states in such insulators may be strongly confined in their corners which leads to considerable enhancement of nonlinear processes involving such ***,all nonlinear HoTIs demonstrated so far were built on periodic bulk lattice ***,we demonstrate the first nonlinear photonic HoTI with the fractal *** their fractional effective dimensionality,the HoTIs constructed here on two different types of the Sierpiński gasket waveguide arrays,may support topological corner states for unexpectedly wide range of coupling strengths,even in parameter regions where conventional HoTIs become *** demonstrate thresholdless spatial solitons bifurcating from corner states in nonlinear fractal HoTIs and show that their localization can be efficiently controlled by the input beam *** observe sharp differences in nonlinear light localization on outer and multiple inner corners and edges representative for these fractal *** findings not only represent a new paradigm for nonlinear topological insulators,but also open new avenues for potential applications of fractal materials to control the light flow.

关键词： materials. flow. topological

Pharmacological evaluation of a novel enhydrazone ester (CEE-1) as a dual inhibitor of the release of pro-inflammatory cytokines and prostanoids from human monocytes

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Advances in Bioscience and Biotechnology 2013年第8期4卷 54-63页

作者： Charles I. Ezeamuzie Hanan Zamil Hawraa Al-Baghli ivan o. Edafiogho Department of Pharmaceutical Sciences School of Pharmacy University of Saint Joseph Hartford USA Department of Pharmacology & Toxicology Faculty of Medicine Kuwait University Kuwait City Kuwait

CEE-1 (ethyl 4-phenylhydrazinocyclohex-3-en-2-oxo-6-phenyl-1-oate)—a novel enhydrazone ester, was tested in vitro for anti-inflammatory activity against the release of pro-inflammatory cytokine and prostanoid from lipopolysaccharide-activated human monocytes or human monocytic cell line (U937). The effects were compared with those of standard anti-inflammatory drugs dexamethasone and indomethacin. CEE-1 potently and strongly inhibited the release of both tumor necrosis factor-alpha (TNF-α) and prostaglandin E2 (PGE2). The concentrations producing 50% inhibition (IC50 values) were 2.0 μM and 2.4 μM for TNF-α and PGE2, respectively. At 30 μM, the drug achieved almost complete inhibition of both mediators. Dexamethasone had similar effects but indomethacin inhibited only the PGE2 release, and although CEE-1 was less potent than these two drugs, it had comparable efficacy. The compound appeared to act, at least, in part by inhibiting the up-regulation of the mRNA for TNF-α as well as that of the prostanoid-synthetic enzyme, cyclo-oxygenase-2 (CoX-2). However, like dexamethasone, but unlike indomethacin, CEE-1 did not affect CoX-2 enzyme function. Thus, the profile of activity of CEE-1 is similar to that of steroids rather than the non-steroidal anti-inflammatory drugs. Structure-activity study showed that the presence of a simple aromatic ring attached via an NH-NH group was critical for activity. At the concentrations that completely inhibited mediator release, the compound displayed no significant in vitro toxicity on the cells. These results show that CEE-1 is a dual inhibitor of the release of cytokines and prostanoids, and therefore could be a potential alternative to steroids in the treatment of inflammatory diseases.

关键词： Enhydrazone Ester Prostaglandin E2 Monocyte Anti-Inflammatory Tumor Necrosis Factor-Alpha Cytokines

Long-period eclipsing binaries:towards the true mass-luminosity *** test sample,observations and data analysis

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Research in Astronomy and Astrophysics 2020年第8期20卷 169-176页

作者： Alexei Yu.Kniazev oleg Yu.Maikov ivan Yu.Katkov Leonid N.Berdnikov South African Astronomical observatory P.O.Box 9ObservatoryCape Town7935South Africa Southern African Large Telescope P.O.Box 9ObservatoryCape Town7935South Africa Sternberg Astronomical Institute Lomonosov Moscow State UniversityMoscow119992Russia Institute of Astronomy of RAS Moscow 119017Russia New York University Abu Dhabi PO Box 129188Abu DhabiUAE Center for Astro Particleand Planetary PhysicsNYU Abu DhabiPO Box 129188Abu DhabiUAE

The mass-luminosity relation is a fundamental law of *** have suggested that the currently used mass-luminosity relation is not correct for the M/M⊙>2.7 range of mass since it was created utilizing double-lined eclipsing binaries,where the components are synchronized and consequently change each other's evolutionary *** exclude this effect,we have started a project to study longperiod massive eclipsing binaries in order to construct radial velocity curves and determine masses for the *** outline our project and present the selected test sample together with the first HRS/SALT spectral observations and the software package,FITTING BINARY STARS(FBS),that we developed for the analysis of our spectral *** the first result,we present the radial velocity curves and best-fit orbital elements for the two components of the FP Car binary system from our test sample.

