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Microbial,immune and antioxidant responses of Nile tilapia with dietary nano-curcumin supplements under chronic low temperatures

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Aquaculture and Fisheries 2024年第1期9卷 57-65页

作者： Mohammed F.El Basuini Mohamed A.A.Zaki Abdelaziz M.El-Hais Mohamed G.Elhanafy Emad H.El-Bilawy Amr i.Zaineldin Mohamed F.A.Abdel-Aziz ibrahim A.Abouelsaad ibrahim TEl-Ratel Kumbukani Mzengereza Ronick S.Shadrack islam i.teiba Faculty of Agriculture Tanta UniversityTanta31527Egypt King Salman international University South Sinai46618Egypt Faculty of Agriculture Alexandria UniversityAlexandria21526Egypt Animal Health Research institute(AHRi-DOKi) Agriculture Research CenterGiza12619Egypt Fish Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt Horticulture Department Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Department of Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of Aquatic Animal Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Department of Aquatic and Fisheries Science Mzuzu UniversityMzuzuPrivate Bag 201Malawi Faculty of Aquaculture and Marine Fisheries Arish UniversityArish45516Egypt

A 56-day feeding period was performed to investigate the possible impacts of dietary nano curcumin(0,50,100,150,and 200 ppm)on the growth,nutrient utilization,non-specific immune parameters,antioxidants in Nile tilapia under chronic low temperature(21.02±0.11◦C).Fishes(n=225;initial weight=4.39±0.08 g/fish)were randomly stocked at 15 fish/tank for five experimental groups in *** low-temperature circumstances,dietary curcumin in nano form showed no notable alteration in growth variable,nutrient efficiency,digestive enzymes efficiency,biometric indices,survival rates,and hematological ***,the serum of fishes with nano curcumin diets under low-temperature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol compared with the control ***,fish fed nano curcumin diets displayed higher lysozyme and bactericidal activities compared to the control group and the best performance was found at dietary nano curcumin level of≥100 ***,groups fed the basal diet demonstrated the poorest antioxidant capacity,and the best superoxide dismutase(SOD)and glutathione peroxidase(GPx)existed in fish with nano curcumin diets while the best catalase(CAT)efficiency occurred at higher nano curcumin levels≥100 *** addition,higher counts of intestinal microbiota in terms of total bacterial count(TBC),total yeast and molds count(TYMC),and coliform were noticed in fish consumed the basal diet compared to groups fed on nano curcumin *** conclusion,incorporating nano curcumin at a level of≥100 mg/kg diet(particularly at 150 mg/kg)improved a non-specific immune response,antioxidant,and healthier gastrointestinal microbiota in Nile tilapia under chronic low-temperature stress.

关键词： Nano curcumin Gastrointestinal microbiota Antioxidants Non-specific immune responses Temperature stress

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Comparative efficacy of sodium glucose cotransporter-2 inhibitors in the management of type 2 diabetes mellitus:A real-world experience

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World Journal of Diabetes 2024年第3期15卷 463-474页

作者： Lubna islam Dhanya Jose Mohammed Alkhalifah Dania Blaibel Vishnu Chandrabalan Joseph M Pappachan Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of Community Medicine Goa Medical CollegeGoa 403202India Department of Family Medicine King Faisal Specialist HospitalRiyadh 11564Saudi Arabia Department of Data Science Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityAll Saints BuildingManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT-2i)are a class of drugs with modest antidiabetic efficacy,weight loss effect,and cardiovascular benefits as proven by multiple randomised controlled trials(RCTs).However,real-world data on the comparative efficacy and safety of individual SGLT-2i medications is *** To study the comparative efficacy and safety of SGLT-2i using real-world clinical *** We evaluated the comparative efficacy data of 3 SGLT-2i drugs(dapagliflozin,canagliflozin,and empagliflozin)used for treating patients with type 2 diabetes *** on the reduction of glycated hemoglobin(HbA1c),body weight,blood pressure(BP),urine albumin creatinine ratio(ACR),and adverse effects were recorded *** Data from 467 patients with a median age of 64(14.8)years,294(62.96%)males and 375(80.5%)Caucasians were *** diabetes duration was 16.0(9.0)years,and the duration of SGLT-2i use was 3.6(2.1)***-2i molecules used were dapagliflozin 10 mg(n=227;48.6%),canagliflozin 300 mg(n=160;34.3%),and empagliflozin 25 mg(n=80;17.1).Baseline median(interquartile range)HbA1c in mmol/mol were:dapagliflozin-78.0(25.3),canagliflozin-80.0(25.5),and empagliflozin-75.0(23.5)*** respective median HbA1c reduction at 12 months and the latest review(just prior to the study)were:66.5(22.8)&69.0(24.0),67.0(16.3)&66.0(28.0),and 67.0(22.5)&66.5(25.8)respectively(Pisons from baseline).Significant improvements in body weight(in kilograms)from baseline to study end were noticed with dapagliflozin-101(29.5)to 92.2(25.6),and canagliflozin 100(28.3)to 95.3(27.5)*** reductions in median systolic and diastolic BP,from 144(21)mmHg to 139(23)mmHg;(P=0.015),and from 82(16)mmHg to 78(19)mmHg;(Pively were also observed.A significant reduction of microalbuminuria was observed with canagliflozin only[ACR 14.6(42.6)at baseline to 8.9(23.7)at the study end;P=0.043].Adverse effects

