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Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases

Cellular & Molecular Immunology 2023年第6期20卷 600-612页

作者： Annu Devi isha pahuja Shashi Prakash Singh Akanksha Verma Debapriya Bhattacharya Ashima Bhaskar Ved Prakash Dwivedi Gobardhan Das Special Centre for Molecular Medicine Jawaharlal Nehru UniversityNew DelhiIndia Immunobiology Group International Centre for Genetic Engineering and Biotechnology New DelhiIndia Department of Molecular Medicine Jamia Hamdard UniversityNew DelhiIndia Centre for Biotechnology Siksha O Anusandhan UniversityBhubneshwarOdishaIndia

Mesenchymal stem cells(MsCs)play diverse roles ranging from regeneration and wound healing to immune *** investigations have indicated the crucial role of these multipotent stem cells in regulating various aspects of the immune *** express unique signaling molecules and secrete various soluble factors that play critical roles in modulating and shaping immune responses,and in some other cases,MSCs can also exert direct antimicrobial effects,thereby helping with the eradication of invading ***,it has been demonstrated that MSCs are recruited at the periphery of the granuloma containing Mycobacterium tuberculosis and exert"Janus"-like functions by harboring pathogens and mediating host protective immune *** leads to the establishment of a dynamic balance between the host and the *** function through various immunomodulatory factors such as nitric oxide(NO),IDO,and immunosuppressive ***,our group has shown that *** uses MSCs as a niche to evade host protective immune surveillance mechanisms and establish *** also express a large number of ABC efflux pumps;therefore,dormant *** residing in MSCs are exposed to a suboptimal dose of ***,it is highly likely that drug resistance is coupled with dormancy and originates within *** this review,we discussed various immunomodulatory properties of MsCs,their interactions with important immune cells,and soluble *** also discussed the possible roles of MsCs in the outcome of multiple infections and in shaping the immune system,which may provide insight into therapeutic approaches using these cells in different infection models.

关键词： Mesenchymal Stem Cells(MsCs) Macrophages Tuberculosis Infectious Diseases T cells Immunomodulation Immunotherapy.

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Tear biomarkers for keratoconus

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Eye and Vision 2016年第1期3卷 147-153页

作者： Krishnatej Nishtala Natasha pahuja Rohit Shetty Rudy M.M.A.Nuijts Arkasubhra Ghosh Cornea Department Narayana NethralayaBangaloreIndia GROW Research Laboratory Narayana Nethralaya FoundationBangaloreIndia Cornea Clinic Department of OphthalmologyMaastricht University Medical CenterMaastrichtNetherlands

Keratoconus is a progressive corneal thinning,ectatic condition,which affects *** advances in corneal topography measurements has helped advance proper diagnosis of this condition and increased research and clinical interests in the disease *** progress has been achieved in understanding the progression of the disease and tear fluid has played a major role in the *** review discusses the importance of tear fluid as a source of biomarker for keratoconus and how advances in technology have helped map the complexity of tears and thereby molecular readouts of the *** knowledge of the tear proteome,lipidome and metabolome opened up new avenues to study keratoconus and to identify probable prognostic or diagnostic biomarkers for the disease.A multidimensional approach of analyzing tear fluid of patients layering on proteomics,lipidomics and metabolomics is necessary in effectively decoding keratoconus and thereby identifying targets for its treatment.