关键词： stars:luminosity function mass function stars:binaries:spectroscopic

Genetic link between saline and carbonatitic mantle fluids:The system NaCl-CaCo_(3)-MgCo_(3)±H_(2)o±Fe^(0) at 6 GPa

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Geoscience Frontiers 2022年第6期13卷 59-74页

作者： Anton Shatskiy ivan V.Podborodnikov Anton V.Arefiev Altyna Bekhtenova Konstantin D.Litasov Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Science Moscow 119991Russia Vereshchagin Institute for High Pressure Physics of the Russian Academy of Science TroitskMoscow108840Russia

Melt inclusions in kimberlitic minerals and diamonds indicate that chlorides are important constituents of mantle carbonatite ***,alkaline chlorides are important constituents of saline high-density fluids(HDFs)found in diamonds from kimberlites and placers around the *** compositional variations suggest that saline and carbonatitic HDFs could be genetically ***,the essence of this link remains unclear owing to the lack of data on phase relations in the chloridecarbonate systems under *** we studied subsolidus and melting phase relations in the system NaCl–CaCo_(3)–MgCo_(3)at 6 GPa and 1000–1600℃using a Kawai-type multianvil *** found that at 1000℃,subsolidus assemblage consists of halite,magnesite,and *** higher temperatures,the stabilization of dolomite splits the subsolidus area into two partial ternary fields:halite+magnesite+dolomite and halite+dolomite+*** minimum on the liquidus surface corresponds to the halite-dolomite-aragonite ternary eutectic,situated at 1100℃.The eutectic melt has Ca#89 and contains 30 wt.%Na Cl(26 mol%2NaCl).The system has two ternary peritectics:halite+dolomite=magnesite+liquid located near the ternary eutectic and magnesite+dolomite=Mg-dolomite+liquid situated between 1300 and 1400℃.Although under dry conditions incipient melting yields carbonatedominated melt,the addition of water facilitates the fusion of Na Cl and expands the liquid field to Na Cl-rich compositions with up to 70 wt.%Na *** obtained results favor the idea that hydrous saline melts/fluids(brines)found as inclusions in diamonds could be a lower temperature derivative of mantle carbonatite melts and disagree with the hypothesis on chloride melt generation owing to the chloridecarbonate liquid immiscibility since no such immiscibility was *** also studied the interaction of the NaCl–CaCo_(3)–MgCo_(3)system with iron metal and found that carbonate reduction produces Cbearing species(Fe^(0)

关键词： Chloride Carbonate Halite Melting T-X diagram Earth’s mantle

Contribution of functional KIR3DL1 to ankylosing spondylitis

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Cellular & Molecular Immunology 2010年第6期7卷 471-476页

作者： ivan V Zvyagin Ilgar Z Mamedov olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy o Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov Shemiakin-ovchinnikov Institute of Bioorganic Chemistry RASMoscowRussia Institute of Rheumatology RAMSMoscowRussia DNA-Technology JSC MoscowRussia Vavilov Institute of General Genetics MoscowRussia

Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune *** particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several ***,none of the studies analyzed these associations in the context of functionality of polymorphic *** better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)*** genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 *** the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low ***3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1**** finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating ***,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1**** activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective ***,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS.

关键词： ankylosing spondylitis autoimmune disease HLA-B27 KIR KIR3DL1 KIR3DS1 KIR3DL1*004 NK cell T cell

The challenges on operating a zero net energy building facing global warming conditions

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Building Simulation 2022年第3期15卷 435-451页

作者： Alberto Hernandez Neto Luciane Cleonice Durante ivan Julio Apolonio Callejas Emeli Lalesca Aparecida da Guarda JoséVinnicius Ranieri Moreira Escola Politécnica University of São PauloBrazil Federal University of Mato Grosso Brazil Federal University of Santa Catarina Brazil

This study proposes a methodology to evaluate the energy performance of existing Zero Energy Buildings and to prospect retrofit strategies in a Savannah climate,concerning the A2 scenario of emissions from the Fourth Report of the Intergovernmental Panel on Climate *** selected building to study is recognized for its high energy performance,named Centro SEBRAE de Sustentabilidade(CSS).Two efficient measures were considered:(i)improvement in the air conditioning system coefficient of performance(CoP)and(ii)in the energy efficiency of the photovoltaic plates of generation *** methodology is grounded in the potential bioclimatic concept and the employed steps applied were:preparation of climate archives in the 2020,2050 and 2080 time-slices;calibration of the computational model;evaluation of the retrofit strategies on its energy consumption efficiency through computer *** the CSS has already attended mostly the bioclimatic strategies for the local climate and has high efficiency measures in its systems,the retrofit focused the air conditioning and PV *** isolated retrofit of the air conditioning system was unable to guarantees the NZEB condition despite providing an adequate level of energy efficiency until *** retrofit of the PV system was the only one that provides the NZEB condition for climate change *** contribution of this paper is to provide a guide to be used in NZEBs,with measures of optimization that provide high potential bioclimatic face to the local where it is built,making it possible to maintain this condition in scenarios of global warming.

