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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI EHAB I.taha SAYED H.AUDA FAIQAH RAMZAN MUHAMMAD JAMIL The Second Affiliated Hospital of Harbin Medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

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Delivering audiovisual content with MPEG-21-enabled cross-layer QoS adaptation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 784-793页

作者： ahmed Toufik DJAMA ismail CNRS-LaBRI Laboratory University of Bordeaux-1.351 Cours de la Libération Talence F-33405 France

Future multimedia communication systems have to support the user’s needs, the terminal capabilities, the content specification and the underlying networking technologies. The related protocols and applications must be designed from this integration perspective in a cross-layer centric manner. In this paper, we propose an implementation of a streaming service (e.g., Television over IP service) with a unified QoS management concept that enables an IP driven integration of different system components (terminal, user, content, and network). The MPEG-21 framework is used to provide a common support for imple- menting and managing the end-to-end QoS. The main focus of this paper is on the architecture design, protocols specification and implementation evaluation. Performance evaluations using PSNR and SSIM objective video quality metrics show the benefit of the proposed MPEG-21-enabled cross-layer adaptation.

关键词： Cross-layer adaptation, MPEG-21 multimedia framework, Real-time streaming, QoS

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A Comparative Analysis on Surgical Outcomes and Complications of Endoscopic and Open Vein Harvesting Techniques

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Open Journal of Thoracic Surgery 2024年第2期14卷 29-39页

作者： Mohammed Fawzy Eltaweel ismail N. El-Sokkary ahmed Alherazi Mohamed Wael Badawi Mohammed G. Abdellatif Bahaa A. Elkhonezy Ibrahim K. Gamil Haytham Mohamed Abd El Moaty Sarra Sadmi Mahmoud Khalil Department of Cardiothoracic Surgery Faculty of Medicine Menoufia University Shibin El Kom Egypt Department of Cardiovascular & Thoracic Surgery Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiothoracic Surgery Faculty of Medicine Alexandria University Alexandria Egypt Faculty of Medicine University of Algiers Algiers Algeria Department of Cardiac Surgery Sabah Al-Ahmed Cardiac Center Al-Amiri Hospital Kuwait City Kuwait

Objective: The great saphenous vein (GSV) is commonly used as a conduit for grafting during CABG surgery, and open GSV harvesting (OVH), commonly used with long incision to expose the vein. However, endoscopic vein harvesting (EVH) is an alternative approach, utilizing specialized instruments and small incisions to harvest the vein. Methods: A retrospective analysis was conducted on a cohort of patients who underwent Coronary artery bypass graft (CABG) requiring great saphenous vein (GSV) harvesting which was done by EVH or OVH procedures. Demographic variables, including age and gender, were assessed for both groups. Intraoperative variables such as the number of grafts, cardiopulmonary bypass time, X clamp time, and type of procedure were analyzed. Postoperative variables, including infection and bleeding rates, were also evaluated. Results: The study included 30 patients each undergoing Coronary artery bypass graft (CABG) with need of great saphenous vein harvesting which was done by EVH and OVH. Demographic variables were well-matched between the two groups in terms of age, while a significant difference in gender distribution was observed. Obesity and smoking were more prevalent in the OVH group, and EVH was associated with a higher mean number of grafts compared to OVH. Conversion to an open technique occurred in a portion of the EVH cases, and infection rates did not significantly differ between the EVH and OVH groups. However, the incidence of postoperative bleeding was significantly higher in the EVH group. Conclusion: This study provides valuable insights into the demographic, intraoperative, and postoperative variables associated with EVH and OVH techniques. EVH demonstrated advantages in terms of reduced infection rates compared to OVH. However, the higher incidence of postoperative bleeding associated with EVH raises concerns about potential risks.

关键词： Endoscopic Vein Harvesting (EVH) Open Vein Harvesting (OVH) Coronary Artery Bypass Grafting (CABG) Great Saphenous Vein (GSV) Surgical Outcomes

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Finite element modeling assumptions impact on seismic response demands of MRF-buildings

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 821-834页

作者： Shehata E Abdel Raheem ahmed K Abdel Zaher ahmed MA taha Civil Engineering Department Engineering College Taibah University Civil Engineering Department Faculty of Engineering Assiut University

Recent seismic events have raised concerns over the safety and vulnerability of reinforced concrete moment resisting frame ＂RC-MRF＂ buildings. The seismic response of such buildings is greatly dependent on the computational tools used and the inherent assumptions in the modelling process. Thus, it is essential to investigate the sensitivity of the response demands to the corresponding modelling assumption. Many parameters and assumptions are justified to generate effective structural finite element（FE） models of buildings to simulate lateral behaviour and evaluate seismic design demands. As such, the present study focuses on the development of reliable FE models with various levels of refinement. The effects of the FE modelling assumptions on the seismic response demands on the design of buildings are investigated. the predictive ability of a FE model is tied to the accuracy of numerical analysis; a numerical analysis is performed for a series of symmetric buildings in active seismic zones. The results of the seismic response demands are presented in a comparative format to confirm drift and strength limits requirements. A proposed model is formulated based on a simplified modeling approach, where the most refined model is used to calibrate the simplified model.

