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Nutritional Supplement Ocoxin® Combined with Gemcitabine-Based Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma

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Open Journal of Gastroenterology 2024年第8期14卷 267-287页

作者： Mayté Lima-Pérez Jorge Luis Soriano-García Masiel González-Meisozo Jorge Luis Soriano-Lorenzo Vilma Fleites-Calvo Dunia Morales-Morgado Carlos Domínguez-Álvarez iván Ramón-Concepción Raidel Rodríguez-Barrios Alicia Tarinas-Reyes ivis Mendoza-Hernández Rolando Uranga-Piña Clinical Oncology Department Ameijeiras Hospital Havana Cuba Clinical Pathology Department Ameijeiras Hospital Havana Cuba Clinical Section National Coordinating Centre for Clinical Trials Havana Cuba Biostatistics Section National Coordinating Centre for Clinical Trials Havana Cuba

Background: the quality of life (QoL) of patients with pancreatic ductal adenocarcinoma (PDAC), with its limited survival, can be affected by chemotherapy-induced toxicity. The main objective was to evaluate the effect of introducing ocoxin oral solution (OOS) in combination with standard therapy on quality of life. Methods: Thirty patients were enrolled in an exploratory, prospective, single-centre clinical trial in the oncology department of “Hermanos Ameijeiras” University Hospital in Havana, Cuba. Quality of life was measured using the EORTC QLQ-C30 questionnaire and toxicity was assessed using the NCI-CTC-AE classification version 5.0. Results: There was stability in the scores over time for overall QoL and the functional scale criteria, while in terms of symptoms, fatigue, pain and loss of appetite were reduced. No grade 3 - 4 adverse events (AEs) were recorded, and only 14.9% of toxicities were classified as grade 2, and these were considered to be unrelated to OOS. Biochemical and nutritional parameters were normalised at 12 months compared to the baseline values. Conclusions: This clinical study is the first report of the use of OOS in patients with advanced pancreatic cancer, and demonstrates that it is able to maintain optimal quality of life with reduced severity of toxicity during and after combination treatment with gemcitabine-based chemotherapy.

关键词： EORTC QLQ-C30 Ocoxin Chemotherapy Pancreatic Cancer Quality of Life

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Glial cells in the center of future ischemic stroke treatments

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Neural Regeneration Research 2022年第12期17卷 2659-2660页

作者： ivóH.Hernández Maria JoséPérez-Álvarez Genomic Instability Group Spanish National Cancer Research Centre(CNIO)MadridSpain Departamento de Biología(Fisiología Animal)Facultad de Ciencias Universidad Autónoma de Madridand Instituto de Biología Molecular-CBMSOUAM/CSICMadridSpain

In the last century,increasing knowledge about glial cells has revealed their importance in brain physiology and disease and an exciting potential target for new therapeutic interventions(Hernández et al.,2021).Ischemic stroke is the most common of all types of *** the second leading cause of disability and mortality,ischemic stroke is a serious socio-economic burden *** it has been strongly associated with aging,during 2020 COVID-19 emerged as a new risk factor for ischemic stroke in younger patients(Cagnazzo et al.,2021).The only therapy or intervention currently available for humans is early reperfusion after the onset of the first ***,due to the high risk of brain hemorrhage,these treatments are suitable for only a small percentage of ***,reperfusion does not prevent post-injury neurodegeneration,hence the importance of finding new therapeutic alternatives to ameliorate ischemic damage and improve post-stroke quality of life.

关键词： mortality treatment younger

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Corrigendum to“The new ichnotaxon Eubrontes nobitai *** other saurischian tracks from the Lower Cretaceous of Sichuan Province and a review of Chinese Eubrontes-type tracks”[Journal of Palaeogeography(10)(2021)17]

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Journal of Palaeogeography 2024年第2期13卷 372-372页

作者： Li-Da Xing Martin G. Lockley Hendrik Klein Li-Jun Zhang Anthony Romilio W. Scott Persons iv Guang-Zhao Peng Yong Ye Miao-Yan Wang State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Beijing 100083 China School of the Earth Sciences and Resources China University of Geosciences Beijing 100083 China Dinosaur Trackers Research Group University of Colorado Denver Denver 80217 USA Saurierwelt Paläontologisches Museum Alte Richt 7 92318 Neumarkt Germany Institute of Resources and Environment Key Laboratory of Biogenic Traces and Sedimentary Minerals of Henan Province Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic Region Henan Polytechnic University Jiaozuo 454003 Henan Province China School of Biological Sciences The University of Queensland Brisbane Queensland 4072 Australia Mace Brown Museum of Natural History Department of Geology and Environmental Geosciences College of Charleston Charleston 29401 USA Zigong Dinosaur Museum Zigong 643013 Sichuan Province China

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High-Temperature Thermodynamic Investigation of Nano-Dispersed Nitrides Obtained in Thermal Plasma

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Plasma Science and Technology 2007年第2期9卷 174-176页

作者： M. GEORGIEVA G. VISSOKOV iv. GRANCHAROV L. BRAKALOV Department of Technology of Inorganic Substances University of Chemical Technology andMetal|urgy 8 K. Okhridski Blvd. 1756 Sofia Bulgaria

The nitrides of transient metals have a high hardness, thermal stability, remarkable wear resistance in aggressive chemical mediums, melted metals and alloys, high corrosion resistance, and low coefficient of electric resistance. Under the conditions of low-temperature argon plasma （LTP）, thermodynamic investigations were conducted in the process of obtaining of A1N, TiN and Si3N4 in a temperature range of 1000 K to 6000 K. To investigate the thermodynamic possibility of obtaining nitrides, a computer model was used which provided the equilibrium composition of gaseous and solid phases at different temperatures. The conditions for chemical equilibrium of the system were based on the minimization of Gibbs＇ energy.

