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Cellular & Molecular Immunology 2021年第8期18卷 2078-2080页

作者： Haoran Wang Sananda Pai shun ishiyama Xin Guo Wei Dong Gao Lakshmi Santhanam Kathy Gabrielson Dolores B.Njoku Department of Anesthesiology and Critical Care Medicine Johns Hopkins UniversityBaltimoreMDUSA Molecular and Comparative Pathobiology Johns Hopkins UniversityBaltimoreMDUSA Department of Pathology Johns Hopkins UniversityBaltimoreMDUSA Department of Pediatrics Johns Hopkins UniversityBaltimoreMDUSA

In our prior publication[1],we elucidated IL-33-dependent mechanisms that regulate drug-induced liver *** this commentary,we mechanistically connected IL-33-dependent drug-induced steatohepatitis with nonalcoholic ***-induced steatohepatitis(DISH)is a rare form of drug-induced liver injury caused by drugs that are capable of inducing metabolic injury,steatosis or steatohepatitis[2].

关键词： drug hepatitis drugs

The Nile and Recent Changes in Its Basin Environment:Evidences from Literature

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Journal of Resources and Ecology 2015年第5期6卷 345-352页

作者： Shamik CHAKRABORTY YASUDA Hiroshi Abhik CHAKRABORTY NABETA Hajime KAWAI Takayuki ishiyama shun 独立研究人员日本大分县874-0844别府市松川町4-1寓302室鸟取大学干旱土地研究中心日本鸟取市680-00011390Hamasaka 伊豆半岛地质公园日本Ito414-85552-1-1Ohara 新泻大学自然灾害及灾难恢复研究所日本新泻西区950-2181IkarashiNinomachi8050 人文与自然研究所日本京都市603-8047KamigamoHonyama457-4Kita-ku

The Nile is one of the longest rivers on the planet and an important freshwater source for the arid regions of Africa. It is also a river that is extensively affected by anthropogenic impact. This paper aims to provide an account of the social drivers that combine to cause extensive changes in the Nilotic environments. This paper is based on extensive review of literature backed up by ifeld research. The main focus is on the lower Nile, where the effects of anthropogenic disturbances are most prominent. We argue that the Nile Basin is characterized by interrelated and compound problems of resource management, and managing this river system effectively requires shifting the focus from water related problems to a basin wide management agenda. We contend that knowledge of environmental history is important for this agenda shift, and the idea of beneift sharing can aleviate the growing stress on this extremely sensitive arid river basin.

关键词： Nile Basin environmental changes social parameters beneift sharing holistic approach

Efficacy of Postoperative Adjuvant Chemotherapy According to Prognostic Factor in Patients with Stage III Colon Cancer

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Journal of Cancer Therapy 2014年第8期5卷 806-816页

作者： Kiichi Sugimoto Kazuhiro Sakamoto Yuichi Tomiki Michitoshi Goto Yutaka Kojima Hiromitsu Komiyama Makoto Takahashi shun ishiyama Koichiro Niwa Haruna Okubo Department of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan

Background: We retrospectively identified prognostic factors in patients with Stage III colon cancer and considered the effectiveness of postoperative adjuvant chemotherapy based on these prognostic factors. Methods: Two hundred and thirty four patients with lymph node metastases who underwent curative surgery for colon cancer between 1999 and 2005 were enrolled in the present study. Firstly, clinicopathological factors and survival data, were analyzed to determine prognostic factors related to cancer-specific survival. Secondly, we examined the effectiveness of postoperative adjuvant chemotherapy based upon these prognostic factors. Results: The multivariate analysis revealed that differentiation (P = 0.03, Hazard ratio = 2.50), lymphatic invasion (P = 0.02, Hazard ratio = 3.23) and the TNM classification, 7th?edition (P = 0.04, Hazard ratio = 1.94) were found to be significant independent prognostic factors. Among the patients classified as TNM IIIA, the recurrence-free survival rates were extremely good. Among the patients classified as IIIB and IIIC, there was no significant difference between the patients with and without postoperative adjuvant chemotherapy. Conclusion: The present study suggests that the patients with Stage IIIA colon cancer may not require postoperative adjuvant chemotherapy. The addition of oxaliplatin to 5-FU should be considered for the patients with Stage IIIB and IIIC colon cancer, for whom the prognoses are far from satisfactory.

