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塔式系统定日镜场的热经济性优化设计

太阳能学报 2009年第1期30卷 55-60页

作者：张宏丽 isabelle Juchli Daniel Favrat Xavier Pelet 沈阳工程学院沈阳110136 洛桑联邦理工大学洛桑1015 Holcim SA 洛桑1007

采用辐射网格分布,在避免相邻定日镜之间发生机械碰撞的前提下,以接收最多能量和花费最少成本为目标,对塔式太阳能热发电系统中传统跟踪方式下的定日镜场的分布进行了优化设计,优化结果得到了以单位能量成本与投资成本为横、纵坐标的Par... 详细信息

采用辐射网格分布,在避免相邻定日镜之间发生机械碰撞的前提下,以接收最多能量和花费最少成本为目标,对塔式太阳能热发电系统中传统跟踪方式下的定日镜场的分布进行了优化设计,优化结果得到了以单位能量成本与投资成本为横、纵坐标的Pareto曲线。与文献中已发表先例相比,所得到定日镜场的单位能量花费较小,具有较好的热经济性,且场的分布均匀合理。同时还分析了获得能量与主要决策变量之间的关系,可为定日镜场的优化设计提供一定的理论依据。

关键词：太阳能塔式热发电定日镜场热经济性多目标优化

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A de novo germline MLH1 mutation in a Lynch syndrome patient with discordant immunohistochemical and molecular biology test results

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World Journal of Gastroenterology 2012年第39期18卷 5635-5639页

作者： Fabrice Airaud Sébastien Küry isabelle Valo Ingrid Maury Dominique Bonneau Olivier Ingster Stéphane Bezieau CHU Nantes Service de Génétique Médicale9 quai Moncousu44093 Nantes Cedex 1France Institut de Cancérologie de l'Ouest Service d'Anatomie et Cytologie Pathologique2 rue Moll49933 Angers Cedex 9France CHU Angers Service de Génétique Médicale4 rue Larrey49933 AngersFrance

We describe a patient with a Homo sapiens mutL homolog 1 (MLH1)-associated Lynch syndrome with previous diagnoses of two distinct primary cancers:a sigmoid colon cancer at the age of 39 years, and a right colon cancer at the age of 50 years. The mutation identified in his blood and buccal cells, c.1771delG, ***591Ilefs*25, appears to be a de novo event, as it was not transmitted by either of his parents. This type of de novo event is rare in MLH1 as only three cases have been reported in the literature so far. Further-more, the discordant results observed between repli-cation error phenotyping and immunohistochemistry highlight the importance of the systematic use of both pre-screening tests in the molecular diagnosis of Lynch syndrome.

关键词： Lynch syndrome Homo sapiens mutL ho-molog 1 De novo mutation Replication error pheno- type Immunohistochemistry

A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes

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Cellular & Molecular Immunology 2019年第11期16卷 887-889页

作者： Rocío Amoretti-Villa Mélanie Rogier isabelle Robert Vincent Heyer Bernardo Reina-San-Martin Institut de Génétique et de Biologie Moléculaire et Cellulaire(IGBMC) IllkirchFrance Institut National de la Santéet de la Recherche Médicale(INSERM) U1258IllkirchFrance Centre National de la Recherche Scientifique(CNRS) UMR7104IllkirchFrance Universitéde Strasbourg IllkirchFrance

Class switch recombination(CSR)occurs at the IgH locus and replaces the immunoglobulin(Ig)isotype expressed from IgM to IgG,IgE or IgA,endowing the B cell receptor with novel effector *** is triggered by activation-induced cytidine deaminase(AID),1 an enzyme that deaminates cytosines to uracils in single-stranded DNA exposed by *** distinct antibody isotypes are encoded in the IgH locus in individual transcription units composed of a cytokine-inducible promoter,an intronic exon,and a switch region(Sx),followed by the exons encoding the constant region(Cx)(Fig.S1a).During CSR,the choice of recombination to a particular isotype is determined by the stimulation-dependent activation of specific promoters,triggering the generation of noncoding germline transcripts(GLTs).2 Thus far,the transcriptional regulation of the IgH locus is known to be controlled by the Eμenhancer,located downstream of the variable region and upstream of the donor switch region(Sμ),and the 3′regulatory region(3′RR)super-enhancer located downstream of Cα.