关键词： plasma-chemical treatment nitrides thermodynamic analysis

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Enhanced optical absorption in semiconductor nano- particles enabled by nearfield dielectric scattering

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Nano Research 2017年第4期10卷 1292-1301页

作者： Kowsalya D. Rasamani Jonathan J. Foley iv Brittney Beidelman Yugang Sun Department of Chemistry Temple University 1901 North 13th Street Philadelphia Pennsylvania 19122 USA Department of Chemistry William Paterson University 300 Pompton Road Wayne New Jersey 07470 USA Department of Physics Bryn Mawr College 101 North Merion Avenue Bryn Mawr Pennsylvania 19010 USA

The optical absorption of semiconducting AgBr nanocubes is significantly increased by up to 5 times in the measured spectral range when they are bonded to the surface of dielectric SiO2 nanospheres through electrostatic interaction. The absorption enhancement factor depends on the wavelength and the size of the SiO2 nanoparticles （NPs）. Finite-difference time-domain calculations provide the nearfield intensity mapping of a heterostructure that is composed of a AgBr nanocube in close contact with a SiO2 nanosphere. The electric-field distributions indicate the field enhancement near the SiO2/AgBr interface due to light scattering and absorption enhancement in the AgBr nanocube, implying that the enhanced scattering nearfield increases the absorption cross section of the AgBr nanocube. The absorption cross-section spectra calculated using Mie theory agree with the experimental observations. This discovery sheds light on the utilization of dielectric spherical particles to increase the absorption in semiconductor NPs, thus improving the light-harvesting efficiency for solar-energy conversion.

关键词： enhanced scattering nearfield dielectric scattering absorption enhancement Mie theory

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Hordedane diterpenoid phytoalexins restrict Fusarium graminearum infection but enhance Bipolaris sorokiniana colonization of barley roots

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Molecular Plant 2024年第8期17卷 1307-1327页

作者： Yaming Liu Dario Esposto Lisa K.Mahdi Andrea Porzel Pauline Stark Hidayat Hussain Anja Scherr-Henning Simon Isfort Ulschan.Bathe ivan F.Acosta Alga Zuccaro Gerd U.Balcke Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryHalleGermany Institute for Plant Sciences Cluster of Excellence on Plant Sciences(CEPLAS)Cologne BiocenterUniversity of CologneCologneGermany Department of Bioorganic Chemistry Leibniz Institute of Plant BiochemistryHalleGermany Max Planck Institute for Plant Breeding Research CologneGermany Horticultural Sciences University of FloridaGainesvilleFLUSA.

Plant immunity is a multilayered process that includes recognition of patterns or effectors from pathogens to elicit defense *** include the induction of a cocktail of defense metabolites that typically restrict pathogen ***,we investigate the interaction between barley roots and the fungal pathogens Bipolaris sorokiniana(Bs)and Fusarium graminearum(Fg)at the metabolite *** identify hordedanes,a previously undescribed set of labdane-related diterpenoids with antimicrobial properties,as critical players in these *** of barley roots by Bs and Fg elicits hordedane synthesis from a 60o-kb gene *** reconstruction of the biosynthesis pathway in yeast and Nicotiana benthamiana produced several hordedanes,including one of the most functionally decorated products 19-β-hydroxy-hordetrienoic acid(19-OH-HTA).Barley mutants in the diterpene synthase genes of this cluster are unable to produce hordedanes but,unexpectedly,show reduced Bs *** contrast,colonization by Fusarium graminearum,another fungal pathogen of barley and wheat,is 4-fold higher in the mutants completely lacking ***,19-OH-HTA enhances both germination and growth of Bs,whereas it inhibits other pathogenic fungi,including *** of microscopy and transcriptomics data suggest that hordedanes delay the necrotrophic phase of *** together,these results show that adapted pathogens such as Bs can subvert plant metabolic defenses to facilitate root colonization.

关键词： barley Hordeum vulgare diterpenoid phytoalexins gene cluster pathogenic fungi Bipolaris sorokininiana Fusarium graminearum

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Following New Philanthropy by Network Ethnography:How Did the Varkey Foundation Land and Expand in Latin America?

