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3D printing of patient-specific 316l–stainless–steel medical implants using fused filament fabrication technology: two veterinary case studies

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Bio-Design and Manufacturing 2022年第4期5卷 808-815页

作者： j.M.Chacón P.j.núñez M.A.Caminero E.garcía-Plaza j.Vallejo M.Blanco Escuela Técnica Superior de Ingeniería Industrial Universidad de Castilla-La ManchaAvdaCamilo JoséCela213071 Ciudad RealSpain Protresde Ingeniería y Soluciones C/Solana 60nave 313005 Ciudad RealSpain

Biomedical fracture fixation implants have complex sculptured geometries to adapt perfectly to fractured bones,making them difficult and expensive to manufacture with conventional machining methods. Fused filament fabrication(FFF) is a very popular Additive Manufacturing technology that simplifies the manufacture of parts with complex geometries, making it ideal for the manufacture of customized medical implants.

关键词： steel fracture fused

Practical update on imaging and transcatheter aortic valve implantation

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World journal of Cardiology 2015年第4期7卷 178-186页

作者： gisela Feltes iv.n j nú ez-g.l Cardiovascular Unit Centro Médico Paris Interventional Cardiology Hospital Clínico San Carlos

After very rapid advances in the development of the technique and devices,transcatheter aortic valve implantation(named TAVI or TAVR),is today a reality that is here to *** has become the minimallyinvasive treatment option for high-risk and non-surgical patients with severe symptomatic aortic *** the participation of a multidisciplinary team for its implementation,cardiac imaging plays an important *** pre-assessment to determine the suitability of the patient,the access site,the type of device,to the guidance during the procedure,and ultimately the long term monitoring of the *** selection of the patient and device,correct placement of the stent-valve and early detection of complications are of paramount importance for procedural success and for patient *** technique has advantages and disadvantages,being the cardiologist who will determine the best approach according to the type of patient and the expertise of the center in each one of *** article summarizes the last contributions of the most common used imaging techniques,in each step of the procedure.

关键词： TAVI TAVR Echocardiography Multislice tomography Cardiac magnetic resonance Aortic stenosis

Re-folded structure of syn-orogenic granitoids(Padrón dome, nW Iberia):Assessing rheological evolution of cooling continental crust in a collisional setting

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geoscience Frontiers 2019年第2期10卷 651-669页

作者： Rubén Díez Fernández Francisco j.Rubio Pascual luis Miguel Martín Parra Departamento de geodinámica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de Madrid Instituto geológico y Minero de Espana

This contribution discusses about the rheological, kinematic and dynamic frameworks necessary to produce recumbent and upright folds from syn-orogenic granitic massifs that were formed during an early stage of magma genesis related to the onset of a migmatitic dome. Syn-kinematic granitoids occurring within the high-grade infrastructure of the Padron migmatitic dome(nW Iberia) are deformed into largescale recumbent folds(D_2) that are later affected by upright folds(D_3). Petrostructural analysis of a selected area of this dome reveals that after a period of crustal thickening(D_1), nnW-directed extensional flow gave way to recumbent folds and penetrative axial plane foliation(S_2). Superimposed subhorizontal compression resulted in upright folds(D_3). A closer view into the dynamics of the dome allows exploring the factors that may condition the nucleation of folds with contrasting geometries during progressive deformation of molten continental crust. The formation of folds affecting syn-kinematic granitoids suggests a cooling metamorphic path in migmatitic domes. Active and passive folding mechanisms require a crystallizing(cooling) magma to nucleate folds. A more competent metamorphic host inhibits fold nucleation from much less competent magmas. As it crystallizes, magma becomes more rigid(competent),and approaches viscosity values of its host. Passive folding is favored when no significant competence contrast exists between magma and host, so this folding mechanism is more likely shortly after magma genesis and emplacement. In such conditions, and under dominant subhorizontal flow accompanied by flattening(D_2),passive folding would produce isoclinal recumbent geometries. Further magma cooling introduces a shift into the rheological behavior of partially molten crust. Thereon, crystallizing magma bodies would represent significant competence contrasts relative to their host. At this point, buckling is a more likely folding mechanism, and more reg.lar, buckle fo

关键词： Recumbent folds Migmatitic domes Partial melting Crustal-derived granitoids Orogenic collapse Variscan orogen

Iron,the endolysosomal system and neuroinflammation:a matter of balance

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neural Regeneration Research 2022年第5期17卷 1003-1004页

作者： Daniel A.Bórquez Pamela j.Urrutia Marco T.núñez Center for Biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Department of Biology Faculty of SciencesUniversidad de ChileSantiagoChile

