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Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： ivan Sarabia Kyle M.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;M1 and M2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Investigation of the tribological performance of ionic liquids in non-conformal EHL contacts under electric field activation

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Friction 2020年第5期8卷 982-994页

作者： Michal MICHALEC Petr SVOBODA ivan KRUPKA martin HARTL Aleksandar VENCL Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic Central European Institute of Technology Brno University of TechnologyBrno 61200Czech Republic Faculty of Mechanical Engineering University of BelgradeBelgrade 11120Serbia South Ural State University Chelyabinsk 454080Russia

Real-time external alteration of the internal properties of lubricants is highly desirable in all mechanical systems. However, fabricating a suitable and effective smart lubricant is a long-lasting experimental process. In this study, the film thickness and frictional response of ionic liquid-lubricated non-conformal contacts to an electric field excitation under elastohydrodynamic conditions were examined. Film thickness was evaluated using a "ball-on-disc" optical tribometer with an electric circuit. Friction tests were carried on a mini traction machine (MTM) tribometer with a "ball-on-disc" rotation module and an electric circuit for contact area excitation. The results demonstrate that there is a difference in the behaviour of the ionic liquid during electric field excitation at the evaluated film thicknesses. The results of evaluated film thicknesses demonstrate that there is a difference in the behaviour of the ionic liquid during electric field excitation. Therefore, the ionic liquids could be a new basis for the smart lubrication of mechanical components. Moreover, the proposed experimental approach can be used to identify electrosensitive fluids.

关键词： friction thin film lubrication electro-rheological fluid smart fluid lubrication

Running-in friction of hip joint replacements can be significantly reduced:The effect of surface-textured acetabular cup

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Friction 2020年第6期8卷 1137-1152页

作者： David NECAS Hatsuhiko USAMI Tatsuya NIIMI Yoshinori SAWAE ivan KRUPKA martin HARTL Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic Faculty of Science and Technology Meijo UniversityNagoya 468-8502Japan Kanefusa Corporation Nagoya 480-0192Japan Faculty of Engineering Kyushu UniversityFukuoka 819-0395Japan

Hip joint replacements represent the most effective way of treatment for patients suffering from joint *** the rapid improvement of implant materials over the last few decades,limited longevity associated with wear-related complications persists as the main ***,improved tribological perfor-mance is required in order to extend the service life of *** effect of surface texturing of ultra-high molecular weight polyethylene(UHMWPE)acetabular cup was investigated in the present *** tilling method was utilized for manufacturing the dimples with controlled diameter and depths on the contact surface of the *** experiments with four commercial femoral components and two model lubricants were *** main attention was paid to a coefficient of friction considering the differences between the original and the dimpled *** showed remarkable lowering of friction,in *** on the simulated human synovial fluid,friction was reduced by 40%(alumina ceramic),38.8%(zirconia toughened ceramic),25.5%(metal),and 9.9%(oxinium).In addition,the dimples helped to keep the friction stable without *** conclude,the paper brings a new insight into frictional behaviour of the hip replacements during running-in phase which is essential for overall implant *** is believed that proper surface texturing may rapidly improve the life quality of millions of patients and may lead to considerable financial savings.

关键词： hip joint replacement friction texturing dimple longevity

Ziegler-Nichols Customization for Quadrotor Attitude Control under Empty and Full Loading Conditions

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 65-75页

作者： ivan Paulo Canal Manuel martin Pérez Reimbold Maurício de Campos Federal Institute of Education Science and Technology FarroupilhaCampus PanambiPanambiBrazil Regional University of the Northwest of the State of Rio Grande do Sul IjuíBrazil

