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Dengue outbreaks in northern Nigeria: Evaluating the recommended Takeda vaccine and future prevention strategies

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World Journal of Virology 2024年第3期13卷 41-48页

作者： ismail Rabiu Hafsat Abubakar Musa Zephaniah Isaiah Mujahid Hussaini Muhammad Muhsin Umar Suleiman Mustapha Jaafaru Isah Abdullahi Aminu Shehu Mariya Abdullahi Sani College of Life Science Department of Biomedical Science and Environmental BiologyKaohsiung Medical UniversityKaohsiung 80708TaiwanChina Department of Microbiology Faculty of Life ScienceBayero University KanoKano 700006Kano StateNigeria Department of Microbiology Umaru Musa Yar’adua UniversityKatsina 820102Katsina StateNigeria Department of Microbiology Faculty of ScienceKaduna State UniversityTafawa Balewa Way 800283Kaduna StateNigeria National Reference Laboratory Nigeria Center for Disease ControlGaduwa 900231AbujaNigeria Department of Microbiology and Biotechnology Federal UniversityDutse 720223Jigawa StateNigeria Monitoring and Evaluation Unit(Jigawa State Office) World Health OrganizationDutse 720223Jigawa StateNigeria

Dengue fever,caused by the dengue virus(DENV),poses a significant public health challenge globally,with Nigeria experiencing sporadic outbreaks.A clear understanding of the dengue burden has not been achieved in Nigeria,just as in other African *** the epidemiology and burden of dengue fever is essential for effective prevention and control *** paper examines the recent dengue outbreaks in northern Nigeria,particularly in Sokoto state,and evaluates the recommended Takeda dengue vaccine(TDV)along with future prevention *** limited surveillance and underreporting,dengue fever is endemic in Nigeria(with over 5 million cases and 5000 dengue-related deaths in 2023),with recent outbreaks indicating a growing *** TDV,a live attenuated tetravalent vaccine,has shown promise in preventing dengue fever,but challenges such as vaccine acceptance and access-ibility need to be *** urbanization contributes to the disease's spread,which is influenced by factors such as population density,cultural beliefs,water storage practices,hygiene,and water supply *** prevention strategies must focus on government intervention,community practices,and innovative vector control measures to mitigate the spread of DENV in *** study will serve as a valuable reference for policy-makers,researchers,and clinicians in the management and control of DENV in Nigeria and Africa as a whole.

关键词： Dengue outbreaks Northern Nigeria Takeda dengue vaccine Vaccine acceptance Epidemiology

Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis

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World Journal of Virology 2024年第4期13卷 120-134页

作者： Mutali Musa Babatunde ismail Bale Ayuba Suleman Gladness Aluyi-Osa Ekele Chukwuyem FabianaD’Esposito Caterina Gagliano Antonio Longo Andrea Russo Marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser Centre LtdBenin 300105Nigeria Department of Ophthalmology Centre for Sight Africa LtdNkpor 434212Nigeria Imperial College Ophthalmic Research Group Unit Imperial CollegeLondon NW15QHUnited Kingdom GENOFTA srl Via A.Balsamo93Naples 80065Italy Department of Medicine and Surgery University of Enna"Kore"Catania 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Ophthalmology University Hospital of CataniaCatania 95123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

BACKGROUND Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology,including viral *** can be acute or chronic,selflimiting,or needing medical *** To review possible viral agents crucial for accurate differential diagnosis in cases of *** The PubMed database was searched for records relating to viral *** search string generated was“("virally"[All Fields]OR"virals"[All Fields]OR"virology"[MeSH Terms]OR"virology"[All Fields]OR"viral"[All Fields])AND"Blepharoconjunctivitis"[All Fields]".RESULTS A total of 24 publications were generated from the search *** lists from each relevant article were also searched for more information and included in this *** etiologies such as adenovirus,herpes simplex virus(HSV),varicella-zoster virus(VZV),and Epstein-Barr virus(EBV)are frequently *** infections manifest with follicular conjunctivitis and preauricular lymphadenopathy,often presenting as epidemic *** and VZV infections can result in herpetic keratitis and may exhibit characteristic dendritic corneal ***,although less common,can cause unilateral or bilateral follicular conjunctivitis,particularly in immunocompromised *** potential viral agents,such as enteroviruses and molluscum contagiosum virus,should also be considered,especially in pediatric *** Prompt recognition of these viral etiologies is essential for appropriate management and prevention of ***,a thorough understanding of the clinical presentation,epidemiology,and diagnostic modalities is crucial for accurate identification and management of viral blepharoconjunctivitis.