关键词： RC-MRF buildings design codes provisions seismic design finite element modeling modeling assumptions response demands

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Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not:A systematic review and meta-analysis

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World Journal of Methodology 2024年第3期14卷 141-162页

作者： Kinza Iqbal Akshat Banga taha Bin Arif Sawai Singh Rathore Abhishek Bhurwal Syeda Kisa Batool Naqvi Muhammad Mehdi Pankaj Kumar Mitali Madhu Salklan Ayman Iqbal Jawad ahmed Nikhil Sharma Amos Lal Rahul Kashyap Vikas Bansal Juan Pablo Domecq Department of Internal Medicine Dow Medical CollegeKarachi 74200Pakistan Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Internal Medicine Dr.Sampurnanand Medical CollegeJodhpur 342003RajasthanIndia Department of Gastroenterology and Hepatology Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019(COVID-19)*** is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 *** To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 *** A Literature search was performed on LitCovid PubMed,WHO,and Scopus databases from inception(December 2019)till June 2023 for original studies reporting an association between prior use of anticoagulants and patient outcomes in adults with *** primary outcome was the risk of thromboembolic events in COVID-19 patients taking *** outcomes included COVID-19 disease severity,in terms of intensive care unit admission or invasive mechanical ventilation/intubation requirement in patients hospitalized with COVID-19 infection,and *** random effects models were used to calculate crude and adjusted odds ratios(aORs)with 95%confidence intervals(95%CIs).RESULTS Forty-six observational studies met our inclusion *** unadjusted analysis found no association between prior anticoagulation and thromboembolic event risk[n=43851,9 studies,odds ratio(OR)=0.67(0.22,2.07);P=0.49;I2=95%].The association between prior anticoagulation and disease severity was non-significant[n=186782;22 studies,OR=1.08(0.78,1.49);P=0.64;I2=89%].However,pre-hospital anticoagulation significantly increased all-cause mortality risk[n=207292;35 studies,OR=1.72(1.37,2.17);P<0.00001;I2=93%].Pooling adjusted estimates revealed a statistically non-significant association between pre-hospital anticoagulation and thromboembolic event risk[aOR=0.87(0.42,1.80);P=0.71],mortality[aOR=0.94(0.84,1.05);P=0.31],and disease severity[aOR=0.96(0.72,1.26);P=0.76].CONCLUSION Prehospital anticoagulation was not significantly associated with reduced risk of thromboembolic events,improved survival,and lower disease seve

关键词： Prior anticoagulation COVID-19 Prehospital anticoagulation Chronic anticoagulation Mortality Severity Thromboembolic events

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Preparation and application of amino functionalized mesoporous nanofiber membrane via electrospinning for adsorption of Cr^(3+) from aqueous solution

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Journal of Environmental Sciences 2012年第4期24卷 610-616页

作者： ahmed A.taha Junlian Qiao Fengting Li Bingru Zhang College of Environmental Science and Engineering UNEP Tongji Institute of Environment for Sustainable DevelopmentState Key Laboratory of Pollution Control and Resource ReuseTongji University

Novel amino （-NH2） functionalized mesoporous polyvinyl pyrrolidone （PVP）/SiO2 composite nanofiber membranes were fabricated by a one-step electrospinning method using poly （vinyl alcohol） and tetraethyl orthosilicate （TEOS） mixed with cationic surfactant, cety｜trimethyl ammonium bromide （CTAB） as the structure directing agent. Ureidopropyltriethoxysilane was used for functionalization of the internal pore surfaces. The membranes were characterized by scanning electron microscopy （SEM）, high-resolution transmission electron microscopy （HRTEM） images, X-ray diffraction （XRD）, Fourier-transform infrared spectroscopy （FT-IR）, element analyzer and Nz adsorption-desorption isotherms, The nanofiber diameters, average pore diameters and surface areas were 100-700 nm, 2.86 nm and 873,62 m2/g, respectively. These mesoporous membranes functionalized with -NH2 groups exhibited very high adsorptions properties based on the adsorption of Cr3＋ from an aqueous solution. Equilibrium adsorption was achieved after approximately 20 rain and more than 97% of chronium ions in the solution were removed. The membrane could be regenerated through acidification.