An aircraft quadrotor is a complex control system that allows for great flexibility in *** multirotor aerial systems such as quadrotors is complex because the variables involved are not always available,known,and *** inclusion of payload changes the dynamic characteristics of the aircraft,making it necessary to adapt the control system for this *** the various control methods that have been investigated,proportional-integralderivative(PID)control offers good results and simplicity of application;however,achieving stability and high performance is challenging,with the most critical task being tuning the controller *** Ziegler-Nichols(ZN)theory was used to tune the controller gains for pitch and roll attitude command;however,the performance results were not *** response of this system was refined,resulting in an improvement in the reference tracking and the rejection of *** particular refinement was applied to the quadrotor,and via a reverse calculation,the parameters that allow the tuning of PID gains were obtained,based on *** particularization of the ZN theory applied to a quadrotor with and without a load(termed ZNAQ and ZNAQL,respectively)is proposed and results in a significant improvement in the control system response performance(up to 75%),demonstrating that ZNAQ and ZNAQL are valid for tuning the controller PID gains and are more efficient than the original ZN theory approach.

关键词： Ziegler-Nichols quadrotor control PID tuning multirotor

Raman analysis of chemisorbed tribofilm for metal-on-polyethylene hip joint prostheses

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Biosurface and Biotribology 2021年第1期7卷 1-11页

作者： Risha Rufaqua martin Vrbka Dušan Hemzal Dipankar Choudhury David Rebenda ivan Křupka martin Hartl Faculty of Mechanical Engineering Brno University of TechnologyBrnoCzech Republic Department of Condensed Matter Physics Faculty of ScienceMasaryk UniversityBrnoCzech Republic Nano Mechanics and Tribology Laboratory Department of Mechanical EngineeringUniversity of ArkansasFayettevilleArkansasUSA

The biochemical reaction during the formation of lubricant film the in case of a cobalt-chromium ball on an ultrahigh-molecular weight polyethylene cup was *** types of model synovial fluids and hyaluronic acid(HA)at physiologic concentrations were used in the *** coefficient of friction was measured using a pendulum hip simulator,and Raman spectroscopy was used to perceive chemical reactions between the synovial fluid and implant *** spectra evidenced that the three model fluids and HA chemisorbed onto the cobalt-chromium ***α-helix structure of the model fluid components was detected on the surface of the prosthesis.

关键词： material surface experiment

Integrating Functional Status Information into Knowledge Graphs to Support Self-Health Management

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Data Intelligence 2023年第3期5卷 636-662页

作者： Mauro Dragoni Tania Bailoni ivan Donadello Jean-Claude martin Helena Lindgren Fondazione Bruno Kessler TrentoItaly Free University of Bolzano BolzanoItaly LISN-CNRS Universite Paris SaclayParisFrance Umea University UmeaSweden

Functional Status Information(FSI)describes physical and mental wellness at the whole-person *** includes information on activity performance,social role participation,and environmental and personal factors that affect the well-being and quality of *** and analyzing this information is critical to address the needs for caring for an aging global population,and to provide effective care for individuals with chronic conditions,multi-morbidity,and *** knowledge graphs(PKGs)represent a suitable way for meaning in a complete and structured way all information related to people's FSI and reasoning over them to build tailored coaching solutions supporting them in daily life for conducting a healthy *** this paper,we present the development process related to the creation of a PKG by starting from the HeLis ontology in order to enable the design of an Al-enabled system with the aim of increasing,within people,the self-awareness of their own functional *** particular,we focus on the three modules extending the HeLis ontology aiming to represent(i)enablers and(ii)barriers playing potential roles in improving(or deteriorating)own functional status and(iii)arguments driving the FSI collection ***,we show how these modules have been instantiated into real-world scenarios.

