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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 55-56页

作者： Quinn D.W pagano D Bonser R.S. 程敏 Department of Cardiothoracic Surgery Queen Elizabeth Hospital University Hospital Birmingham NHS Trust Edgbaston Birmingham B15 2TH United Kingdom

Objective: We sought to assess the role of glucose-insulin-potassium in providing myocardial protection in nondiabetic patients undergoing coronary artery surgery with cardiopulmonary bypass. Methods: A prospective, randomized, double-blind, placebo-controlled trial was conducted at a single-center university hospital performing adult cardiac surgery. Two hundred eighty nondiabetic adult patients undergoing first-time elective or urgent isolated multivessel coronary artery bypass grafting were prospectively randomized to receive glucose-insulin-potas- sium infusion or placebo(dextrose 5% )before, during, and for 6 hours after surgical intervention. Anesthetic, cardiopulmonary bypass, myocardial protection, and surgical techniques were standardized. The primary end point was postreperfusion cardiac index. Secondary end points were systemic vascular resistance index, the incidence of low cardiac output episodes, inotrope and vasoconstrictor use, and biochemical-electrocardiographic evidence of myocardial injury. The incidence of dysrhythmias and infections requiring treatment was recorded prospectively. Results: The glucose-insulin-potassium group experienced higher cardiac indices(P< .001) throughout infusion and reduced vascular res istance(P< .001). The incidence of low cardiac output episodes was 15.9% (22/138) in the glucose-insulin-potassium group and 27.5% (39/142) in the placebo group(P=.021). Inotropes were required in 18.8% (26/138) of the glucose-insulin-potassium group and 40.8% (58/142) of the placebo group(P< .001). Fewer patients in the glucose-insulin-potassium group(12.3% [16/133]) versus those in the placebo group(23.4% [32/137]) had significant myocardial injury(P=.017). Noncardiac morbidity was not different. Conclusion: Glucose-insulin-potassium therapy improves early postoperative cardiovascular performance, reduces inotrope requirement, and might reduce myocardial injury. These potential benefits are not at the expense of increased noncardiac mo

关键词：随机对照试验 5%葡萄糖冠状动脉手术手术中应用心肌保护胰岛素多支冠状动脉搭桥术钾血管阻力指数体外循环

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Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV

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Nuclear Science and Techniques 2013年第5期24卷 82-88页

作者： FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A pagano A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L INFN Laboratori Nazionali del Sud-LNS Catania 95123Italy Dipartimento di Fisica Universitàdi Catania I-95129Italy INFN Sezione di Trieste Trieste I-34127Italy Dipartimento di Fisica Universitàdi FirenzeINFN Sezione di Firenze 1-50139Italy LPC Caen IN2P3-CNRS/ENSICAEN and UniversitéF-14050 Caen cedex 5-140France Dipartimento di Fisica Universitàdi Bologna and INFN Sezione di Bologna 4-50121Italy INFN Sezione di Catania I-95129 Italy INFN Sezione di Firenze I-50139 Italy Dipartimento di Fisica Universitàdi Milano and INFN Sezione di Milano1-20126Italy INFN Laboratori Nazionali di Legnaro 1-35020 Italy Centro Siciliano di Fisica Nucleare e Struttura della Materia Catania 1-95129Italy UniversitàKore Enna 1-94100Italy

The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy *** a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy *** the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been *** main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their *** emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear *** evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport *** approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy *** deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light *** simulations are in *** experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having

关键词：多重碎裂中心碰撞蒸发过程 MeV 竞争熔合国际货币基金组织事件分析

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资本主义多样性远未抵达终点 007

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社会科学报

作者：帕格诺(Ugo pagano) 孙寿涛

技术和制度变迁毫无疑问，我们正经历着第三次工业革命，即信息技术革命。这场革命对生产组织中个人所具有的权利产生了深远的影响。新制度经济学有助于澄清这种影响发生的机制。但只考虑从生产中所使用的资源的快速变化的?

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Viral proteins and Src family kinases: Mechanisms of pathogenicity from a “liaison dangereuse”

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World Journal of Virology 2013年第2期2卷 71-78页

作者： Mario Angelo pagano Elena Tibaldi Giorgio Palù Anna Maria Brunati Department of Molecular Medicine University of Padua

To complete their life cycle and spread, viruses interfere with and gain control of diverse cellular processes, this most often occurring through interaction between viral proteins(VPs) and resident protein partners. Among the latter, Src family kinases(SFKs), a class of non-receptor tyrosine kinases that contributes to the conversion of extracellular signals into intracellular signaling cascades and is involved in virtually all cellular processes, have recently emerged as critical mediators between the cell's infrastructure and the viral demands. In this scenario, structural or ex novo synthesized VPs are able to bind to the different domains of these enzymes through specific short linear motifs present along their sequences. Proline-rich motifs displaying the conserved minimal consensus PxxP and recognizing the SFK Src homology(SH)3 domain constitute a cardinal signature for the formation of multiprotein complexes and this interaction may promote phosphorylation of VPs by SFKs, thus creating phosphotyrosine motifs that become a docking site for the SH2 domains of SFKs or other SH2 domain-bearing signaling molecules. Importantly, the formation of these assemblies also results in a change in the activity and/or location of SFKs, and these events are critical in perturbing key signalingpathways so that viruses can utilize the cell's machinery to their own benefit. In the light of these observations, although VPs as such, especially those with enzyme activity, are still regarded as valuable targets for therapeutic strategies, multiprotein complexes composed of viral and host cell proteins are increasingly becoming objects of investigation with a view to deeply characterize the structural aspects that favor their formation and to develop new compounds able to contrast viral diseases in an alternative manner.