关键词： Sodium glucose cotransporter-2 inhibitors Empagliflozin Canagliflozin Dapagliflozin Type 2 diabetes mellitus Cardiovascular disease Albumin creatinine ratio Diabesity

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Soil erosion susceptibility mapping of Hangu Region,Kohat Plateau of Pakistan using GiS and RS-based models

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Journal of Mountain Science 2024年第8期21卷 2547-2561页

作者： Fakhrul islam Liaqat Ali WASEEM Tehmina BiBi Waqar AHMAD Muhammad SADiQ Matee ULLAH Walid SOUFAN Aqil TARiQ Department of Geology Khushal Khan Khattak UniversityKarak 27200Pakistan Department of Geography Government College University FaisalabadPunjab 38000Pakistan institute of Geology The University of Azad Jammu&KashmirMuzaffarabad 13100Pakistan Department of Earth Sciences Changan UniversityXi’an 710003China NCEG University of PeshawarPeshawar 25120Pakistan Faculty of Earth Sciences Geography and AstronomyUniversity of ViennaVienna 1090Austria Plant Production Department College of Food and Agriculture SciencesKing Saud UniversityRiyadh 11451Saudi Arabia Department of Wildlife Fisheries and AquacultureCollege of Forest ResourcesMississippi State UniversityMS 39762USA

Soil erosion is a crucial geo-environmental hazard worldwide that affects water quality and agriculture,decreases reservoir storage capacity due to sedimentation,and increases the danger of flooding and ***,this study uses geospatial modeling to produce soil erosion susceptibility maps(SESM)for the Hangu region,Khyber Pakhtunkhwa(KPK),*** Hangu region,located in the Kohat Plateau of KPK,Pakistan,is particularly susceptible to soil erosion due to its unique geomorphological and climatic ***,the Hangu region is characterized by a combination of steep slopes,variable rainfall patterns,diverse land use,and distinct soil types,all of which contribute to the complexity and severity of soil erosion *** factors necessitate a detailed and region-specific study to develop effective soil conservation *** this research,we detected and mapped 1013 soil erosion points and prepared 12 predisposing factors(elevation,aspect,slope,Normalized Differentiate Vegetation index(NDVi),drainage network,curvature,Land Use Land Cover(LULC),rainfall,lithology,contour,soil texture,and road network)of soil erosion using GiS ***,GiS-based statistical models like the weight of evidence(WOE)and frequency ratio(FR)were applied to produce the SESM for the study *** SESM was reclassified into four classes,i.e.,low,medium,high,and very high *** results of WOE for SESM show that 16.39%,33.02%,29.27%,and 21.30%of areas are covered by low,medium,high,and very high zones,*** contrast,the FR results revealed that 16.50%,24.33%,35.55%,and 23.59%of the areas are occupied by low,medium,high,and very high ***,the reliability of applied models was evaluated using the Area Under Curve(AUC)*** validation results utilizing the area under curve showed that the success rate curve(SRC)and predicted rate curve(PRC)for WOE are 82%and 86%,respectively,while SRC and PRC for FR are 85%and 96%,res

