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Role of myelin sheath energy metabolism in neurodegenerative diseases

Neural Regeneration Research 2015年第10期10卷 1570-1571页

作者： Silvia Ravera isabella panfoli Pharmacy Department Biochemistry Laboratory University of Genova

More than any other organs,brain energy demand is entirely dependent on glucose catabolism through the oxidative phosphorylation（OXPHOS）.Glucose is the major cerebral energy substrate in the nervous system（NS）.Ket... 详细信息

关键词： Role of myelin sheath energy metabolism in neurodegenerative diseases RGC

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The good and bad sides of exosomes:pre-metastatic niche formation,cancer biomarker and therapy carriers

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 417-424页

作者： isabella panfoli Maurizio Bruschi Dipartimento di Farmacia-DIFAR Universitàdi GenovaGenoaItaly Laboratory of Molecular Nephrology IRCCS Istituto Giannina GasliniGenoa 16147Italy

Exosomes,nanovesicles of endocytic origin,are secreted by most cell types;cancer cells representing no *** facilitate intercellular communication as they deliver diverse proteins,mRNA,miRNA and *** this review,we discuss how exosomes represent one of the main risks associated with cancer but also one of the most promising new tools to fight *** appear to function as signalling molecules between the tumour microenvironment,i.e.,the complex of both cancer and stromal cells,and the rest of the *** exosomes have been shown to drive the initiation and progression of metastasis,by transporting their cargoes to target *** this respect,exosomes are implicated in cancer progression,dissemination and therapy ***,exosomes are also emerging as a key tool in precision medicine,pivotal for cancer liquid biopsy in early diagnosis and for assessing when there is a *** exosomal cancer-derived nucleic acids by ultrasensitive next-generation sequencing along with mapping the protein profile utilizing highthroughput proteomics will allow earlier cancer detection,therapeutic stratification and monitoring of response to *** are also a promising new tool for cancer *** utilizing exosomes for these applications in cancer diagnosis and therapeutics will be the next challenge.

关键词： Biomarkers cancer exosomes immunotherapy liquid biopsy precision medicine proteomics

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Exosomes:Key tools for cancer liquid biopsy

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BIOCELL 2022年第10期46卷 2167-2176页

作者： isabella panfoli MAURIZIO BRUSCHI GIOVANNI CANDIANO Dipartimento di Farmacia-DIFAR Universitàdi GenovaGenoa16132Italy Laboratory of Molecular Nephrology IRCCS Istituto Giannina GasliniGenoa16147Italy

Precision medicine is based on the identification of biomarkers of tumor development and *** biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors,as it can be noninvasively performed prior or during *** biopsy mostly utilizes circulating tumor cells,or free DNA,but also *** latter are nanovesicles secreted by most cell types,found in any body fluid that deliver proteins,nucleic acids and lipids to nearby and distant cells with a unique homing *** function in signalling between the tumor microenvironment and the rest of the body,promoting metastasis,immune remodelling and drug *** are emerging as a key tool in precision medicine for cancer liquid biopsy,as they efficiently preserve their biomarker ***,exosomes strongly resemble the parental cell,which can help in assessing the oxidative and metabolic state of the donor *** this respect,exosomes represent one of the most promising new tools to fight *** review will discuss the clinical applications of profiling exosomal proteins and lipids by high-throughput proteomics and metabolomics,and nucleic acids by next generation sequencing,as well as how this may allow cancer diagnosis,therapy response monitoring and recurrence detection.

关键词： Cancer Exosome Liquid biopsy Precision medicine

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