关键词： Interaction Phosphotyrosine Proline-rich motif Src homology 2 domain Src homology 3 domain

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Transsphenoidal Surgery for Secreting Pituitary Microadenomas:Results with Intraoperative Application of Absolute Alcohol

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International Journal of Clinical Medicine（临床医学国际期刊） 2014年第17期

作者： Mario F. Fraioli Andrea pagano Giuseppe Giovinazzo Pierpaolo Lunardi Bernardo Fraioli

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Liver resections for liver transplantations

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World Journal of Gastrointestinal Surgery 2010年第3期2卷 51-56页

作者： Salvatore Gruttadauria Fabrizio di Francesco Duilio pagano Sergio Li Petri Davide Cintorino Marco Spada Bruno Gridelli Mediterranean Institute for Transplantation and High Specialization Therapies University of Pittsburgh Medical Center in ItalyPalermo 90127Italy Department of Surgery University of PittsburghPittsburghPA 15213United States

Split-Liver and living-related donor liver transplantation are the newest and both technically and ethically most challenging developments in liver transplantation and have contributed to a reduction in donor *** report the technical aspects of surgical procedures performed to achieve a partial graft from a cadaveric and a live donor.

关键词： Living-related liver transplantation Split liver transplantation Liver resections Liver transplantation Liver surgery

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Biliary and pancreatic stenting:Devices and insertiontechniques in therapeutic endoscopic retrogradecholangiopancreatography and endoscopic ultrasonography

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 143-156页

作者： Benedetto Mangiavillano Nico pagano Todd H Baron Monica Arena Giuseppe Iabichino Pierluigi Consolo Enrico Opocher Carmelo Luigiano Unit of Gastroenterology and Digestive Endoscopy General Hospital of Sanremo18038 SanremoItaly Unit of Gastroenterology Department of Medical and Surgical SciencesS.Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Division of Gastroenterology and Hepatology University of North CarolinaChapel HillNC 27599United States Unit of Digestive Endoscopy San Paolo Hospital20142 MilanoItaly Endoscopy Unit University Hospital“G.Martino”98125 MessinaItaly Department of Surgery Unit of Hepatobiliopancreatic and Digestive SurgerySan Paolo HospitalUniversity of Milan20142 MilanoItaly

Stents are tubular devices made of plastic or metal. Endoscopic stenting is the most common treatment for obstruction of the common bile duct or of the main pancreatic duct, but also employed for the treatment of bilio-pancreatic leakages, for preventing post- endoscopic retrograde cholangiopancreatography pancreatitis and to drain the gallbladder and pancreatic fluid collections. Recent progresses in techniques of stent insertion and metal stent design are represented by new, fullycovered lumen apposing metal stents. These stents are specifically designed for transmural drainage, with a saddle-shape design and bilateral flanges, to provide lumen-to-lumen anchoring, reducing the risk of migration and leakage. This review is an update of the technique of stent insertion and metal stent deployment, of the most recent data available on stent types and characteristics and the new applications for biliopancreatic stents.

关键词： Biliary stent Pancreatic stent Endoscopicretrograde cholangiopancreatography Self-expandable metal stent Endoscopic ultrasonography

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胃腺瘤患者的口部黑棘皮症,三叶掌和累-特症

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 34-34页

作者： Pentenero M. Carrozzo M. pagano M. Gandolfo S. 阎小宁 Clinica Odontostomatologica Sezione di Patol. e Medicina Orale Corso Dogliotti 14 10126 Torino Italy Dr.

Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trělat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy. 2004 The International Society of Dermatology.

关键词：胃腺瘤黑棘皮症口部三叶癌性癌转移恶性瘤瘤状颊黏膜口腔黏膜

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采用不使用泻药的CT结肠成像筛查结直肠癌家族史病人结直肠内新生物

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国际医学放射学杂志 2014年第3期 275-275页

作者： L.Fini L.Laghi C.Hassan A.Pestalozza N.pagano L.Balzarini 秦乃姗 Digestive Endoscopy Unit Nuovo Regina Margherita HospitalVia Morosini 30Rome 00153Italy

摘要目的以结肠镜和组织学检查为参考标准,前瞻性评价不使用泻药的CT结肠成像探查一级亲属患有结直肠癌(CRC)的人群临床相关结直肠病灶(≥6 mm息肉或肿块)的

关键词：结肠成像结直肠癌泻药病人 CT

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前交叉韧带重建联合外侧闭合楔形胫骨高位截骨术的长期疗效

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实用骨科杂志 2023年第10期29卷 957-957页

作者： Agostinone P Lucidi GA Dal Fabbro G Di Paolo S pagano A Viotto M Neri MP Grassi A Zaffagnini S 冯宇华(整理) 张民(整理) 不详山西医科大学第二医院骨科

研究表明,与胫骨高位截骨术(high tibial osteotomy,HTO)相比,膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)术后的关节活动度可能会降低,更有一些研究人员认为UKA应该仅应用于体力活动减少的老年患者。近年来有文献报道,... 详细信息

研究表明,与胫骨高位截骨术(high tibial osteotomy,HTO)相比,膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)术后的关节活动度可能会降低,更有一些研究人员认为UKA应该仅应用于体力活动减少的老年患者。近年来有文献报道,前交叉韧带(anterior cruciate ligament reconstruction,ACL)重建联合HTO是一种有效治疗前交叉韧带损伤和内翻型膝关节内侧间室骨关节炎的手术方法。

关键词：胫骨高位截骨术前交叉韧带损伤关节活动度前交叉韧带重建膝关节单髁置换术体力活动长期疗效有效治疗

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