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nteraction between natural killer cells and regulatory 7 ：ells： perspectives for immunotherapy

Cellular & Molecular Immunology 2013年第3期10卷 222-229页

作者： isabela pedroza-pacheco alejandro madrigal aurore saudemont Anthony Nolan Research Institute and University College London Royal Free Campus London UK

Regulatory T （Treg） cells and natural killer （NK） cells are key players in the immune system. The interaction between these two cell types has been reported to be beneficial in healthy conditions such as pregnancy. However, in the case of certain pathologies such as autoimmune diseases and cancer this interaction can become detrimental, as Treg cells have been described to suppress NK cells and in particular to impair NK cell effector functions. This review aims to discuss the recent information on the interaction between Treg cells and NK cells under healthy and pathologic conditions, to describe the specific conditions in which this interaction takes place, the effect of Treg cells on hematopoietic stem cell differentiation and the consequences of this interaction on the optimization of immunotherapeutic protocols.

关键词： differentiation effector functions natural killer cells regulatory T cells

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B cell regulation in cancer and anti-tumor immunity

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Cellular & Molecular Immunology 2017年第8期14卷 662-674页

作者： Anushruti Sarvaria J alejandro madrigal aurore saudemont Anthony Nolan and University College London LondonUK

The balance between immune effector cells and immunosuppressive cells and how this regulates the tumor microenvironment has been well described.A significant contribution of immune regulatory cells,including regulatory T cells,to tumor progression has been widely *** emerging body of evidence has recently recognized a role for B cells in modulating the immune response to tumors and lymphoid *** B cells(Bregs)are a newly designated subset of B cells that have been shown to play a pivotal role in regulating immune responses involved in inflammation,autoimmunity and,more recently,*** can suppress diverse cell subtypes,including T cells,through the secretion of anti-inflammatory mediators,such as IL-10,and can facilitate the conversion of T cells to regulatory T cells,thus attenuating anti-tumor immune *** B-cell subpopulations have been reported to be recruited to the tumor but to acquire their immunosuppressive properties within the tumor bed and thereby attenuate anti-tumor immune ***,despite a pivotal role for Bregs in promoting inflammation and carcinogenesis,the phenotypic diversity of the cell surface markers that are unique to Bregs remains unclear in mice and *** this review,we summarize the characteristics of Bregs and review our current knowledge of Bregs and their inhibition of anti-tumor immune responses in murine tumor models and cancer patients.

关键词： cancer immunotherapy regulatory B cells

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Generation of natural killer cells from hematopoietic stem cells in vitro for immunotherapy

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Cellular & Molecular Immunology 2012年第4期9卷 310-320页

作者： Martha Luevano alejandro madrigal aurore saudemont Anthony Nolan Research Institute and University College London Royal Free Campus London UK

Natural killer （NK） cells are part of the innate immune system and are an alluring option for immunotherapy due to their ability to kill infected cells or cancer cells without prior sensitization. Throughout the past 20 years, different groups have been able to reproduce NK cell development in vitro, and NK cell ontogeny studies have provided the basis for the establishment of protocols to produce NK cells in vitro for immunotherapy. Here, we briefly discuss NK cell development and NK cell immunotherapy approaches. We review the factors needed for NK cell differentiation in vitro, which stem cell sources have been used, published protocols, challenges and future directions for Good Manufacturing Practice protocols.

关键词： cord blood natural killer cells differentiation

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