关键词： Viral Blepharoconjunctivitis Herpes simplex virus Varicella-Zoster Epstein-Barr

Does wet-cupping therapy improve repeated sprint ability,perceived wellness,and rating of perceived exertion in young active males?

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Sports Medicine and Health Science 2024年第4期6卷 378-384页

作者： ismail Dergaa Amine Ghram Mohamed Romdhani Amine Souissi Achraf Ammar Ramadan Abdelmoez Farahat Mohamed Saifeddin Fessi Khadijeh Irandoust Morteza Taheri Tasnim Masmoudi Mohamed Amine Dergaa Nizar Souissi Omar Hammouda Katja Weiss Karim Chamari Helmi Ben Saad Beat Knechtle Primary Health Care Corporation(PHCC) DohaP.O.Box 26555Qatar Research Unit Physical Activity Sportand HealthUR18JS01National Observatory of SportTunis 1003Tunisia High Institute of Sport and Physical Education University of SfaxSfaxTunisia Department of Cardiac Rehabilitation Heart HospitalHamad Medical CorporationDohaQatar Universite de Sousse Faculte de Medecine de SousseHopital Farhat HACHEDLaboratoire de Recherche(Insuffisance CardiaqueLR12SP09)SousseTunisia Healthy Living for Pandemic Event Protection(HL-PIVOT)Network ChicagoILUSA Interdisciplinary Laboratory in Neurosciences Physiology and Psychology:Physical ActivityHealth and LearningUFR STAPSUPLParis Nanterre UniversityNanterreFrance Department of Training and Movement Science Institute of Sport ScienceJohannes Gutenberg-University Mainz55128 MainzGermany Research Laboratory Molecular Bases of Human PathologyLR19ES13Faculty of Medicine of SfaxUniversity of SfaxSfax 3029Tunisia Faculty of Medicine Kafrelsheikh UniversityKafrelsheikh33511Egypt Department of Behavioral and Cognitive Sciences in Sport Faculty of Sport Sciences and HealthUniversity of TehranIran University of Sousse Farhat HACHED HospitalForensic ServiceSousseTunisia Medbase St.Gallen Am Vadianplatz St.GallenSwitzerland Aspetar Orthopaedic and Sports Medicine HospitalFIFA Medical Centre of ExcellenceDohaP.O.Box 29222Qatar Institute of Primary Care University of ZurichZurichSwitzerland

Wet-cupping therapy(WCT)is one of the oldest known medical techniques,used as a traditional and complementary therapy with a wide application all around the world for general *** on the effects of WCT on sports performance are sparse and ***,we aimed to explore the effects of WCT on repeated sprint ability,wellness,and exertion in young active ***-nine active adult males(age:[28±5]years;body height[177±8]cm;body mass:[79±7]kg;body mass index:[25.4±1.8]kg/m^(2))were selected for the *** participants performed a running-based sprint test on two separate occasions(Control and Post-WCT).WCT was performed 24 h before the testing *** completed the Hooper questionnaire to assess their well-being(i.e.,sleep,stress,fatigue,and soreness)before each *** rating of perceived exertion(RPE)was collected after each testing session.A higher maximum power(p<0.05,effect size[ES]=0.6),mean power(p<0.01,ES=0.5)and minimum power(p<0.01,ES=0.6)were recorded post-WCT as compared to Control session along with a better perceived sleep(p<0.01,ES=0.85).Perceived stress(p<0.01,ES=0.6)and RPE(p<0.001;ES=1.1)were lower during the post-WCT compared to the Control *** present findings demonstrated that WCT moderately enhanced repeated sprint ability and had positive effects on perceived sleep,stress,and *** may be an effective ergogenic aid to improve repeated sprint ability and general wellbeing in young adult *** large-scale multicentric clinical studies are paramount to confirm the results of our study.

关键词： Alternative medicine Complementary medicine Hijama Short-term maximal performance Sports medicine

Partial Fusion (F) Gene Analysis of Newcastle Disease Virus Detected in Pakistan during 2021-2022

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Journal of Biosciences and Medicines 2024年第5期12卷 256-275页

作者： Muhammad Danish Mehmood Huma Anwar Ul-Haq Rauf Khalid Yasir Amin Muhammad Usman Ghani Muhammad ismail Rabia Habib Fareeha Arshed Abdul Rasheed Shaukat Institute of Molecular Biology & Biotechnology University of Lahore Lahore Pakistan Research & Development Division Ottoman Pharma Lahore Pakistan Quality Assurance Department Ottoman Pharma Lahore Pakistan Veterinary Research and Disease Investigation Center Abbottabad Pakistan Quality Control Department Ottoman Pharma Immuno Lahore Pakistan Production Department Ottoman Pharma Lahore Pakistan Poultry Production Department Sabir&#8217s Poultry Pvt. Ltd. Sabroso Pakistan

