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Genetics pathogenesis in the ovarian insufficiency

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Open Journal of Preventive Medicine 2012年第3期2卷 344-349页

作者： Lilliana Ciotta isabella pagano Vito Leanza Mariagrazia Stracquadanio Carlo Pafumi Institute of Obstetric and Gynecological pathology – University of Catania

Premature Ovarian Failure (POF) is a heterogeneous syndrome characterized by Hypergonadotropic Hypogonadism that affects about 1% of women younger than 40 years old, while an incidence of 1/1000 is reported in women younger than 30 years old. [1] This hormonal disorder is caused by the loss of the ovarian response towards the pituitary gonadrotropins synthesis (FSH and LH) that are secreted according to the inhibitory feedback between hypothalamus, pituitary gland and gonads.

关键词： Premature Ovarian Failure Hypergonadotropic Hypogonadism Inhibitory Feedback

Evaluation of the CO<sub>2</sub>Laser Therapy on Vulvo-Vaginal Atrophy (VVA) in Oncological Patients: Preliminary Results

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Journal of Cancer Therapy 2017年第5期8卷 452-463页

作者： isabella pagano Stefania Gieri Francesca Nocera Giuseppe Scibilia Filippo Fraggetta Antonio Galia Mauro Gioè Basilio Pecorino Paolo Scollo Department of Obstetrics and Gynecology Cannizzaro Hospital Catania Italy Institute of Molecular Bioimaging and Physiology National Research Council (IBFM-CNR)-LATO Cefalù (PA) Italy Pathology Unit Cannizzaro Hospital Catania Italy

Objective: To evaluate the impact of fractionated CO2 laser therapy on vaginal atrophy and mild/moderate stress urinary incontinence (SUI) symptoms in patients with physiological or surgically-induced menopause. Materials and Methods: Post-menopausal patients (n = 33) presenting vaginal atrophy and/or SUI, underwent three vaginal CO2 laser treatment sessions, performed at 1-month intervals. Vaginal symptoms were evaluated using the Vaginal Health Index Score (VHI-S), Visual Analogue Scales (VAS) for dyspareunia and global patient satisfaction. The impact of urinary incontinence on patient quality of life was evaluated using the International Consultation on Incontinence Questionnaire (ICIQ). Symptoms were evaluated before treatment and at every subsequent treatment session, as well as 3 months following the last treatment session. RESULTS: The three-session treatment series led to a significant improvement in both subjective symptoms (dryness, burning, dyspareunia) and clinical signs (VHI-S) (P Conclusions: Fractionated CO2 laser therapy is a safe, effective and easy-to-perform treatment modality for menopause-related vaginal atrophy and SUI.

关键词： Laser CO2 Vaginal Atrophy Urinary Incontinence Menopause

Genetics pathogenesis in the ovarian insufficiency

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Is diabetes mellitus a risk factor for pancreatic cancer?

Open Journal of Preventive Medicine（预防医学期刊） 2012年第3期

作者： Lilliana Ciotta isabella pagano Vito Leanza Mariagrazia Stracquadanio Carlo Pafumi

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World Journal of Gastroenterology 2013年第30期19卷 4861-4866页

作者： Raffaele Pezzilli Nico pagano Department of Digestive Diseases and Internal Medicine Sant'Orsola-Malpighi Hospital40138 BolognaItaly

The relationship between diabetes mellitus and the risk of pancreatic cancer has been a matter of study for a long period of *** importance of this topic is due to two main causes:the possible use of recent onset diabetes as a marker of the disease and,in particular,as a specific marker of pancreatic cancer,and the selection of a population at risk for pancreatic ***,we decided to make an in-depth study of this topic;thus,we carried out an extensive literature search in order to re-assess the current knowledge on this *** if diabetes is found a decade before the appearance of pancreatic cancer as reported in meta-analytic studies,we cannot select those patients already having non detectable pancreatic cancer,at least with the imaging and biological techniques available *** believe that more studies are necessary in order to definitively identify diabetes mellitus as a risk factor for pancreatic cancer taking into consideration that approximately 10 years are needed to diagnose symptomatic pancreatic *** present,the answer to the as to whether diabetes and pancreatic cancer comes first similar to the adage of the chicken and the egg is that diabetes is the egg.