关键词： mesoporous electrospinning nanofiber amino groups adsorption

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Mitigation of the blast load effects on a building structure using newly composite structural configurations

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Defence Technology（防务技术） 2021年第1期17卷 75-84页

作者： ahmed K.taha M.S.Zahran Zhengguo Gao School of Transportation Science and Engineering Beihang University(Beijing University of Aeronautics and Astronautics)Beijing100191PR China Department of Civil Engineering Military Technical CollegeEgypt

In this study,a nonlinear three-dimensional hydrocode numerical simulation was carried out using AUTODYN-3D to investigate the effect of blasting of a high explosive material(TNT)against several configurations of the composite *** numerical models were carried out to study the effect of varying the thickness of the walls and the effect of adding an air layer or aluminum foam layer inside two layers of concrete in mitigating the effect of blast waves on the structure *** results showed that increasing the thickness of walls has a good effect on mitigating the effect of blast *** a layer of air was added,the effect of blast waves was exaggerated,while when a layer of aluminum foam was added the blast wave effects were mitigated with a reasonable percentage.

关键词： Concrete structures Blast waves Numerical simulation TNT

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Modified particle swarm optimization for optimum design of spread footing and retaining wall

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第6期12卷 415-427页

作者： Mohammad KHAJEHZADEH Mohd Raihan taha ahmed EL-SHAFIE Mahdiyeh ESLAMI Department of Civil Engineering Anar BranchIslamic Azad University Department of Civil and Structural Engineering University Kebangsaan Malaysia Department of Electrical Engineering Anar BranchIslamic Azad University

This paper deals with the economically optimized design and sensitivity of two of the most widely used systems in geotechnical engineering: spread footing and retaining wall. Several recent advanced optimization methods have been developed, but very few of these methods have been applied to geotechnical problems. The current research develops a modified particle swarm optimization (MPSO) approach to obtain the optimum design of spread footing and retaining wall. The algorithm handles the problem-specific constraints using a penalty function approach. The optimization procedure controls all geotechnical and structural design constraints while reducing the overall cost of the structures. To verify the effectiveness and robustness of the proposed algorithm, three case studies of spread footing and retaining wall are illustrated. Comparison of the results of the present method, standard PSO, and other selected methods employed in previous studies shows the reliability and accuracy of the algorithm. Moreover, the parametric performance is investigated in order to examine the effect of relevant variables on the optimum design of the footing and the retaining structure utilizing the proposed method.

关键词： Particle swarm optimization (PSO) Spread footing Retaining wall Sensitivity analysis

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Structural and Physicochemical Properties of Dust and Their Effect on Solar Modules Efficiency in Agadir-Morocco

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Journal of Renewable Materials 2023年第5期11卷 2249-2264页

作者： Abdellah Asbayou ahmed Ihlal ismail Isknan ahmed Soussi Lahoussine Bouhouch Materials and Renewable Energies Laboratory University Ibn ZohrAgadir80000Morocco

Experiments of soiling effects on the performances of a PV panel have been performed using dust collected from two sites in the region of *** optical transmittance of the front glass was found to depend on the nature and density of *** nature of dust was studied by means of scanning electron microscopy and energy dispersive x-ray *** was found that the granulometry of dust particles depends on the study *** a dust density of around 20 g/m^(2),the maximum power Pmax of the solar panel decreases drastically from 30 to 20 W for the(HP)site,and no more than 14 W for the(AD)*** diversity of the behavior of the soiled panel was explained in terms of the size of the particles collected from each *** transmission of light across the front glass of the PV panel is more affected when the sizes of particles are small.

关键词： Agadir PV panel soiling optical transmittance dust characterization

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Experimental and mathematical modeling of Cr(Ⅵ) removal using nano-magnetic Fe3O4-coated perlite from the liquid phase

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1582-1590页

作者： ismail M.ahmed Mostafa M.Hamed Sayed S.Metwally Chemistry Department College of ScienceJouf UniversitySkakaSaudi Arabia Hot Laboratories and Waste Management Center Atomic Energy Authority13759 CairoEgypt

Modification of perlite using nano-magnetic iron oxide was implemented to produce nano-magneticFe3O4-coated perlite composite(Fe3O4/Perlite).The prepared composite was characterized using Scanning Electron Microscopy,Fourier-Transform Infrared spectroscopy and Powder X-ray *** potentiality of both perlite and Fe3O4/Perlite composite to eliminate Cr(VI)from the environmentally relevant water was *** influence of main factors which could affect the adsorption was studied including;pH of medium,shaking time and Cr(VI)ions *** experimental outcome demonstrated that the modification of perlite by nano-magnetic Fe3O4 showed a significantly enhanced Cr(VI)removal efficiency relative to that of unmodified *** the kinetic studies,the experimental data fitted well with the pseudo-second-order ***,it proposes that Langmuir isotherm is more adequate than the Freundlich isotherm for both perlite and modified *** results recommended that Fe3O4/Perlite composite had a great potential as an economic and efficient adsorbent of Cr(VI)from contaminated water,which has huge application potential.

关键词： Nano-magnetic Composite Kinetics Isotherm Perlite Adsorption

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