关键词： IgH stimulation replace

When Can We Eat Safely？

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China's Foreign Trade 2012年第12期 48-49页

作者： isabelle Guo

Food and drug safety is still a topic of concern to people in 2012.3-he toxic capsule event in April, Joincare＇s illegal cooking oil event in August,and Jiugui Liquor＇s overproof plasticizers event in November all d... 详细信息

关键词：药品安全事件地沟油塑化剂酒鬼酒食品

Hybrid photonic-plasmonic cavities based on the nanoparticle-on-a-mirror configuration

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Photonics Research 2021年第12期9卷 2398-2419页

作者： ANGELA I.BARREDA MARIO ZAPATA-HERRERA isabelle M.PALSTRA LAURA MERCADÉ JAVIER AIZPURUA A.FEMIUS KOENDERINK ALEJANDRO MARTÍNEZ Institute of Solid State Physics Friedrich Schiller University Jena07743 JenaGermany Institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller University Jena07745 JenaGermany Nanophotonics Technology Center Universitat Politècnica de ValènciaCamino de Vera s/n46022 ValenciaSpain Materials Physics Center CSIC-UPV/EHU 20018 Donostia-San SebastianSpain Donostia International Physics Center DIPC 20018 Donostia-San SebastianSpain Center for Nanophotonics AMOLF1098 XG AmsterdamThe Netherlands Van der Waals-Zeeman Institute Institute of PhysicsUniversity of Amsterdam1090 GL AmsterdamThe Netherlands

Hybrid photonic-plasmonic cavities have emerged as a new platform to increase light-matter interaction capable to enhance the Purcell factor in a singular way not attainable with either photonic or plasmonic cavities *** the hybrid cavities proposed so far,the plasmonic element is usually a metallic bow-tie antenna,so the plasmonic gap—defined by lithography-is limited to minimum values of several ***-on-a-mirror(NPoM)cavities are far superior to achieve the smallest possible mode volumes,as plasmonic gaps smaller than 1 nm can be ***,we design a hybrid cavity that combines an NPoM plasmonic cavity and a dielectric-nanobeam photonic crystal cavity operating at transverse-magnetic *** metallic nanoparticle can be placed very close(<1 nm)to the upper surface of the dielectric cavity,which acts as a low-reflectivity *** demonstrate through numerical calculations of the local density of states that this hybrid plasmonic-photonic cavity exhibits quality factors𝑄above 10^(3) and normalized mode volumes𝑉down to 10^(−3),thus resulting in high Purcell factors(F_(P)≈10^(5)),while being experimentally feasible with current *** results suggest that hybrid cavities with sub-nanometer gaps should open new avenues for boosting light-matter interaction in nanophotonic systems.

关键词： mirror cavity nanoparticle

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Prevalence of chronic infections and susceptibility to measles and varicellazoster virus in Latin American immigrants

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Infectious Diseases of Poverty 2016年第1期5卷 340-345页

作者： Yves Jackson Lilian Santos isabelle Arm-Vernez Anne Mauris Hans Wolff François Chappuis Laurent Getaz Division of Primary Care Medicine Geneva University Hospitals and Faculty of MedicineUniversity of GenevaRue Gabrielle Perret Gentil 6Geneva 1211Switzerland Institute of Global Health University of GenevaGenevaSwitzerland Division of Tropical and Humanitarian Medicine Geneva University Hospitals and Faculty of MedicineUniversity of GenevaGenevaSwitzerland Department of Genetics and Laboratory Medicine Geneva University Hospitals and Faculty of MedicineUniversity of GenevaGenevaSwitzerland Division of Correctional Medicine and Psychiatry Geneva University Hospitals and Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Background:Large numbers of Latin American immigrants recently arrived in Western *** and preventive programmes need to take account of their risk of suffering and transmitting imported chronic infections and of their susceptibility to cosmopolitan *** aimed to assess the prevalence and co-occurrence of imported chronic infections among Latin American immigrants,and their susceptibility to highly prevalent cosmopolitan ***:Adult participants were recruited in the community and in a primary health centre in Geneva in *** tests were performed on stored sera for HIV,HBV,syphilis,Strongyloides stercoralis,Trypanosoma cruzi,varicella and *** considered only chronic active infections in the *** and discussion:The 1012 participants,aged 37.2(SD 11.3)years,were mostly female(82.5%)and Bolivians(48%).Overall,209(20.7%)had at least one and 27(2.7%)two or more chronic ***(12.8%)and ***(8.4%)were the most prevalent chronic active infections compared to syphilis(0.4%),HBV(0.4%)and HIV(1.4%).Concomitant infections affected 28.2 and 18.5%of *** and *** infected *** origin(aOR:13.6;95%CI:3.2–57.9)was associated with risk of multiple *** for VZV and measles were 0.7 and 1.4%,*** American immigrants are at risk of complications and possible reactivation of chronic parasitic infections but have overall low risks of chronic viral and syphilitic active ***:Systematic screening for chronic active parasitic infections is therefore necessary especially among *** high protection rate against measles and VZV doesn’t require specific preventive interventions.

