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Utilization of soil nailing technique to increase shear strength of cohesive soil and reduce settlement

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Journal of rock Mechanics and Geotechnical Engineering 2017年第6期9卷 1104-1111页

作者： W.r.Azzam A.Basha Faculty of Engineering Tanta UniversityTantaEgypt Faculty of Engineering Kafrelsheikh UniversityKafrelsheikhEgypt

This article deals with the assessment of the soil nailing technique with a vertical inclusion to improve the geotechnical parameters of cohesive soil. A series of unconfined compression tests and direct shear tests were carried out to establish the stressestrain relationship and strength characteristics of the reinforced clay sample by vertical steel nails. The shear strength performance of the new composite material was tested by varying the number of vertical inclusions, the embedment depth and the alignment radius. The results confirmed that the vertical bars/inclusions shared the vertical applied load with clay. Increase in the number of vertical inclusions significantly increases the shear strength and the stiffness with a remarkable reduction in settlement. When the clay samples were reinforced with six inclusions along the perimeter, the shear strength was increased to 231% for the embedment depth ratio equal to 0.85. To obtain the optimum effect in eliminating shear failure, the vertical inclusions should be extended to a deeper zone with sufficient numbers. It has been found that the vertical inclusions significantly influence the shear strength, and the brittle or general shear failure of the unreinforced sample can be diverted to partial/plastic shear failure.

关键词： Cohesive soil Shear strength Vertical inclusion Stiffness Settlement

Mouse modelling of the MDM2/MDMX-p53 signalling axis

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Journal of Molecular Cell Biology 2017年第1期9卷 34-44页

作者： nicole r. Tackmann Yanping Zhang Department of radiation Oncology Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA Curriculum in Genetics and MoLecular Biology School of Medicine University of North Carolina at Chapel HiLl Chapel HILL NC 27514 USA Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer Institute Xuzhou Medical College Xuzhou 221002 China

It is evident that p53 activity is critical for tumour prevention and stress response through its transcriptional activation of genes affecting cellular senescence, apoptosis, cellular metabolism, and DnA repair. The regulation of p53 is highly complex, and MDM2 and MDMX are thought to be critical for deciding the fate of p53, both through inhibitory binding and post-translational modification. Many mouse models have been generated to study the regulation of p53 in vivo, and they have altered our inter- pretations of how p53 is regulated by MDM2 and MDMX. Although MDM2 is absolutely required for p53 regulation, certain func- tions are dispensable under unstressed conditions, including the ability of MDM2 to degrade p53. MDMX, on the other hand, may only be required in select situations, like embryogenesis. These models have also clarified how cellular stress signals modify the p53-inhibiting activities of MDM2 and MDMX in vivo. It is clear that more work will need to be performed to further understand the contexts for each of these signals and the requirements of various MDM2 and MDMX functions. Here, we will discuss what we have learned from mouse modelling of MDM2 and MDMX and underscore the ways in which these models could inform future therapies.

关键词： p53 MDM2 MDMX E3 ubiquitin ligase cancer

reactive navigation of Underwater Mobile robot Using AnFIS Approach in a Manifold Manner

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International Journal of Automation and computing 2017年第3期14卷 307-320页

作者： Shubhasri Kundu Dayal r. Parhi robotics Lab Department of Mechanical Engineering Rourkela National Institute of Technology Rourkela 769008 India

Learning and self-adaptation ability is highly required to be integrated in path planning algorithm for underwater robot during navigation through an unspecified underwater environment. High frequency oscillations during underwater motion are responsible for nonlinearities in dynamic behavior of underwater robot as well as uncertainties in hydrodynamic coefficients. reactive behaviors of underwater robot are designed considering the position and orientation of both target and nearest obstacle from robot s current position. Human like reasoning power and approximation based learning skill of neural based adaptive fuzzy inference system（AnFIS）has been found to be effective for underwater multivariable motion control. More than one AnFIS models are used here for achieving goal and obstacle avoidance while avoiding local minima situation in both horizontal and vertical plane of three dimensional *** error gradient approach based on input-output training patterns for learning purpose has been promoted to spawn trajectory of underwater robot optimizing path length as well as time taken. The simulation and experimental results endorse sturdiness and viability of the proposed method in comparison with other navigational methodologies to negotiate with hectic conditions during motion of underwater mobile robot.

关键词： Adaptive fuzzy inference system(AnFIS) error gradient optimal path obstacle avoidance behavior steering angle target seeking behavior

An improved smoke-wire flow visualization technique using capacitor as power source

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Theoretical & Applied Mechanics Letters 2018年第6期8卷 378-383,I0004页

作者： n.Gao X.H.Liu School of Aeronautics and Astronautics Dalian University of Technology

An improved smoke-wire flow visualization technique using a large capacitor as the power source was proposed. Electric current discharged from capacitors was used to heat a fine metal wire suspended in the flow field. The oil droplets attached to the wire were vaporized and smoke filaments followed the flow motions. A digital camera was used to record the images of the smoke filaments. The actions of discharging and camera shutter were triggered by signals from a microcontroller to ensure the accurate timing. Clear images of the streaklines were captured at a freestream velocity up to 12.9 m/s, much higher than the limits of the existing techniques.

