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Management of renal replacement therapy among adults in French intensive care units: A bedside practice evaluation

Journal of Intensive Medicine 2023年第2期3卷 147-154页

作者： Florian Jolly Marine Jacquier Delphine Pecqueur Marie Labruyère Christophe Vinsonneau isabelle Fournel Jean-Pierre Quenot The READIAL Study group Service de Médecine Intensive-Réanimation CHU Dijon-BourgogneDijon 21000France Equipe Lipness Centre de recherche INSERM UMR1231 et LabEx LipSTICUniversitéde Bourgogne-Franche ComtéDijon 21000France INSERM CIC 1432Module Epidémiologie CliniqueDijon 21000France CHU Dijon-Bourgogne Centre d’Investigation CliniqueModule Epidémiologie Clinique/Essais CliniquesDijon 21000France Service de Médecine Intensive Réanimation-Unitéde Sevrage Ventilatoire et Réhabilitation CH de BethuneBethune 62408France 不详

Background:This study aimed to investigate renal replacement therapy (RRT) practices in a representative nationwide sample of French intensive care units (ICUs).Methods:From July 1 to October 5 2021, 67 French ICUs provided data regarding their ICU and RRT implementation. We used an online questionnaire to record general data about each participating ICU, including the type of hospital, number of beds, staff ratios, and RRT implementation. Each center then prospectively recorded RRT parameters from 5 consecutive acute kidney injury (AKI) patients, namely the indication, type of dialysis catheter used, type of catheter lock used, type of RRT (continuous or intermittent), the RRT parameters initially prescribed (dose, blood flow, and duration), and the anticoagulant agent used for the ***:A total of 303 patients from 67 ICUs were analyzed. Main indications for RRT were oligo-anuria (57.4%), metabolic acidosis (52.1%), and increased plasma urea levels (47.9%). The commonest insertion site was the right internal jugular (45.2%). In 71.0% of cases, the dialysis catheter was inserted by a resident. Ultrasound guidance was used in 97.0% and isovolumic connection in 90.1%. Citrate, unfractionated heparin, and saline were used as catheter locks in 46.9%, 24.1%, and 21.1% of cases, ***:Practices in French ICUs are largely compliant with current national guidelines and international literature. The findings should be interpreted in light of the limitations inherent to this type of study.

关键词： Renal replacement therapy Acute kidney injury Intensive care unit Practice evaluation Bedside

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Presence of three dengue serotypes in Ouagadougou(Burkina Faso):research and public health implications

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Infectious Diseases of Poverty 2016年第1期5卷 208-220页

作者： Valéry Ridde isabelle Agier Emmanuel Bonnet Mabel Carabali Kounbobr Roch Dabiré Florence Fournet Antarou Ly Ivlabèhiré Bertrand Meda Beatriz Parra Department of Social and Preventive Medicine University of Montreal School of Public Health(ESPUM)MontréalCanada University of Montreal Public Health Research Institute(IRSPUM) Pavillon 7101 Avenue du ParcP.O.Box 6128Centre-ville StationMontrealQuebec H3C 3J7Canada Identités et Différenciations de l’Environnement des Espaces et des Sociétés–Caen(IDEES) University of Caen Basse-NormandieCaenFrance International Vaccine Institute Dengue Vaccine InitiativeSNU Research Park1 Gwanak-roGwanak-guSeoul 151-742Korea Institut de Recherche en Sciences de la Santé(IRSS) B.P.545 Bobo-DioulassoBurkina Faso UnitéMaladies infectieuses et vecteurs:écologie génétiqueévolution et contrôle(MIVEGEC)Institut de recherche pour le développement(IRD)B.P.171 Bobo-DioulassoBurkina Faso Institut de Recherche en Sciences de la Santé(IRSS) 03 B.P.7192 OuagadougouBurkina Faso Grupo de Virus Emergentes y Enfermedad Departamento de Microbiología Universidad del ValleCaliColombia

Background:The significant malaria burden in Africa has often eclipsed other febrile *** Faso’s first dengue epidemic occurred in 1925 and the most recent in *** there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity ***:An exploratory cross-sectional survey was performed from December 2013 to January *** primary healthcare centers in Ouagadougou were selected based on previously reported presence of *** patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to *** data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a *** samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)*** a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and *** were collected and brought to the laboratory to monitor the emergence of adults and identify the ***:Of the 379 subjects,8.7%(33/379)had positive RDTs for *** the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory *** 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were *** serotypes observed were DENV2,DENV3,and *** of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under *** total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.