Iron accumulation and neuroinflammation are cardinal features of many neurodegenerative diseases(Urrutia et al.,2021).However,the hierarchy in the pathogenic mechanisms and the molecular connections between these proc... 详细信息

关键词： Iron system showing

Influence of biomass burning on ozone levels in the Meg.lopolis of Central Mexico during the COVID-19 lockdown

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journal of Environmental Sciences 2024年第9期143卷 99-115页

作者： Victor Almanza luis gerardo Ruiz-Suárez Ricardo Torres-jardón Agustín garcía-Reynoso iv.n Y.Hernández-Paniagua Institute for Atmospheric Sciences and Climate Change National Autonomous University of MexicoCoyoacan 04510Mexico CityMexico

The massive reductions in anthropogenic emissions resulting from the COVID-19 lockdown provided a unique opportunity to evaluate the effect of mitigation measures aiming to abate air *** Mexico,the total lockdown period took place during the dry-hot season when biomass burning activity is ***,we investigate the role of biomass burning emissions on regional ozone levels in the Meg.lopolis of Central *** studied period covers the lockdown phases 2 and 3,and the first month of the new *** applied a factor separation technique and process analysis to estimate the pure and synergistic contributions of emission reductions under lockdown and that from biomass burning to daily ozone maximum concentrations in 7 metropolitan areas of different states in the *** results revealed that biomass burning plumes likely masked the effect of massive reductions from mobile emissions,impacted the PBl development during phase 3 and favored transition and mixed nO_(x)-limited and VOC-limited regional *** contributed to increased ozone production in the middle to lower PBl by changing the regional background levels which potentially could bias high ozone production efficiency *** the Meg.lopolis contribution to economic and societal development at national scale,our study suggests that ozone mitigation measures during the dry-hot season targeting mainly mobile emissions will likely be offset by biomass burning plumes.A regional and synergic policy aiming to control biomass burning would help to reduce the occurrence of high ozone levels in Central Mexico with the co-benefit of tackling short-lived climate pollutants.

关键词： COVID-19 Mexico Meg.lopolis Ozone Factor Separation Process Analysis

How to express tumours using membrane systems

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Progress in natural Science:Materials International 2007年第4期17卷 449-457页

作者： Miguel A. gutiérrez-naranjo Mario j. Pérez-jiménez Agustín Riscos-núez Francisco j. Romero-Campero Department of Computer Science and Artificial Intelligence University of Seville Avda. Reina Mercedes s/n41012SevillaSpain

In this paper we discuss the potential usefulness of membrane systems as tools for modelling tumours. The approach is followed both from a macroscopic and a microscopic point of view. In the first case, one considers the tumour as a growing mass of cells, focusing on its external shape. In the second case, one descends to the microscopic level, studying molecular signalling pathways that are crucial to determine if a cell is cancerous or not. In each of these approaches we work with appropriate variants of membrane systems.

关键词： tumour membrane system modeling.

Use of Mussel Shells as a Soil Amendment:Effects on Bulk and Rhizosphere Soil and Pasture Production

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Pedosphere 2012年第2期22卷 152-164页

作者： E.lVARez M.j.FERnnDez-SAnjURjO n.SECO A.nUez Departamento de Edafologia y Quimica Agricola Escuela Politécnica SuperiorUniversidad de Santiago de CompostelaCampus Universitario

large quantities of mussel shells （66000-94000 t year^-1）, an alkaline material that can be used as a soil amendment, are generated as waste in g.licia, nW Spain. A field trial was carried out by planting different pasture species in a Haplic Umbrisol using a randomized block design with four blocks and six treatments （not amended control or soil amended with lime, finely ground shell, coarsely ground shell, finely ground calcined shell or coarsely ground calcined shell） to compare the effects of lime and mussel shells additions on a soil with a low cation exchange capacity and high AI saturation. The trial was established in March 2007, and samples of plants and soil were collected when plots were harvested in summer 2008 （separating the bulk and rhizosphere soil）. The soils were analyzed for pH, total C, total n, available P, exchangeable cations, effective cation exchange capacity and available micronutrients. Dry matter yield was measured in all plots and plants were analyzed for nutrients. Application of mussel shells and the commercial lime resulted in an increase in pH and exchangeable Ca and a decrease in exchangeable Al and Al were most noticeable in the rhizosphere. The amendment of Ca in the plant. saturation. The stability of pH over time was high. These effects also had a positive effect on dry matter yield and concentration