关键词： Keratoconus Tears Biomarkers Proteins Metabolites

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Correlation between tear fluid and serum vitamin D levels

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Eye and Vision 2016年第1期3卷 178-182页

作者： Swaminathan Sethu Rohit Shetty Kalyani Deshpande Natasha pahuja Nandini Chinnappaiah Aarti Agarwal Anupam Sharma Arkasubhra Ghosh GROW Research Laboratory Narayana Nethralaya Foundation#258/A Hosur RoadNarayana Health CityBommasandra560099 BangaloreIndia Cornea and Refractive Surgery Division Narayana NethralayaBangaloreIndia

Background:Vitamin D deficiency is associated with a range of systemic diseases including ocular *** objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D ***:A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort *** was collected using clot activator coated Vacutainer®Plus *** fluid was collected using Schirmer’s *** and tear total 25-hydroxyvitamin D levels were measured by competitive chemiluminescent ELISA and the correlation between the levels were ***:The measured serum 25-hydroxyvitamin D level ranged between 3.3 and 27.5 ng/ml(Mean±SEM,9.4±0.7 ng/ml;Median 8.4 ng/ml).Significantly(p<0.0001)higher level of 25-hydroxyvitamin D was detected in the tears(Mean±SEM,17.0±1.6 ng/ml;Range 3.2–45.8 ng/ml;Median,16.3 ng/ml)compared to *** average of~2 fold(Mean±SEM,1.9±0.2;Range 0.4–5.8;Median,1.7)higher 25-hydroxyvitamin D was observed in tears compared to serum in the *** addition,a positive correlation was observed between serum and tear 25-hydroxyvitamin D levels(r=0.5595;p<0.0001).Conclusions:A higher level of 25-hydroxyvitamin D was observed in the tear fluid compared to that of the *** would be beneficial to consider tear vitamin D levels to study its role with reference to ocular surface diseases.

关键词： Vitamin D 25-hydroxyvitamin D 1,25-dihydroxyvitamin D Tears Serum

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Design and Implementation of GUSNI 1.1： VI Tool for WSN Data Monitoring Applications

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通讯和计算机（中英文版） 2011年第7期8卷 550-559页

作者： Roop pahuja Harish Kumar Verma Moin Uddin Department of Instrumentation and Control Engineering National Institute of Technology Jalandhar 144011 India Department of Electrical Engineering Indian Institute of Technology Roorkee 247667 India Delhi Technological University Delhi 110042 India

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A practical approach to data structures and algorithms

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2009年

作者： pahuja Sanjay.

来源：畅想之星图书光盘版（南... 评论

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Electrical impedance tomography based image reconstruction and feto-maternal monitoring in pregnancy

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Health 2011年第8期3卷 482-486页

作者： Sharvan Kumar pahuja Sneh Anand Amit Sengupta 不详

Standard methods of monitoring the fetus and maternal health during labor are cardioto-cogram, tocography, ultrasound and magneto-cardiograpghy. These methods have some limi-tations in real time continuous monitoring and cause some degree of inconvenience to the pa-tient and demand special attendance of the ob-stetrician also these methods cannot be used for continuous monitoring of the fetal well being. To overcome the limitations of above techniques, a non-invasive bioimpedance measuring method is proposed. This technique helps in monitoring and recording of the electrical field distribution of a closed object. The output variation on the outer surface is likely to provide information because of fetal movements and related physio-logical parameters. It will also help in the de-velopment of Electrical Impedance Tomography based imaging technique for a closed body system with special reference to fetal monitor-ing in-utero during pregnancy and labor. Also we have developed the data acquisition system of 16 electrodes with software for image recon-struction.

关键词： Impedance Plethysmography Electrical Impedance Tomography Phantom

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A Study to Observe Pulse Pressure Variation after Induction with Propofol for General Anesthesia

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World Journal of Cardiovascular Diseases 2024年第5期14卷 343-350页

作者： Kunal Tewari Vibhu Raghuvanshi Deepak Mishra Nitin pahuja Maj Jyotsna Om Bahadur Thapa Department of Anaesthesiology and Critical Care Armed Forces Medical College Pune India Chauhan Medicity and Trauma Centre Pathankot India Department of Anaesthesiology and Critical Care Command Hospital (Southern Command) Pune India