关键词： Smoke-wire visualization Capacitor Timing circuit

Acoustic stop bands in almost-periodic and weakly randomized stratified media:perturbation analysis

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Acta Mechanica Sinica 2008年第5期24卷 549-556页

作者： S.Guenneau A.B.Movchan n.V.Movchan J.Trebicki Department of Mathematical Sciences University of LiverpoolPeach StreetLiverpool L69 3BXUK Polish Academy of Sciences Institute of Fundamental Technology ResearchSwietokrzyska 21Warsaw 00049Poland

In this paper, we analyze the effect of both deter- ministic and random perturbations of a regular multi-layered elastic structure on its stop band properties. The tool of choice is the transfer matrix method, which is both versatile and easy to implement. In both cases, we find that the stop-bands widen. We observe the appearance of very narrow pass-bands within the stop-bands, which can be observed in other instances in optics.

关键词： Transmission problem Small random perturbations Stop bands

receptor-type protein tyrosine phosphatases in cancertype protein tyrosine phosphatases in cancer

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Chinese Journal of Cancer 2015年第2期34卷 61-69页

作者： Yu Du Jennifer r.Grandis Department of Otolaryngology University of Pittsburgh School of Medicine Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine School of Medicine Tsinghua University

Protein tyrosine phosphatases(PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. receptor-type protein tyrosine phosphatases(PTPrs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPrs in cancer and consider the consequences of PTPr alterations in different types of cancers. We also summarize recent developments using PTPrs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPrs in cancer may provide opportunities to improve therapeutic approaches.

关键词：蛋白酪氨酸磷酸酶癌症体型表观遗传细胞增殖细胞信号 PTP 酶调控

Atomistic material behavior at extreme pressures

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npj Computational Materials 2016年第1期2卷 93-96页

作者： Laurent Karim Béland Yuri n Osetsky roger E Stoller Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTNUSA

Computer simulations are routinely performed to model the response of materials to extreme environments,such as neutron(or ion)*** latter involves high-energy collisions from which a recoiling atom creates a so-called atomic displacement *** cascades involve coordinated motion of atoms in the form of supersonic *** shockwaves are characterized by local atomic pressures 415 GPa and interatomic distances o2Å.Similar pressures and interatomic distances are observed in other extreme environment,including short-pulse laser ablation,high-impact ballistic collisions and diamond anvil *** cascade simulations using four different force fields,with initial kinetic energies ranging from 1 to 40 keV,show that there is a direct relationship between these high-pressure states and stable defect *** important shortcoming in the modeling of interatomic interactions at these short distances,which in turn determines final defect production,is brought to light.

关键词： extreme defect latter

Peptide aptamer-mediated modulation of prion protein α-cleavage as treatment strategy for prion and other neurodegenerative diseases

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neural regeneration research 2018年第12期13卷 2108-2110页

作者： Antonia n.Klein Erica Corda Sabine Gilch Department of Ecosystem and Public Health Faculty of Veterinary Medicine University of Calgary Calgary Prion research Unit University of Calgary Hotchkiss Brain Institute University of Calgary

Despite intensive research,most neurodegenerative diseases cannot be cured and for some of them no treatment is available to increase survival or quality of *** the latter are prion diseases,fatal and transmissible ne... 详细信息

关键词： Peptide aptamer-mediated modulation of prion protein cleavage as treatment strategy for prion and other neurodegenerative diseases

Assessment of bone turnover and bone quality in type 2 diabetic bone disease： current concepts and future directions

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Bone research 2016年第1期4卷 1-9页

作者： Mishaela r rubin Janina M Patsch Metabolic Bone Disease Unit Department of Medicine Columbia University College of P&S New York USA Division of General radiology and Pediatric radiology Department of Biomedical Imaging and Image-Guided Therapy Medical University of Vienna Vienna Austria

Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due to altered bone properties in diabetes. Circulating biochemical markers of bone turnover have been found to be decreased in type 2 diabetes （T2D） and may be predictive of fractures independently of bone mineral density （BMD）. Serum sclerostin levels have been found to be increased in T2D and appear to be predictive of fracture risk independent of BMD. Bone imaging technologies, including trabecular bone score （TBS） and quantitative CT testing have revealed differences in diabetic bone as compared to non-diabetic individuals. Specifically, high resolution peripheral quantitative CT （HrpQCT） imaging has demonstrated increased cortical porosity in diabetic postmenopausal women. Other factors such as bone marrow fat saturation and advanced glycation endproduct （AGE） accumulation might also relate to bone cell function and fracture risk in diabetes. These data have increased our understanding of how T2D adversely impacts both bone metabolism and fracture risk.

关键词： bone Assessment of bone turnover and bone quality in type 2 diabetic bone disease type