关键词： sustainable constructions potential bioclimatic building energy consumption weather scenarios

Magnetocaloric and magneto-transport properties of Gd_(10)Co_(20)Si_(70) alloy

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Journal of Rare Earths 2019年第1期37卷 74-79,M0004页

作者： T.P.Rashid K.Arun ivan Curlik Sergej Ilkovic Marian Reiffers ANDrea Dzubinska R.Nagalakshmi Intermetallics and Non-Linear optics Laboratory Department of Physics National Institute of Technology(India) Faculty of Humanities and Natural Sciences Presov University Faculty of Natural Sciences P.J.Safarik University

We report the results of magnetic, thermodynamic, transport and magnetocaloric effect (MCE) studies of newly synthesized Gd_(10)Co_(20)Si_(70) alloy. These measurements confirm an antiferromagnetic transition at T_N=9 K. Both MCE and magnetoresistance (MR) show quadratic dependence on the applied magnetic field, indicating the presence of spin fluctuations in the alloy. The maximum values of the magnetic entropy change determined from the isothermal magnetization data for magnetic field change of 7 and9 T are found to be 10.5 and 15.6 J/kg·K, respectively. As a consequence of the spin fluctuations effect, the MCE peaks are pulled towards high temperature side as asymmetrically broadened peak. The MR attains a large positive value of 73%at 2 K in 8 T. The large MR and reversible MCE make this alloy an attractive multifunctional magnetic material.

关键词： Rare earth-transition metal alloy Magnetic properties Magnetocaloric effect Magnetoresistance Spin fluctuations

An ultra-narrow linewidth solution-processed organic laser

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Light(Science & Applications) 2016年第1期5卷 660-664页

作者： oussama Mhibik Sebastien Forget Dan ott George Venus ivan Divliansky Leonid Glebov Sebastien Chénais UniversitéParis 13 Sorbonne Paris CitéLaboratoire de Physique des LasersF-93430 VilletaneuseFrance CNRS UMR 7538LPLF-93430 VilletaneuseFrance CREoL College of Optics and PhotonicsUniversity of Central FloridaP.O.Box 162700OrlandoFL 32816-2700USA

optically pumped lasers based on solution-processed thin-film gain media have recently emerged as low-cost,broadly tunable,and versatile active photonics components that can fit any substrate and are useful for,e.g.,chemo-or biosensing or visible *** single-mode operation has been demonstrated in various resonator architectures with a large variety of gain media-including dye-doped polymers,organic semiconductors,and,more recently,hybrid perovskites-the reported linewidths are typically on the order of a fraction of a nanometer or broader,i.e.,the coherence lengths are no longer than a few millimeters,which does not enable high-resolution spectroscopy or coherent *** linewidth is fundamentally constrained by the short photon cavity lifetime in the standard resonator *** demonstrate here a novel structure for an organic thin-film solid-state laser that is based on a vertical external cavity,wherein a holographic volume Bragg grating ensures both spectral selection and output coupling in an otherwise very compact(,cm3)*** short-pulse(0.4 ns)pumping,Fourier-transform-limited laser pulses are obtained,with a full width at half-maximum linewidth of 900 MHz(1.25 pm).Using 20-ns-long pump pulses,the linewidth can be further reduced to 200 MHz(0.26 pm),which is four times above the Fourier limit and corresponds to an unprecedented coherence length of *** concept is potentially transferrable to any type of thin-film laser and can be ultimately made tunable;it also represents a very compact alternative to bulky grating systems in dye lasers.

关键词： narrow linewidth organic lasers VECSEL volume Bragg grating

Crystal structure prediction at finite temperatures

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npj Computational Materials 2023年第1期9卷 306-313页

作者： ivan A.Kruglov Alexey V.Yanilkin Yana Propad Arslan B.Mazitov Pavel Rachitskii Artem R.oganov Moscow Institute of Physics and Technology 9 Institutsky laneDolgoprudny 141700Russia Dukhov Research Institute of Automatics(VNIIA) Moscow 127055Russia Emerging Technologies Research Center XPANCEODubai Investment Park FirstDubaiUnited Arab Emirates Skolkovo Institute of Science and Technology Skolkovo Innovation Center30-1 Bolshoy blvdMoscow 121205Russia.

Crystal structure prediction is a central problem of crystallography and materials science, which until mid-2000s was consideredintractable. Several methods, based on either energy landscape exploration or, more commonly, global optimization, largely solvedthis problem and enabled fully non-empirical computational materials discovery. A major shortcoming is that, to avoid expensivecalculations of the entropy, crystal structure prediction was done at zero Kelvin, reducing to the search for the global minimum ofthe enthalpy rather than the free energy. As a consequence, high-temperature phases (especially those which are not quenchableto zero temperature) could be missed. Here we develop an accurate and affordable solution, enabling crystal structure prediction atfinite temperatures. Structure relaxation and fully anharmonic free energy calculations are done by molecular dynamics with aforcefield (which can be anything from a parametric forcefield for simpler cases to a trained on-the-fly machine learning interatomicpotential), the errors of which are corrected using thermodynamic perturbation theory to yield accurate results with full ab initioaccuracy. We illustrate this method by applications to metals (probing the P–T phase diagram of Al and Fe), a refractory covalentsolid (WB), an Earth-forming silicate MgSio_(3) (at pressures and temperatures of the Earth’s lower mantle), and ceramic oxide Hfo_(2).

关键词： prediction structure Crystal