关键词： Dengue Fever Acute febrile non-malaria cases Burkina Faso Aedes Health system Cost Mobility

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SV2B defines a subpopulation of synaptic vesicles

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Journal of Molecular Cell Biology 2023年第9期15卷 1-13页

作者： isabelle Paulussen Hannes Beckert Timothy FMusial Lena J.Gschossmann Julia Wolf Mathieu Schmitt Jérôme Clasadonte Georges Mairet-Coello Christian Wolff Susanne Schoch Dirk Dietrich Synaptic Neuroscience Team Department of NeurosurgeryUniversity Hospital BonnBonn 53127Germany Synaptic Neuroscience Team Department of NeuropathologyUniversity Hospital BonnBonn 53127Germany Microscopy Core Facility Medical FacultyUniversity of BonnBonn 53127Germany UCB Pharma Braine l’Alleud 1420Belgium

Synaptic vesicles can undergo several modes of exocytosis,endocytosis,and trafficking within individual synapses,and their fates may be linked to different vesicular protein ***,we mapped the intrasynaptic distribution of the synaptic vesicle proteins SV2B and SV2A in glutamatergic synapses of the hippocampus using three-dimensional electron ***2B was almost completely absent from docked vesicles and a distinct cluster of vesicles found near the active *** contrast,SV2A was found in all domains of the synapse and was slightly enriched near the active ***2B and SV2A were found on the membrane in the peri-active zone,suggesting the recycling from both clusters of ***2B knockout mice displayed an increased seizure induction threshold only in a model employing high-frequency *** data show that glutamatergic synapses generate molecularly distinct populations of synaptic vesicles and are able to maintain them at steep spatial *** almost complete absence of SV2B from vesicles at the active zone of wildtype mice may explain why SV2A has been found more important for vesicle release.

关键词： 3D electron microscopy synaptic vesicles synaptic vesicle proteins endocytosis trafficking spatial organization

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Black soldier fly larvae in broiler diets improve broiler performance and modulate the immune system

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Animal Nutrition 2021年第3期7卷 695-706页

作者： Jessica de Souza Vilela Nicholas M.Andronicos Manisha Kolakshyapati Matthew Hilliar Terence Z.Sibanda Nigel R.Andrew Robert A.Swick Stuart Wilkinson isabelle Ruhnke School of Environmental and Rural Science Faculty of ScienceAgricultureBusiness and LawUniversity of New EnglandArmidaleNSWAustralia School of Science and Technology University of New EnglandArmidaleNSWAustralia Insect Ecology Lab Natural History MuseumZoologyUniversity of New EnglandArmidaleNSWAustralia Feedworks Pty Ltd. RomseyVICAustralia

Non-conventional feed ingredients are receiving more interest in their ability to increase farming effi-ciency,sustainability and animal *** objective of this study was to determine the optimal rate of inclusion level of the full-fat black soldier fly larvae(BSFL)in broiler diets and to evaluate their impact on performance,nutrient digestibility,and the immune system(blood cells and intraepithelial lymphocytes).A total of 400 male day-old Ross 308 broilers were randomly assigned to 5 treatment groups with 8 replicates *** inclusion levels of full-fat BSFL were investigated across starter(0,2.5%,5%,7.5%and 10%),grower and finisher diets(0,5%,10%,15%and 20%).All diets were formulated based on digestible amino acid values according to the Aviagen(2016)recommendations.A polynomial regression at different degrees was performed to analyse broiler performance parameters(body weight,body weight gain,feed intake,and feed conversion ratio),nutrient digestibility,and blood cell *** lymphocyte population data was analysed performing univariate linear *** the entire experimental period(from 2 to 42 d),BSFL inclusion levels decreased the feed conversion ratio by 10%in broilers that received 20%BSFL in their diets(P<0.05).Lymphocytes and white blood cell count decreased linearly by 47.7%and 35.9%,respectively,with up to 20%BSFL inclusion(P<0.001).A 4-fold decrease in CD3+T lymphocytes and a 9.7-fold decrease of CD3+CD8+intestinal cytotoxic T lymphocytes occurred in broilers fed 20%BSFL compared to the control *** findings suggest that the inclusion of BSFL can improve broiler performance and potentially reduce immune response energy expenditure in birds fed 20%BSFL for 42 d.