Newcastle disease (ND) virus is a leading threat to commercial and domestic poultry in Pakistan. The virus infects and constitutes irreversible impairment to the nervous system, damages the respiratory system, and marks severe gastrointestinal lesions leading to heavy mortality in short-living birds and substantial losses in layers and breeders. The continuous emergence and evolution of the virus made it inclined to evade the humoral response and indirectly the circumvention of artificial active immunization. Newcastle disease is caused by the orthoavula genus of the paramyxoviridae family and has shown high genetic diversity even in their genotypes while information regarding enzootic trends of the virus is scanty in Pakistan. A total of 40 tracheal samples of NDV were collected from different commercial broiler farms and 11 isolates of NDV were identified. In the current study, we determined the genetic diversity of the Newcastle disease virus based on the partial sequencing of the fusion protein gene available in the NCBI database. Genetic analysis showed that seven isolates belonged to class I genotype VII and four belonged to class II genotype II. Interestingly, two isolates had epidemiological connections with vaccine-like class II genotype II. Our findings, concerning the recent outbreaks of class I genotype VII and class II genotype II of NDV in vaccinated commercial flocks, suggest possible potential partial mutations in the fusion protein gene. Genetic diversity and formation of the new cleavage site in an important neutralizing protein of wild strain are linked with the potency of artificial active immunization and a major cause of vaccine failure.

关键词： Newcastle Disease Virus Haemagglutination Inhibition Polymerase Chain Reaction Phylogenetic Tree Mutation Analysis

Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

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World Journal of Experimental Medicine 2024年第1期14卷 113-123页

作者： Suriati Mohd Nasir Anis Farihan ismail Tuan Salwani Tuan ismail Wan Faiziah Wan Abdul Rahman Wan Amir Nizam Wan Ahmad Tengku Ahmad Damitri Al-Astani Tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Endocrinology Laboratory Department of Chemical PathologySchool of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Biomedicine Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Basic Medical Sciences Kuliyyah of MedicineInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia

BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney *** is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic ***,the effect of stingless bee honey(SBH)administration in relieving liver and kidney damage in diabetes has not been *** To investigate the effect of SBH administration on the kidney and liver of streptozotocin-induced(STZ;55 mg/kg)diabetic Sprague Dawley *** The rats were grouped as follows(n=6 per group):non-diabetic(ND),untreated diabetic(UNT),metformin-treated(MET),and SBH+metformin-treated(SBME)*** successful diabetic induction,ND and UNT rats were given normal saline,whereas the treatment groups received SBH(2.0 g/kg and/or metformin(250 mg/kg)for 12 *** biochemical parameters and histological changes using hematoxylin and eosin(H&E)and periodic acid–Schiff(PAS)staining were *** On H&E and PAS staining,the ND group showed normal architecture and cellularity of Bowman’s capsule and tubules,whereas the UNT and MET groups had an increased glomerular cellularity and thickened basement *** SBH-treated group showed a decrease in hydropic changes and mild cellularity of the glomerulus vs the ND group based on H&E staining,but the two were similar on PAS ***,the SBME-treated group had an increase in cellularity of the glomerulus on H&E staining,but it was comparable to the SBH and ND groups on PAS *** diabetic rats had tubular hydropic tubules,which were smaller than other *** fatty vacuole formation and dilated blood sinusoids in liver tissue were seen in the SBH ***,the UNT group had high glucose levels,which subsequently increased MDA levels,ultimately leading to liver *** treatment reduced this damage,as evidenced by having the lowest fasting glucose,serum alanine transaminase,aspartate transaminase,and alkaline phosphatase l

关键词： Diabetes Streptozotocin Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney

基于ABAQUS旋转防喷器胶芯的非线性有限元分析

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兰州石化职业技术大学学报 2024年第3期24卷 1-8页

作者：田海疆 ismail SAAD YOONG HOU PIN 王翠凤福建信息职业技术学院智能制造学院福建福州350003 沙巴大学工程学院马来西亚沙巴州亚庇88670

旋转防喷器(RBOP)是欠平衡钻井中必不可少的安全保障设备,其中胶芯是旋转防喷器(RBOP)的关键部件和密封单元,其密封性能决定了旋转防喷器(RBOP)的密封能力。研究了旋转防喷器胶芯的工作机理及故障,依据国家标准和专利建立了胶芯的三维... 详细信息