关键词： Immigrants Europe Chronic infection Co-infection Trypanosma cruzi Strongyloides stercoralis HIV

Alanine minimises hepatocyte injury after ischemia-reperfusion in an ex vivo rat liver model

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BIOCELL 2014年第1期38卷 25-32页

作者： Berengere PAPEGAY Michaela STADLER Vincent Nuyens isabelle SALMON Veronique KRUYS Jean G.BOOGAERTS Laboratory of Experimental Medicine(ULB unit 222) University Hospital CentreCharleroiBelgium I.Salmon Laboratory of Pathological Anatomy(ULB unit 724) Free University of BrusselsBrusselsBelgium V.Kruys Laboratory of Molecular Biology of the Gene Department of Molecular BiologyFree University of Brussels(ULB)GosseliesBelgium.

Ischemia-reperfusion injury is a determinant in liver injury occurring during surgery,ischemic states and multiple organ *** pre-existing nutritional status of the liver,i.e.,fasting,might contribute to the extent of tissue *** study investigated whether alanine,an amino acid precursor of glucose,could protect ex vivo perfused livers of fasting rats from reperfusion *** portal vein was cannulated,the liver re-moved and perfused in a closed ex vivo *** livers were perfused either with glucose 1 g/L and 10 g/L,or with equal concentrations of alanine(n=10 in each group).The experiment consisted of perfusion for 15 min,ischemia for 60 min,and reoxygenation during 60 ***,glucose,lactate and bilirubin were analysed in perfusate *** proportion of glycogen as well as activation of caspase 3 was determined in *** at a concentration of 10 g/L attenuated enzymes release in the perfusate during reoxygenation when com-pared to glucose-treated *** level in the perfusate was lowest in alanine ***-reperfusion and mainly alanine activated apoptosis,specifically in Kupffer and endothelial *** presents a pro-tective effect on normothermic ischemia-reperfusion injury of the fasting rat liver when compared to glucose.

关键词： oxidative stress amino acids metabolism

Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males

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Asian Journal of Andrology 2013年第5期15卷 626-629页

作者： Nathalie Sermondade Charlotte Dupont Celine Faure Marouane Boubaya isabelle Cedrin-Durnerin Pascale Chavatte-Palmer Christophe Sifer Rachel Levy Service d'Histologie-Embryologie-Cytogenetique-Biologie de la Reproduction-CECOS Hopital Jean Verdier (AP-HP) HUPSSD Bondy 93143 France INSERM U557 INRA U 1125 CNAM EA3200 Univ Paris 13 CRNH IdF Unite de Recherche en Epidemiologie Nutritionnelle Bobigny 93017 France INRA UMR1198 Biologie du Developpement et Reproduction Jouy-en-Josas 78352 France Unite de Recherche Clinique Hopital Avicenne Bobigny 93009 France Service d'Assistance Medicale a la Procreation Hopital Jean Verdier (AP-HP) Bondy 93143 France

Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index （BMI） and sperm-zona pellucida binding ability assessed according to the zona binding （ZB） test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization （IVF） ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated.

关键词： body mass index (BMI) fertilization ability obesity semen quality zona binding test

Chiral supramolecular gold-cysteine nanoparticles: Chiroptical and nonlinear optical properties

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Progress in Natural Science:Materials International 2016年第5期26卷 455-460页

作者： isabelle Russier-Antoine Franck Bertorelle Alexander Kulesza Antonin Soleilhac Amina Bensalah-Ledoux Stephan Guy Philippe Dugourd Pierre-Fran?ois Brevet Rodolphe Antoine Univ Lyon Université Claude Bernard Lyon 1 CNRS Institut Lumière Matière

Cysteine is a sulfur-containing amino acid that easily coordinates to soft metal ions and grafts to noble metal surfaces. We report a simple synthetic approach for the production of chiral gold-cysteine polymeric nanoparticles soluble in water. Conjugation of cysteine with gold in a polymeric way, leading to;0 nm diameter nanoparticles, resulted in the generation of new characteristic circular dichroism（CD） signals in the region of 250–400 nm, whereas no CD signal changes were found with cysteine alone. We also investigate their nonlinear optical properties after two-photon absorption. Two-photon emission spectra and first hyperpolarizabilities, as obtained by the hyper-Rayleigh scattering technique, of these particles are presented.

关键词： Gold Cysteine Supramolecular chemistry Nanoparticles Chirality Nonlinear optics