关键词： Soil erosion Geospatial technology Statistical models Hangu Pakistan

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increasingβ-hexosaminidase A activity using genetically modified mesenchymal stem cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovуeva Shaza S.issa Aysilu i.Mullagulova Angelina A.Titova Yana O.Mukhamedshina Anna V.Timofeeva Alexander M.Aimaletdinov islam R.Nigmetzyanov Albert A.Rizvanov institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 gangliosidoses are a group of autosomal-recessive lysosomal storage disorde *** diseases result from a deficiency of lysosomal enzymeβ-hexosaminidase A(HexA),which is responsible for GM2 ganglioside *** deficiency causes the accumulation of GM2-gangliosides mainly in the nervous system cells,leading to severe progressive neurodegeneration and *** date,there is no treatment for these ***-mediated gene therapy is considered a promising treatment for GM2 *** study aimed to evaluate the ability of genetically modified mesenchymal stem cells(MSCs-HEXA-HEXB)to restore HexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of MSCs in *** effectiveness of HexA deficiency cross-correction was shown in mutant MSCs upon intera ction with *** results also showed that the MSCs-HEXA-HEXB express the functionally active HexA enzyme,detectable in vivo,and intravenous injection of the cells does not cause an immune response in *** data suggest that genetically modified mesenchymal stem cells have the potentials to treat GM2 gangliosidoses.

关键词： adeno-associated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosaminidase

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Diabetic cardiomyopathy:importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis

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World Journal of Diabetes 2024年第8期15卷 1659-1662页

作者： Lu Cai Yi Tan Md Shahidul islam Michael Horowitz Kupper A Wintergerst Pediatric Research institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Department of Medicine University of AdelaideAdelaide 5005Australia Pediatric Research institute Division of EndocrinologyDepartment of PediatricsWendy Novak Diabetes InstituteNorton Children’s HospitalUniversity of LouisvilleLouisvilleKY 40202United States

Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively ***,most studies have focused mainly on whether diabetes increases the NLRP3 inflammasome and associated pyroptosis in the heart of type 1 or type 2 diabetic rodent models,and whether various medications and natural products prevent the development of DCM,associated with decreased levels of cardiac NLRP3 inflammasome and *** direct link of NLRP3 inflammasome and associated pyroptosis to the pathogenesis of DCM remains unclear based on the limited evidence derived from the available studies,with the approaches of NLRP3 gene silencing or pharmaceutical application of NLRP3 specific *** thus emphasize the requirement for more systematic studies that are designed to provide direct evidence to support the link,given that several studies have provided both direct and indirect evidence under specific *** editorial emphasizes that the current investigation should be circumspect in its conclusion,i.e.,not overemphasizing its role in the pathogenesis of DCM with the fact of only significantly increased expression or activation of NLRP3 inflammasome and pyroptosis in the heart of diabetic rodent *** clear-cut evidence-based causative roles of NLRP3 inflammasome and pyroptosis in the pathogenesis of DCM can help to develop effective and safe medications for the clinical management of DCM,targeting these biomarkers.

关键词： Diabetic cardiomyopathy Nucleotide oligomerization domain NOD-like receptor protein 3 inflammasome Cardiac cell death Pyroptosis

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improved voltage tracking of autonomous microgrid technology using a combined resonant controller with lead-lag compensator adopting negative imaginary theorem

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Protection and Control of Modern Power Systems 2022年第1期7卷 149-164页

作者： Md.Yah-Ya Ul Haque Md.Rashidul islam Tanvir Ahmed Md.Rafiqul islam Sheikh Department of Electrical and Electronic Engineering Varendra UniversityRajshahi 6204Bangladesh Department of Electrical and Electronic Engineering Rajshahi University of Engineering&TechnologyRajshahi 6204Bangladesh

Growing application of distributed generation units at remote places has led to the evolution of microgrid(MG)*** an MG system functions independently,i.e.,in autonomous mode,unpredictable loads and uncertainties emerge throughout the *** obtain stable and flexible operation of an autonomous MG,a rigid control mechanism is *** this paper,a robust high-performance controller is introduced to improve the performance of voltage tracking of an MG system and to eliminate stability problems.A combination of a resonant controller and a lead-lag compensator in a positive position feedback path is designed,one which obeys the negative imaginary(Ni)theorem,for both single-phase and three-phase autonomous MG *** controller has excellent tracking *** is investigated through considering various uncertainties with different load *** feasibility and effectiveness of the controller are also determined with a comparative analysis with some well-known controllers,such as linear quadratic regulator,model predictive and Ni approached resonant *** confirms the superi-ority of the designed controller.