Background and Aims: Pulse pressure variation (PPV) is a reliable and predictive dynamic parameter presently being utilized for fluid responsiveness. In the operating room, fluid administration based on PPV monitoring helps the physician in deciding whether to volume resuscitate or use interventions in patients undergoing surgery. Propofol is an intravenous induction agent which lowers blood pressure. There are multiple causes such as depression in cardiac output, and peripheral vasodilatation for hypotension. We undertook this study to observe the utility of PPV as a guide to fluid therapy after propofol induction. Primary outcome of our study was to monitor PPV as a marker of fluid responsiveness for the hypotension caused by propofol induction. Secondary outcome included the correlation of PPV with other hemodynamic parameters like heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP);after induction with propofol at regular interval of time. Methods: A total number of 90 patients were recruited. Either of the radial artery was then cannulated under local anaesthesia with 20G VygonLeadercath arterial cannula and invasive monitoring transduced. A baseline recording of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and PPV was then recorded. Patients were then induced with predetermined doses of propofol (2 mg/kg) and recordings of HR, SBP, DBP, and PPV were taken at 5, 10 and 15 minutes. Results: Intraoperatively, PPV was significantly higher at 5 minutes and significantly lower at 15 minutes after induction. It was observed that there were no statistically significant correlations between PPV and SBP or DBP. PPV was strongly and directly associated with HR. Conclusion: We were able to establish that PPV predicts fluid responsiveness in hypotension caused by propofol induction;and can be used to administer fluid therapy in managing such hypotension. However, PPV was not directly correlated with hypotensi

关键词： Pulse Pressure Variation (PPV) Propofol Fluid Responsiveness

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Comparison of efficacy of lung ultrasound and chest X-ray in diagnosing pulmonary edema and pleural effusion in ICU patients: A single centre, prospective, observational study

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Open Journal of Anesthesiology 2024年第3期14卷 41-50页

作者： Kunal Tewari Sumanth Pelluru Deepak Mishra Nitin pahuja Akash Ray Mohapatra Jyotsna Sharma Om Bahadur Thapa Manjot Multani Department of Anesthesiology and Critical Care Armed Forces Medical College Pune India Department of Anesthesiology and Critical Care Military Hospital Bhopal India

Background and Aims While chest X-ray (CXR) has been a conventional tool in intensive care units (ICUs) to identify lung pathologies, computed tomography (CT) scan remains the gold standard. Use of lung ultrasound (LUS) in resource-rich ICUs is still under investigation. The present study compares the utility of LUS to that of CXR in identifying pulmonary edema and pleural effusion in ICU patients. In addition, consolidation and pneumothorax were analyzed as secondary outcome measures. Material and Methods This is a prospective, single centric, observational study. Patients admitted in ICU were examined for lung pathologies, using LUS by a trained intensivist;and CXR done within 4 hours of each other. The final diagnosis was ascertained by an independent senior radiologist, based on the complete medical chart including clinical findings and the results of thoracic CT, if available. The results were compared and analyzed. Results Sensitivity, specificity and diagnostic accuracy of LUS was 95%, 94.4%, 94.67% for pleural effusion;and 98.33%, 97.78%, 98.00% for pulmonary edema respectively. Corresponding values with CXR were 48.33%, 76.67%, 65.33% for pleural effusion;and 36.67%, 82.22% and 64.00% for pulmonary edema respectively. Sensitivity, specificity and diagnostic accuracy of LUS was 91.30%, 96.85%, 96.00% for consolidation;and 100.00%, 79.02%, 80.00% for pneumothorax respectively. Corresponding values with CXR were 60.87%, 81.10%, 78.00% for consolidation;and 71.3%, 97.20%, 96.00% for pneumothorax respectively. Conclusion LUS has better diagnostic accuracy in diagnosis of pleural effusion and pulmonary edema when compared with CXR and is thus recommended as an effective alternative for diagnosis of these conditions in acute care settings. Our study recommends that a thoracic CT scan can be avoided in most of such cases.

关键词： Chest X ray (CXR) Consolidation Pulmonary edema Pleural effusion Lung ultrasound (LUS) Pneumothorax

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