旋转防喷器(RBOP)是欠平衡钻井中必不可少的安全保障设备,其中胶芯是旋转防喷器(RBOP)的关键部件和密封单元,其密封性能决定了旋转防喷器(RBOP)的密封能力。研究了旋转防喷器胶芯的工作机理及故障,依据国家标准和专利建立了胶芯的三维模型。通过分析研究,选择了适合胶芯材料的本构模型Yeoh模型,通过橡胶材料的单轴拉伸试验所获得的实验数据,使用ABAQUS软件拟合出本构模型的待定系数;在ABAQUS软件中建立钻杆与胶芯接触的三维力学模型,研究计算在不同井压下,钻杆与胶芯之间的接触压力大小和变形情况,得到了不同井口压力下,胶芯密封压力的变化规律——当井口压力逐渐增加时,胶芯内锥面开始发生变形,变形随压力的增加而增大,同时,内锥面和主密封面接触发生应力集中的现象;分析了井口压力为0时,钻杆接头通过胶芯内孔时,胶芯接触压力情况,得到了接触压力在胶芯内锥面各个节点的变化规律,为胶芯的失效分析和设计制造提供了理论依据。

关键词：旋转防喷器有限元分析力学模型胶芯

ANN-based empirical modelling of pile behaviour under static compressive loading

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Frontiers of Structural and Civil Engineering 2018年第4期12卷 594-608页

作者： Abdussamad ismail Department of Civil Engineering Bayero UniversityKanoNigeria

Artificial neural networks have been widely used over the past two decades to successfully develop empirical models for a variety of geotechnical problems. In this paper, an empirical model based on the product-unit neural network (PUNN) is developed to predict the load-deformation behaviour of piles based SPT values of the supporting soil. Other parameters used as inputs include particle grading, pile geometry, method of installation as well as the elastic modulus of the pile material. The model is trained using full-scale pile loading tests data retrieved from FHWA deep foundations database. From the results obtained, it is observed that the proposed model gives a better simulation of pile load-deformation curves compared to the Fleming’s hyperbolic model and t-z approach.

关键词： piles in compression load-deformation behaviour product-unit neural network

Estimating moment capacity of ferrocement members using self-evolving network

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Frontiers of Structural and Civil Engineering 2019年第4期13卷 926-936页

作者： Abdussamad ismail Department of Civil Engineering Bayero University Kano Kano State PMB 3011 Nigeria

In this paper, an empirical model based on self-evolving neural network is proposed for predicting the flexural behavior of ferrocement elements. The model is meant to serve as a simple but reliable tool for estimating the moment capacity of ferrocement members. The proposed model is trained and validated using experimental data obtained from the literature. The data consists of information regarding flexural tests on ferrocement specimens which include moment capacity and cross-sectional dimensions of specimens, concrete cube compressive strength, tensile strength and volume fraction of wire mesh. Comparisons of predictions of the proposed models with experimental data indicated that the models are capable of accurately estimating the moment capacity of ferrocement members. The proposed models also make better predictions compared to methods such as the plastic analysis method and the mechanism approach. Further comparisons with other data mining techniques including the back-propagation network, the adaptive spline, and the Kriging regression models indicated that the proposed models are superior in terms prediction accuracy despite being much simpler models. The performance of the proposed models was also found to be comparable to the GEP-based surrogate model.

关键词： ferrocement moment capacity self-evolving neural network

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旋转防喷器外壳体的有限元分析与优化设计

机电产品开发与创新 2024年第2期37卷 6-10页

作者：田海疆 ismail SAAD YOONG Hou Pin 王翠凤福建信息职业技术学院智能制造学院福建福州350003 沙巴大学工程学院马来西亚沙巴州亚庇马来西亚88670

针对国外生产的一款旋转防喷器,使用三维造型软件中望3D建立该型号旋转防喷器的三维实体模型;将底座外壳体三维实体模型导入ANSYS软件中,通过有限元分析,求解出了外壳体的应力强度分布情况,设定两条路径分别进行等效线性化,获得了两条... 详细信息

针对国外生产的一款旋转防喷器,使用三维造型软件中望3D建立该型号旋转防喷器的三维实体模型;将底座外壳体三维实体模型导入ANSYS软件中,通过有限元分析,求解出了外壳体的应力强度分布情况,设定两条路径分别进行等效线性化,获得了两条路径上的一次整体薄膜应力、一次局部薄膜应力、一次弯曲应力、二次应力和峰值应力,校核了旋转防喷器底座外壳体的强度;通过ANSYS WorkBench仿真平台对底座外壳体进行了优化设计,获得了底座外壳体的优化参数。

关键词：旋转防喷器有限元分析优化设计 ANSYS