关键词： Negative imaginary theorem Resonant controller Lead-lag compensator Autonomous microgrid Voltage tracking

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Reduced tillage with residue retention improves soil labile carbon pools and carbon lability and management indices in a seven-year trial with wheat-mung bean-rice rotation

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Pedosphere 2022年第6期32卷 916-927页

作者： Rafeza BEGUM Mohammad M.R.JAHANGiR Mohammad JAHiRUDDiN Mohammad Rafiqul islam Shaikh M.BOKHTiAR Khandakar R.islam Department of Soil Science Bangladesh Agricultural UniversityMymensingh 2202(Bangladesh) Soil Resource Development institute Dhaka 1215(Bangladesh) South Asian Association for Regional Cooperation(SAARC)Agriculture Center Dhaka 1215(Bangladesh) The Ohio State University Columbus OH 43235(USA)

Soil total organic carbon(TOC)is a composite indicator of soil quality with implications for crop production and the regulation of soil ecosystem *** reports on the dynamics of TOC as a consequence of soil management practices in subtropical climatic conditions,where microbial carbon(C)loss is high,are very *** objective of our study was to evaluate the impact of seven years of continuous tillage and residue management on soil TOC dynamics(quantitative and qualitative)with respect to lability and stratification under an annual wheat-mung bean-rice cropping *** soil samples were collected at 0-15 and 15-30 cm depths from a three-replicate split-plot experiment with tillage treatment as the main plots and crop residue levels as the *** tillage treatments included conventional tillage(CT)and strip tillage(ST).Residue levels were high residue level(HR),30%of the plant height,and low residue level(LR),15%.in addition to TOC,soil samples were analyzed for particulate organic C(POC),permanganate oxidizable C(POXC),basal respiration(BR),specific maintenance respiration rate(qCO_(2)),microbial biomass C(MBC),potentially mineralizable C(PMC),and TOC lability and management *** ST treatment significantly increased the TOC and labile C pools at both depths compared with the CT treatment,with the effect being more pronounced in the surface *** HR treatment increased TOC and labile C pools compared with the LR *** ST+HR treatment showed significant increases in MBC,metabolic quotient(qR),C pool index(CPi),C lability index(CL_(i)),and C management index(CMi),indicating improved and efficient soil biological activities in such systems compared with the CT ***,the stratification values,a measure of soil quality improvement,for POC and MBC were>2,indicating improved soil quality in the ST+HR treatment compared with the CT *** ST+HR treatment not only significantly increased the contents o

关键词： basal respiration carbon management index carbon stratification particulate organic carbon permanganate oxidizable carbon total organic carbon

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An overview of benign prostatic hyperplasia and its appreciation in Greco-Arab (Unani) system of medicine

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Asian Journal of Urology 2022年第2期9卷 109-118页

作者： Shabir Ahmad Bhat Shameem Ahmad Rather Naquibul islam Department of Moalajat Regional Research Institute of Unani MedicineNaseem BaghUniversity of KashmirSrinagarJammu and KashmirIndia

Objective:Conventional treatments for benign prostatic hyperplasia(BPH)like 5alpha-reductase inhibitors and invasive surgery are associated with some obvious side ***,evidence,though limited,has shown that alternative medicines are safer and have potential to improve the lower urinary tract symptoms(LUTS)and quality of life in addition to improving sexual dysfunction in patients with *** current article aimed to include an overview of BPH,different ways of its management,and particularly its appreciation in Greco-Arab(Unani)system of medicine,one of the alternative medicinal ***:PubMed,Scopus,ScienceDirect,Web of Sciences,Google Scholar databases and classical texts of Greco-Arab medicine were searched for data ***:in Unani system of medicine,BPH,traced under the headings of Waram unuq al-mathana(bladder neck swelling)and insidad majra-i-mathana(bladder outlet obstruction),has been managed for centuries with herbal medicines yet demanding a comprehensive scientific *** the herbs,Cucurbita pepo,Tribulus terrestris,Urtica dioica,and Linum usitatissimum are worth ***:For achieving the goal of LUTS-free ageing men,and safer and cost-effective future management of BPH,Unani herbal medicine could hopefully prove beneficial.