关键词： Diabetes mellitus Obesity Pancreatic neoplasms Risk factors Clinical studies

Detecting patterns of climate change in long-term forecasts of marine environmental parameters

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International Journal of Digital Earth 2020年第5期13卷 567-585页

作者： Gianpaolo Coro Pasquale pagano Anton Ellenbroek Istituto di Scienza e Tecnologie dell’Informazione“A.Faedo”–CNR PisaItaly b Food and Agriculture Organization of the United Nations(FAO) RomeItaly

Forecasting environmental parameters in the distant future requires complex modelling and large computational *** to the sensitivity and complexity of forecast models,long-term parameter forecasts(*** to 2100)are uncommon and only produced by a few organisations,in heterogeneous formats and based on different assumptions of greenhouse gases ***,data mining techniques can be used to coerce the data to a uniform time and spatial representation,which facilitates their use in many *** this paper,streams of big data coming from AquaMaps and NASA collections of 126 long-term forecasts of nine types of environmental parameters are processed through a cloud computing platform in order to(i)standardise and harmonise the data representations,(ii)produce intermediate scenarios and new informative parameters,and(iii)align all sets on a common time and spatial *** series crosscorrelation applied to these aligned datasets reveals patterns of climate change and similarities between parameter trends in 10 marine *** results highlight that(i)the Mediterranean Sea may have a standalone‘response’to climate change with respect to other areas,(ii)the Poles are most representative of global forecasted change,and(iii)the trends are generally alarming for most oceans.

关键词： Climate change environmental parameters forecasting environmental parameters time series ecological modelling species distribution modelling AquaMaps NASA Earth Exchange

Exploring new trends in living related liver transplantation

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 229-230页

作者： Salvatore Gruttadauria Duilio pagano Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation Mediterranean Institute for Transplantation and Specialization Therapies (IRCCS-ISMETT)PalermoItaly

We read with great pleasure the article entitled "Use of robotics in liver donor right hepatectomy" by Chen et al., which was published in last year's October issue of Hepatobiliary Surgery Nutrition (1). This review of robotic hepatobiliary surgery focused on the brief history of minimally-invasive surgery (MIS) in the field of living-related liver transplantation (LRLT).

关键词： Surgery al. surgery

Cardiac stromal cells on stage:From dull filler to specialized actors

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BIOCELL 2022年第8期46卷 1875-1877页

作者： VITTORIO PICCHIO FRANCESCA pagano ISOTTA CHIMENTI Department of Medical Surgical Sciences and Biotechnologies Sapienza UniversityLatina04100Italy Institute of Biochemistry and Cell Biology National Council of Research(IBBC-CNR)Monterotondo00015Italy Mediterranea Cardiocentro Napoli80122Italy

Cardiac stromal cells have faced through the years a significant evolution in their definitions concerning their phenotypes,markers,and *** are surging to key roles in physiopathology,becoming important targets to be exploited for cardiac *** this perspective,we briefly discuss their role in novel therapeutic strategies for enhancing cardiac repair and regeneration.

关键词： Cardiac fibroblasts Cardiac stroma Cardiac repair Cardiac remodeling

Small-for-size syndrome in adult-to-adult living-related liver transplantation

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World Journal of Gastroenterology 2010年第40期16卷 5011-5015页

作者： Salvatore Gruttadauria Duilio pagano Angelo Luca Bruno Gridelli Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione University of Pittsburgh Medical Center in Italy Department of Surgery University of Pittsburgh Medical Center

Small-for-size syndrome (SFSS) in adult-to-adult living-related donor liver transplantation (LRLT) remains the greatest limiting factor for the expansion of segmental liver transplantation from either cadaveric or living donors. Portal hyperperfusion, venous pathology, and the arterial buffer response signif icantly contribute to clinical and histopathological manifestations of SFSS. Here, we review the technical aspects of surgical and radiological procedures developed to treat SFSS in LRLT, along with the pathophysiology of this condition.

关键词： Adult-to-adult living-related liver transplantation Small-for-size syndrome Liver resection Liver transplantation

Gossypibomas as a rare cause of common bile duct dilation

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 498-500页

作者： Raffaele Pezzilli Paula A.Mauloni Nico pagano Department of Gastroenterology Sant’Orsola Hospital

Gossypibomas are any foreign bodies left inside the patient after an operation. It represents a diagnostic challenge in clinical practice because the clinical consequence may manifest in different forms immediately, m... 详细信息

关键词： Gossypibomas common bile duct dilation clinical consequence