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ECNU Review of Education 2023年第4期6卷 541-567页

作者： iván Matovich Tomás Esper Monash University Columbia University

Purpose:New philanthropy develops new forms of policy“problem-solving”through the influx of private actors’money and *** adopts singular configurations across different policy spaces,with implications for education *** address this phenomenon by analyzing the Varkey Foundation’s(VF)“landing”and“expansion”in Latin *** is a global philanthropic organization registered in the United Kingdom in 2011 with a main hub in Argentina,where it landed in ***/Approach/Methods:We use network ethnography to examine the influence of new philanthropy on education governance as this phenomenon demands new methods to grasp the“realities”of governing beyond conventional ways and understanding policy ***:Results indicate how VF“landed”in a little pro-market space via productive uses of policy *** second phase of data collection and analysis presents further consolidation of VF in Argentina,its expansion into Latin America,and its establishment as a legitimate education policy ***/Value:This study provides new evidence and insights into how policy networks enable new philanthropy to land and consolidate within national boundaries and,later,across the region as a legitimate actor in education.

关键词： Education policy policy networks network ethnography new philanthropy Varkey Foundation

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Magnetic systems for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2172-2196页

作者： Nicole B.Day William C.Wixson C.Wyatt Shields iv Department of Chemical&Biological Engineering University of ColoradoBoulderCO 80303USA

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional *** cell modulation through the administration of drugs,proteins,and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive *** systems offer several advantages for improving the performance of immunotherapies,including increased spatiotemporal control over transport,release,and dosing of immunomodulatory drugs within the body,resulting in reduced off-target effects and improved *** to alternative methods for stimulating drug release such as light and pH,magnetic systems enable several distinct methods for programming immune ***,we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug ***,we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target ***,we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated ***,we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor ***,we discuss translational considerations of these systems,such as toxicity,clinical compatibility,and future opportunities for improving cancer treatment.

关键词： Drug delivery Immunotherapy Magnetic hyperthermia Magnetic nanoparticles Microrobotics Biomaterials

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Stone–Wales defects in hexagonal boron nitride as ultraviolet emitters

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npj Computational Materials 2020年第1期6卷 169-175页

作者： Hanen Hamdi GergőThiering Zoltán Bodrog Viktor ivády Adam Gali Wigner Research Centre for Physics P.O.Box 49Budapest 1525Hungary Department of Physics Chemistry and BiologyLinköping UniversityLinköping SE-58183Sweden Budapest University of Technology and Economics Budafokiút 8.Budapest 1111Hungary

Many quantum emitters have been measured close or near the grain boundaries of the two-dimensional hexagonal boron nitride where various Stone–Wales defects *** show by means of first principles density functional theory calculations that the pentagon–heptagon Stone–Wales defect is an ultraviolet emitter and its optical properties closely follow the characteristics of a 4.08-eV quantum emitter,often observed in polycrystalline hexagonal boron *** also show that the square–octagon Stone–Wales line defects are optically active in the ultraviolet region with varying gaps depending on their density in hexagonal boron *** results may introduce a paradigm shift in the identification of fluorescent centres in this material.

关键词： Wales boron hexagonal

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New advances in hepatocellular carcinoma

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World Journal of Hepatology 2016年第9期8卷 421-438页

作者： Sonia Pascual iván Herrera Javier Irurzun Liver Unit Gastroenterology Department Interventional Radiological Unit Hospital General Universitario de Alicante03010 AlicanteSpain

AIM: To determine if gene-specific DNA methylation in prospectively collected blood samples is associated with later development of hepatocellular carcinoma(HCC).METHODS: Comparing genome-wide DNA methylation profiles using Illumina Human methylation 450 K arrays, we previously identified a list of loci that were differentially methylated between tumor and adjacent nontumor tissues. To examine if dysregulation of DNAmethylation patterns observed in tumor tissues can be detected in white blood cell(WBC) DNA, we conducted a prospective case-control study nested within a community-based cancer screening cohort in Taiwan with 16 years of follow up. We measured methylation levels in ninety-six loci that were aberrant in DNA methylation in HCC tumor tissues compared to adjacent tissues. Baseline WBC DNA from 159 HCC cases and 312 matched controls were bisulfite treated and assayed by Illumina Bead Array. We used the χ2 test for categorical variables and student's t-test for continuous variables to assess the difference in selected characteristics between cases and controls. To estimate associations with HCC risk, we used conditional logistic regression models stratified on the matching factors to calculate odds ratios(OR) and 95%CI. RESULTS: We found that high methylation level in cg10272601 in WNK2 was associated with increased risk of HCC, with an OR of 1.91(95%CI: 1.27-2.86). High methylation levels in both cg12680131 in TPO and cg22511877 in MYT1 L, however, were associated with decreased risk. The ORs(95%CI) were 0.59(0.39-0.87) and 0.50(0.33-0.77), respectively, for those with methylation levels of cg12680131 and cg22511877 above the median compared with those with levels below the median. These associations were still statistically significant in multivariable conditional logistic regression models after adjusting for hepatitis B virus infection and alcohol consumption. CONCLUSION: These findings support the measurement of methylation markers in WBC DNA as biomarke

关键词： DNA methylation Epigenetics Hepatitis B virus Hepatocellular carcinoma White blood cell DNA

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