关键词： Colorectal Cancer Postoperative Adjuvant Chemotherapy Prognostic Factor Stage III Colon Cancer TNM Classification 7th Edition

The validity of predicting prognosis by the number of lymph node metastases in node-positive colon cancer

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Open Journal of Gastroenterology 2013年第4期3卷 217-222页

作者： Kiichi Sugimoto Masaya Kawai Kazuhiro Takehara Yoshihiko Tashiro Shinya Munakata Kiichi Nagayasu Koichiro Niwa shun ishiyama Hiromitsu Komiyama Makoto Takahashi Yutaka Kojima Michitoshi Goto Yuichi Tomiki Kazuhiro Sakamoto Department of Coloproctological Surgery Faculty of Medicine Juntendo University Tokyo Japan

Background: We examined the possibility of predicting prognosis by the number of lymph node metastases. Methods: Two hundred and forty nine patients with lymph node metastases who underwent curative surgery for colon cancer were enrolled in this study. We calculated cancer-specific survival according to the number of lymph node metastases. Results: There was a tendency toward better rates of cancer-specific survivals among the patients with 1 LNM, compared with those with 2 LNM (p = 0.07). When comparing cancer-specific survival between the patients with 1, 2-3 and 4 or more lymph node metastases, cancer-specific survival was well stratified (p i.e., the patients with 1, 2 and 3 and 4 or more lymph node metastases. This study was in favor of the TNM classification in which N category is classified by the number of lymph node metastases.

关键词： Colon Cancer Lymph Node Metastasis Stage Classification TNM Classification Prognostic Factors

Prognostic factors after palliative resection for colorectal cancer with incurable synchronous liver metastasis

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Open Journal of Gastroenterology 2013年第5期3卷 259-266页

作者： Kiichi Sugimoto Kazuhiro Sakamoto Yuichi Tomiki Michitoshi Goto Yutaka Kojima Hiromitsu Komiyama Makoto Takahashi Yukihiro Yaginuma shun ishiyama Koichiro Niwa Kiichi Nagayasu Shingo Ito Masaya Kawai Kazuhiro Takehara Yoshihiko Tashiro Shinya Munakata Department of Coloproctological Surgery Faculty of Medicine Juntendo University Tokyo Japan

Purpose: With the improvements in newer chemotherapeutic agents, there is currently no consensus regarding the validity of palliative resection of the primary tumor for colorectal cancer with incurable distant metastasis. We retrospectively analyzed prognostic factor in patients with colorectal cancer accompanied by incurable synchronous liver metastasis. Methods: 82 patients with incurable synchronous liver metastases, who underwent primary tumor resection alone, were enrolled. Results: The multivariate analysis revealed that the presence of ascites (P = 0.001, Hazard ratio = 2.96) and differentiation (P = 0.003, Hazard ratio = 3.68) were found to be significant independent prognostic factors. The median survival time among the patients with ascites was 4.8 months and that among the patients with poorly-differentiated or mucinous adenocarcinoma, or signet ring cell carcinoma (high grade differentiation) was 1.4 months, respectively. Conclusion: The presence of ascites and differentiation were prognostic factors in the patients with incurable liver metastases. Therefore, because prognosis is generally poor after primary tumor resection in the patients with ascites or high grade differentiation, the introduction of systemic chemotherapy with alleviation of symptoms related to the primary tumor should be taken into account as one of the therapeutic strategies.

关键词： Colorectal Carcinoma Liver Metastasis Primary Tumor Resection Palliative Resection Systemic Chemotherapy Postoperative Morbidity