关键词： Antimicrobial peptides Chitin Feed insects Poultry Protein

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Impulse Control Problem of Partially Observed Diffusion Processes

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Computer Technology and Application 2011年第1期2卷 80-84页

作者： Baghery-Kabbaj Fouzia Massa-Turpin isabelle Laboratoire de Mathematiques Universite de Valenciennes et du Ifainaut Cambrdsis 59313 Valenciennes Cedex 09 France

The authors investigate the problem of impulse control of a partially observed diffusion process. The authors study the impulse control of Zakai type equations. The associated value function is characterized as the only viscosity solution of the corresponding quasi-variational inequality. The authors show the optimal cost function for the problem with incomplete information can be approximated by a sequence of value functions of the previous type.

关键词： Impulse control partially observed diffusion process nonlinear filtering diffusion process Hamilton Jacobi Bellmanquasi-variational inequality viscosity solutions.

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TOM9.2 Is a Calmodulin-Binding Protein Critical for TOM Complex Assembly but Not for Mitochondrial Protein Import in Arabidopsis thaliana

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Molecular Plant 2017年第4期10卷 575-589页

作者： Nargis Parvin Chris Carrie isabelle Pabst Antonia Laber Debabrata Laha Melanie V. Paul Peter Geigenberger Ralf Heermann Kirsten Jung Ute C. Vothknecht Fatima Chigri Department Biology I Botany Ludwig-Maximilians-University Munich GroBhaderner Stra6e 2-4 82152 Martinsried Germany Department Biology 1 Microbiology Ludwig-Maximilians-University Munich Grobhaderner Strabe 2-4 82152 Martinsried Germany Department of Biology Center for Integrated Protein Science (Munich) Ludwig-Maximilians-University Munich 81377 Munich Germany Center for Plant Molecular Biology Plant Physiology University of Tuebingen Auf der Morgenstelle 32 72076 Tuebingen Germany present address: Plant Cell Biology IZMB University of Bonn Kirschallee 153115 Bonn Germany Present address: Center for Plant Molecular Biology Developmental Genetics University of Tubingen Auf der Morgenstelle 32 72076 Tubingen Germany

The translocon on the outer membrane of mitochondria （TOM） facilitates the import of nuclear-encoded proteins. The principal machinery of mitochondrial protein transport seems conserved in eukaryotes; however, divergence in the composition and structure of TOM components has been observed between mammals, yeast, and plants. TOM9, the plant homolog of yeast Tom22, is significantly smaller due to a truncation in the cytosolic receptor domain, and its precise function is not understood. Here we provide evidence showing that TOM9.2 from Arabidopsis thaliana is involved in the formation of mature TOM com- plex, most likely by influencing the assembly of the pore-forming subunit TOM40. Dexamethasone- induced RNAi gene silencing of TOM9.2 results in a severe reduction in the mature TOM complex, and the assembly of newly imported TOM40 into the complex is impaired. Nevertheless, mutant plants are fully viable and no obvious downstream effects of the loss of TOM complex, i.e., on mitochondrial import ca- pacity, were observed. Furthermore, we found that TOM9.2 can bind calmodulin （CAM） in vitro and that CaM impairs the assembly of TOM complex in the isolated wild-type mitochondria, suggesting a regula- tory role of TOM9.2 and a possible integration of TOM assembly into the cellular calcium signaling network.