关键词： Knowledge Graph Personal Healthcare Functional Status Enablers Barriers Arguments

Comparing the removal of polycyclic aromatic hydrocarbons in soil after different bioremediation approaches in relation to the extracellular enzyme activities

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Journal of Environmental Sciences 2019年第2期31卷 249-258页

作者： Zdeněk Ko?ná? Tereza ?ástková Lucie Wiesnerová Luká? Praus ivan Jablonsky martin Koudela Pavel Tlusto? Department of Agroenvironmental Chemistry and Plant Nutrition Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences Prague Department of Horticulture Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences Prague

A 120-day experiment was conducted to compare the removal of polycyclic aromatic hydrocarbons(PAHs) from agricultural soil after natural attenuation(NA), phytoremediation(P), mycoremediation(M), and plant-assisted mycoremediation(PAM) approaches in relation to the extracellular enzyme activities in soil. The NA treatment removed the total soil PAH content negligibly. The P treatment using maize(Zea mays) enhanced only the removal of low and medium molecular PAHs. The Pleurotus ostreatus cultivated on 30–50 mm wood chip substrate used in M treatment was the most successful in the removal of majority PAHs. Therefore,significantly(p < 0.05) highest total PAH removal by 541.4 μg/kg dw(dry weight)(36%) from all tested M treatments was observed. When using the same fungal substrate together with maize in PAM treatment, the total PAH removal was not statistically different from the previous M treatment. However, the maize-assisted mycoremediation treatment significantly boosted fungal biomass, microbial and manganese peroxidase activity in soil which strongly correlated with the removal of total PAHs. The higher PAH removal in that PAM treatment could be reflected in the following post-harvest time. Our suggested M and PAM approaches could be promising in situ bioremediation strategies for PAH-contaminated soils.

关键词： PAHs Biodegradation White-rot fungi Ligninolytic enzymes Microbial activity

Social play in African savannah elephants may inform selection against aggression

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CURRENT ZOOLOGY 2024年第6期70卷 765-779页

作者： Norscia, ivan Hecker, martin Caselli, Marta Collarini, Edoardo Gallego Aldama, Beatriz Borragan Santos, Santiago Cordoni, Giada Univ Torino Dept Life Sci & Syst Biol Turin Italy Cantur SA Parque Nat Cabarceno Obregon 39690 Cantabria Spain

In social groups, competition for individual advantage is balanced with cooperation, for the collective benefit. Selection against aggression has favored cooperation and non-aggressive competitive strategies. Because social play is a behavioral system that fluctuates between cooperation and competition, selection against aggression might have especially influenced this behavior. African savannah elephants (Loxodonta africana) are a low aggressive species, therefore suitable to investigate this aspect. We collected all occurrences observational audio-video data on social play, aggression/threats, and affiliation on an African elephant colony housed in a 25-ha open space at Parque de la Naturaleza de Cabarceno (Cantabria, Spain) and composed of 4 family groups (3 immature males, 3 immature females, and 7 adult females) and 2 adult males. Anticipating the influence of reduced aggression, we found that social play decreased with age, persisting in adults, and that it was highest in males. Social play was associated with affiliation (informing cooperation). Indeed, individuals that were central in the social play network were also central in the affiliation network. For immature subjects, we found a correlation between social play and affiliation sociomatrices. However, such correlation was absent in adults and social play mostly occurred between families. Despite the limitations related to dealing with a small captive group, this study largely supports the idea that the features of social play in African savannah elephants may be related to low aggression. This investigation hints toward a non-purely cooperative use of play, possibly as a non-aggressive interaction that accommodates different levels of cooperation and competition.

关键词： captive elephants domestication syndrome self-domestication social behaviors social play

REGULARITY FOR A GENERALIZED JEFFREY'S INTEGRAL MODEL FOR VISCOELASTIC FLUIDS

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Acta Mathematica Scientia 2015年第6期35卷 1251-1284页

作者： ivan SOUKUP Department of Numerical Mathematics Faculty of Mathematics and PhysicsCharles University in Prague

We prove a local existence of a strong solution v ：Ω×T→R^3 for a system of nonlinear integrodifferential equations describing motion of an incompressible viscoelastic fluid using standard mathematical tools. The problem is considered in a bounded, smooth domain ΩСR^3 with a Dirichlet boundary condition and a standard initial condition.

关键词： integral model viscoelastic fluid strong solution