关键词： dry matter production exchangeable A1 liming pasture quality soil nutrients

large dinosaur egg accumulations and their significance for understanding nesting behaviour

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geoscience Frontiers 2024年第5期15卷 467-488页

作者： l.ezquerro R.Coimbra B.Bauluz C.núñez-lahuerta T.Román-Berdiel M.Moreno-Azanza Departamento de geodinámica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de MadridC/JoséAntonio Novais1228040MadridSpain Aragosaurus-IUCA:Recursos geológicos y Paleoambientales.Departamento de Ciencias de la Tierra.Facultad de Ciencias Universidad de ZaragozaC/Pedro Cerbuna 1250009 ZaragozaSpain Museu da lourinha LourinhaPortugal geoBioTec Department of Earth SciencesNOVA School of Science and TechnologyUniversidade Nova de LisboaCaparicaPortugal geoBioTec Departamento de GeocienciasUniversidade de AveiroAveiroPortugal Insitut Catalàde Paleoecologia Humana i EvolucióSocial(IPHES-CERCA) Zona Educacional 4Campus Sescelades URV(Edifici W3)43007 TarragonaSpain Departament d´Història i Història de l´Art Universitat Rovira i VirgiliAv.Catalunya 3543002 TarragonaSpain geotransfer IUCA Departamento de Ciencias de La TierraFacultad de CienciasUniversidad de ZaragozaZaragozaSpain

The accurate identification of dinosaur egg accumulations as nests or clutches is crucial for understanding the reproductive behaviour of these extinct ***,existing methods often rely on the presence of complete eggs and embryo remains,and sedimentological criteria that are only applicable to well-structured *** this study,we introduce an innovative approach to characterize egg accumulations in structureless sediments,where traditional nest structures may not be *** methodology employs a unique combination of sedimentological,taphonomic,geochemical,and geophysical proxies for the study of egg *** applied this approach to the egg accumulation from Paimogo(jurassic,Portug.l),traditionally interpreted as a *** findings reveal that the Paimogo egg assemblage is a secondary deposit,resulting from a flooding event in a fluvial plain that dismantled several allosauroid and crocodylomorph *** eggshell vapor conductance results,coupled with sedimentological evidence,suggest that allosauroid dinosaurs buried their eggs in the dry terrain of overbank areas close to a main channel during the breeding season,likely during the dry season to prevent the embryos from *** research underscores the necessity of multidisciplinary approaches in interpreting egg accumulations and offers a novel methodology for studying these accumulations in structureless *** findings provide new insights into the breeding behaviour and nesting preferences of these extinct organisms,contributing to our understanding of dinosaur ecology.

关键词： Breeding behaviour Theropod Taphonomy Stable isotopes Magnetic susceptibility jurassic

Effect of full-fat sunflower or flaxseed seeds dietary inclusion on performance,egg yolk fatty acid profile and egg quality in laying hens

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Animal nutrition 2020年第2期6卷 179-184页

作者： Yandy j.Aguillón-Páez laura A.Romero gonzalo j.Diaz Facultad de Ciencias Agropecuarias Universidad de CundinamarcaFusagasugá252211Colombia Facultad de Medicina Veterinaria y de Zootecnia Universidad Nacional de ColombiaBogotá111321Colombia

A study was conducted to evaluate the effect of the dietary inclusion of full-fat flaxseed of full-fat sunflower seeds on performance parameters,egg quality parameters and egg yolk fatty acid profile in laying hens.A total of 150 Babcock Brown hens at 27 weeks of age were distributed in 3 experimental treatments,as follows:T1,control;T2,diet containing 13.5% full-fat whole flaxseed seeds;and T3,diet containing 13.5% full-fat ground sunflower *** and water were provided ad libitum and the experiment lasted for 8 *** significant differences were found on egg quality parameters,but total egg production and rate of lay were significantly(P lower in the group receiv.ng sunflower seeds compared with the control,and significant differences(P n egg yolk saturated,monounsaturated,polyunsaturated,omega-6(n-6) and omega-3(n-3) fatty acids were observed,as well as in the n-6:n-3 *** results show that the dietary inclusion of 13.5% flaxseed full-fat seeds significantly increases the n-3 polyunsaturated fatty acid(PUFA) content in the eggs and lowers the n-6:n-3 ratio without affecting performance *** of full-fat sunflower seeds increases the n-6 PUFA content but affects total egg production and rate of *** studies are needed to determine the level of inclusion of full-fat sunflower seeds that does not affect performance.

关键词： Flaxseed Sunflower Polyunsaturated fatty acid laying hens Egg quality Performance