关键词： protein import plant mitochondria TOM complex calmodulin calcium signaling

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Effects of tillage, fallow and burning on selected properties and fertility status of Andosols in the Mounts Bambouto, West Cameroon

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Agricultural Sciences 2011年第3期2卷 334-340页

作者： Paul Tematio Ertine isabelle Tsafack Lucas Kengni Department of Earth Science University of Dschang Dschang Cameroon

To assess the impact of land use on the Andosol fertility, changes in chemical and physical properties affecting soil quality were monitored on Andosols from Mount Bambouto submitted to four different land use and management systems: natural cover, tillage, burning and fallow. In comparison with the natural cover, tillage reduces Andosol OC (6.5 to 4.8%), total N (4.51 to 2.95‰), CEC (22.0 to 20.9 ***–1) and the abundance of soil macro-aggregates expressed by the water stable aggregates (WSA) varies from 53.8 to 12.0%;and increases the bulk density (0.69 to 1.09 ***–3) and the sum of exchangeable cations (3.58 to 4.84 ***–1). Burning also reduces Andosol OC (6.5 to 0.8%), total N (4.51 to 0.95‰) and CEC (22.0 to 10.2 ***–1), but increases soil pH (4.62 to 6.54), the sum of exchangeable cations (3.58 to 5.74 ***–1) and the abundance of soil macroaggregates (WSA: 38.2 to 57.0%). In comparison with tillage, fallow increases Andosol OC (4.8 to 6.5%), total N (2.95 to 5.04‰), CEC (18.0 to 21.6 ***–1), the sum of exchangeable cations (3.58 to 5.05 ***–1) and the abundance of soil macroaggregates (WSA: 12.0 to 48.8%). Globally, the tillage management deteriorates Andosol chemical and physical properties affecting fertility, whereas the fallow management restores them. The burning management also improves some Andosol chemical and physical properties affecting quality, but it won’t last long.

关键词： Andosols Land Use Management Systems Soil Physic-Chemical Properties Soil Fertility

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Genome-Wide Association Study of Nitrogen Use Efficiency and Agronomic Traits in Upland Rice

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Rice science 2021年第4期28卷 379-390,I0027-I0034页

作者： Tatiana Rakotoson Julie Dusserre Philippe Letourmy Julien Frouin isabelle Ramonta Ratsimiala Noronirina Victorine Rakotoarisoa Tuong-Vi CAO Kirsten Vom Brocke Alain Ramanantsoanirina Nourollah Ahmadi Louis-Marie Raboin National Center for Applied Research on Rural Development Regional Research Station AntsirabeAntsirabe 110Madagascar Faculty of Sciences University of AntananarivoAntananarivo 101Madagascar Higher Education Institute of Antsirabe Vakinankaratra University of AntananarivoAntsirabe 110Madagascar Agroecology and Sustainable Intensification of Annual Crops Research Unit French Agricultural Research Centre for International Development(CIRAD)Avenue AgropolisMontpellier 34398France Genetic Improvement and Adaptation of Mediterranean and Tropical Plants Research Unit(UMR AGAP) CIRADAvenue AgropolisMontpellier 34398France UMR AGAP Highland Production Systems and Sustainability in Madagascar Platform in PartnershipCIRADAntsirabe 110Madagascar University of Montpellier/CIRAD Montpellier 34398France