关键词： Benign prostatic hyperplasia Herbal Lower urinary tract symptoms Tribulus terrestris Unani

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Left-Handed Characteristics Tunable C-Shaped Varactor Loaded Textile Metamaterial for Microwave Applications

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Computers, Materials & Continua 2022年第4期71卷 611-628页

作者： Samir Salem Al-Bawri Mohammad Tariqul islam Kabir Hossain Thennarasan Sabapathy Muzammil Jusoh Space Science Centre Climate Change InstituteUniversiti Kebangsaan MalaysiaBangi43600Malaysia Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaUKMBangi43600SelangorMalaysia Advanced Communication Engineering(ACE) Centre of ExcellenceUniversiti Malaysia Perlis(UniMAP)PerlisMalaysia Faculty of Electronic Engineering Technology Universiti Malaysia Perlis(UniMAP)PerlisMalaysia

This paper presents a textile-based C-shaped split-ring resonators(SRR)metamaterial(MTM)unit cells with an electrical tunability *** proposed MTM was composed of two symmetrical C-shaped SRR combined with a central diagonal metal bar,whereas the RF varactor diode is placed on the backside of the splitted ground *** behavior of single and array MTM unit cells were analyzed while the achieved negative index physical characteristics were widely *** four different MTM arrays(i.e.,1×1,1×2,2×1,and 2×2)were analyzed in simulation,a 2×2-unit cell array was chosen to fabricate,and it was further undergone experimental *** proposed tunable MTM exhibits double negative(DNG)/left-handed properties with an average bandwidth of more than 2.8 ***,attainable negative permittivity and negative permeability are within 2.66 to 9.59 GHz and within 2.77 to 15 GHz,respectively,at the frequency of interest(between 1 and 15 GHz).Moreover,the proposed tunable MTM also showed tunable transmission coefficient *** proposed electrically tunable textile MTM might function in a dynamic mode,making it suitable for a variety of microwave-wearable applications.A satisfactory agreement between simulations and experiments were achieved,demonstrating that the proposed MTM can operate over a wide bandwidth.

关键词： Textile metamaterial metamaterial wearable antennas tunable metamaterials metasurface antennas DNG metamaterials

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Systematic mutational analysis of epitope-grafted ED3 immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant

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Asian Pacific Journal of Tropical Medicine 2022年第2期15卷 63-70,I0001-I0004页

作者： Mamtaz Sultana Nazmul Hasan Mamunur R.Mahib Mohammad M.islam Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh

Objective:To identify the residue determinants of the serospecificity and sero-cross-reactivity of dengue virus(DENV)envelope protein domain 3(ED3),which contains two major putative epitopes of ***:We constructed ED3 from DENV3(3ED3)and DENV4(4ED3),and six epitope-grafted variants,where we transferred epitope 1(L304i,K305D,V309M,and S310A)and/or epitope 2(D383N,K384S,K387T,and N389H)of 4ED3 onto 3ED3 and *** albino mice aged 3-4 weeks were immunized against wildtype and epitope-grafted ED3 variants and anti-ED3 igG antibody responses were determined using ***:Mouse immunization using 3ED3 and 4ED3 generated serotype-specific antisera,as ***,most epitope-grafted ED3s produced antisera serospecific to the template ED3 with little or no cross-recognition of ED3 of the serotype from which the epitopes were *** indicated that a mere grafting of the epitope was not sufficient to transfer serospecificity,contrary to our ***,one epitope-grafted ED3 mutant,where epitope 1 of 3ED3 was grafted onto 4ED3(4ED3^(epi1)),generated antisera that was serospecific to both 4ED3 and ***:The 4ED3^(epi1)is a chimeric ED3 that produces antisera possessing serospecificity to both 3ED3 and 4ED3 onto a common 4ED3 *** 4ED3^(epi1),therefore,provides a unique tool for analyzing serospecificity and sero-cross-reactivity in *** believe that chimeric ED3 may provide a template for future recombinant ED3 possessing serospecificity of multiple DENVs onto a single scaffold and may pave a way developing tri-and/or tetravalent anti-DENV antisera.

关键词： Dengue virus serospecificity Sero-cross-recognition Anti-ED3 antibodies Epitope-grafting Chimeric ED3

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