Genome-wide association study(GWAS)was performed for 16 agronomic traits including nitrogen use efficiency(NUE)and yield-related components using a panel of 190 mainly japonica rice varieties and a set of 38390 single nucleotide polymorphism(SNP)*** panel was evaluated under rainfed upland conditions in Madagascar in two consecutive cropping seasons with two contrasted nitrogen input *** another set of five grain traits,we identified previously known genes(GW5,GS3,Awn1 and Glabrous1),thus validating the pertinence and accuracy of our datasets for GWAS.A total of 369 significant associations were detected between SNPs and agronomic traits,gathered into 46 distinct haplotype groups and 28 isolated *** association signals were identified for the complex quantitative trait NUE,however,larger number of quantitative trait loci(QTLs)were detected for its component traits,with 10 and 2 association signals for nitrogen utilization efficiency and nitrogen uptake efficiency,*** detected association signals co-localized with genes involved in nitrogen transport or nitrogen remobilization within 100 *** present study thus confirmed the potential of GWAS to identify candidate genes and new loci associated with agronomic ***,because of the quantitative and complex nature of NUE-related traits,GWAS might have not captured a large number of QTLs with limited effects.

关键词： genome-wide association study nitrogen use efficiency agronomic trait upland rice

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A Machine Learning Approach: Enhancing the Predictive Performance of Pharmaceutical Stock Price Movement during COVID

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Journal of Data Analysis and Information Processing 2022年第1期10卷 1-21页

作者： Beilei He Weiyi Han Suet Ying isabelle Hon Jacobs School of Engineering University of California San Diego San Diego USA Xiaohongshu Inc. Shanghai China Centre of Industrial Relations and Human Resources University of Toronto (St. George) Toronto Canada

Predicting stock price movement direction is a challenging problem influenced by different factors and capricious events. The conventional stock price prediction machine learning models heavily rely on the internal financial features, especially the stock price history. However, there are many outside-of-company features that deeply interact with the companies’ stock price performance, especially during the COVID period. In this study, we selected 9 COVID vaccine companies and collected their relevant features over the past 20 months. We added handcrafted external information, including COVID-related statistics and company-specific vaccine progress information. We implemented, evaluated, and compared several machine learning models, including Multilayer Perceptron Neural Networks with logistic regression and decision trees with boosting and bagging algorithms. The results suggest that the application of feature engineering and data mining techniques can effectively enhance the performance of models predicting stock price movement during the COVID period. The results show that COVID-related handcrafted features help to increase the model prediction accuracy by 7.3% and AUROC by 6.5% on average. Further exploration showed that with data selection the decision tree model with gradient, boosting algorithm achieved 70% in AUROC and 66% in the accuracy.

关键词： Machine Learning Stock Price Trend Prediction Feature Engineering

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Personality Characteristics among Patients Waiting for Liver or Kidney Transplants

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Open Journal of Medical Psychology 2013年第1期2卷 7-11页

作者： isabelle Varescon Franck Zenasni Emmanuelle Corruble UniversitéParis Descartes Sorbonne Paris CitéIUPDPParisFrance Hôpital Bicêtre Département de PsychiatrieINSERMUniversitéParis XILe Kremlin BicêtreFrance

Introduction: Personality characteristics are believed to predict post-transplant adherence and outcome. However, data concerning the prevalence and type of personality disorders (PDs) among transplant populations are sparse. Objectives: To evaluate the prevalence and types of PDs among patients waiting for liver or kidney transplants, to compare the results obtained between the two groups and to identify predictors of the prevalence of PDs. Method: In a prospective cohort study, 629 patients waiting for liver (n = 196) or kidney (n = 433) transplants were assessed by the Personality Diagnostic Questionnaire, fourth edition (PDQ-4+). Results: The 629 pre-transplant patients were 46.1 years old on average (SD: 11.5). The PDQ total score was 25.5 (SD: 13.7). 36.5% had a total score equal to or greater than 30. Paranoid (42.1%), avoidant (31.1%) and obsessive-compulsive (29.8%) were the most common possible PDs identified. Patients waiting for a kidney transplant had a higher total score than those waiting for a liver transplant (p 0.001) and they also had significantly more paranoid (p = 0.001), obsessive-compulsive (p = 0.002) and avoidant (p = 0.001) PDs. Comment: In case of possible PDs, an assessment of other clinical variables for helping patients is needed so that a specific treatment could be offered to patients at the time of their inclusion on the waiting list, during the waiting period and after the organ transplant.

关键词： Personality Disorder Transplantation Kidney Liver

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